{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T11:37:37Z","timestamp":1783078657605,"version":"3.54.6"},"reference-count":119,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T00:00:00Z","timestamp":1543190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.biopha.2018.11.116","type":"journal-article","created":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T00:03:59Z","timestamp":1544141039000},"page":"2561-2572","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":346,"special_numbering":"C","title":["Anti-inflammatory mechanism of various metal and metal oxide nanoparticles synthesized using plant extracts: A review"],"prefix":"10.1016","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9079-6596","authenticated-orcid":false,"given":"Happy","family":"Agarwal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amatullah","family":"Nakara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3021-6406","authenticated-orcid":false,"given":"Venkat Kumar","family":"Shanmugam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.11.116_bib0005","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.fjps.2016.03.001","article-title":"Antioxidant, cytotoxic and antimicrobial activities of green synthesized silver nanoparticles from crude extract of Bergenia ciliata","volume":"2","author":"Phull","year":"2016","journal-title":"Future J. Pharm. Sci."},{"key":"10.1016\/j.biopha.2018.11.116_bib0010","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.1080\/10717544.2016.1178825","article-title":"Nanoparticle delivery of anticancer drugs overcomes multidrug resistance in breast cancer","volume":"23","author":"Yuan","year":"2016","journal-title":"Drug Deliv."},{"key":"10.1016\/j.biopha.2018.11.116_bib0015","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s12551-016-0246-2","article-title":"Biomedical applications of nanotechnology","volume":"9","author":"Ramos","year":"2017","journal-title":"Biophys. Rev."},{"key":"10.1016\/j.biopha.2018.11.116_bib0020","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.nantod.2016.07.002","article-title":"Nanoparticles with multiple properties for biomedical applications: a strategic guide","volume":"11","author":"De Crozals","year":"2016","journal-title":"Nano Today"},{"key":"10.1016\/j.biopha.2018.11.116_bib0025","doi-asserted-by":"crossref","unstructured":"D.G. and G.X. and J. Luo, Mechanical properties of nanoparticles: basics and applications, J. Phys. D. Appl. Phys. 47 (2014) 13001. http:\/\/stacks.iop.org\/0022-3727\/47\/i=1\/a=013001.","DOI":"10.1088\/0022-3727\/47\/1\/013001"},{"key":"10.1016\/j.biopha.2018.11.116_bib0030","series-title":"Green Synthesis of Metallic Nanoparticles via Biological Entities","author":"Shah","year":"2015"},{"key":"10.1016\/j.biopha.2018.11.116_bib0035","doi-asserted-by":"crossref","first-page":"95","DOI":"10.5487\/TR.2016.32.2.095","article-title":"Bio-inspired green nanoparticles: synthesis, mechanism, and antibacterial application","volume":"32","author":"Velusamy","year":"2016","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.biopha.2018.11.116_bib0040","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3121\/cmr.2007.698","article-title":"An evidence-based update on nonsteroidal anti-inflammatory drugs","volume":"5","author":"Ong","year":"2007","journal-title":"Clin. Med. Res."},{"key":"10.1016\/j.biopha.2018.11.116_bib0045","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1186\/ar4175","article-title":"Nonsteroidal anti-inflammatory drugs and upper and lower gastrointestinal mucosal damage","volume":"15","author":"Sostres","year":"2013","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.biopha.2018.11.116_bib0050","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.crohns.2014.02.024","article-title":"Nanotechnology in the treatment of inflammatory bowel diseases","volume":"8","author":"Viscido","year":"2014","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.biopha.2018.11.116_bib0055","doi-asserted-by":"crossref","unstructured":"S. V, D. MK, Green Synthesis of Silver Nanoparticles from Glycyrrhiza glabra Root Extract for the Treatment of Gastric Ulcer, 2016. doi:10.4172\/2329-6631.1000152.","DOI":"10.4172\/2329-6631.1000152"},{"key":"10.1016\/j.biopha.2018.11.116_bib0060","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1159\/000454882","article-title":"Preparation, characterization and anti-ulcer efficacy of sanguinarine loaded solid lipid nanoparticles","volume":"100","author":"Sun","year":"2017","journal-title":"Pharmacology"},{"key":"10.1016\/j.biopha.2018.11.116_bib0065","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1586\/14787210.2014.930663","article-title":"The potential utility of chitosan micro\/nanoparticles in the treatment of gastric infection","volume":"12","author":"Gon\u00e7alves","year":"2014","journal-title":"Expert Rev. Anti-innfective. Ther."