{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T20:26:58Z","timestamp":1788640018626,"version":"build-2803163510"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T00:00:00Z","timestamp":1543276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005279","name":"Universidade Federal do Piau\u00ed","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005279","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.biopha.2018.11.131","type":"journal-article","created":{"date-parts":[[2018,12,8]],"date-time":"2018-12-08T22:58:23Z","timestamp":1544309903000},"page":"631-640","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Antidiarrheal activity of \u03b1-terpineol in mice"],"prefix":"10.1016","volume":"110","author":[{"given":"Polyanna","family":"dos Santos Negreiros","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas Soares","family":"da Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdel\u00e2nia Gomes","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela Borges","family":"de Carvalho Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Barbosa","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca Beatriz","family":"de Melo Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago","family":"de Souza Lopes Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7234-3382","authenticated-orcid":false,"given":"Jand Venes Rolim","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosimeire Ferreira","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"de C\u00e1ssia Meneses Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.11.131_bib0005","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.clinmicnews.2016.08.001","article-title":"Molecular detection of diarrheal pathogens","volume":"38","author":"Smieja","year":"2016","journal-title":"Clin. Microbiol. Newsl."},{"key":"10.1016\/j.biopha.2018.11.131_bib0010","series-title":"Diarrheal Diseases. Encyclopedia of Food and Health","first-page":"361","author":"Bhutta","year":"2016"},{"key":"10.1016\/j.biopha.2018.11.131_bib0015","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.mpmed.2008.11.003","article-title":"Diarrhoea","volume":"37","author":"Patel","year":"2009","journal-title":"Medicine"},{"key":"10.1016\/j.biopha.2018.11.131_bib0020","first-page":"262","article-title":"Diarreia e Constipa\u00e7\u00e3o Intestinal","volume":"37","author":"Dantas","year":"2004","journal-title":"Medicina"},{"key":"10.1016\/j.biopha.2018.11.131_bib0025","unstructured":"Unicef Brazil. Diarrhoea remains a leading killer of young children, despite the availability of a simple treatment solution. https:\/\/data.unicef.org\/topic\/child-health\/diarrhoeal-disease (Accessed 2 June 2018)."},{"key":"10.1016\/j.biopha.2018.11.131_bib0030","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.paed.2016.06.003","article-title":"Investigation of chronic diarrhoea","volume":"26","author":"Auth","year":"2016","journal-title":"Paediatr. Child Health"},{"key":"10.1016\/j.biopha.2018.11.131_bib0035","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.cgh.2013.12.001","article-title":"Discovery and development of antisecretory drugs for treating diarrheal diseases","volume":"12","author":"Thiagarajah","year":"2014","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.biopha.2018.11.131_bib0040","first-page":"410","article-title":"The treatment of small intestinal bacterial overgrowth with enteric-coated peppermint oil: a case report. (Peppermint oil)","volume":"7","author":"Logan","year":"2002","journal-title":"Altern. Med. Rev."},{"key":"10.1016\/j.biopha.2018.11.131_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1472-6882-10-33","article-title":"Newer insights into the mechanism of action of Psidium guajavaL. leaves in infectious diarrhoea","volume":"10","author":"Birdi","year":"2010","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.biopha.2018.11.131_bib0050","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1089\/jmf.2011.1707","article-title":"Antidiarrheal activity of Laurus nobilis L. leaf extract in rats","volume":"15","author":"Qnais","year":"2012","journal-title":"J. Med. Food"},{"key":"10.1016\/j.biopha.2018.11.131_bib0055","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S2095-4964(17)60327-3","article-title":"Antidiarrheal activity of hexane extract of Citrus limon peel in an experimental animal model","volume":"15","author":"Adeniyi","year":"2017","journal-title":"J. Integr. Med."},{"key":"10.1016\/j.biopha.2018.11.131_bib0060","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1590\/S0102-695X2008000300023","article-title":"Survey of medicinal plants used in the region Northeast of Brazil","volume":"18","author":"Agra","year":"2008","journal-title":"Braz. J. Pharm."},{"key":"10.1016\/j.biopha.2018.11.131_bib0065","first-page":"1","article-title":"Medicinal plants from the Brazilian Amazonian region and their antileishmanial activity: a review","author":"Silva","year":"2018","journal-title":"J. Integr. Med."