{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:26:46Z","timestamp":1793122006887,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T00:00:00Z","timestamp":1543363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.biopha.2018.11.149","type":"journal-article","created":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T17:09:25Z","timestamp":1543943365000},"page":"371-379","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"special_numbering":"C","title":["Dendrobium candidum extract inhibits proliferation and induces apoptosis of liver cancer cells by inactivating Wnt\/\u03b2-catenin signaling pathway"],"prefix":"10.1016","volume":"110","author":[{"given":"Zongbing","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiping","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.biopha.2018.11.149_bib0005","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1002\/ijc.31280","article-title":"Fraction and incidence of liver cancer attributable to hepatitis B and C viruses worldwide","volume":"142","author":"Maucort-Boulch","year":"2018","journal-title":"Int. J. Cancer"},{"issue":"4","key":"10.1016\/j.biopha.2018.11.149_bib0010","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1053\/j.gastro.2016.11.048","article-title":"Liver cancer cell of origin, molecular class, and effects on patient prognosis","volume":"152","author":"Sia","year":"2017","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.biopha.2018.11.149_bib0015","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.cell.2009.04.021","article-title":"Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model","volume":"137","author":"Kota","year":"2009","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.biopha.2018.11.149_bib0020","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.bbrc.2012.07.127","article-title":"Upregulated miR-130a increases drug resistance by regulating RUNX3 and Wnt signaling in cisplatin-treated HCC cell","volume":"425","author":"Xu","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.biopha.2018.11.149_bib0025","doi-asserted-by":"crossref","first-page":"221","DOI":"10.21037\/apm.2018.03.09","article-title":"Efficacy of the combination neurokinin-1 receptor antagonist, palonosetron, and dexamethasone compared to others for the prophylaxis of chemotherapy-induced nausea and vomiting: a systematic review and meta-analysis of randomized controlled trials","volume":"7","author":"Chow","year":"2018","journal-title":"Ann. Palliat. Med."},{"issue":"7","key":"10.1016\/j.biopha.2018.11.149_bib0030","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1111\/j.1478-3231.2007.01527.x","article-title":"Traditional Chinese herbal medicines for treatment of liver fibrosis and cancer: from laboratory discovery to clinical evaluation","volume":"27","author":"Luk","year":"2007","journal-title":"Liver Int."},{"issue":"6","key":"10.1016\/j.biopha.2018.11.149_bib0035","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1007\/s00253-017-8169-9","article-title":"The medicinal and pharmaceutical importance of Dendrobium species","volume":"101","author":"Teixeira da Silva","year":"2017","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"1","key":"10.1016\/j.biopha.2018.11.149_bib0040","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00592-013-0543-1","article-title":"The inflammatory status score including IL-6, TNF-alpha, osteopontin, fractalkine, MCP-1 and adiponectin underlies whole-body insulin resistance and hyperglycemia in type 2 diabetes mellitus","volume":"51","author":"Daniele","year":"2014","journal-title":"Acta Diabetol."},{"issue":"3","key":"10.1016\/j.biopha.2018.11.149_bib0045","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.colsurfb.2004.12.015","article-title":"A method for isolating functional RNA from callus of Dendrobium candidum contented rich polysaccharides","volume":"42","author":"Liu","year":"2005","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"5","key":"10.1016\/j.biopha.2018.11.149_bib0050","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1007\/s00253-011-3829-7","article-title":"Review of research on Dendrobium, a prized folk medicine","volume":"93","author":"Ng","year":"2012","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"5","key":"10.1016\/j.biopha.2018.11.149_bib0055","doi-asserted-by":"crossref","first-page":"487","DOI":"10.4162\/nrp.2014.8.5.487","article-title":"D. Candidum has in vitro anticancer effects in HCT-116 cancer cells and exerts in vivo anti-metastatic effects in mice","volume":"8","author":"Zhao","year":"2014","journal-title":"Nutr. Res. Pract."},{"key":"10.1016\/j.biopha.2018.11.149_bib0060","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/753451","article-title":"Antitumor activity of ethanolic extract of Dendrobium formosum in T-cell lymphoma: an in vitro and in vivo study","volume":"2014","author":"Prasad","year":"2014","journal-title":"Biomed Res. Int."