},{"key":"10.1016\/j.biopha.2018.11.116_bib0070","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1039\/C4BM00441H","article-title":"Micro- and nanoparticles for treating cardiovascular disease","volume":"3","author":"Suarez","year":"2015","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.biopha.2018.11.116_bib0075","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.ihj.2017.02.007","article-title":"Nanomedicine in coronary artery disease","volume":"69","author":"Ambesh","year":"2017","journal-title":"Indian Heart J."},{"key":"10.1016\/j.biopha.2018.11.116_bib0080","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nri915","article-title":"Anti-inflammatory lipid mediators and insights into the resolution of inflammation","volume":"2","author":"Lawrence","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.biopha.2018.11.116_bib0085","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2018.11.116_bib0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-9255-1-1","article-title":"The journal of inflammation","volume":"1","author":"Punchard","year":"2004","journal-title":"J. Inflamm."},{"key":"10.1016\/j.biopha.2018.11.116_bib0095","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s11515-011-1123-9","article-title":"An overview of inflammation: mechanism and consequences","volume":"6","author":"Ahmed","year":"2011","journal-title":"Front. Biol. China"},{"key":"10.1016\/j.biopha.2018.11.116_bib0100","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.cell.2010.03.006","article-title":"Inflammation 2010: new adventures of an old flame","volume":"140","author":"Medzhitov","year":"2010","journal-title":"Cell."},{"key":"10.1016\/j.biopha.2018.11.116_bib0105","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.cell.2015.02.010","article-title":"Homeostasis, inflammation, and disease susceptibility","volume":"160","author":"Kotas","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2018.11.116_bib0110","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1212\/WNL.0b013e3181b6bb95","article-title":"Systemic inflammation and disease progression in alzheimer disease","volume":"73","author":"Holmes","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.biopha.2018.11.116_bib0115","series-title":"Preparation, Characterization and Anti- Inflammatory Activity of Chitosan Stabilized Silver Nanoparticles","author":"Sekar","year":"2013"},{"key":"10.1016\/j.biopha.2018.11.116_bib0120","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/toxsci\/kfu202","article-title":"In vivo and in vitro toxicity and anti-inflammatory properties of gold nanoparticle bioconjugates to the vascular system","volume":"142","author":"Uchiyama","year":"2014","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.biopha.2018.11.116_bib0125","doi-asserted-by":"crossref","first-page":"5158","DOI":"10.1021\/acsami.6b15515","article-title":"H2O2-depleting and O2-generating selenium nanoparticles for fluorescence imaging and photodynamic treatment of proinflammatory-activated macrophages","volume":"9","author":"Lu","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.biopha.2018.11.116_bib0130","doi-asserted-by":"crossref","first-page":"51459","DOI":"10.1039\/C4RA10003D","article-title":"One-step biofabrication of copper nanoparticles from Aegle marmelos correa aqueous leaf extract and evaluation of its anti-inflammatory and mosquito larvicidal efficacy","volume":"4","author":"Angajala","year":"2014","journal-title":"RSC Adv."},{"key":"10.1016\/j.biopha.2018.11.116_bib0135","doi-asserted-by":"crossref","unstructured":"S. H P, A. M. G., R. N. D., S. S, Synthesis of nickel nanoparticles via biological entity and their Anti- inflammatory activity, 2017. doi:10.24896\/jmbr.2017731.","DOI":"10.24896\/jmbr.2017731"},{"key":"10.1016\/j.biopha.2018.11.116_bib0140","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12989-014-0038-4","article-title":"Topically applied ZnO nanoparticles suppress allergen induced skin inflammation but induce vigorous IgE production in the atopic dermatitis mouse model","volume":"11","author":"Ilves","year":"2014","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.biopha.2018.11.116_bib0145","doi-asserted-by":"crossref","first-page":"6059","DOI":"10.2147\/IJN.S141201","article-title":"Synthesized zinc peroxide nanoparticles (ZnO2-NPs): a novel antimicrobial, anti-elastase, anti-keratinase, and anti-inflammatory approach toward polymicrobial burn wounds","volume":"12","author":"Ali","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.biopha.2018.11.116_bib0150","first-page":"2706","article-title":"Evaluation