{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T07:18:58Z","timestamp":1769757538454,"version":"3.49.0"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,11,10]],"date-time":"2018-11-10T00:00:00Z","timestamp":1541808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.biopha.2018.11.053","type":"journal-article","created":{"date-parts":[[2018,11,17]],"date-time":"2018-11-17T05:35:41Z","timestamp":1542432941000},"page":"37-46","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Synergistic therapeutic effects of Vitis vinifera extract and Silymarin on experimentally induced cardiorenal injury: The pertinent role of Nrf2"],"prefix":"10.1016","volume":"110","author":[{"given":"Hani M.","family":"Abdelsalam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai A.","family":"Samak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amira E.","family":"Alsemeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"13","key":"10.1016\/j.biopha.2018.11.053_bib0005","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1056\/NEJMoa041365","article-title":"Relation between renal dysfunction and cardiovascular outcomes after myocardial infarction","volume":"351","author":"Anavekar","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biopha.2018.11.053_bib0010","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cbi.2014.12.035","article-title":"Reversal of radiocontrast medium toxicity in human renal proximal tubular cells by white grape juice extract","volume":"229","author":"Andreucci","year":"2015","journal-title":"Chem. Biol. Interact."},{"issue":"1","key":"10.1016\/j.biopha.2018.11.053_bib0015","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000440775","article-title":"The role of congestion in cardiorenal syndrome type 2: new pathophysiological insights into an experimental model of heart failure","volume":"6","author":"Angelini","year":"2016","journal-title":"Cardiorenal Med."},{"issue":"3","key":"10.1016\/j.biopha.2018.11.053_bib0020","first-page":"3","article-title":"A review on the extraction methods use in medicinal plants, principle, strength and limitation","volume":"4","author":"Azwanida","year":"2015","journal-title":"Med. Aromat. Plants (Los Angel)"},{"key":"10.1016\/j.biopha.2018.11.053_bib0025","unstructured":"Bancroft, J., Layton, C., (2013). The Hematoxylin and eosin. Suvarna SK, Layton C and Bancroft JD. Theory and Practice of histological techniques. 7th ed. Churchill Livingstone of El Sevier, Philadelphia, Ch. 10 and 11, pp: 172-214."},{"key":"10.1016\/j.biopha.2018.11.053_bib0030","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.intimp.2016.12.012","article-title":"Nutritionally relevant concentrations of resveratrol and hydroxytyrosol mitigate oxidative burst of human granulocytes and monocytes and the production of pro-inflammatory mediators in LPS-stimulated RAW 264.7 macrophages","volume":"43","author":"Bigagli","year":"2017","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2018.11.053_bib0035","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/eurheartj\/ehi020","article-title":"The severe cardiorenal syndrome:\u2018Guyton revisited\u2019","volume":"26","author":"Bongartz","year":"2004","journal-title":"Eur. Heart J."},{"issue":"3","key":"10.1016\/j.biopha.2018.11.053_bib0040","doi-asserted-by":"crossref","first-page":"H845","DOI":"10.1152\/ajpheart.00261.2011","article-title":"Subtotal nephrectomy plus coronary ligation leads to more pronounced damage in both organs than either nephrectomy or coronary ligation","volume":"302","author":"Bongartz","year":"2012","journal-title":"Am. J. Physiol.-Heart Circulat. Physiol."},{"issue":"1","key":"10.1016\/j.biopha.2018.11.053_bib0045","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nrneph.2013.250","article-title":"Cardiorenal syndrome\u2014current understanding and future perspectives","volume":"10","author":"Braam","year":"2014","journal-title":"Nat. Rev. Nephrol."},{"issue":"2","key":"10.1016\/j.biopha.2018.11.053_bib0050","first-page":"101","article-title":"Effect of Azadirachta indica leaf extract on serum lipid profile changes in normal and streptozotocin induced diabetic rats","volume":"8","author":"Chattopadhyay","year":"2005","journal-title":"Afr. J. Biomed. Res."