{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T14:52:16Z","timestamp":1793112736026,"version":"4.5.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T00:00:00Z","timestamp":1543190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"National Science Foundation for Young Scientists of China","award":["81601910"],"award-info":[{"award-number":["81601910"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571887"],"award-info":[{"award-number":["81571887"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science Foundation for Post Doctorate Research from the Secondary Military Medical University"},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2016M592936"],"award-info":[{"award-number":["2016M592936"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Rising-Star Program","award":["18QA1405400"],"award-info":[{"award-number":["18QA1405400"]}]},{"name":"Shanghai Sailing Program","award":["17YF1425000"],"award-info":[{"award-number":["17YF1425000"]}]},{"name":"Military Medical Research Foundation from the Secondary Military Medical University","award":["2017JS15"],"award-info":[{"award-number":["2017JS15"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.biopha.2018.11.102","type":"journal-article","created":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T05:55:52Z","timestamp":1545026152000},"page":"31-35","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Synergistic effect of vancomycin and l-homocarnosine alleviates Staphylococcus aureus-induced osteomyelitis in rats"],"prefix":"10.1016","volume":"111","author":[{"given":"Panyu","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demeng","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuogui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.11.102_bib0005","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1055\/s-0029-1214167","article-title":"Animal models for the study of osteomyelitis","volume":"23","author":"Patel","year":"2009","journal-title":"Semin. Plast. Surg."},{"key":"10.1016\/j.biopha.2018.11.102_bib0010","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1055\/s-0029-1214158","article-title":"Osteomyelitis of the long bones","volume":"23","author":"Calhoun","year":"2009","journal-title":"Semin. Plast. Surg."},{"key":"10.1016\/j.biopha.2018.11.102_bib0015","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/01.blo.0000088564.81746.62","article-title":"A clinical staging system for adult osteomyelitis","volume":"414","author":"Cierny","year":"2003","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.biopha.2018.11.102_bib0020","doi-asserted-by":"crossref","first-page":"5","DOI":"10.20538\/1682-0363-2016-2-5-12","article-title":"Study of biochemical activities of extracts of Saussurea controversa DC and Filipendula ulmaria (L.) Maxim. In experimental osteomyelitis","volume":"2","author":"Avdeeva","year":"2016","journal-title":"Bull. Siberian Med."},{"key":"10.1016\/j.biopha.2018.11.102_bib0025","doi-asserted-by":"crossref","first-page":"e0123857","DOI":"10.1371\/journal.pone.0123857","article-title":"Effects of beta-alanine supplementation on brain homocarnosine\/carnosine signal and cognitive function: an exploratory study","volume":"10","author":"Solis","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2018.11.102_bib0030","first-page":"1484","volume":"83","author":"Bondarenko","year":"1983","journal-title":"Zh. Nevropatol. Psikhiatr. im S. S. Korsakova."},{"key":"10.1016\/j.biopha.2018.11.102_bib0035","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1073\/pnas.85.9.3175","article-title":"Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain","volume":"85","author":"Kohen","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biopha.2018.11.102_bib0040","first-page":"71","article-title":"Homocarnosine metabolism in brain tissue","volume":"11","author":"Promyslov","year":"1976","journal-title":"Vopr. Biokhim. Mozga"},{"key":"10.1016\/j.biopha.2018.11.102_bib0045","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/jnr.10228","article-title":"Neuroprotective effects of carnosine and homocarnosine on pheochromocytoma PC12 cells exposed to ischemia","volume":"68","author":"Tabakman","year":"2002","journal-title":"J. Neurosci. Res."},{"issue":"2","key":"10.1016\/j.biopha.2018.11.102_bib0050","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0304-4165(02)00158-7","article-title":"Protective effects of carnosine, homocarnosine and anserine against peroxyl radical-mediated Cu, Zn-superoxide dismutase modification","volume":"1570","author":"Kang","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.biopha.2018.11.102_bib0055","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/cid\/cir034","article-title":"Clinical practice guidelines by the infectious diseases society of America for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children: executive summary","volume":"52","author":"Liu","year":"2011","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.biopha.2018.11.102_bib0060","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1093\/jac\/14.3.253","article-title":"Renal tolerance and pharmacokinetics of vancomycin in rats","volume":"14","author":"Marre","year":"1984","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.biopha.2018.11.102_bib0065","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.2147\/DDDT.S84486","article-title":"Treatment of Staphylococcus aureus-induced chronic osteomyelitis with bone-like hydroxyapatite\/poly amino acid loaded with rifapentine microspheres","volume":"9","author":"Yan","year":"2015","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.biopha.2018.11.102_bib0070","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.joad.2016.08.028","article-title":"Aluminium-induced acute neurotoxicity in rats: treatment with aqueous extract of Arthrophytum (Hammada scoparia)","volume":"5","author":"Kaddour","year":"2016","journal-title":"J. Acute Dis."