of analgesic and anti-inflammatory effect of nanoparticles of magnesium oxide in mice with and without ketamine","volume":"17","author":"Jahangiri","year":"2013","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.biopha.2018.11.116_bib0155","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/eht309.P4174","article-title":"Anti-inflammatory and antioxidant effects of cerium oxide nanoparticles in human endothelial cells","volume":"34","author":"Del Turco","year":"2013","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.biopha.2018.11.116_bib0160","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1743-8977-10-46","article-title":"Iron oxide nanoparticles suppress the production of IL-1beta via the secretory lysosomal pathway in murine microglial cells","volume":"10","author":"Wu","year":"2013","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.biopha.2018.11.116_bib0165","first-page":"737","article-title":"Titanium dioxide nanoparticles prime a specific activation state of macrophages","volume":"11","author":"Huang","year":"2017","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.biopha.2018.11.116_bib0170","doi-asserted-by":"crossref","unstructured":"P.S.B. and T. Krakauer, Regulation of Inflammation: A Review of Recent Advances in Anti- Inflammatory Strategies, Curr. Med. Chem. - Anti-Inflamm. Anti-Allergy Agents. 2 (2003) 274\u2013283. doi:https:\/\/doi.org\/10.2174\/1568014033483752.","DOI":"10.2174\/1568014033483752"},{"key":"10.1016\/j.biopha.2018.11.116_bib0175","doi-asserted-by":"crossref","unstructured":"M.E. Bianchi, A.A. Manfredi, How macrophages ring the inflammation alarm, 111 (2014) 2866\u20132867. doi:10.1073\/pnas.1324285111.","DOI":"10.1073\/pnas.1324285111"},{"key":"10.1016\/j.biopha.2018.11.116_bib0180","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.immuni.2016.02.015","article-title":"Review Macrophages in Tissue Repair, Regeneration, and Fibrosis","volume":"44","author":"Wynn","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.biopha.2018.11.116_bib0185","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.immuni.2014.06.013","article-title":"Origin and functions of tissue macrophages","volume":"41","author":"Epelman","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.biopha.2018.11.116_bib0190","series-title":"Macrophage Polarization in Inflammatory Diseases","author":"Liu","year":"2014"},{"key":"10.1016\/j.biopha.2018.11.116_bib0195","doi-asserted-by":"crossref","unstructured":"D.J. L., The macrophage and its role in inflammation and tissue repair: mathematical and systems biology approaches, Wiley Interdiscip. Rev. Syst. Biol. Med. 8 (2015) 87\u201399. doi:10.1002\/wsbm.1320.","DOI":"10.1002\/wsbm.1320"},{"key":"10.1016\/j.biopha.2018.11.116_bib0200","doi-asserted-by":"crossref","unstructured":"N.F. and K. Kobayashi, Macrophages in Inflammation, Curr. Drug Targets - Inflamm. Allergy. 4 (2005) 281\u2013286. doi:https:\/\/doi.org\/10.2174\/1568010054022024.","DOI":"10.2174\/1568010054022024"},{"key":"10.1016\/j.biopha.2018.11.116_bib0205","first-page":"1","article-title":"Toxicity of nanoparticles and an overview of current experimental models","volume":"20","author":"Bahadar","year":"2016","journal-title":"Iran. Biomed. J."},{"key":"10.1016\/j.biopha.2018.11.116_bib0210","doi-asserted-by":"crossref","unstructured":"J. Zheng, Serum protein adsorption and excretion pathways of metal nanoparticles, 10 (2015) 2781\u20132794.","DOI":"10.2217\/nnm.15.97"},{"key":"10.1016\/j.biopha.2018.11.116_bib0215","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1365-2249.2009.04026.x","article-title":"Natural antibodies, intravenous immunoglobulin and their role in autoimmunity, cancer and inflammation","volume":"158","author":"Schwartz-Albiez","year":"2009","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.biopha.2018.11.116_bib0220","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1365-2249.2009.04081.x","article-title":"The other side of immunoglobulin G: suppressor of inflammation","volume":"160","author":"Aschermann","year":"2010","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.biopha.2018.11.116_bib0225","series-title":"Nanoparticle-Protein Corona Complexes Govern the Biological Fates and Functions of Nanoparticles the Biological Fates and Functions of Nanoparticles","author":"Gunawan","year":"2014"},{"key":"10.1016\/j.biopha.2018.11.116_bib0230","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1039\/C1CS15233E","article-title":"Understanding and controlling the interaction of nanomaterials with proteins in a physiological environment","volume":"41","author":"Walkey","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.biopha.2018.11.116_bib0235","first-page":"1","article-title":"The impact of nanoparticles on cellular functions","volume":"007","author":"Simk\u00f3","year":"2011","journal-title":"Nanotrust Dossiers."