},{"issue":"5","key":"10.1016\/j.biopha.2018.11.149_bib0065","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1039\/C5FO00060B","article-title":"Antiproliferative effect of Dendrobium catenatum Lindley polypeptides against human liver, gastric and breast cancer cell lines","volume":"6","author":"Zheng","year":"2015","journal-title":"Food Funct."},{"issue":"6","key":"10.1016\/j.biopha.2018.11.149_bib0070","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1021\/np500015v","article-title":"Gigantol, a bibenzyl from Dendrobium draconis, inhibits the migratory behavior of non-small cell lung cancer cells","volume":"77","author":"Charoenrungruang","year":"2014","journal-title":"J. Nat. Prod."},{"issue":"6","key":"10.1016\/j.biopha.2018.11.149_bib0075","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1142\/S0192415X14500967","article-title":"Denbinobin, a phenanthrene from Dendrobium nobile, impairs prostate cancer migration by inhibiting Rac1 activity","volume":"42","author":"Lu","year":"2014","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.biopha.2018.11.149_bib0080","first-page":"21","article-title":"Dendrobium candidum inhibits MCF-7 cells proliferation by inducing cell cycle arrest at G2\/M phase and regulating key biomarkers","volume":"9","author":"Sun","year":"2016","journal-title":"Onco. Ther."},{"issue":"5","key":"10.1016\/j.biopha.2018.11.149_bib0085","doi-asserted-by":"crossref","first-page":"487","DOI":"10.4162\/nrp.2014.8.5.487","article-title":"D. Candidum has in vitro anticancer effects in HCT-116 cancer cells and exerts\u2009in vivo anti-metastatic effects in mice","volume":"8","author":"Zhao","year":"2014","journal-title":"Nutr. Res. Pract."},{"issue":"2","key":"10.1016\/j.biopha.2018.11.149_bib0090","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1007\/s13277-015-3993-y","article-title":"Effect of silencing NEK2 on biological behaviors of HepG2 in human hepatoma cells and MAPK signal pathway","volume":"37","author":"Zhang","year":"2016","journal-title":"Tumour Biol."},{"issue":"2","key":"10.1016\/j.biopha.2018.11.149_bib0095","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s11101-013-9310-8","article-title":"Chemistry, bioactivity and quality control of Dendrobium, a commonly used tonic herb in traditional Chinese medicine","volume":"12","author":"Xu","year":"2013","journal-title":"Phytochem. Rev."},{"issue":"12","key":"10.1016\/j.biopha.2018.11.149_bib0100","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/j.cellsig.2013.08.044","article-title":"Activation of integrin beta1-focal adhesion kinase-RasGTP pathway plays a critical role in TGF beta1-induced podocyte injury","volume":"25","author":"Zhang","year":"2013","journal-title":"Cell. Signal."},{"issue":"Supplement C","key":"10.1016\/j.biopha.2018.11.149_bib0105","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.freeradbiomed.2017.10.345","article-title":"CHAC2 is essential for self-renewal and glutathione maintenance in human embryonic stem cells","volume":"113","author":"Wang","year":"2017","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.biopha.2018.11.149_bib0110","first-page":"252","article-title":"Research of the relationship between beta-catenin and c-myc-mediated Wnt pathway and laterally spreading tumors occurrence","volume":"21","author":"Shi","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"9","key":"10.1016\/j.biopha.2018.11.149_bib0115","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0962-8924(00)01803-1","article-title":"Mitochondria as the central control point of apoptosis","volume":"10","author":"Desagher","year":"2000","journal-title":"Trends Cell Biol."},{"issue":"43","key":"10.1016\/j.biopha.2018.11.149_bib0120","doi-asserted-by":"crossref","first-page":"6020","DOI":"10.1038\/onc.2017.207","article-title":"Wnt\/beta-catenin activation and macrophage induction during liver cancer development following steatosis","volume":"36","author":"Debebe","year":"2017","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.biopha.2018.11.149_bib0125","doi-asserted-by":"crossref","first-page":"823","DOI":"10.3748\/wjg.v22.i2.823","article-title":"Targeting Wnt\/beta-catenin pathway in hepatocellular carcinoma treatment","volume":"22","author":"Vilchez","year":"2016","journal-title":"World J. Gastroenterol."},{"issue":"9","key":"10.1016\/j.biopha.2018.11.149_bib0130","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1158\/1535-7163.MCT-17-0139","article-title":"Wnt\/beta-catenin signaling contributes to tumor malignancy and is targetable in gastrointestinal stromal tumor","volume":"16","author":"Zeng","year":"2017","journal-title":"Mol. Cancer Ther."