{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:49:44Z","timestamp":1789498184014,"version":"build-2803163510"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T00:00:00Z","timestamp":1543190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006395","name":"Alabama Commission on Higher Education","doi-asserted-by":"publisher","award":["213-58222-2BM2-162"],"award-info":[{"award-number":["213-58222-2BM2-162"]}],"id":[{"id":"10.13039\/100006395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006395","name":"Alabama Commission on Higher Education","doi-asserted-by":"publisher","award":["6380\/Punjab\/NRPU\/R&D\/HEC\/2016"],"award-info":[{"award-number":["6380\/Punjab\/NRPU\/R&D\/HEC\/2016"]}],"id":[{"id":"10.13039\/100006395","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.biopha.2018.11.123","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T14:29:39Z","timestamp":1543415379000},"page":"2285-2292","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"special_numbering":"C","title":["Protective effects of Cinnamomum zeylanicum L. (Darchini) in acetaminophen-induced oxidative stress, hepatotoxicity and nephrotoxicity in mouse model"],"prefix":"10.1016","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2691-7293","authenticated-orcid":false,"given":"Zulfia","family":"Hussain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2630-1744","authenticated-orcid":false,"given":"Junaid Ali","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arfa","family":"Arshad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palwasha","family":"Asif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haroon","family":"Rashid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Imran","family":"Arshad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.11.123_bib0005","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2015.00363","article-title":"Drug-induced liver toxicity and prevention by herbal antioxidants: an overview","volume":"6","author":"Singh","year":"2016","journal-title":"Front. Physiol."},{"key":"10.1016\/j.biopha.2018.11.123_bib0010","first-page":"233","article-title":"Drug-induced hepatotoxicity: a review","volume":"2","author":"Pandit","year":"2012","journal-title":"Int. J. Appl. Pharm. Sci. Res."},{"key":"10.1016\/j.biopha.2018.11.123_bib0015","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1136\/gutjnl-2016-313369","article-title":"Drug-induced liver injury: recent advances in diagnosis and risk assessment","volume":"66","author":"Kullak-Ublick","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.biopha.2018.11.123_bib0020","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1016\/S0140-6736(13)60248-2","article-title":"Infectious diseases in Pakistan: a clear and present danger","volume":"381","author":"Sultan","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.biopha.2018.11.123_bib0025","first-page":"252","article-title":"Drug-induced renal injury","volume":"29","author":"Decloedt","year":"2011","journal-title":"Cont. Med. Educ."},{"key":"10.1016\/j.biopha.2018.11.123_bib0030","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0140-6736(13)60687-X","article-title":"Chronic kidney disease: global dimension and perspectives","volume":"382","author":"Jha","year":"2013","journal-title":"Lancet Lond. Engl."},{"key":"10.1016\/j.biopha.2018.11.123_bib0035","doi-asserted-by":"crossref","first-page":"268","DOI":"10.4062\/biomolther.2012.20.3.268","article-title":"Drug-induced nephrotoxicity and its biomarkers","volume":"20","author":"Kim","year":"2012","journal-title":"Biomol. Ther."},{"key":"10.1016\/j.biopha.2018.11.123_bib0040","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.vetmic.2015.03.010","article-title":"Exposure to environmental stressors result in increased viral load and further reduction of production parameters in pigs experimentally infected with PCV2b","volume":"177","author":"Patterson","year":"2015","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.biopha.2018.11.123_bib0045","article-title":"Protective effects of Glycyrrhizin on LPS and amoxicillin\/potassium clavulanate-induced liver injury in chicken","volume":"6","author":"Yu","year":"2017","journal-title":"Pak. Vet. J."},{"key":"10.1016\/j.biopha.2018.11.123_bib0050","first-page":"2","article-title":"Acetaminophen-induced nephrotoxicity: pathophysiology, clinical manifestations, and management","volume":"4","author":"Mazer","year":"2008","journal-title":"J. Med. Toxicol. Off. J. Am. Coll. Med. Toxicol."},{"key":"10.1016\/j.biopha.2018.11.123_bib0055","first-page":"58","article-title":"Ibuprofen induced nephrotoxicity in adult albino rats","volume":"1","author":"Thangapandian","year":"2012","journal-title":"Int. J. Adv. Life Sci."},{"key":"10.1016\/j.biopha.2018.11.123_bib0060","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jep.2008.12.006","article-title":"Carbon tetrachloride-induced nephrotoxicity in rats: protective role of Digera muricata","volume":"122","author":"Khan","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2018.11.123_bib0065","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3329\/bjp.v8i1.12862","article-title":"Bioactive traditional plant Cinnamomum zeylanicum successfully combat against nephrotoxic effects of aminoglycosides","volume":"8","author":"Ullah","year":"2013","journal-title":"Bangladesh J. Pharmacol."