},{"key":"10.1016\/j.biopha.2018.11.116_bib0240","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.3762\/bjnano.5.174","article-title":"Different endocytotic uptake mechanisms for nanoparticles in epithelial cells and macrophages","volume":"5","author":"Kuhn","year":"2014","journal-title":"Beilstein J. Nanotechnol."},{"key":"10.1016\/j.biopha.2018.11.116_bib0245","doi-asserted-by":"crossref","first-page":"5610","DOI":"10.1021\/cr100440g","article-title":"Protein\u2212Nanoparticle interactions: opportunities and challenges","volume":"111","author":"Mahmoudi","year":"2011","journal-title":"Chem. Rev."},{"key":"10.1016\/j.biopha.2018.11.116_bib0250","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.2217\/nnm-2016-0233","article-title":"Differential uptake of nanoparticles by human M1 and M2 polarized macrophages: protein corona as a critical determinant","volume":"11","author":"Binnemars-Postma","year":"2016","journal-title":"Nanomedicine"},{"key":"10.1016\/j.biopha.2018.11.116_bib0255","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1602230113","article-title":"Nanoparticles size-dependently initiate self-limiting NETosis-driven inflammation","volume":"113","author":"Mu\u00f1oz","year":"2016","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.biopha.2018.11.116_bib0260","series-title":"Mitochondrial Formation of Reactive Oxygen Species","first-page":"335","author":"Turrens","year":"2003"},{"key":"10.1016\/j.biopha.2018.11.116_bib0265","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1021\/nl902830x","article-title":"Phagocytosis independent extracellular nanoparticle clearance by human immune cells","volume":"10","author":"Bartneck","year":"2010","journal-title":"Nano Lett."},{"key":"10.1016\/j.biopha.2018.11.116_bib0270","article-title":"Green synthesis of silver nanoparticles from ethanolic seed extract of acranythes aspera (Linn.) and its anti-inflammatory activities","volume":"7","author":"Vijayaraj","year":"2016","journal-title":"Int. J. Pharm. Ther."},{"key":"10.1016\/j.biopha.2018.11.116_bib0275","first-page":"2588","article-title":"Biosynthesis of silver nano particles from Leucas aspera (Willd.) link and its anti-inflammatory potential against carrageen induced paw edema in rats","volume":"8","author":"Sri Kumaran","year":"2017","journal-title":"Int. J. Pharm. Sci. Res."},{"key":"10.1016\/j.biopha.2018.11.116_bib0280","doi-asserted-by":"crossref","first-page":"665","DOI":"10.13005\/bbra\/1320","article-title":"Studies on green synthesis, characterization and anti-proliferative potential of silver nano particle using Dodonaea viscosa and Capparis decidua","volume":"11","author":"Giridharan","year":"2014","journal-title":"Biosci. Biotechnol. Res. Asia"},{"key":"10.1016\/j.biopha.2018.11.116_bib0285","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.saa.2014.10.043","article-title":"Biosynthesis of silver nanoparticles using ethanolic petals extract of Rosa indica and characterization of its antibacterial, anticancer and anti-inflammatory activities, Spectrochim","volume":"138","author":"Manikandan","year":"2015","journal-title":"Acta - Part A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.biopha.2018.11.116_bib0290","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.msec.2017.05.122","article-title":"In vitro and in vivo anti-in fl ammatory properties of green synthesized silver nanoparticles using Viburnum opulus L. fruits extract","volume":"79","author":"Moldovan","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.biopha.2018.11.116_bib0295","doi-asserted-by":"crossref","first-page":"5789","DOI":"10.2147\/IJN.S108208","article-title":"Biosynthesis, characterization, and evaluation of bioactivities of leaf extract-mediated biocompatible silver nanoparticles from an early tracheophyte, Pteris tripartita Sw","volume":"11","author":"Baskaran","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.biopha.2018.11.116_bib0300","doi-asserted-by":"crossref","DOI":"10.1088\/2043-6262\/5\/3\/035008","article-title":"Antioxidant and anti-inflammatory activities of silver nanoparticles biosynthesized from aqueous leaves extracts of four Terminalia species","volume":"5","author":"Mohamed El-Rafie","year":"2014","journal-title":"Adv. Nat. Sci. Nanosci. Nanotechnol."