},{"key":"10.1016\/j.biopha.2018.11.053_bib0055","series-title":"Muscadine Grape Extract Inhibits Breast Cancer Brain Metastatic Cells by Multiple Mechanisms","author":"Chen","year":"2017"},{"issue":"3","key":"10.1016\/j.biopha.2018.11.053_bib0060","first-page":"40","article-title":"A review of clinically relevant cardiac biochemical markers","volume":"101","author":"Chu","year":"2002","journal-title":"WMJ"},{"issue":"4","key":"10.1016\/j.biopha.2018.11.053_bib0065","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/jpi.12357","article-title":"The cardioprotective effect of melatonin and exendin\u20104 treatment in a rat model of cardiorenal syndrome","volume":"61","author":"Chua","year":"2016","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.biopha.2018.11.053_bib0070","series-title":"NRF2 As an Emerging Therapeutic Target","author":"Copple","year":"2017"},{"issue":"6","key":"10.1016\/j.biopha.2018.11.053_bib0075","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1016\/j.bbagen.2013.02.008","article-title":"Natural products: a continuing source of novel drug leads","volume":"1830","author":"Cragg","year":"2013","journal-title":"Biochim. Biophys. Acta (BBA)-Gen.Subj."},{"key":"10.1016\/j.biopha.2018.11.053_bib0080","series-title":"Antiaging Properties of a Grape-derived Antioxidant Are Regulated by Mitochondrial Balance of Fusion and Fission Leading to Mitophagy Triggered by a Signaling Network of Sirt1-Sirt3-Foxo3-PINK1-PARKIN","author":"Das","year":"2014"},{"issue":"10","key":"10.1016\/j.biopha.2018.11.053_bib0085","doi-asserted-by":"crossref","first-page":"12154","DOI":"10.3390\/molecules181012154","article-title":"Effect of black grape juice against heart damage from acute gamma TBI in rats","volume":"18","author":"de Freitas","year":"2013","journal-title":"Molecules"},{"issue":"6","key":"10.1016\/j.biopha.2018.11.053_bib0090","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.3390\/ijms19061812","article-title":"Anti-inflammatory effects of resveratrol: mechanistic insights","volume":"19","author":"de S\u00e1 Coutinho","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.biopha.2018.11.053_bib0095","article-title":"Antioxidant and Anti-hypercholesterolemic potential of Vitis vinifera leaves","volume":"9","author":"Devi","year":"2017","journal-title":"Pharmacogn. Prelim. Phytochem. Investig. Jatrophae Curcatis Semen"},{"issue":"4","key":"10.1016\/j.biopha.2018.11.053_bib0100","first-page":"462","article-title":"Retrospective analysis of the effects of a highly standardized mixture of Berberis aristata, Silybum marianum, and monacolins K and KA in diabetic patients with dyslipidemia","volume":"88","author":"Di Pierro","year":"2018","journal-title":"Acta Bio Medica Atenei Parmensis"},{"issue":"6","key":"10.1016\/j.biopha.2018.11.053_bib0105","doi-asserted-by":"crossref","first-page":"393","DOI":"10.4103\/1995-7645.234768","article-title":"Potential effect of Silybum marianum L. And Cistus ladaniferus L. Extracts on urine volume, creatinine clearance and renal function","volume":"11","author":"El Menyiy","year":"2018","journal-title":"Asian Pac. J. Trop. Med."},{"issue":"280","key":"10.1016\/j.biopha.2018.11.053_bib0110","first-page":"2","article-title":"Efficacy of intradermal injection of tranexamic acid, topical silymarin and glycolic acid peeling in treatment of melasma: a comparative study","volume":"6","author":"Elfar","year":"2015","journal-title":"J. Clin. Exp. Dermatol. Res."},{"issue":"5","key":"10.1016\/j.biopha.2018.11.053_bib0115","first-page":"404","article-title":"Effect of ethanol and aqueous solutions as extraction solvents on phytochemical screening and antibacterial activity of fruit and stem bark extracts of tetrapleura tetrapteraon Streptococcus salivarus and Streptococcus mutans","volume":"4","author":"Gberikon","year":"2015","journal-title":"Int. J. Curr. Microbiol. App. Sci"},{"issue":"6","key":"10.1016\/j.biopha.2018.11.053_bib0120","first-page":"464","article-title":"The effects of milk thistle on hepatic fibrosis due to methotrexate in rat","volume":"11","author":"Ghaffari","year":"2011","journal-title":"Hepat. Mon."},{"key":"10.1016\/j.biopha.2018.11.053_bib0125","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/542026","article-title":"Vitis vinifera (Muscat Variety) seed ethanolic extract preserves activity levels of enzymes and histology of the liver in adult male rats with diabetes","author":"Giribabu","year":"2015","journal-title":"Evid. Based Complement. Altern. Med."