},{"key":"10.1016\/j.biopha.2018.11.102_bib0075","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jobaz.2014.01.003","article-title":"Potential anti-inflammatory effect of lemon and hot pepper extracts on adjuvant-induced arthritis in mice","volume":"67","author":"Hend","year":"2014","journal-title":"J. Basic Appl. Zool."},{"key":"10.1016\/j.biopha.2018.11.102_bib0080","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.jinf.2014.12.016","article-title":"Comparative activities of vancomycin, tigecycline, and rifampin in a rat model of methicillin-resistant Staphylococcus aureus osteomyelitis","volume":"70","author":"Vergidis","year":"2015","journal-title":"J. Infect."},{"key":"10.1016\/j.biopha.2018.11.102_bib0085","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1293\/tox.26.293","article-title":"Biochemical and histological study of rat liver and kidney injury induced by cisplatin","volume":"26","author":"Palipoch","year":"2013","journal-title":"J. Toxicol. Pathol."},{"key":"10.1016\/j.biopha.2018.11.102_bib0090","first-page":"61","article-title":"Useful markers to predict the risk of diabetic and non-diabetic osteomyelitis","volume":"1","author":"Shetty","year":"2010","journal-title":"Res. J. Pharm. Biol. Chem. Sci."},{"key":"10.1016\/j.biopha.2018.11.102_bib0095","first-page":"23","article-title":"The study of the antioxidant enzymes in erythrocytes in lung diseases","volume":"2","author":"Matskevich","year":"2003","journal-title":"Patol. Fiziol. Eksp. Ter. Russian"},{"key":"10.1016\/j.biopha.2018.11.102_bib0100","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S2221-1691(11)60005-1","article-title":"Nitric oxide-mediated Staphylococcus aureus pathogenesis and the protective role of nanoconjugate vancomycin","volume":"1","author":"Chakraborty","year":"2011","journal-title":"Asian Pac. J. Trop. Med."},{"key":"10.1016\/j.biopha.2018.11.102_bib0105","first-page":"12","article-title":"A comparative study of oxidative stress in diabetic and non-diabetic osteomyelitis","volume":"2","author":"D\u2019Silva","year":"2011","journal-title":"Res. J. Pharm. Biol. Chem. Sci."},{"key":"10.1016\/j.biopha.2018.11.102_bib0110","doi-asserted-by":"crossref","first-page":"513","DOI":"10.3109\/00365513.2012.700058","article-title":"The activity of paraoxonase and arylesterase in patients with osteomyelitis","volume":"72","author":"Koruk","year":"2012","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1016\/j.biopha.2018.11.102_bib0115","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.ijbiomac.2018.06.032","article-title":"L-Homocarnosine attenuates inflammation in cerebral ischemia-reperfusion injury through inhibition of Nod-like receptor protein 3 inflammasome","volume":"118","author":"Huang","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.biopha.2018.11.102_bib0120","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s13205-018-1357-1","article-title":"l-Carnosine, and anserine attenuate brain oxidative damage in a pentylenetetrazole-induced epilepsy model of ovariectomized rats","volume":"8","author":"Qi","year":"2018","journal-title":"3 Biotech"},{"key":"10.1016\/j.biopha.2018.11.102_bib0125","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.phymed.2008.06.008","article-title":"Synergism between natural products and antibiotics against infectious diseases","volume":"15","author":"Hemaiswarya","year":"2018","journal-title":"Phytomedicine"},{"key":"10.1016\/j.biopha.2018.11.102_bib0130","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3389\/fcimb.2017.00379","article-title":"Combination of erythromycin and curcumin alleviates Staphylococcus aureus induced osteomyelitis in rats","volume":"7","author":"Zhou","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.biopha.2018.11.102_bib0135","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s12011-016-0662-y","article-title":"The efficacy of boric acid used to treat experimental osteomyelitis caused by methicillin-resistant Staphylococcus aureus: an in vivo study","volume":"173","author":"Guzel","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.biopha.2018.11.102_bib0140","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0140-6736(04)16727-5","article-title":"Osteomyelitis","volume":"364","author":"Lew","year":"2004","journal-title":"Lancet"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218370562?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218370562?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T11:28:53Z","timestamp":1760095733000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218370562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":28,"alternative-id":["S0753332218370562"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.11.102","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synergistic effect of vancomycin and l-homocarnosine alleviates Staphylococcus aureus-induced osteomyelitis in rats","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.11.102","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}