},{"key":"10.1016\/j.biopha.2018.11.116_bib0305","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.colsurfb.2014.08.018","article-title":"Green synthesis, characterization and anti-inflammatory activity of silver nanoparticles using European black elderberry fruits extract","volume":"122","author":"David","year":"2014","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.biopha.2018.11.116_bib0310","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.rinp.2018.02.049","article-title":"Characterization, antibacterial, antioxidant, antidiabetic, anti-inflammatory and antityrosinase activity of green synthesized silver nanoparticles using Calophyllum tomentosum leaves extract","volume":"9","author":"Govindappa","year":"2018","journal-title":"Results Phys."},{"key":"10.1016\/j.biopha.2018.11.116_bib0315","doi-asserted-by":"crossref","DOI":"10.4172\/2157-7439.1000268","article-title":"Evaluation of in-vitro anti-inflammatory activity of silver nanoparticles synthesised using Piper nigrum extract","volume":"06","author":"Seethalakshmi S","year":"2015","journal-title":"J. Nanomed. Nanotechnol."},{"key":"10.1016\/j.biopha.2018.11.116_bib0320","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.procbio.2014.03.015","article-title":"Green synthesis of silver nanoparticles with Dalbergia spinosa leaves and their applications in biological and catalytic activities","volume":"49","author":"Muniyappan","year":"2014","journal-title":"Process Biochem."},{"key":"10.1016\/j.biopha.2018.11.116_bib0325","first-page":"P575","article-title":"Enhanced anti inflammatory activity of phyto-stabilized silver nanoparticles on carrageenan induced paw edema in rats","volume":"6","author":"Mani","year":"2015","journal-title":"Int. J. Pharma Biol. Sci."},{"key":"10.1016\/j.biopha.2018.11.116_bib0330","series-title":"Antioxidant and Anti-inflammatory Activity of Green Synthesized Silver Nanoparticles Using Salvia officinalis Extract","author":"Baharara","year":"2017"},{"key":"10.1016\/j.biopha.2018.11.116_bib0335","first-page":"7019","article-title":"Phytofabrication of bioinduced silver nanoparticles for biomedical applications","volume":"10","author":"Ahmad","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.biopha.2018.11.116_bib0340","doi-asserted-by":"crossref","unstructured":"K. S, N. K L, D.A. KP, N. Rajendran, B. K, P. Brindha, IN VITRO ANTI- INFLAMMATORY STUDIES ON SILVER NANOPARTICLES SYNTHESIZED FROM CENTRATHERUM PUNCTATUM CASS., 2016. doi:10.7897\/2277-4343.07258.","DOI":"10.7897\/2277-4343.07258"},{"key":"10.1016\/j.biopha.2018.11.116_bib0345","doi-asserted-by":"crossref","first-page":"370","DOI":"10.22159\/ajpcr.2017.v10i11.19904","article-title":"Anti-inflammatory activity of Syzygium aromaticum silver nanoparticles: in vitro and in silico study","volume":"10","author":"Varghese","year":"2017","journal-title":"Asian J. Pharm. Clin. Res."},{"key":"10.1016\/j.biopha.2018.11.116_bib0350","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1049\/iet-nbt.2016.0245","article-title":"Effect of Ag-NPs synthesised by Chamaemelum nobile extract on the inflammation and oxidative stress induced by carrageenan in mice paw","volume":"11","author":"Erjaee","year":"2017","journal-title":"IET Nanobiotechnol."},{"key":"10.1016\/j.biopha.2018.11.116_bib0355","series-title":"Synthesis of Silver and Gold Nanoparticles from Leaf of Litchi chinensis and its Biological Activities","author":"Murad","year":"2018"},{"key":"10.1016\/j.biopha.2018.11.116_bib0360","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12906-017-1791-3","article-title":"A multi-target therapeutic potential of Prunus domestica gum stabilized nanoparticles exhibited prospective anticancer, antibacterial, urease-inhibition, anti-inflammatory and analgesic properties","volume":"17","author":"Islam","year":"2017","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.biopha.2018.11.116_bib0365","first-page":"1","article-title":"In vitro anti-inflammatory activity of spherical silver nanoparticles and monodisperse hexagonal gold nanoparticles by fruit extract of Prunus serrulata: a green synthetic approach","volume":"0","author":"Singh","year":"2017","journal-title":"Artif. Cells, Nanomed. Biotechnol."},{"key":"10.1016\/j.biopha.2018.11.116_bib0370","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.freeradbiomed.2013.06.006","article-title":"Enhanced antilipopolysaccharide (LPS) induced changes in macrophage functions by Rubia cordifolia (RC) embedded with Au nanoparticles","volume":"65","author":"Singh","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biopha.2018.11.116_bib0375","doi-asserted-by":"crossref","first-page":"21621","DOI":"10.1039\/C8RA03500H","article-title":"Ameliorative effect of biofabricated ZnO nanoparticles of Trianthema portulacastrum Linn. on dermal wounds via removal of oxidative stress and inflammation","volume":"8","author":"Yadav","year":"2018","journal-title":"RSC Adv."