{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:15:35Z","timestamp":1791000935964,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T00:00:00Z","timestamp":1542585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2016YFC0904103"],"award-info":[{"award-number":["2016YFC0904103"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400722"],"award-info":[{"award-number":["81400722"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470944"],"award-info":[{"award-number":["81470944"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670653"],"award-info":[{"award-number":["81670653"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.biopha.2018.11.081","type":"journal-article","created":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T02:50:27Z","timestamp":1543546227000},"page":"2375-2386","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Differential toxicities of triptolide to immortalized podocytes and the podocytes in vivo"],"prefix":"10.1016","volume":"109","author":[{"given":"Mengjie","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaolin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinquan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"June (Supplement)","key":"10.1016\/j.biopha.2018.11.081_bib0005","doi-asserted-by":"crossref","first-page":"S271","DOI":"10.4103\/0973-1482.235340","article-title":"Triptolide: a new star for treating human malignancies","volume":"14","author":"Yan","year":"2018","journal-title":"J. Cancer Res. Ther."},{"issue":"January (2)","key":"10.1016\/j.biopha.2018.11.081_bib0010","doi-asserted-by":"crossref","first-page":"E376","DOI":"10.3390\/ijms19020376","article-title":"The effect of triptolide in rheumatoid arthritis: from basic research towards clinical translation","volume":"19","author":"Fan","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"February (198)","key":"10.1016\/j.biopha.2018.11.081_bib0015","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jep.2016.12.042","article-title":"Traditional Chinese medicine for pulmonary fibrosis therapy: progress and future prospects","volume":"23","author":"Li","year":"2017","journal-title":"J. Ethnopharmacol."},{"issue":"October (3)","key":"10.1016\/j.biopha.2018.11.081_bib0020","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1159\/000449030","article-title":"The clinical manifestation and management of autosomal dominant polycystic kidney disease in China","volume":"2","author":"Xue","year":"2016","journal-title":"Kidney Dis. (Basel)"},{"issue":"September (2)","key":"10.1016\/j.biopha.2018.11.081_bib0025","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1159\/000437288","article-title":"Management of membranous nephropathy in Asia","volume":"1","author":"Xu","year":"2015","journal-title":"Kidney Dis. (Basel)"},{"issue":"July (13)","key":"10.1016\/j.biopha.2018.11.081_bib0030","first-page":"2416","article-title":"Pathomechanisms of podocyte injury in diabetic nephropathy and interventional effects of Chinese herbal medicine","volume":"41","author":"Shi","year":"2016","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"10.1016\/j.biopha.2018.11.081_bib0035","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/ki.2008.203","article-title":"Triptolide protects podocytes from puromycin aminonucleoside induced injury in vivo and in vitro","volume":"74","author":"Zheng","year":"2008","journal-title":"Kidney Int."},{"key":"10.1016\/j.biopha.2018.11.081_bib0040","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1038\/ki.2010.41","article-title":"Triptolide reduces proteinuria in experimental membranous nephropathy and protects against C5b-9 induced podocyte injury in vitro","volume":"77","author":"Chen","year":"2010","journal-title":"Kidney Int."},{"issue":"November (11)","key":"10.1016\/j.biopha.2018.11.081_bib0045","first-page":"5150","article-title":"Triptolide protects podocytes from TGF-\u03b2-induced injury by preventing miR-30 downregulation","volume":"9","author":"Yang","year":"2017","journal-title":"Am. J. Transl. Res."},{"issue":"July (1)","key":"10.1016\/j.biopha.2018.11.081_bib0050","doi-asserted-by":"crossref","first-page":"10843","DOI":"10.1038\/s41598-018-29203-1","article-title":"Triptolide attenuates proteinuria and podocyte apoptosis via inhibition of NF-\u03baB\/GADD45B","volume":"8","author":"Wang","year":"2018","journal-title":"Sci. Rep."