{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:44:46Z","timestamp":1793814286326,"version":"4.6.1"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T00:00:00Z","timestamp":1542153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","award":["931523"],"award-info":[{"award-number":["931523"]}],"id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.biopha.2018.11.056","type":"journal-article","created":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T12:42:08Z","timestamp":1543236128000},"page":"1834-1840","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":121,"special_numbering":"C","title":["Amelioration of clinical symptoms of patients with refractory rheumatoid arthritis following treatment with autologous bone marrow-derived mesenchymal stem cells: A successful clinical trial in Iran"],"prefix":"10.1016","volume":"109","author":[{"given":"Mohsen","family":"Ghoryani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaleh","family":"Shariati-Sarabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jalil","family":"Tavakkol-Afshari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Ghasemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javad","family":"Poursamimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojgan","family":"Mohammadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.11.056_bib0005","first-page":"175","article-title":"One year in review 2018: pathogenesis of rheumatoid arthritis","volume":"36","author":"Calabresi","year":"2018","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.biopha.2018.11.056_bib0010","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.biopha.2018.11.056_bib0015","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.berh.2017.08.003","article-title":"Genetic and environmental risk factors for rheumatoid arthritis","volume":"31","author":"Deane","year":"2017","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.biopha.2018.11.056_bib0020","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.rdc.2017.04.002","article-title":"Genomic influences on susceptibility and severity of rheumatoid arthritis","volume":"43","author":"Knevel","year":"2017","journal-title":"Rheum. Dis. Clin. North Am."},{"key":"10.1016\/j.biopha.2018.11.056_bib0025","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.imlet.2017.05.010","article-title":"Biomarkers for rheumatoid arthritis: from molecular processes to diagnostic applications-current concepts and future perspectives","volume":"189","author":"Nakken","year":"2017","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.biopha.2018.11.056_bib0030","first-page":"144","article-title":"Biomarkers in Rheumatoid Arthritis, what is new?","volume":"9","author":"Gavrila","year":"2016","journal-title":"J. Med. Life"},{"issue":"Suppl 1","key":"10.1016\/j.biopha.2018.11.056_bib0035","doi-asserted-by":"crossref","DOI":"10.1186\/ar2412","article-title":"T cells in rheumatoid arthritis","volume":"10","author":"Cope","year":"2008","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.biopha.2018.11.056_bib0040","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.autrev.2012.07.011","article-title":"Potential roles for CD8(+) T cells in rheumatoid arthritis","volume":"12","author":"Carvalheiro","year":"2013","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.biopha.2018.11.056_bib0045","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cyto.2014.10.006","article-title":"The role of the Th17 cytokines IL-17 and IL-22 in Rheumatoid Arthritis pathogenesis and developments in cytokine immunotherapy","volume":"74","author":"Roeleveld","year":"2015","journal-title":"Cytokine."},{"key":"10.1016\/j.biopha.2018.11.056_bib0050","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/1756-185X.12132","article-title":"Th17 Cells in Immunopathogenesis and treatment of rheumatoid arthritis","volume":"16","author":"Azizi","year":"2013","journal-title":"Int. J. Rheum. Dis."},{"key":"10.1016\/j.biopha.2018.11.056_bib0055","doi-asserted-by":"crossref","first-page":"R126","DOI":"10.1186\/ar3431","article-title":"Increasing levels of circulating Th17 cells and interleukin-17 in rheumatoid arthritis patients with an inadequate response to anti-TNF-alpha therapy","volume":"13","author":"Chen","year":"2011","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.biopha.2018.11.056_bib0060","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s11926-009-0052-y","article-title":"The role of interleukin-17 in the pathogenesis of rheumatoid arthritis","volume":"11","author":"Gaffen","year":"2009","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.biopha.2018.11.056_bib0065","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/805875","article-title":"The role of different subsets of regulatory T cells in immunopathogenesis of rheumatoid arthritis","volume":"2012","author":"Gol-Ara","year":"2012","journal-title":"Arthritis"},{"key":"10.1016\/j.biopha.2018.11.056_bib0070","first-page":"62","article-title":"The role of T regulatory and TH17 cells in the pathogenesis of rheumatoid arthritis (review)","author":"Kikodze","year":"2016","journal-title":"Georgian Med. News"},{"key":"10.1016\/j.biopha.2018.11.056_bib0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0162306","article-title":"The proportion of regulatory t cells in patients with rheumatoid arthritis: a meta-analysis","volume":"11","author":"Morita","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2018.11.056_bib0080","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.clinthera.2011.05.044","article-title":"Use of biologics in rheumatoid arthritis: current and emerging paradigms of care","volume":"33","author":"Curtis","year":"2011","journal-title":"Clin. Ther."