},{"key":"10.1016\/j.biopha.2018.11.116_bib0380","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.jphotobiol.2016.07.029","article-title":"Photo-mediated green synthesis of silver and zinc oxide nanoparticles using aqueous extracts of two mangrove plant species, Heritiera fomes and Sonneratia apetala and investigation","volume":"163","author":"Thatoi","year":"2016","journal-title":"J. Photochem. Photobiol. B: Biol. Photo-Mediated, JPB"},{"key":"10.1016\/j.biopha.2018.11.116_bib0385","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jphotobiol.2015.02.008","article-title":"Antioxidant and anti-inflammatory activities of zinc oxide nanoparticles synthesized using Polygala tenuifolia root extract","volume":"146","author":"Nagajyothi","year":"2015","journal-title":"J. Photochem. Photobiol. B, Biol."},{"key":"10.1016\/j.biopha.2018.11.116_bib0390","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00449-017-1840-9","article-title":"Green approach for synthesis of zinc oxide nanoparticles from Andrographis paniculata leaf extract and evaluation of their antioxidant, anti-diabetic, and anti-inflammatory activities","volume":"41","author":"Rajakumar","year":"2018","journal-title":"Bioprocess Biosyst. Eng."},{"key":"10.1016\/j.biopha.2018.11.116_bib0395","doi-asserted-by":"crossref","DOI":"10.1088\/2043-6254\/aa9f4d","article-title":"Comparison of biological activities of selenium and silver nanoparticles attached with bioactive phytoconstituents: green synthesized using Spermacoce hispida extract","volume":"9","author":"Vennila","year":"2018","journal-title":"Adv. Nat. Sci. Nanosci. Nanotechnol."},{"key":"10.1016\/j.biopha.2018.11.116_bib0400","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12951-017-0252-y","article-title":"Selenium nanoparticles decorated with Ulva lactuca polysaccharide potentially attenuate colitis by inhibiting NF-KB mediated hyper inflammation","volume":"15","author":"Zhu","year":"2017","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.biopha.2018.11.116_bib0405","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a001651","article-title":"The nuclear factor NF-\u03baB pathway in inflammation","volume":"1","author":"Lawrence","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.biopha.2018.11.116_bib0410","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1097\/ALN.0b013e3181ee2f17","article-title":"Caspase-1 modulates incisional sensitization and inflammation","volume":"113","author":"Liang","year":"2010","journal-title":"Anesthesiology"},{"key":"10.1016\/j.biopha.2018.11.116_bib0415","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.rmed.2011.09.007","article-title":"The role of mast cells in allergic inflammation","volume":"106","author":"Amin","year":"2012","journal-title":"Respir. Med."},{"key":"10.1016\/j.biopha.2018.11.116_bib0420","doi-asserted-by":"crossref","first-page":"6509","DOI":"10.1166\/jnn.2015.10319","article-title":"Zinc oxide nanoparticles suppress LPS-Induced NF- \u03ba B activation by inducing A20, a negative regulator of NF- \u03ba B, in RAW 264.7 macrophages","volume":"15","author":"Kim","year":"2015","journal-title":"J. Nanosci. Nanotechnol."},{"key":"10.1016\/j.biopha.2018.11.116_bib0425","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1177\/0885328216629822","article-title":"Aluminum-doped zinc oxide nanoparticles attenuate the TSLP levels via suppressing caspase-1 in activated mast cells","volume":"30","author":"Kim","year":"2016","journal-title":"J. Biomater. Appl."},{"key":"10.1016\/j.biopha.2018.11.116_bib0430","doi-asserted-by":"crossref","first-page":"43126","DOI":"10.1038\/srep43126","article-title":"ZnO nanoparticles act as supportive therapy in DSS-induced ulcerative colitis in mice by maintaining gut homeostasis and activating Nrf2 signaling","volume":"7","author":"Li","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2018.11.116_bib0435","series-title":"Thymic Stromal Lymphopoietin is Released by Human Epithelial Cells in Response to Microbes, Trauma, or Infl Ammation and Potently Activates Mast Cells","first-page":"253","author":"Allakhverdi","year":"2007"},{"key":"10.1016\/j.biopha.2018.11.116_bib0440","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.jhep.2013.05.029","article-title":"p53 promotes inflammation-associated hepatocarcinogenesis by inducing HMGB1 release","volume":"59","author":"Yan","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.biopha.2018.11.116_bib0445","doi-asserted-by":"crossref","first-page":"138","DOI":"10.2119\/molmed.2013.00164","article-title":"The role of HMGB1 in the pathogenesis of inflammatory and autoimmune diseases","volume":"20","author":"Magna","year":"2014","journal-title":"Mol. Med."