},{"issue":"13","key":"10.1016\/j.biopha.2018.11.053_bib0130","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1056\/NEJMoa041031","article-title":"Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization","volume":"351","author":"Go","year":"2004","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.biopha.2018.11.053_bib0135","first-page":"1524","article-title":"Effect of Ethanolic extract of Solanum lycopersicum & Vitis vinifera on lipid profile of diet and drug induced obesity","volume":"4","author":"Goyal","year":"2013","journal-title":"Int. J. Adv. Pharm. Res."},{"issue":"22","key":"10.1016\/j.biopha.2018.11.053_bib0140","doi-asserted-by":"crossref","first-page":"8481","DOI":"10.1021\/jf058015+","article-title":"Antiinflammatory properties of the muscadine grape (Vitis rotundifolia)","volume":"53","author":"Greenspan","year":"2005","journal-title":"J. Agric. Food Chem."},{"issue":"2","key":"10.1016\/j.biopha.2018.11.053_bib0145","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1203\/00006450-200202000-00020","article-title":"Serum lipid and fatty acid profiles in adriamycin-treated rats after administration of L-carnitine","volume":"51","author":"Hong","year":"2002","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.biopha.2018.11.053_bib0150","series-title":"Vascular Incompetence in Dialysis patients\u2014Protein\u2010Bound Uremic Toxins and Endothelial Dysfunction. Seminars in Dialysis (Vol. 24, No. 3, pp. 327-337)","author":"Jourde\u2010Chiche","year":"2011"},{"issue":"2","key":"10.1016\/j.biopha.2018.11.053_bib0155","first-page":"87","article-title":"Protective effects of hydroalcoholic extract of red grape seed (VITIS VENIFERA) in nephrotoxicity induced by amikacin in mice","volume":"2","author":"Kalantari","year":"2007","journal-title":"Jundishapur J. Nat. Pharm. Prod."},{"key":"10.1016\/j.biopha.2018.11.053_bib0160","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3109\/09513590.2013.864270","article-title":"Ultra-structural changes and apoptotic activity in cerebellum of post-menopausal-diabetic rats: a histochemical and ultra-structural study","volume":"30","author":"Kara","year":"2014","journal-title":"J. Gynecol. Endocrinol."},{"issue":"1","key":"10.1016\/j.biopha.2018.11.053_bib0165","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1365-2249.1992.tb05844.x","article-title":"Mesangial sclerotic change with persistent proteinuria in rats after two consecutive injections of monoclonal antibody 1\u201322\u20133","volume":"90","author":"Kawachi","year":"1992","journal-title":"Clin. Exp. Immunol."},{"issue":"6","key":"10.1016\/j.biopha.2018.11.053_bib0170","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1097\/01.ASN.0000064946.94590.46","article-title":"Distant effects of experimental renal ischemia\/reperfusion injury","volume":"14","author":"Kelly","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"issue":"3","key":"10.1016\/j.biopha.2018.11.053_bib0175","doi-asserted-by":"crossref","first-page":"606","DOI":"10.3892\/ijmm.2012.1045","article-title":"Grape skin and loquat leaf extracts and acai puree have potent anti-atherosclerotic and anti-diabetic activity in vitro and in vivo in hypercholesterolemic zebrafish","volume":"30","author":"Kim","year":"2012","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.biopha.2018.11.053_bib0180","doi-asserted-by":"crossref","first-page":"6193","DOI":"10.3390\/molecules15096193","article-title":"Antioxidant activities of celery and parsley juices in rats treated with doxorubicin","volume":"15","author":"Kolarovic","year":"2010","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2018.11.053_bib0185","first-page":"41","article-title":"Cardioprotective effect of lipistat against doxorubicin induced myocardial toxicity in albino rats","volume":"47","author":"Koti","year":"2009","journal-title":"Indian J. Exp. Biol."},{"issue":"2","key":"10.1016\/j.biopha.2018.11.053_bib0190","first-page":"295","article-title":"Silymarin extends lifespan and reduces proteotoxicity in C. Elegans Alzheimer\u2019s model","volume":"14","author":"Kumar","year":"2015","journal-title":"CNS Neurol. Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders)"},{"key":"10.1016\/j.biopha.2018.11.053_bib0195","first-page":"7","article-title":"Protective effect of Vitis vinifera in doxorubicin-induced oxidative stress in rats-A preliminary study","volume":"2","author":"Lakshmi","year":"2014","journal-title":"Int J Adv Pharmacy Med Bioallied Sci"},{"issue":"3","key":"10.1016\/j.biopha.2018.11.053_bib0200","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.etap.2013.01.008","article-title":"Protective potential of Black grapes against lead induced oxidative stress in rats","volume":"35","author":"Lakshmi","year":"2013","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"3","key":"10.1016\/j.biopha.2018.11.053_bib0205","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.etap.2013.01.008","article-title":"Protective \u2009potential of Black grapes against lead induced oxidative stress in rats","volume":"35","author":"Lakshmi","year":"2013","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"9","key":"10.1016\/j.biopha.2018.11.053_bib0210","doi-asserted-by":"crossref","first-page":"H1884","DOI":"10.1152\/ajpheart.00967.2011","article-title":"Myocardial infarction impairs renal function, induces renal interstitial fibrosis, and increases renal KIM-1 expression: implications for cardiorenal syndrome","volume":"302","author":"Lekawanvijit","year":"2012","journal-title":"Am. J. Physiol.-Heart Circulat. Physiol."},{"key":"10.1016\/j.biopha.2018.11.053_bib0215","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.fct.2017.01.021","article-title":"Silymarin protects against acrylamide-induced neurotoxicity via Nrf2 signalling in PC12 cells","volume":"102","author":"Li","year":"2017","journal-title":"Food Chem. Toxicol."},{"issue":"1-2","key":"10.1016\/j.biopha.2018.11.053_bib0220","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1023\/A:1024164608148","article-title":"Protective effect of lipoic acid on adriamycin induced lipid peroxidation in rat kidney","volume":"247","author":"Malarkodi","year":"2003","journal-title":"Mol. Cell. Biochem."},{"issue":"4","key":"10.1016\/j.biopha.2018.11.053_bib0225","first-page":"OC11","article-title":"Effect of silymarin in the prevention of cisplatin nephrotoxicity, a clinical trial study","volume":"9","author":"Momeni","year":"2015","journal-title":"J. Clin. Diagnostic Res.: JCDR"},{"issue":"1","key":"10.1016\/j.biopha.2018.11.053_bib0230","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1159\/000093258","article-title":"Efficacy of darbepoetin in doxorubicin-induced cardiorenal injury in rats","volume":"104","author":"Noiri","year":"2006","journal-title":"Nephron Exp. Nephrol."},{"issue":"2","key":"10.1016\/j.biopha.2018.11.053_bib0235","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2174\/1573402111666141231144228","article-title":"RAAS inhibition and cardiorenal syndrome","volume":"10","author":"Onuigbo","year":"2014","journal-title":"Curr. Hypertens. Rev."},{"issue":"10","key":"10.1016\/j.biopha.2018.11.053_bib0240","first-page":"1029","article-title":"Protective effect of quercetin against adriamycin-induced cardiotoxicity and its mechanism in mice","volume":"42","author":"Pei","year":"2007","journal-title":"Yao xue xue bao= Acta pharmaceutica Sinica"},{"issue":"1","key":"10.1016\/j.biopha.2018.11.053_bib0245","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.tox.2012.07.004","article-title":"Uremic toxin p-cresol induces disassembly of gap junctions of cardiomyocytes","volume":"302","author":"Peng","year":"2012","journal-title":"Toxicology"},{"key":"10.1016\/j.biopha.2018.11.053_bib0250","unstructured":"Petrie A, Sabin C. (2005). Basic techniques for analysing data, Medical statistics at a glance. 2nd ed. Sugden M., Moore K. editors. USA. Blackwell Publishing Ltd. pp:55\u201356."},{"issue":"9","key":"10.1016\/j.biopha.2018.11.053_bib0255","doi-asserted-by":"crossref","first-page":"751","DOI":"10.3109\/00498254.2015.1010633","article-title":"Improvement bioavailability of silymarin ameliorates severe dyslipidemia associated with metabolic syndrome","volume":"45","author":"Poruba","year":"2015","journal-title":"Xenobiotica"},{"issue":"8","key":"10.1016\/j.biopha.2018.11.053_bib0260","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.jfca.2008.07.003","article-title":"Phenolic compounds and antioxidant activities of skins and seeds of five wild grapes and two hybrids native to Japan","volume":"21","author":"Poudel","year":"2008","journal-title":"J. Food Compos. Anal."