},{"issue":"September (3)","key":"10.1016\/j.biopha.2018.11.081_bib0055","doi-asserted-by":"crossref","first-page":"649","DOI":"10.3892\/etm.2013.1226","article-title":"Triptolide markedly attenuates albuminuria and podocyte injury in an animal model of diabetic nephropathy","volume":"6","author":"Ma","year":"2013","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.biopha.2018.11.081_bib0060","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1681\/ASN.V133630","article-title":"A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression","volume":"13","author":"Saleem","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"issue":"September (6)","key":"10.1016\/j.biopha.2018.11.081_bib0065","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1172\/JCI200112367","article-title":"Apoptosis in podocytes induced by TGF-beta and Smad7","volume":"108","author":"Schiffer","year":"2001","journal-title":"J. Clin. Invest."},{"issue":"September (9)","key":"10.1016\/j.biopha.2018.11.081_bib0070","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1681\/ASN.2004121084","article-title":"Role of p38 mitogen-activated protein kinase activation in podocyte injury and proteinuria in experimental nephrotic syndrome","volume":"16","author":"Koshikawa","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"issue":"September (9)","key":"10.1016\/j.biopha.2018.11.081_bib0075","article-title":"Smad2-dependent downregulation of miR-30 is required for TGF-\u03b2-induced apoptosis in podocytes","volume":"8","author":"Shi","year":"2013","journal-title":"PLoS One"},{"issue":"September (9)","key":"10.1016\/j.biopha.2018.11.081_bib0080","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1681\/ASN.2005020142","article-title":"Dexamethasone prevents podocyte apoptosis induced by puromycin aminonucleoside: role of p53 and Bcl-2-related family proteins","volume":"16","author":"Wada","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"issue":"November (5)","key":"10.1016\/j.biopha.2018.11.081_bib0085","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.kint.2017.04.022","article-title":"Genome-wide identification of genes essential for podocyte cytoskeletons based on single-cell RNA sequencing","volume":"92","author":"Lu","year":"2017","journal-title":"Kidney Int."},{"issue":"January (1)","key":"10.1016\/j.biopha.2018.11.081_bib0090","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1681\/ASN.2012111101","article-title":"Downregulation of microRNA-30 facilitates podocyte injury and is prevented by glucocorticoids","volume":"25","author":"Wu","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"issue":"November (11)","key":"10.1016\/j.biopha.2018.11.081_bib0095","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1172\/JCI81061","article-title":"MicroRNA-30 family members regulate calcium\/calcineurin signaling in podocytes","volume":"125","author":"Wu","year":"2015","journal-title":"J. Clin. Invest."},{"issue":"September (6)","key":"10.1016\/j.biopha.2018.11.081_bib0100","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1038\/sj.ki.5001655","article-title":"Direct effects of dexamethasone on human podocytes","volume":"70","author":"Xing","year":"2006","journal-title":"Kidney Int."},{"issue":"April (4)","key":"10.1016\/j.biopha.2018.11.081_bib0105","article-title":"Microarray analyses of glucocorticoid and vitamin D3 target genes in differentiating cultured human podocytes","volume":"8","author":"Cheng","year":"2013","journal-title":"PLoS One"},{"issue":"April (4)","key":"10.1016\/j.biopha.2018.11.081_bib0110","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1111\/j.1523-1755.2005.00205.x","article-title":"Differential proteomic analysis of proteins induced by glucocorticoids in cultured murine podocytes","volume":"67","author":"Ransom","year":"2005","journal-title":"Kidney Int."},{"issue":"8","key":"10.1016\/j.biopha.2018.11.081_bib0115","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1093\/ndt\/gfu363","article-title":"One hundred ways to kill a podocyte","volume":"30","author":"Saleem","year":"2015","journal-title":"Nephrol. Dial. Transplant."