},{"key":"10.1016\/j.biopha.2018.11.056_bib0085","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1136\/annrheumdis-2016-209201","article-title":"Tapering biologic and conventional DMARD therapy in rheumatoid arthritis: current evidence and future directions","volume":"75","author":"Schett","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.biopha.2018.11.056_bib0090","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.2165\/11316650-000000000-00000","article-title":"Benefit-risk assessment of leflunomide: an appraisal of leflunomide in rheumatoid arthritis 10 years after licensing","volume":"32","author":"Alcorn","year":"2009","journal-title":"Drug Saf."},{"key":"10.1016\/j.biopha.2018.11.056_bib0095","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1136\/ard.2008.093690","article-title":"Long-term safety of methotrexate monotherapy in patients with rheumatoid arthritis: a systematic literature research","volume":"68","author":"Salliot","year":"2009","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.biopha.2018.11.056_bib0100","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41413-018-0016-9","article-title":"Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies","volume":"6","author":"Guo","year":"2018","journal-title":"Bone Res."},{"key":"10.1016\/j.biopha.2018.11.056_bib0105","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/BOR.0000000000000370","article-title":"Mesenchymal stem cells for the management of rheumatoid arthritis: immune modulation, repair or both?","volume":"29","author":"Ansboro","year":"2017","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.biopha.2018.11.056_bib0110","first-page":"S58","article-title":"Human mesenchymal stem cells as a tool for joint repair in rheumatoid arthritis","volume":"33","author":"Tanaka","year":"2015","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.biopha.2018.11.056_bib0115","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.berh.2014.10.023","article-title":"Mesenchymal stromal cells for treatment of arthritis","volume":"28","author":"Swart","year":"2014","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.biopha.2018.11.056_bib0120","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/3595941","article-title":"In vitro characterization of human mesenchymal stem cells isolated from different tissues with a potential to promote complex bone regeneration","volume":"2016","author":"Szepesi","year":"2016","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.biopha.2018.11.056_bib0125","first-page":"154","article-title":"Biological properties of mesenchymal Stem Cells from different sources","volume":"2","author":"Via","year":"2012","journal-title":"Muscles Ligaments Tendons J."},{"key":"10.1016\/j.biopha.2018.11.056_bib0130","article-title":"Immunomodulation by mesenchymal stromal cells and their clinical applications","volume":"3","author":"Cagliani","year":"2017","journal-title":"J. Stem Cell Regen. Biol."},{"key":"10.1016\/j.biopha.2018.11.056_bib0135","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/3162743","article-title":"Mesenchymal stem cells regulate the innate and adaptive immune responses dampening arthritis progression","volume":"2016","author":"Contreras","year":"2016","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.biopha.2018.11.056_bib0140","doi-asserted-by":"crossref","first-page":"142","DOI":"10.5966\/sctm.2011-0018","article-title":"Concise review: role of mesenchymal stem cells in wound repair","volume":"1","author":"Maxson","year":"2012","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.biopha.2018.11.056_bib0145","doi-asserted-by":"crossref","DOI":"10.19104\/jbtr.2014.107","article-title":"Mesenchymal stem cell paracrine factors in vascular repair and regeneration","volume":"1","author":"Pankajakshan","year":"2014","journal-title":"J. Biomed. Technol. Res."},{"key":"10.1016\/j.biopha.2018.11.056_bib0150","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/art.20203","article-title":"Enumeration and phenotypic characterization of synovial fluid multipotential mesenchymal progenitor cells in inflammatory and degenerative arthritis","volume":"50","author":"Jones","year":"2004","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.biopha.2018.11.056_bib0155","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1002\/jor.20394","article-title":"Synovial fluid recruits human mesenchymal progenitors from subchondral spongious bone marrow","volume":"25","author":"Endres","year":"2007","journal-title":"J. Orthop. Res."