},{"issue":"1","key":"10.1016\/j.biopha.2018.11.053_bib0265","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3390\/molecules22010068","article-title":"Grape Polyphenols\u2019 effects in human cardiovascular diseases and diabetes","volume":"22","author":"Rasines-Perea","year":"2017","journal-title":"Molecules"},{"issue":"10","key":"10.1016\/j.biopha.2018.11.053_bib0270","doi-asserted-by":"crossref","first-page":"8601","DOI":"10.3390\/molecules16108601","article-title":"The protective effects of silymarin against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats","volume":"16","author":"Ra\u0161kovi\u0107","year":"2011","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.biopha.2018.11.053_bib0275","first-page":"738","article-title":"Effect of Vitis vinifera L seed extract on hepatic marker enzymes and oxidative stress against acetaminophen-induced hepatotoxicity in rats","volume":"2","author":"Rekha","year":"2013","journal-title":"Int. J. Pharm. Chem. Sci."},{"issue":"3","key":"10.1016\/j.biopha.2018.11.053_bib0280","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1093\/clinchem\/47.3.418","article-title":"Evaluation of nine automated high-sensitivity C-reactive protein methods: implications for clinical and epidemiological applications. Part 2","volume":"47","author":"Roberts","year":"2001","journal-title":"Clin. Chem."},{"issue":"2","key":"10.1016\/j.biopha.2018.11.053_bib0285","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.hfc.2013.12.003","article-title":"Cardiorenal syndrome","volume":"10","author":"Ronco","year":"2014","journal-title":"Heart Fail. Clin."},{"issue":"11","key":"10.1016\/j.biopha.2018.11.053_bib0290","doi-asserted-by":"crossref","first-page":"R917","DOI":"10.1152\/ajpregu.00395.2012","article-title":"Antioxidant-based therapies for angiotensin II-associated cardiovascular diseases","volume":"304","author":"Rosenbaugh","year":"2013","journal-title":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"},{"key":"10.1016\/j.biopha.2018.11.053_bib0295","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.fitote.2017.04.012","article-title":"Flavonolignan 2, 3-dehydrosilydianin activates Nrf2 and upregulates NAD (P) H: quinone oxidoreductase 1 in Hepa1c1c7 cells","volume":"119","author":"Roubalov\u00e1","year":"2017","journal-title":"Fitoterapia"},{"issue":"2","key":"10.1016\/j.biopha.2018.11.053_bib0300","doi-asserted-by":"crossref","first-page":"78","DOI":"10.4103\/0975-1483.96620","article-title":"Changes in serum electrolytes, urea, and creatinine in Aloe vera-treated rats","volume":"4","author":"Saka","year":"2012","journal-title":"J. Young Pharm."},{"issue":"17","key":"10.1016\/j.biopha.2018.11.053_bib0305","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1161\/01.CIR.0000095676.90936.80","article-title":"Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on kidney in cardiovascular disease, high blood pressure research, clinical cardiology, and epidemiology and prevention","volume":"108","author":"Sarnak","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2018.11.053_bib0310","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3389\/fnmol.2018.00310","article-title":"p62-Keap1-NRF2-ARE pathway: a contentious player for selective targeting of autophagy, oxidative stress and mitochondrial dysfunction in prion diseases","volume":"11","author":"Shah","year":"2018","journal-title":"Front. Mol. Neurosci."},{"issue":"3","key":"10.1016\/j.biopha.2018.11.053_bib0315","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.fct.2009.12.011","article-title":"Silymarin, the antioxidant component and Silybum marianum extracts prevent liver damage","volume":"48","author":"Shaker","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2018.11.053_bib0320","doi-asserted-by":"crossref","first-page":"106","DOI":"10.17221\/6585-CJFS","article-title":"Extract from Silybum marianum as a nutraceutical: a double-blind placebo-controlled study in healthy young men","volume":"19","author":"\u0160im\u00e1nek","year":"2001","journal-title":"Czech J. Food Sci."