{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:25:05Z","timestamp":1789503905177,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,11,7]],"date-time":"2018-11-07T00:00:00Z","timestamp":1541548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.biopha.2018.11.033","type":"journal-article","created":{"date-parts":[[2018,11,18]],"date-time":"2018-11-18T23:22:16Z","timestamp":1542583336000},"page":"74-84","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Leea macrophylla root extract upregulates the mRNA expression for antioxidative enzymes and repairs the necrosis of pancreatic \u03b2-cell and kidney tissues in fructose-fed Type 2 diabetic rats"],"prefix":"10.1016","volume":"110","author":[{"given":"Jannatul","family":"Mawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Atiar","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Hashem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md.","family":"Juwel Hosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.11.033_bib0005","series-title":"Global status report on non-communicable diseases 2010","author":"World Health Organization","year":"2011"},{"key":"10.1016\/j.biopha.2018.11.033_bib0010","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.2337\/dc10-S062","article-title":"Diagnosis and Classification of Diabetes Mellitus","volume":"33","author":"American Diabetes Association","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.biopha.2018.11.033_bib0015","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1161\/CIRCULATIONAHA.106.175744","article-title":"Preventive cardiology by lifestyle intervention: opportunity and\/or challenge? Presidential address at the 2005 American Heart Association Scientific Sessions","volume":"113","author":"Eckel","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2018.11.033_bib0020","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.numecd.2009.04.002","article-title":"F. Toorang. The efficacy of omega-3 fatty acid supplementation on plasma homocysteine and malondialdehyde levels of type 2 diabetic patients","volume":"20","author":"Pooya","year":"2010","journal-title":"Nutri. metab. Cardiovas. dis."},{"key":"10.1016\/j.biopha.2018.11.033_bib0025","first-page":"S1043","article-title":"Natural products for the treatment of type 2 diabetes mellitus: Pharmacology and mechanisms","author":"Xu","year":"2018","journal-title":"Pharmacol. Res"},{"key":"10.1016\/j.biopha.2018.11.033_bib0030","doi-asserted-by":"crossref","first-page":"e100379","DOI":"10.1371\/journal.pone.0100379","article-title":"Vitamin B12 status in metformin treated patients: systematic review","volume":"9","author":"Q","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2018.11.033_bib0035","doi-asserted-by":"crossref","first-page":"974","DOI":"10.3904\/kjim.2017.354","article-title":"Committee of Clinical Practice Guidelines of the Korean Diabetes Association. Combination therapy of oral hypoglycemic agents in patients with type 2 diabetes mellitus","volume":"32","author":"Moon","year":"2017","journal-title":"Korean J. Intern. Med."},{"key":"10.1016\/j.biopha.2018.11.033_bib0040","series-title":"Definition, diagnosis and classification of diabetes mellitus and its complications: report of a WHO consultation. Part 1, Diagnosis and classification of diabetes mellitus","author":"World Health Organization","year":"1999"},{"key":"10.1016\/j.biopha.2018.11.033_bib0045","first-page":"219","article-title":"On the identity and economic-medical uses of Hastikarnapalsa (Leea macrophylla Roxb., Family Ampelidaceae) as evinced in the ancient texts and traditions","volume":"16","author":"Singh","year":"1981","journal-title":"Ind. J. History Sci."},{"key":"10.1016\/j.biopha.2018.11.033_bib0050","first-page":"2480","article-title":"Evaluation & Study of Minerals from Leea macrophylla Roxb (Leeaceae)","volume":"22","author":"Jadhao","year":"2010","journal-title":"Asian J. Chem."},{"key":"10.1016\/j.biopha.2018.11.033_bib0055","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/356729","article-title":"Antioxidative role of Hatikana (Leea macrophylla Roxb.) partially improves the hepatic damage induced by CCl4 in wister albino rats","author":"Akhter","year":"2015","journal-title":"BioMed Res. Int"},{"key":"10.1016\/j.biopha.2018.11.033_bib0060","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3329\/bjpt.v13i1.596","article-title":"Ethnobotanical survey of medicinal plants in Phulbari Upozila of Dinajpur District, Bangladesh","volume":"13","author":"Uddin","year":"2006","journal-title":"Bangladesh J. Plant Taxonomy."