},{"issue":"13","key":"10.1016\/j.biopha.2018.11.149_bib0135","first-page":"1715","article-title":"Chemical constituents of Dendrobium candidum","volume":"35","author":"Li","year":"2010","journal-title":"Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica"},{"issue":"2","key":"10.1016\/j.biopha.2018.11.149_bib0140","doi-asserted-by":"crossref","first-page":"493","DOI":"10.3892\/ol.2013.1728","article-title":"Inhibitory effects of Dendrobium candidum Wall ex Lindl. on azoxymethane- and dextran sulfate sodium-induced colon carcinogenesis in C57BL\/6 mice","volume":"7","author":"Wang","year":"2014","journal-title":"Oncol. Lett."},{"issue":"8","key":"10.1016\/j.biopha.2018.11.149_bib0145","doi-asserted-by":"crossref","first-page":"12831","DOI":"10.18632\/oncotarget.14606","article-title":"A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma","volume":"8","author":"Dai","year":"2017","journal-title":"Oncotarget"},{"issue":"5","key":"10.1016\/j.biopha.2018.11.149_bib0150","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1023\/A:1009616228304","article-title":"Role of reactive oxygen species (ROS) in apoptosis induction","volume":"5","author":"Simon","year":"2000","journal-title":"Apoptosis"},{"issue":"6","key":"10.1016\/j.biopha.2018.11.149_bib0155","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.3390\/md11061961","article-title":"Fucoidan derived from Undaria pinnatifida induces apoptosis in human hepatocellular carcinoma SMMC-7721 cells via the ROS-mediated mitochondrial pathway","volume":"11","author":"Yang","year":"2013","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.biopha.2018.11.149_bib0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.2010.05608.x","article-title":"Role of oxidative\/nitrosative stress-mediated Bcl-2 regulation in apoptosis and malignant transformation","volume":"1203","author":"Azad","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"1-2","key":"10.1016\/j.biopha.2018.11.149_bib0165","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s11010-007-9520-8","article-title":"Mitochondria: a hub of redox activities and cellular distress control","volume":"305","author":"Kakkar","year":"2007","journal-title":"Mol. Cell. Biochem."},{"issue":"20","key":"10.1016\/j.biopha.2018.11.149_bib0170","doi-asserted-by":"crossref","first-page":"28935","DOI":"10.18632\/oncotarget.7898","article-title":"Cinobufagin inhibits tumor growth by inducing intrinsic apoptosis through AKT signaling pathway in human nonsmall cell lung cancer cells","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget"},{"issue":"36","key":"10.1016\/j.biopha.2018.11.149_bib0175","first-page":"15968","article-title":"Inhibitory effects of water extracts from four species of dendrobiums on HelaS3 cells and HepG2 cells","volume":"36","author":"Bao","year":"2008","journal-title":"J. Anhui Agric. Sci."},{"issue":"22","key":"10.1016\/j.biopha.2018.11.149_bib0180","doi-asserted-by":"crossref","first-page":"12584","DOI":"10.1073\/pnas.2134840100","article-title":"Nitric oxide-donating aspirin inhibits beta-catenin\/T cell factor (TCF) signaling in SW480 colon cancer cells by disrupting the nuclear beta-catenin-TCF association","volume":"100","author":"Nath","year":"2003","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"17","key":"10.1016\/j.biopha.2018.11.149_bib0185","doi-asserted-by":"crossref","first-page":"6027","DOI":"10.1073\/pnas.0501535102","article-title":"G protein-coupled lysophosphatidic acid receptors stimulate proliferation of colon cancer cells through the {beta}-catenin pathway","volume":"102","author":"Yang","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"}],"updated-by":[{"DOI":"10.1016\/j.biopha.2022.113049","type":"expression_of_concern","label":"Expression of concern","source":"retraction-watch","updated":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"record-id":"37824"},{"DOI":"10.1016\/j.biopha.2022.113049","type":"expression_of_concern","label":"Expression of concern","source":"publisher","updated":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000}}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217370014?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217370014?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T21:19:06Z","timestamp":1764105546000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217370014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":37,"alternative-id":["S0753332217370014"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.11.149","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dendrobium candidum extract inhibits proliferation and induces apoptosis of liver cancer cells by inactivating Wnt\/\u03b2-catenin signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.11.149","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}