},{"issue":"Suppl 6","key":"10.1016\/j.biopha.2018.11.056_bib0160","first-page":"vi5","article-title":"ACR\/EULAR 2010 rheumatoid arthritis classification criteria","volume":"51","author":"Kay","year":"2012","journal-title":"Rheumatol. Oxford (Oxford)"},{"key":"10.1016\/j.biopha.2018.11.056_bib0165","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1089\/scd.2013.0023","article-title":"Human umbilical cord mesenchymal stem cell therapy for patients with active rheumatoid arthritis: safety and efficacy","volume":"22","author":"Wang","year":"2013","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.biopha.2018.11.056_bib0170","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1001\/archneurol.2010.248","article-title":"Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis","volume":"67","author":"Karussis","year":"2010","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.biopha.2018.11.056_bib0175","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1136\/gut.2010.214841","article-title":"Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn\u2019s disease","volume":"60","author":"Ciccocioppo","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.biopha.2018.11.056_bib0180","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1136\/ard.2009.123463","article-title":"Allogenic mesenchymal stem cells transplantation in refractory systemic lupus erythematosus: a pilot clinical study","volume":"69","author":"Liang","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.biopha.2018.11.056_bib0185","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/bmt.2012.184","article-title":"Mesenchymal SCT ameliorates refractory cytopenia in patients with systemic lupus erythematosus","volume":"48","author":"Li","year":"2013","journal-title":"Bone Marrow Transplant."},{"key":"10.1016\/j.biopha.2018.11.056_bib0190","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s13317-010-0008-2","article-title":"Role of regulatory T cells in rheumatoid arthritis: facts and hypothesis","volume":"1","author":"Alunno","year":"2010","journal-title":"Auto Immun. Highlights"},{"key":"10.1016\/j.biopha.2018.11.056_bib0195","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11538-010-9519-2","article-title":"Self-tolerance and autoimmunity in a regulatory T cell model","volume":"73","author":"Alexander","year":"2011","journal-title":"Bull. Math. Biol."},{"key":"10.1016\/j.biopha.2018.11.056_bib0200","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nm.3432","article-title":"Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis","volume":"20","author":"Komatsu","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.biopha.2018.11.056_bib0205","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1136\/annrheumdis-2015-208918","article-title":"Intravenous administration of expanded allogeneic adipose-derived mesenchymal stem cells in refractory rheumatoid arthritis (Cx611): results of a multicentre, dose escalation, randomised, single-blind, placebo-controlled phase Ib\/IIa clinical trial","volume":"76","author":"Alvaro-Gracia","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.biopha.2018.11.056_bib0210","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s10067-011-1816-0","article-title":"Allogeneic mesenchymal stem cells transplantation in patients with refractory RA","volume":"31","author":"Liang","year":"2012","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.biopha.2018.11.056_bib0215","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/acr.21649","article-title":"Rheumatoid arthritis disease activity measures: American College of Rheumatology recommendations for use in clinical practice","volume":"64","author":"Anderson","year":"2012","journal-title":"Arthritis Care Res. (Hoboken)"},{"key":"10.1016\/j.biopha.2018.11.056_bib0220","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/698192","article-title":"Clinical biomarkers and pathogenic-related cytokines in rheumatoid arthritis","volume":"2014","author":"Niu","year":"2014","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.biopha.2018.11.056_bib0225","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00281-017-0627-z","article-title":"The role of autoantibodies in the pathophysiology of rheumatoid arthritis","volume":"39","author":"Derksen","year":"2017","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.biopha.2018.11.056_bib0230","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1136\/ard.2007.076174","article-title":"Functional, molecular and proteomic characterisation of bone marrow mesenchymal stem cells in rheumatoid arthritis","volume":"67","author":"Kastrinaki","year":"2008","journal-title":"Ann. Rheum. Dis."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218368082?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218368082?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:25:38Z","timestamp":1777875938000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218368082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":46,"alternative-id":["S0753332218368082"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.11.056","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amelioration of clinical symptoms of patients with refractory rheumatoid arthritis following treatment with autologous bone marrow-derived mesenchymal stem cells: A successful clinical trial in Iran","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.11.056","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}