},{"key":"10.1016\/j.biopha.2018.11.033_bib0065","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.jfda.2015.10.010","article-title":"Phytochemical standardization, antioxidant, and antibacterial evaluations of Leea macrophylla: A wild edible plant","volume":"24","author":"Joshi","year":"2016","journal-title":"J. Food Drug Anal."},{"key":"10.1016\/j.biopha.2018.11.033_bib0070","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1002\/fsn3.625","article-title":"Leea macrophylla Roxb. leaf extract potentially helps normalizeislet of \u03b2-cells damaged in STZ-induced albino rats","volume":"6","author":"Rahman","year":"2018","journal-title":"Food Sci. Nutri"},{"key":"10.1016\/j.biopha.2018.11.033_bib0075","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3329\/jsr.v5i2.13213","article-title":"Phytochemical screening and antimicrobial activity studies on Leea macrophylla seed extracts","volume":"5","author":"Islam","year":"2013","journal-title":"J. Sci. Res."},{"key":"10.1016\/j.biopha.2018.11.033_bib0080","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S1995-7645(12)60094-7","article-title":"Whole Leea macrophylla ethanolic extract normalizes kidney deposits and recovers renal impairments in an ethylene glycol-induced urolithiasis model of rats","volume":"5","author":"Nizami","year":"2012","journal-title":"Asian Pac. J. Trop. Med."},{"key":"10.1016\/j.biopha.2018.11.033_bib0085","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.fct.2013.06.038","article-title":"Potential anti-inflammatory effect of Leea macrophylla Roxb. leaves: a wild edible plant","volume":"59","author":"Dewanjee","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2018.11.033_bib0090","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S1734-1140(12)70739-9","article-title":"Fructose-fed streptozotocin-injected rat: an alternative model for type 2 diabetes","volume":"64","author":"Wilson","year":"2012","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.biopha.2018.11.033_bib0095","first-page":"234","volume":"28","author":"Lo","year":"1970","journal-title":"A.W. Taylor. Determination of glycogen in small tissue samples. J. Appl. Physiol."},{"key":"10.1016\/j.biopha.2018.11.033_bib0100","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jep.2011.02.029","article-title":"Centaurium erythrea leaf extract alleviates streptozotocin-induced oxidative stress and \u03b2-cell damage in rat pancreas","volume":"135","author":"Sefi","year":"2011","journal-title":"J. Ethnoparmacol."},{"key":"10.1016\/j.biopha.2018.11.033_bib0105","first-page":"55","article-title":"Ethnobotanical survey of medicinal plants used for the treatment of diabetes mellitus in the north western region of Nigeria","volume":"1","author":"Etuk","year":"2010","journal-title":"Asian J Exp. Biol Sci."},{"key":"10.1016\/j.biopha.2018.11.033_bib0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/JOE-09-0260","article-title":"Current views on type 2 diabetes","volume":"204","author":"Lin","year":"2010","journal-title":"J. Endocrinol"},{"key":"10.1016\/j.biopha.2018.11.033_bib0115","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1111\/jcmm.12865","article-title":"Lentinan protects pancreatic \u03b2 cells from STZ\u2010induced damage","volume":"20","author":"Zhang","year":"2016","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.biopha.2018.11.033_bib0120","first-page":"356","article-title":"The Streptozotocin-Induced Diabetic Nude Mouse Model: Differences between Animals from Different Sources","volume":"61","author":"Graham","year":"2011","journal-title":"Comp Med."},{"key":"10.1016\/j.biopha.2018.11.033_bib0125","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1186\/1472-6882-14-243","article-title":"Antidiabetic, renal\/hepatic\/pancreatic\/cardiac protective and antioxidant potential of methanol\/dichloromethane extract of Albizzia Lebbeck Benth. Stem bark (ALEx) on streptozotocin induced diabetic rats","volume":"14","author":"Ahmed","year":"2014","journal-title":"BMC Complement Altern. Med."},{"key":"10.1016\/j.biopha.2018.11.033_bib0130","first-page":"2717","article-title":"Hypolipidemic and hypoglycemic effects of aerial part of Cynara scolymusin streptozotocin-induced diabetic rats","volume":"5","author":"Heidarian","year":"2011","journal-title":"J. Med. Plants Res."