{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:43:14Z","timestamp":1784824994461,"version":"3.55.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T00:00:00Z","timestamp":1543363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81274085"],"award-info":[{"award-number":["81274085"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["J13100340"],"award-info":[{"award-number":["J13100340"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008402","name":"Chengdu University of Traditional Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008402","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.biopha.2018.11.147","type":"journal-article","created":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T06:26:56Z","timestamp":1543818416000},"page":"302-311","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Er Shen Wan extract alleviates polyuria and regulates AQP 2 and AVPR 2 in a rat model of spleen-kidney Yang deficiency\u2013induced diarrhea"],"prefix":"10.1016","volume":"110","author":[{"given":"Rui","family":"Xiong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaixuan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumei","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjiang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.11.147_bib0005","first-page":"47","article-title":"Fructus Psoraleae \u2013 Buguzhi","volume":"Vol. 4","author":"Wagner","year":"2016"},{"issue":"5","key":"10.1016\/j.biopha.2018.11.147_bib0010","first-page":"321","article-title":"Yang-tonifying traditional Chinese medicinal plants and their potential phytoandrogenic activity","volume":"12","author":"Edouard","year":"2014","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.biopha.2018.11.147_bib0015","series-title":"Dietary Chinese Herbs","first-page":"439","article-title":"Myristica fragrans Houtt. \u8089\u8c46\u853b (Roudoukou, Nutmeg)","author":"Ding","year":"2015"},{"issue":"1","key":"10.1016\/j.biopha.2018.11.147_bib0020","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1749-6632.2009.04404.x","article-title":"A traditional Tibetan medical response to advancements in basic longevity research","volume":"1172","author":"Dakpa","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"6","key":"10.1016\/j.biopha.2018.11.147_bib0025","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s11101-016-9469-x","article-title":"Chemical diversity and pharmacological significance of the secondary metabolites of nutmeg (Myristica fragrans Houtt.)","volume":"15","author":"Abourashed","year":"2016","journal-title":"Phytochem. Rev."},{"key":"10.1016\/j.biopha.2018.11.147_bib0030","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.biopha.2018.01.023","article-title":"Er Shen Wan extract reduces diarrhea and regulates AQP 4 and NHE 3 in a rat model of spleen-kidney Yang deficiency\u2013induced diarrhea","volume":"98","author":"Xiong","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"11","key":"10.1016\/j.biopha.2018.11.147_bib0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113398","article-title":"Berberine improves kidney function in diabetic mice via AMPK activation","volume":"9","author":"Zhao","year":"2014","journal-title":"PLoS One"},{"issue":"23","key":"10.1016\/j.biopha.2018.11.147_bib0040","first-page":"4658","article-title":"Research on building method of spleen kidney Yang deficiency diarrhea rats model","volume":"39","author":"Pan","year":"2014","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"issue":"11","key":"10.1016\/j.biopha.2018.11.147_bib0045","doi-asserted-by":"crossref","first-page":"12222","DOI":"10.18632\/oncotarget.7731","article-title":"The mitochondrial and death receptor pathways involved in the thymocytes apoptosis induced by aflatoxin B1","volume":"7","author":"Peng","year":"2016","journal-title":"Oncotarget"},{"issue":"1-3","key":"10.1016\/j.biopha.2018.11.147_bib0050","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s12011-014-9999-2","article-title":"Effects of sodium selenite on aflatoxin B1-induced decrease of ileac T cell and the mRNA contents of IL-2, IL-6, and TNF-\u03b1 in broilers","volume":"159","author":"He","year":"2014","journal-title":"Biol. Trace Elem. Res."},{"issue":"1","key":"10.1016\/j.biopha.2018.11.147_bib0055","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s12011-012-9595-2","article-title":"Dietary high fluorine induces apoptosis and alters bcl-2, bax, and caspase-3 protein expression in the cecal tonsil lymphocytes of broilers","volume":"152","author":"Liu","year":"2013","journal-title":"Biol. Trace Elem. Res."},{"issue":"30","key":"10.1016\/j.biopha.2018.11.147_bib0060","doi-asserted-by":"crossref","first-page":"28607","DOI":"10.18632\/oncotarget.5759","article-title":"Nickel chloride (NiCl2)-caused inflammatory responses via activation of NF-\u03baB pathway and reduction of anti-inflammatory mediator expression in the kidney","volume":"6","author":"Guo","year":"2015","journal-title":"Oncotarget."},{"issue":"34","key":"10.1016\/j.biopha.2018.11.147_bib0065","doi-asserted-by":"crossref","first-page":"35964","DOI":"10.18632\/oncotarget.5934","article-title":"Dietary NiCl2 causes G2\/M cell cycle arrest in the broiler\u2019s kidney","volume":"6","author":"Guo","year":"2015","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.biopha.2018.11.147_bib0070","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.juro.2015.09.076","article-title":"Nocturnal polyuria: excess of nocturnal urine production, excess of definitions\u2014influence on renal function profile","volume":"195","author":"Goessaert","year":"2016","journal-title":"J. Urol."},{"issue":"5","key":"10.1016\/j.biopha.2018.11.147_bib0075","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/S0195-5616(01)50001-7","article-title":"Polyuria and polydipsia: diagnostic approach and problems associated with patient evaluation","volume":"31","author":"Nichols","year":"2001","journal-title":"Vet. Clin. North Am. Small Anim. Pract."