},{"key":"10.1016\/j.biopha.2018.11.123_bib0070","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.jhep.2013.01.035","article-title":"Alcohol and toxicity","volume":"59","author":"Rusyn","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.biopha.2018.11.123_bib0075","article-title":"Comparative evaluation of antioxidant and hepatoprotective activities of some new polyherbal formulations","volume":"6","author":"Sirisha","year":"2013","journal-title":"Int. J. Pharmaceut. Phytopharmacol. Res."},{"key":"10.1016\/j.biopha.2018.11.123_bib0080","first-page":"38","article-title":"Drug-induced liver damage and the problem of its pharmacological correction","volume":"76","author":"Somova","year":"2013","journal-title":"Eksp. Klin. Farmakol."},{"key":"10.1016\/j.biopha.2018.11.123_bib0085","first-page":"743","article-title":"Drug-induced nephrotoxicity","volume":"78","author":"Naughton","year":"2008","journal-title":"Am. Fam. Phys."},{"key":"10.1016\/j.biopha.2018.11.123_bib0090","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3923\/jbs.2015.187.193","article-title":"Acetaminophen induced kidney failure in rats: a dose response study","volume":"15","author":"Roy","year":"2015","journal-title":"J. Biol. Sci."},{"key":"10.1016\/j.biopha.2018.11.123_bib0095","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S1499-3872(17)60014-6","article-title":"Crosstalk of liver immune cells and cell death mechanisms in different murine models of liver injury and its clinical relevance","volume":"16","author":"Khan","year":"2017","journal-title":"Hepatobiliary Pancreat. Dis. Int. HBPD INT."},{"key":"10.1016\/j.biopha.2018.11.123_bib0100","series-title":"Adverse Drug React.","first-page":"369","article-title":"Mechanisms of acetaminophen-induced liver necrosis","author":"Hinson","year":"2010"},{"key":"10.1016\/j.biopha.2018.11.123_bib0105","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0272-6386(96)90046-3","article-title":"Analgesics and the kidney: summary and recommendations to the Scientific Advisory Board of the National Kidney Foundation from an Ad Hoc Committee of the National Kidney Foundation","volume":"27","author":"Henrich","year":"1996","journal-title":"Am. J. Kidney Dis. Off. J. Natl. Kidney Found."},{"key":"10.1016\/j.biopha.2018.11.123_bib0110","first-page":"302","article-title":"Hepatoprotective activity of methanol extract of some medicinal plants against carbon tetrachloride induced hepatotoxicity in albino rats","volume":"37","author":"Ahsan","year":"2009","journal-title":"Eur. J. Sci. Res."},{"key":"10.1016\/j.biopha.2018.11.123_bib0115","first-page":"1685","article-title":"Antidiabetic and hypolipidemic effects of Ceylon cinnamon (Cinnamomum verum) in alloxan-diabetic rats","volume":"6","author":"El-Desoky","year":"2012","journal-title":"J. Med. Plants Res."},{"key":"10.1016\/j.biopha.2018.11.123_bib0120","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/642942","article-title":"Cinnamon: a multifaceted medicinal plant","volume":"2014","author":"Rao","year":"2014","journal-title":"Evid.-Based Complement. Altern. Med. ECAM"},{"key":"10.1016\/j.biopha.2018.11.123_bib0125","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1111\/j.1464-5491.2012.03718.x","article-title":"Efficacy and safety of \u201ctrue\u201d cinnamon (Cinnamomum zeylanicum) as a pharmaceutical agent in diabetes: a systematic review and meta-analysis","volume":"29","author":"Ranasinghe","year":"2012","journal-title":"Diabet. Med. J. Br. Diabet. Assoc."},{"key":"10.1016\/j.biopha.2018.11.123_bib0130","doi-asserted-by":"crossref","first-page":"S652","DOI":"10.4103\/pm.pm_280_16","article-title":"In vitro protoscolicidal effects of Cinnamomum zeylanicum essential oil and its toxicity in mice","volume":"13","author":"Mahmoudvand","year":"2017","journal-title":"Pharmacogn. Mag."},{"key":"10.1016\/j.biopha.2018.11.123_bib0135","doi-asserted-by":"crossref","first-page":"465","DOI":"10.3390\/ijms17040465","article-title":"Hepatoprotective effects of chinese medicinal herbs: a focus on anti-inflammatory and anti-oxidative activities","volume":"17","author":"Lam","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2018.11.123_bib0140","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.2337\/diacare.26.12.3215","article-title":"Cinnamon improves glucose and lipids of people with type 2 diabetes","volume":"26","author":"Khan","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.biopha.2018.11.123_bib0145","doi-asserted-by":"crossref","first-page":"73","DOI":"10.4103\/0974-8490.94719","article-title":"Effects of Cinnamomum zeylanicum (Ceylon cinnamon) on blood glucose and lipids in a diabetic and healthy rat model","volume":"4","author":"Ranasinghe","year":"2012","journal-title":"Pharmacogn. Res."},{"key":"10.1016\/j.biopha.2018.11.123_bib0150","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.clinbiochem.2005.08.008","article-title":"A new automated colorimetric method for measuring total oxidant status","volume":"38","author":"Erel","year":"2005","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.biopha.2018.11.123_bib0155","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.clinbiochem.2003.11.015","article-title":"A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation","volume":"37","author":"Erel","year":"2004","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.biopha.2018.11.123_bib0160","doi-asserted-by":"crossref","first-page":"7S","DOI":"10.1177\/0192623312438738","article-title":"International harmonization of toxicologic pathology nomenclature: an overview and review of basic principles","volume":"40","author":"Mann","year":"2012","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.biopha.2018.11.123_bib0165","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0168-8278(03)00138-7","article-title":"Liver tissue examination","volume":"39","author":"Desmet","year":"2003","journal-title":"J. Hepatol."