},{"key":"10.1016\/j.biopha.2018.11.131_bib0070","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1742-7843.2012.00875.x","article-title":"\u03b1-terpineol reduces mechanical hypernociception and inflammatory response","volume":"111","author":"Oliveira","year":"2012","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.biopha.2018.11.131_bib0075","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1080\/13880200601028388","article-title":"Evolution of the Anticonvulsant Activity of \u03b1-Terpineol","volume":"45","author":"Sousa","year":"2007","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.biopha.2018.11.131_bib0080","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/ffj.3159","article-title":"Cardiovascular effects induced by a-terpineol in hypertensive rats","volume":"28","author":"Sabino","year":"2013","journal-title":"Flavour Fragr. J."},{"key":"10.1016\/j.biopha.2018.11.131_bib0085","unstructured":"Fernandes, H\u00e9lio de Barros. Prepara\u00e7\u00e3o de nanopart\u00edculas contendo \u03b1-terpineol e seus efeitos sobre les\u00f5es g\u00e1stricas em roedores. 2016. 86 f. Tese (Doutorado em Biotecnologia \u2013 RENORBIO) \u2013 Universidade Federal do Piau\u00ed \u2013 UFPI, Teresina."},{"key":"10.1016\/j.biopha.2018.11.131_bib0090","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1080\/13880200701575304","article-title":"Antidiarrheal activity of the aqueous extract of Punica granatum. (Pomegranate) peels","volume":"45","author":"Qnais","year":"2007","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.biopha.2018.11.131_bib0095","unstructured":"Pach\u00fa, C. O. Processamento de plantas medicinais para obten\u00e7\u00e3o de extratos secos e l\u00edquidos. 2007. 117f. Tese (Doutorado em Engenharia de Processos) \u2013 Universidade Federal de Campina Grande, Campina Grande."},{"key":"10.1016\/j.biopha.2018.11.131_bib0100","first-page":"17","article-title":"An\u00e1lise do conhecimento e uso popular de plantas de quintais urbanos no estado de S\u00e3o Paulo, Brasil","volume":"14","author":"Trotta","year":"2012","journal-title":"REA \u2013 Revista de estudos ambientais"},{"key":"10.1016\/j.biopha.2018.11.131_bib0105","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1007\/BF01295711","article-title":"Loperamide: survey of studies on mechanism antidiarrheal activity","volume":"38","author":"Awouters","year":"1993","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.biopha.2018.11.131_bib0110","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/ptr.2650080110","article-title":"Effects of quercetin on gastrointestinal tract in rats and mice","volume":"8","author":"Dicarlo","year":"1994","journal-title":"Phytother. Res."},{"key":"10.1016\/j.biopha.2018.11.131_bib0115","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/0090-6980(76)90189-1","article-title":"Enteropooling Assay: a test for diarrhea produced by prostaglandins","volume":"11","author":"Robert","year":"1976","journal-title":"Prostaglandins"},{"key":"10.1016\/j.biopha.2018.11.131_bib0120","first-page":"3207","article-title":"a natural xanthone, accelerates gastrointestinal transit in mice involving cholinergic mechanism","volume":"18","author":"Morais","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.biopha.2018.11.131_bib0125","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0378-8741(97)00130-X","article-title":"Screening of anti-diarrhoeal profile of some plant extracts of a specific region of West Bengal, India","volume":"60","author":"Mukherjee","year":"1998","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2018.11.131_bib0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pntd.0002674","article-title":"Antidiarrheal effect and cellular mechanisms of a thai herbal remedy","volume":"8","author":"Tradtrantip","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.biopha.2018.11.131_bib0135","doi-asserted-by":"crossref","first-page":"4373","DOI":"10.1128\/AAC.00122-13","article-title":"Role of 6-Gingerol in reduction of cholera toxin activity in vitro and in vivo","volume":"57","author":"Saha","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.biopha.2018.11.131_bib0140","series-title":"Hospital-based Surveillance for Rotavirus Diarrhea in Ulaanbaatar, Mongolia, April 2009 Through March 2016. Vaccine","author":"Samdan","year":"2018"},{"key":"10.1016\/j.biopha.2018.11.131_bib0145","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/ptr.1907","article-title":"Phytochemicals from traditional medicinal plants used in the treatment of diarrhoea: modes of action and effects on intestinal function","volume":"20","author":"Palombo","year":"2006","journal-title":"Phytother. Res."