},{"issue":"4","key":"10.1016\/j.biopha.2018.11.147_bib0080","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s11102-015-0703-0","article-title":"Arginine vasopressin (AVP): a review of its historical perspectives, current research and multifunctional role in the hypothalamo-hypophysial system","volume":"19","author":"Rotondo","year":"2016","journal-title":"Pituitary"},{"issue":"10","key":"10.1016\/j.biopha.2018.11.147_bib0085","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1111\/j.1532-5415.2000.tb02608.x","article-title":"Nocturnal polyuria in older people: pathophysiology and clinical implications","volume":"48","author":"Miller","year":"2000","journal-title":"J. Am. Geriatr. Soc."},{"issue":"12","key":"10.1016\/j.biopha.2018.11.147_bib0090","doi-asserted-by":"crossref","first-page":"5693","DOI":"10.1091\/mbc.e04-04-0337","article-title":"Regulation of the vasopressin V2 receptor by vasopressin in polarized renal collecting duct cells","volume":"15","author":"Robben","year":"2004","journal-title":"Mol. Biol. Cell"},{"issue":"2","key":"10.1016\/j.biopha.2018.11.147_bib0095","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.juro.2006.03.028","article-title":"A clinical investigation of nocturnal polyuria in patients with nocturia: a diurnal variation in arginine vasopressin secretion and its relevance to mean blood pressure","volume":"176","author":"Natsume","year":"2006","journal-title":"J. Urol."},{"issue":"4","key":"10.1016\/j.biopha.2018.11.147_bib0100","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.ecl.2006.09.011","article-title":"Disorders of body water homeostasis in critical illness","volume":"35","author":"Adler","year":"2006","journal-title":"Endocrinol. Metab. Clin. North Am."},{"issue":"6","key":"10.1016\/j.biopha.2018.11.147_bib0105","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1161\/HYPERTENSIONAHA.117.09746","article-title":"Dysregulation of aldosterone secretion in mast cell\u2013Deficient mice","volume":"70","author":"Boyer","year":"2017","journal-title":"Hypertension"},{"issue":"24","key":"10.1016\/j.biopha.2018.11.147_bib0110","doi-asserted-by":"crossref","first-page":"21639","DOI":"10.1074\/jbc.M212388200","article-title":"Dual influence of aldosterone on AQP2 expression in cultured renal collecting duct principal cells","volume":"278","author":"Hasler","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2018.11.147_bib0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep15482","article-title":"Endogenously elevated bilirubin modulates kidney function and protects from circulating oxidative stress in a rat model of adenine-induced kidney failure","volume":"5","author":"Boon","year":"2015","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.biopha.2018.11.147_bib0120","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s12519-015-0073-8","article-title":"Obstructive uropathy and severe acute kidney injury from renal calculi due to adenine phosphoribosyltransferase deficiency","volume":"12","author":"Chong","year":"2016","journal-title":"World J. Pediatr."},{"issue":"5-6","key":"10.1016\/j.biopha.2018.11.147_bib0125","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.mam.2012.01.002","article-title":"Aquaporins in drug discovery and pharmacotherapy","volume":"33","author":"Huber","year":"2012","journal-title":"Mol. Aspects Med."},{"issue":"7","key":"10.1016\/j.biopha.2018.11.147_bib0130","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1128\/MCB.01088-06","article-title":"Phenotypes developed in secretin receptor-null mice indicated a role for secretin in regulating renal water reabsorption","volume":"27","author":"Chu","year":"2007","journal-title":"Mol. Cell. Biol."},{"issue":"6","key":"10.1016\/j.biopha.2018.11.147_bib0135","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1007\/s00424-008-0498-1","article-title":"Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption","volume":"456","author":"Boone","year":"2008","journal-title":"Pflugers Arch."},{"issue":"2","key":"10.1016\/j.biopha.2018.11.147_bib0140","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.beem.2016.02.012","article-title":"Renal aquaporins and water balance disorders","volume":"30","author":"Moeller","year":"2016","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"issue":"3","key":"10.1016\/j.biopha.2018.11.147_bib0145","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.krcp.2013.07.005","article-title":"Regulation of aquaporin-2 in the kidney: a molecular mechanism of body-water homeostasis","volume":"232","author":"Kwon","year":"2013","journal-title":"Kidney Res. Clin. Pract."},{"key":"10.1016\/j.biopha.2018.11.147_bib0150","first-page":"1","article-title":"Effects of Qili Qiangxin Capsule on AQP2, V2R, and AT1R in rats with chronic heart failure","volume":"2015","author":"Cui","year":"2015","journal-title":"Evid. Complement. Alternat. Med."},{"issue":"3","key":"10.1016\/j.biopha.2018.11.147_bib0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10157-018-1544-8","article-title":"Activation of AQP2 water channels without vasopressin: therapeutic strategies for congenital nephrogenic diabetes insipidus","volume":"22","author":"Ando","year":"2018","journal-title":"Clin. Exp. Nephrol."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218363169?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218363169?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T21:18:08Z","timestamp":1764105488000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218363169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":31,"alternative-id":["S0753332218363169"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.11.147","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Er Shen Wan extract alleviates polyuria and regulates AQP 2 and AVPR 2 in a rat model of spleen-kidney Yang deficiency\u2013induced diarrhea","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.11.147","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}