},{"key":"10.1016\/j.biopha.2018.11.123_bib0170","doi-asserted-by":"crossref","first-page":"72","DOI":"10.5539\/gjhs.v8n3p72","article-title":"Histological stains: a literature review and case study","volume":"8","author":"Alturkistani","year":"2015","journal-title":"Glob. J. Health Sci."},{"key":"10.1016\/j.biopha.2018.11.123_bib0175","series-title":"Elementary Statistics: A Step by Step Approach","author":"Bluman","year":"2018"},{"key":"10.1016\/j.biopha.2018.11.123_bib0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000412","article-title":"Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research","volume":"8","author":"Kilkenny","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1016\/j.biopha.2018.11.123_bib0185","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.taap.2017.11.007","article-title":"Individual serum bile acid profiling in rats aids in human risk assessment of drug-induced liver injury due to BSEP inhibition","volume":"338","author":"Cepa","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.biopha.2018.11.123_bib0190","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1590\/S0100-879X1998000900006","article-title":"Gastric emptying in rats with acetaminophen-induced hepatitis","volume":"31","author":"Hessel","year":"1998","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.biopha.2018.11.123_bib0195","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1365-2125.2010.03819.x","article-title":"Overdose pattern and outcome in paracetamol-induced acute severe hepatotoxicity","volume":"71","author":"Craig","year":"2011","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.biopha.2018.11.123_bib0200","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1007\/s00204-015-1519-4","article-title":"Translational biomarkers of acetaminophen-induced acute liver injury","volume":"89","author":"Beger","year":"2015","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.biopha.2018.11.123_bib0205","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1002\/hep.20948","article-title":"Acute Liver Failure Study Group, Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study","volume":"42","author":"Larson","year":"2005","journal-title":"Hepatol. Baltim. Md."},{"key":"10.1016\/j.biopha.2018.11.123_bib0210","doi-asserted-by":"crossref","DOI":"10.1007\/s00210-018-1526-0","article-title":"Antioxidant resveratrol protects against copper oxide nanoparticle toxicity in vivo","author":"Khalid","year":"2018","journal-title":"Naunyn. Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.biopha.2018.11.123_bib0215","doi-asserted-by":"crossref","first-page":"5552","DOI":"10.3748\/wjg.v13.i42.5552","article-title":"Acute renal dysfunction in liver diseases","volume":"13","author":"Betrosian","year":"2007","journal-title":"World J. Gastroenterol. WJG."},{"key":"10.1016\/j.biopha.2018.11.123_bib0220","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1615\/JEnvironPatholToxicolOncol.2017019457","article-title":"Nephrotoxicity in rats exposed to paracetamol: the protective role of moralbosteroid, a steroidal glycoside","volume":"36","author":"Gupta","year":"2017","journal-title":"J. Environ. Pathol. Toxicol. Oncol. Off. Organ Int. Soc. Environ. Toxicol. Cancer"},{"key":"10.1016\/j.biopha.2018.11.123_bib0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/698383","article-title":"Identification of differentially expressed serum proteins in infectious Purpura fulminans","volume":"2014","author":"He","year":"2014","journal-title":"Dis. Markers"},{"key":"10.1016\/j.biopha.2018.11.123_bib0230","first-page":"25","article-title":"Total protein, albumin and globulin levels following the administration of activity directed fractions of Vernonia amygdalina during acetaminophen induced hepatotoxicity in Wistar albino rats","volume":"18","author":"Ekam","year":"2012","journal-title":"Glob. J. Pure Appl. Sci."},{"key":"10.1016\/j.biopha.2018.11.123_bib0235","doi-asserted-by":"crossref","first-page":"797","DOI":"10.12688\/f1000research.8518.1","article-title":"The natural defense system and the normative self model","volume":"5","author":"Kourilsky","year":"2016","journal-title":"F1000Research"},{"key":"10.1016\/j.biopha.2018.11.123_bib0240","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/WOX.0b013e3182439613","article-title":"Oxidative stress and antioxidant defense","volume":"5","author":"Birben","year":"2012","journal-title":"World Allergy Organ. J."},{"key":"10.1016\/j.biopha.2018.11.123_bib0245","first-page":"495","article-title":"Hepatoprotective activity of cinnamon ethanolic extract against CCI4-induced liver injury in rats","volume":"11","author":"Eidi","year":"2012","journal-title":"EXCLI J."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218356245?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218356245?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:26:01Z","timestamp":1777875961000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218356245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":49,"alternative-id":["S0753332218356245"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.11.123","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effects of Cinnamomum zeylanicum L. (Darchini) in acetaminophen-induced oxidative stress, hepatotoxicity and nephrotoxicity in mouse model","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.11.123","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}