},{"key":"10.1016\/j.biopha.2018.11.116_bib0450","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.1093\/emboj\/cdf478","article-title":"Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals","volume":"21","author":"Eliopoulos","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.biopha.2018.11.116_bib0455","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1159\/000337602","article-title":"Lipopolysaccharide-induced Cyclooxygenase-2 expression in mouse transformed clara cells","volume":"29","author":"Britt","year":"2012","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.biopha.2018.11.116_bib0460","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1574-695X.2007.00329.x","article-title":"The role of nitric oxide in inflammatory reactions","volume":"51","author":"Tripathi","year":"2007","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.biopha.2018.11.116_bib0465","doi-asserted-by":"crossref","unstructured":"C. V Suschek, O.S. and V. Kolb-Bachofen, The Role of iNOS in Chronic Inflammatory Processes In Vivo: Is it Damage-Promoting, Protective, or Active at all?, Curr. Mol. Med. 4 (2004) 763\u2013775. doi:https:\/\/doi.org\/10.2174\/1566524043359908.","DOI":"10.2174\/1566524043359908"},{"key":"10.1016\/j.biopha.2018.11.116_bib0470","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/nm1105","article-title":"Vascular endothelial growth factor (VEGF) induces remodeling and enhances T(H)2-mediated sensitization and inflammation in the lung","volume":"10","author":"Lee","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.biopha.2018.11.116_bib0475","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/rr39","article-title":"Th2 cytokines and asthma: an introduction","volume":"2","author":"Barnes","year":"2001","journal-title":"Respir. Res."},{"key":"10.1016\/j.biopha.2018.11.116_bib0480","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1477-3155-7-8","article-title":"Silver nanoparticles inhibit VEGF-and IL-1beta-induced vascular permeability via Src dependent pathway in porcine retinal endothelial cells","volume":"7","author":"Sheikpranbabu","year":"2009","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.biopha.2018.11.116_bib0485","first-page":"105","article-title":"Hypoxia-inducible factors as essential regulators of inflammation","volume":"345","author":"Imtiyaz","year":"2010","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.biopha.2018.11.116_bib0490","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.1172\/JCI84426","article-title":"Hypoxia-inducible factors: key regulators of myeloid cells during inflammation","volume":"126","author":"Lin","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.biopha.2018.11.116_bib0495","doi-asserted-by":"crossref","first-page":"6679","DOI":"10.2147\/IJN.S109695","article-title":"Silver nanoparticles inhibit the function of hypoxia-inducible factor-1 and target genes: insight into the cytotoxicity and antiangiogenesis","volume":"11","author":"Yang","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.biopha.2018.11.116_bib0500","series-title":"Silver Nanoparticles Modify VEGF Signaling Pathway and Mucus Hypersecretion in Allergic Airway Inflammation","first-page":"1329","author":"Kim","year":"2012"},{"key":"10.1016\/j.biopha.2018.11.116_bib0505","first-page":"1329","article-title":"Silver nanoparticles modify VEGF signaling pathway and mucus hypersecretion in allergic airway inflammation","volume":"7","author":"Jang","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.biopha.2018.11.116_bib0510","first-page":"137","article-title":"Effects of silver nanoparticles on primary cell cultures of fibroblasts and keratinocytes in a wound-healing model","volume":"14","author":"Frankov\u00e1","year":"2016","journal-title":"J. Appl. Biomater. Funct. Mater."},{"key":"10.1016\/j.biopha.2018.11.116_bib0515","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1089\/ars.2012.5149","article-title":"Reactive oxygen species in inflammation and tissue injury","volume":"20","author":"Mittal","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.biopha.2018.11.116_bib0520","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3109\/1547691X.2015.1035819","article-title":"Selective inhibitory effects of 50-nm gold nanoparticles on mouse macrophage and spleen cells","volume":"13","author":"Kingston","year":"2016","journal-title":"J. Immunotoxicol."