},{"key":"10.1016\/j.biopha.2018.11.033_bib0135","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.mam.2015.09.003","article-title":"Molecular Pathophysiology of Hepatic Glucose Production","volume":"46","author":"Sharabi","year":"2015","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.biopha.2018.11.033_bib0140","first-page":"1791","article-title":"Circulating MicroRNAs as Biomarkers in Health and Disease","volume":"6","author":"Kuzhandai","year":"2012","journal-title":"J. Clin. Diagn. Res."},{"key":"10.1016\/j.biopha.2018.11.033_bib0145","first-page":"69","article-title":"High Creatine Kinase (CK)-MB and Lactate Dehydrogenase in the Absence of Myocardial Injury or Infarction: A Case Report","volume":"6","author":"Maghamiour","year":"2014","journal-title":"J Cardiovasc. Thorac. Res."},{"key":"10.1016\/j.biopha.2018.11.033_bib0150","first-page":"1318","article-title":"A review of natural products with hepatoprotective activity","volume":"4","author":"Afolayan","year":"2010","journal-title":"J. Med. Plants Res"},{"key":"10.1016\/j.biopha.2018.11.033_bib0155","doi-asserted-by":"crossref","first-page":"13","DOI":"10.15835\/nsb346348","article-title":"Antioxidant and Antidiabetic Effect of Hibiscus rosasinensis Flower Extract on streptozotocin Induced Experimental Rats-a Dose Response Study","volume":"3","author":"Sankaran","year":"2011","journal-title":"Notulae Scientia Biologia."},{"key":"10.1016\/j.biopha.2018.11.033_bib0160","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.toxrep.2014.07.012","article-title":"Metabolic response to chronic bisphenol A exposure in C57bl\/6n mice","volume":"7","author":"Patel","year":"2014","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.biopha.2018.11.033_bib0165","doi-asserted-by":"crossref","first-page":"5510","DOI":"10.1074\/jbc.M113.541110","article-title":"Sterol Regulatory Element-binding Protein-1 (SREBP-1) Is Required to Regulate Glycogen Synthesis and Gluconeogenic Gene Expression in Mouse Liver","volume":"289","author":"Ruiz","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2018.11.033_bib0170","first-page":"13","article-title":"Effects of Momordica charantia on pancreatic histopathological changes associated with streptozotocin-induced diabetes in neonatal rats","volume":"26","author":"Abdollahi","year":"2011","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.biopha.2018.11.033_bib0175","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/j.bbrc.2009.12.119","article-title":"Stearic acid attenuates cholestasis-induced liver injury","volume":"391","author":"Pan","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2018.11.033_bib0180","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1745-7254.2007.00512.x","article-title":"Stearic acid protects primary cultured cortical neurons against oxidative stress","volume":"28","author":"Wang","year":"2007","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.biopha.2018.11.033_bib0185","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.2147\/DDDT.S83514","article-title":"Isolation and evaluation of anticancer efficacy of stigmasterol in a mouse model of DMBA-induced skin carcinoma","volume":"9","author":"Ali","year":"2015","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.biopha.2018.11.033_bib0190","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/01.tp.0000189712.74495.82","article-title":"Streptozotocin-induced diabetes in large animals (pigs, primates): role of GLUT2 transporter and \u03b2-cell plasticity","volume":"81","author":"Dufrane","year":"2006","journal-title":"Transplantation"},{"key":"10.1016\/j.biopha.2018.11.033_bib0195","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/j.bcp.2008.01.004","article-title":"Insulin therapy restores impaired function and expression of P-glycoprotein in blood\u2013brain barrier of experimental diabetes","volume":"75","author":"Liu","year":"2008","journal-title":"Biochem. Pharmacol."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218371087?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218371087?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T21:15:26Z","timestamp":1764105326000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218371087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":39,"alternative-id":["S0753332218371087"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.11.033","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Leea macrophylla root extract upregulates the mRNA expression for antioxidative enzymes and repairs the necrosis of pancreatic \u03b2-cell and kidney tissues in fructose-fed Type 2 diabetic rats","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.11.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}