},{"issue":"August (8)","key":"10.1016\/j.biopha.2018.11.081_bib0120","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1681\/ASN.2015060676","article-title":"Caspase-1, but not caspase-3, promotes diabetic nephropathy","volume":"27","author":"Shahzad","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"issue":"August (8)","key":"10.1016\/j.biopha.2018.11.081_bib0125","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1681\/ASN.2004121101","article-title":"NF-kappaB regulates Fas-mediated apoptosis in HIV-associated nephropathy","volume":"16","author":"Ross","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"issue":"April (2)","key":"10.1016\/j.biopha.2018.11.081_bib0130","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1093\/toxsci\/kfj106","article-title":"Single and combination toxic metal exposures induce apoptosis in cultured murine podocytes exclusively via the extrinsic caspase 8 pathway","volume":"90","author":"Eichler","year":"2006","journal-title":"Toxicol. Sci."},{"issue":"1","key":"10.1016\/j.biopha.2018.11.081_bib0135","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1159\/000487673","article-title":"Palmitic acid-induced podocyte apoptosis via the reactive oxygen species-dependent mitochondrial pathway","volume":"43","author":"Liu","year":"2018","journal-title":"Kidney Blood Press. Res."},{"issue":"May (5)","key":"10.1016\/j.biopha.2018.11.081_bib0140","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1177\/153537020623100513","article-title":"Diversities of podocyte molecular changes induced by different antiproteinuria drugs","volume":"231","author":"Xing","year":"2006","journal-title":"Exp. Biol. Med. (Maywood)"},{"issue":"June (6)","key":"10.1016\/j.biopha.2018.11.081_bib0145","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.1007\/s11033-014-3222-6","article-title":"Role of nephrin phosphorylation inducted by dexamethasone and angiotensin II in podocytes","volume":"41","author":"Yu","year":"2014","journal-title":"Mol. Biol. Rep."},{"issue":"January (1)","key":"10.1016\/j.biopha.2018.11.081_bib0150","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1681\/ASN.2015060672","article-title":"Kr\u00fcppel-like factor 15 mediates glucocorticoid-induced restoration of podocyte differentiation markers","volume":"28","author":"Mallipattu","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"issue":"November (8)","key":"10.1016\/j.biopha.2018.11.081_bib0155","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/j.1440-1797.2012.01645.x","article-title":"\u03b1-Actinin-4 is involved in the process by which dexamethasone protects actin cytoskeleton stabilization from adriamycin-induced podocyte injury","volume":"17","author":"Liu","year":"2012","journal-title":"Nephrology (Carlton)"},{"issue":"June","key":"10.1016\/j.biopha.2018.11.081_bib0160","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.biopha.2017.04.003","article-title":"Toxicity of triptolide and the molecular mechanisms involved","volume":"90","author":"Xi","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"November (11)","key":"10.1016\/j.biopha.2018.11.081_bib0165","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1093\/ndt\/gfq245","article-title":"Treatment of db\/db diabetic mice with triptolide: a novel therapy for diabetic nephropathy","volume":"25","author":"Gao","year":"2010","journal-title":"Nephrol. Dial. Transplant."},{"issue":"December (13-14)","key":"10.1016\/j.biopha.2018.11.081_bib0170","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1016\/j.intimp.2005.06.009","article-title":"(5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide analog mediates immunosuppressive effects in vitro and in vivo","volume":"5","author":"Zhou","year":"2005","journal-title":"Int. Immunopharmacol."},{"issue":"March (3)","key":"10.1016\/j.biopha.2018.11.081_bib0175","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1053\/ajkd.1998.v31.pm9506681","article-title":"Administration of dexamethasone induces proteinuria of glomerular origin in mice","volume":"31","author":"Chen","year":"1998","journal-title":"Am. J. Kidney Dis."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218363315?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218363315?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:29:16Z","timestamp":1777876156000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218363315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":35,"alternative-id":["S0753332218363315"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.11.081","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential toxicities of triptolide to immortalized podocytes and the podocytes in vivo","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.11.081","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}