},{"issue":"6","key":"10.1016\/j.biopha.2018.11.053_bib0325","first-page":"1287","article-title":"Therapeutic intervention of silymarin on the migration of non-small cell lung cancer cells is associated with the axis of multiple molecular targets including class 1 HDACs, ZEB1 expression, and restoration of miR-203 and E-cadherin expression","volume":"6","author":"Singh","year":"2016","journal-title":"Am. J. Cancer Res."},{"issue":"2","key":"10.1016\/j.biopha.2018.11.053_bib0330","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00392-008-0732-z","article-title":"Differential associations between renal function and \u201cmodifiable\u201d risk factors in patients with chronic heart failure","volume":"98","author":"Smilde","year":"2009","journal-title":"Clin. Res. Cardiol."},{"key":"10.1016\/j.biopha.2018.11.053_bib0335","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.freeradbiomed.2014.10.510","article-title":"Skin resistance to oxidative stress induced by resveratrol: from Nrf2 activation to GSH biosynthesis","volume":"78","author":"Soeur","year":"2015","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.biopha.2018.11.053_bib0340","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jplph.2009.07.011","article-title":"Changes of resveratrol and antioxidant enzymes during UV-induced plant defense response in peanut seedlings","volume":"167","author":"Tang","year":"2010","journal-title":"J. Plant Physiol."},{"key":"10.1016\/j.biopha.2018.11.053_bib0345","first-page":"158","article-title":"ADQI consensus on AKI biomarkers and cardiorenal syndromes","volume":"Vol. 182","author":"Tumlin","year":"2013"},{"issue":"2","key":"10.1016\/j.biopha.2018.11.053_bib0350","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s11255-008-9365-4","article-title":"Antioxidant and protective effects of silymarin on ischemia and reperfusion injury in the kidney tissues of rats","volume":"40","author":"Turgut","year":"2008","journal-title":"Int. Urol. Nephrol."},{"issue":"6","key":"10.1016\/j.biopha.2018.11.053_bib0355","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1159\/000438459","article-title":"Pro-apoptotic effects of plasma from patients with cardiorenal syndrome on human tubular cells","volume":"41","author":"Virz\u00ec","year":"2015","journal-title":"Am. J. Nephrol."},{"issue":"3","key":"10.1016\/j.biopha.2018.11.053_bib0360","doi-asserted-by":"crossref","first-page":"312","DOI":"10.2174\/1381612822666151112150346","article-title":"Mechanism of treatment of kidney deficiency and osteoporosis is similar by Traditional Chinese Medicine","volume":"22","author":"Wang","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.biopha.2018.11.053_bib0365","volume":"Vol. 127","author":"Waynforth","year":"1980"},{"issue":"2","key":"10.1016\/j.biopha.2018.11.053_bib0370","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.jss.2010.11.923","article-title":"Surgical sepsis and organ crosstalk: the role of the kidney","volume":"167","author":"White","year":"2011","journal-title":"J. Surg. Res."},{"issue":"3","key":"10.1016\/j.biopha.2018.11.053_bib0375","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1093\/ndt\/gfq580","article-title":"p-Cresyl sulphate and indoxyl sulphate predict progression of chronic kidney disease","volume":"26","author":"Wu","year":"2010","journal-title":"Nephrol. Dial. Transplant."},{"issue":"2","key":"10.1016\/j.biopha.2018.11.053_bib0380","doi-asserted-by":"crossref","first-page":"622","DOI":"10.3390\/ijms11020622","article-title":"Biological activities of polyphenols from grapes","volume":"11","author":"Xia","year":"2010","journal-title":"Int. J. Mol. Sci."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218370987?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218370987?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T21:24:00Z","timestamp":1764105840000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218370987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":76,"alternative-id":["S0753332218370987"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.11.053","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synergistic therapeutic effects of Vitis vinifera extract and Silymarin on experimentally induced cardiorenal injury: The pertinent role of Nrf2","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.11.053","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}