},{"key":"10.1016\/j.biopha.2018.11.116_bib0525","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/smll.201201528","article-title":"Gold nanoparticles downregulate interleukin-1\u03b2-induced pro-inflammatory responses","volume":"9","author":"Sumbayev","year":"2013","journal-title":"Small"},{"key":"10.1016\/j.biopha.2018.11.116_bib0530","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1161\/01.ATV.0000143096.15099.ce","article-title":"PI3K-Akt pathway suppresses coagulation and inflammation in endotoxemic mice","volume":"24","author":"Schabbauer","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.biopha.2018.11.116_bib0535","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/4350965","article-title":"ROS and ROS-Mediated Cellular Signaling","author":"Zhang","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.biopha.2018.11.116_bib0540","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1136\/gut.52.1.144","article-title":"Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets","volume":"52","author":"Hommes","year":"2003","journal-title":"Gut"},{"key":"10.1016\/j.biopha.2018.11.116_bib0545","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.18632\/oncotarget.6744","article-title":"Kupffer cells-dependent inflammation in the injured liver increases recruitment of mesenchymal stem cells in aging mice","volume":"7","author":"Yang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.biopha.2018.11.116_bib0550","doi-asserted-by":"crossref","unstructured":"T.G. de Carvalho, V.B. Garcia, A.A. de Ara\u00fajo, L.H. da Silva Gasparotto, H. Silva, G.C.B. Guerra, E. de Castro Miguel, R.F. de Carvalho Leit\u00e3o, D.V. da Silva Costa, L.J. Cruz, A.B. Chan, R.F. de Ara\u00fajo J\u00fanior, Spherical neutral Gold nanoparticles improve anti-inflammatory response, oxidative stress and fibrosis in alcohol-methamphetamine-induced liver injury in rats, Int. J. Pharm. (n.d.). doi:10.1016\/j.ijpharm.2018.06.008.","DOI":"10.1016\/j.ijpharm.2018.06.008"},{"key":"10.1016\/j.biopha.2018.11.116_bib0555","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.pbj.2017.05.005","article-title":"Role of platelets in immune system and inflammation","volume":"2","author":"Sonmez","year":"2017","journal-title":"Porto Biomed. J."},{"key":"10.1016\/j.biopha.2018.11.116_bib0560","doi-asserted-by":"crossref","first-page":"15448","DOI":"10.1038\/s41598-017-15792-w","article-title":"Dispersion of TiO2 nanoparticles improves burn wound healing and tissue regeneration through specific interaction with blood serum proteins","volume":"7","author":"Seisenbaeva","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2018.11.116_bib0565","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1538-7836.2009.03413.x","article-title":"Critical roles for thrombin in acute and chronic inflammation","volume":"7","author":"CHEN","year":"2009","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.biopha.2018.11.116_bib0570","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.4081\/ni.2010.e1","article-title":"Thrombin antithrombin complex and IL-18 serum levels in stroke patients","volume":"2","author":"Piazza","year":"2010","journal-title":"Neurol. Int."},{"key":"10.1016\/j.biopha.2018.11.116_bib0575","series-title":"Modulation of the Pharmacokinetics of Zinc Oxide Nanoparticles and their Fates in Vivo","author":"Paek","year":"2013"},{"key":"10.1016\/j.biopha.2018.11.116_bib0580","series-title":"Pharmacokinetics, tissue distribution, and excretion of zinc oxide nanoparticles","author":"Baek","year":"2012"},{"key":"10.1016\/j.biopha.2018.11.116_bib0585","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1080\/13698570701306807","article-title":"Toxic effects of nanoparticles and nanomaterials: implications for public health, risk assessment and the public perception of nanotechnology","volume":"9","author":"Handy","year":"2007","journal-title":"Health Risk Soc."},{"key":"10.1016\/j.biopha.2018.11.116_bib0590","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.nantod.2011.10.001","article-title":"Toxicology and clinical potential of nanoparticles","volume":"6","author":"Yildirimer","year":"2011","journal-title":"Nano Today"},{"key":"10.1016\/j.biopha.2018.11.116_bib0595","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12989-017-0193-5","article-title":"Reduction of pulmonary toxicity of metal oxide nanoparticles by phosphonate-based surface passivation","volume":"14","author":"Cai","year":"2017","journal-title":"Part. Fibre Toxicol."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218371956?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218371956?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:56:24Z","timestamp":1777877784000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218371956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":119,"alternative-id":["S0753332218371956"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.11.116","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-inflammatory mechanism of various metal and metal oxide nanoparticles synthesized using plant extracts: A review","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.11.116","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}