},{"key":"10.1016\/j.biopha.2018.11.131_bib0150","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1248\/cpb.33.1669","article-title":"Cholagogic action and characteristics of (+\/-)-alpha-terpineol-beta-D-O-glucopyranoside, a new monoterpenoid glucoside","volume":"33","author":"Yamahara","year":"1985","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.biopha.2018.11.131_bib0155","doi-asserted-by":"crossref","first-page":"S280","DOI":"10.1016\/j.fct.2008.06.027","article-title":"Fragrance material review on alpha-terpineol","volume":"46","author":"Bhatia","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2018.11.131_bib0160","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1111\/j.1476-5381.1993.tb13478.x","article-title":"Inhibitors of nitric oxide synthetase prevent castor-oil-induced diarrhoea in the rat","volume":"108","author":"Mascolo","year":"1993","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.biopha.2018.11.131_bib0165","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0006-2952(62)90078-3","article-title":"Studies on the digestion, absorption and metabolism of castor oil","volume":"11","author":"Watson","year":"1962","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biopha.2018.11.131_bib0170","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/(SICI)1099-1573(199909)13:6<468::AID-PTR504>3.0.CO;2-V","article-title":"Relationship between antidiarrhoeal effects of Hange-Shashin-To and its active components","volume":"13","author":"Yoshio","year":"1999","journal-title":"Phytother. Res."},{"key":"10.1016\/j.biopha.2018.11.131_bib0175","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/(SICI)1099-1573(199909)13:6<468::AID-PTR504>3.0.CO;2-V","article-title":"Relationship between the antidiarrhoeal effects of Hange-Shashin-To and its active componentes","volume":"13","author":"Kase","year":"1999","journal-title":"Phytother. Res."},{"key":"10.1016\/j.biopha.2018.11.131_bib0180","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jep.2016.05.036","article-title":"The effect of methanol rhizome extract of Nymphaea lotus Linn. (Nymphaeaceae) in animal models of diarrhoea","volume":"190","author":"Bello","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2018.11.131_bib0185","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1007\/BF01070759","article-title":"Ricinoleic acid: current view of an ancient oil","volume":"20","author":"Gaginella","year":"1975","journal-title":"Dig. Dis."},{"key":"10.1016\/j.biopha.2018.11.131_bib0190","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1023\/A:1018887525293","article-title":"Nitric oxide as a modulator of intestinal water and electrolyte transport","volume":"43","author":"Izzo","year":"1998","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.biopha.2018.11.131_bib0195","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/j.biopha.2017.11.147","article-title":"Evidence based traditional anti-diarrheal medicinal plants and their phytocompounds","volume":"96","author":"RawatA","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2018.11.131_bib0200","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1093\/toxsci\/62.2.330","article-title":"The frequency of U-shaped dose responses in the toxicological literature","volume":"62","author":"Calabrese","year":"2001","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.biopha.2018.11.131_bib0205","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jep.2015.08.020","article-title":"Antidiarrheal activity of cashew GUM, a complex heteropolysaccharide extracted from exudate of Anacardium occidentale L. in rodents","volume":"174","author":"Ara\u00fajo","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2018.11.131_bib0210","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1007\/s00210-016-1298-3","article-title":"Beta-cyclodextrin enhanced gastroprotective effect of (\u2212)-linalool, a monoterpene present in rosewood essential oil, in gastric lesion models","volume":"389","author":"Silva","year":"2016","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.biopha.2018.11.131_bib0215","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1517\/14740338.6.2.125","article-title":"Naloxone treatment in opioid addiction: the risks and benefits","volume":"6","author":"Van Dorp","year":"2007","journal-title":"Expert Opin. Drug Saf."},{"key":"10.1016\/j.biopha.2018.11.131_bib0220","first-page":"15","article-title":"The role of loperamide in gastrointestinal disorders","volume":"8","author":"Hanauer","year":"2008","journal-title":"Rev. Gastroenterol. Disord."},{"key":"10.1016\/j.biopha.2018.11.131_bib0225","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0024-3205(96)00691-1","article-title":"Interaction of ebeinone, an alkaloid from Fritillaria imperialis, at two muscarinic acetylcholine receptor subtypes","volume":"60","author":"Gilani","year":"1997","journal-title":"Life Sci."},{"key":"10.1016\/j.biopha.2018.11.131_bib0230","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1474-8673.2011.00466.x","article-title":"The effect of boric acid on acethylcholine, bethanechol and potasssium-evoked responses on ileum of rat","volume":"31","author":"Ince","year":"2011","journal-title":"Auton. Autacoid Pharmacol."},{"key":"10.1016\/j.biopha.2018.11.131_bib0235","doi-asserted-by":"crossref","first-page":"142","DOI":"10.3390\/60300142","article-title":"Muscarinic receptor agonists and antagonists","volume":"6","author":"Broadley","year":"2001","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2018.11.131_bib0240","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/sj.bjp.0704958","article-title":"Differential peristaltic motor effects of prostanoid (DP, EP, IP, TP) and leukotriene receptor agonists in the guinea pig isolated small intestine","volume":"137","author":"Shahbazian","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.biopha.2018.11.131_bib0245","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S0140-6736(12)60436-X","volume":"379","author":"Harris","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.biopha.2018.11.131_bib0250","doi-asserted-by":"crossref","first-page":"S66","DOI":"10.1016\/S0163-4453(17)30194-9","article-title":"Cholera \u2013 management and prevention","volume":"74","author":"Davies","year":"2017","journal-title":"J. Infect."},{"key":"10.1016\/j.biopha.2018.11.131_bib0255","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/S0140-6736(17)30559-7","article-title":"Cholera","volume":"390","author":"Clemens","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.biopha.2018.11.131_bib0260","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.cam.2016.11.002","article-title":"An epidemic model for cholera with optimal control treatment","volume":"318","author":"Lemos-Pai\u00e3o","year":"2017","journal-title":"J. Comput. Appl. Math."},{"key":"10.1016\/j.biopha.2018.11.131_bib0265","doi-asserted-by":"crossref","first-page":"15244","DOI":"10.1021\/la5036618","article-title":"Insights into binding of cholera toxin to GM1 containing membrane","volume":"30","author":"Basu","year":"2014","journal-title":"Langmuir"},{"key":"10.1016\/j.biopha.2018.11.131_bib0270","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.tips.2005.02.003","article-title":"New drug targets for cholera therapy","volume":"26","author":"Thiagarajah","year":"2005","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.biopha.2018.11.131_bib0275","first-page":"179","article-title":"Cholera toxin: a paradigm of a multifunctional protein","volume":"133","author":"Bharati","year":"2011","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.biopha.2018.11.131_bib0280","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.ijbiomac.2016.02.028","article-title":"The efficacy of a sulphated polysaccharide fraction from Hypnea musciformis against diarrhea in rodents","volume":"86","author":"Sousa","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.biopha.2018.11.131_bib0285","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ijbiomac.2017.01.006","article-title":"Anti-diarrhoeal therapeutic potential and safety assessment of sulphated polysaccharide fraction from Gracilaria intermedia seaweed in mice","volume":"97","author":"Le\u00f3dido","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.biopha.2018.11.131_bib0290","first-page":"1","article-title":"H2S is a key antisecretory molecule against cholera toxin-induced diarrhoea in mice: evidence for non-involvement of the AC\/cAMP\/PKA pathway and AMPK","author":"Sousa","year":"2017","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.biopha.2018.11.131_bib0295","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.biopha.2017.11.019","article-title":"Antidiarrheal effects of water-soluble proteins from Plumeria pudica latex in mice","volume":"97","author":"Santana","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2018.11.131_bib0300","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1016\/j.bbrc.2017.12.065","article-title":"Effects of dietary glucose and sodium chloride on intestinal glucose absorption of common carp (Cyprinus carpio L.)","volume":"495","author":"Qin","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2018.11.131_bib0305","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/clpt.2012.114","article-title":"CFTR inhibitors for treating diarrheal disease","volume":"92","author":"Thiagarajah","year":"2012","journal-title":"Clin. Pharmacol. Therap."},{"key":"10.1016\/j.biopha.2018.11.131_bib0310","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1007\/s12035-015-9136-z","article-title":"GM1 ganglioside: past studies and future potential","volume":"53","author":"Aureli","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.biopha.2018.11.131_bib0315","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/bcpt.12531","article-title":"Sulphated polysaccharide Isolated from the seaweed Gracilaria caudata exerts an antidiarrhoeal effect in rodents","volume":"118","author":"Costa","year":"2016","journal-title":"Basic Clin. Pharmacol. Toxicol."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218346432?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218346432?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T21:20:41Z","timestamp":1764105641000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218346432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":63,"alternative-id":["S0753332218346432"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.11.131","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antidiarrheal activity of \u03b1-terpineol in mice","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.11.131","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}