{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:47:07Z","timestamp":1786985227545,"version":"build-2736575974"},"reference-count":195,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T00:00:00Z","timestamp":1543968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["24-1"],"award-info":[{"award-number":["24-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["AN372\/23-1"],"award-info":[{"award-number":["AN372\/23-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.biopha.2018.12.018","type":"journal-article","created":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T01:55:51Z","timestamp":1544666151000},"page":"764-774","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":80,"special_numbering":"C","title":["Fiend and friend in the renin angiotensin system: An insight on acute kidney injury"],"prefix":"10.1016","volume":"110","author":[{"given":"Nisha","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Joachim","family":"Anders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil Bhanudas","family":"Gaikwad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.biopha.2018.12.018_bib0005","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1152\/ajprenal.00307.2002","article-title":"Regulation of sodium transporters in the thick ascending limb of rat kidney: response to angiotensin II","volume":"285","author":"Kwon","year":"2003","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.biopha.2018.12.018_bib0010","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1046\/j.1523-1755.64.s86.5.x","article-title":"Renal expression of angiotensin type 2 (AT2) receptors during kidney damage","volume":"64","author":"Ruiz-Ortega","year":"2003","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.biopha.2018.12.018_bib0015","first-page":"20","article-title":"Renal ischemia\/reperfusion injury; from pathophysiology to treatment","volume":"4","author":"Malek","year":"2015","journal-title":"J. Ren. Inj. Prev."},{"issue":"9","key":"10.1016\/j.biopha.2018.12.018_bib0020","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1042\/CS20090554","article-title":"ACE2-angiotensin-(1-7)\u2013mas axis in renal ischaemia\/reperfusion injury in rats","volume":"119","author":"da Silveira","year":"2010","journal-title":"Clin. Sci."},{"key":"10.1016\/j.biopha.2018.12.018_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/594361","article-title":"Protective role of the ACE2\/Ang-(1-9) axis in cardiovascular remodeling","volume":"2012","author":"Ocaranza","year":"2012","journal-title":"Int. J. Hypertens."},{"issue":"7","key":"10.1016\/j.biopha.2018.12.018_bib0030","doi-asserted-by":"crossref","first-page":"341","DOI":"10.2310\/6650.2007.00020","article-title":"Intracardiac and intrarenal renin-angiotensin systems: mechanisms of cardiovascular and renal effects","volume":"55","author":"Raizada","year":"2007","journal-title":"J. Investig. Med."},{"issue":"9843","key":"10.1016\/j.biopha.2018.12.018_bib0035","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/S0140-6736(11)61454-2","article-title":"Acute kidney injury","volume":"380","author":"Bellomo","year":"2012","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.biopha.2018.12.018_bib0040","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1111\/j.1523-1755.2004.761_5.x","article-title":"Endothelial injury and dysfunction: role in the extension phase of acute renal failure","volume":"66","author":"Molitoris","year":"2004","journal-title":"Kidney Int."},{"issue":"3","key":"10.1016\/j.biopha.2018.12.018_bib0045","doi-asserted-by":"crossref","first-page":"F606","DOI":"10.1152\/ajprenal.00434.2005","article-title":"Rho kinase regulates renal blood flow by modulating eNOS activity in ischemia-reperfusion of the rat kidney","volume":"291","author":"Versteilen","year":"2006","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"9","key":"10.1016\/j.biopha.2018.12.018_bib0050","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.2215\/CJN.00710113","article-title":"World incidence of AKI: a meta-analysis","volume":"8","author":"Susantitaphong","year":"2013","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"12","key":"10.1016\/j.biopha.2018.12.018_bib0055","doi-asserted-by":"crossref","first-page":"e012690","DOI":"10.1136\/bmjopen-2016-012690","article-title":"Prescription of renin-angiotensin system blockers and risk of acute kidney injury: a population-based cohort study","volume":"6","author":"Mansfield","year":"2016","journal-title":"BMJ Open"},{"key":"10.1016\/j.biopha.2018.12.018_bib0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/740647","article-title":"The preventive effects of diminazene aceturate in renal ischemia\/reperfusion injury in male and female rats","volume":"2014","author":"Malek","year":"2014","journal-title":"Adv. Prev. Med."},{"key":"10.1016\/j.biopha.2018.12.018_bib0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/808726","article-title":"Renoprotective effects of AVE0991, a nonpeptide mas receptor agonist, in experimental acute renal injury","volume":"2012","author":"Barroso","year":"2012","journal-title":"Int. J. Hypertens."},{"issue":"4","key":"10.1016\/j.biopha.2018.12.018_bib0070","doi-asserted-by":"crossref","first-page":"e5406","DOI":"10.1371\/journal.pone.0005406","article-title":"Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation","volume":"4","author":"Esteban","year":"2009","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.biopha.2018.12.018_bib0075","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1097\/HJH.0000000000000094","article-title":"Angiotensin-(1-9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme\/Ang II axis","volume":"32","author":"Ocaranza","year":"2014","journal-title":"J. Hypertens."},{"issue":"8","key":"10.1016\/j.biopha.2018.12.018_bib0080","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1161\/CIRCRESAHA.113.301077","article-title":"Discovery and characterization of alamandine novelty and significance: a novel component of the renin-angiotensin system","volume":"112","author":"Lautner","year":"2013","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.biopha.2018.12.018_bib0085","first-page":"85","article-title":"Acute kidney injury: definition, pathophysiology and clinical phenotypes","volume":"37","author":"Makris","year":"2016","journal-title":"Clin. Biochem. Rev."},{"key":"10.1016\/j.biopha.2018.12.018_bib0090","series-title":"Sepsis-Associated Acute Kidney Injury, Seminars in Nephrology","first-page":"2","author":"Alobaidi","year":"2015"},{"issue":"6","key":"10.1016\/j.biopha.2018.12.018_bib0095","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1681\/ASN.2006010017","article-title":"Update on mechanisms of ischemic acute kidney injury","volume":"17","author":"Devarajan","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.biopha.2018.12.018_bib0100","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1146\/annurev-med-050214-013407","article-title":"Acute kidney injury","volume":"67","author":"Zuk","year":"2016","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.biopha.2018.12.018_bib0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/4609502","article-title":"Endothelial STAT3 modulates protective mechanisms in a mouse ischemia-reperfusion model of acute kidney injury","volume":"2017","author":"Dube","year":"2017","journal-title":"J Immunol. Res."},{"issue":"2","key":"10.1016\/j.biopha.2018.12.018_bib0110","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.kint.2017.08.014","article-title":"Neutrophil peptidyl arginine deiminase-4 has a pivotal role in ischemia\/reperfusion-induced acute kidney injury","volume":"93","author":"Raup-Konsavage","year":"2018","journal-title":"Kidney Int."},{"issue":"4","key":"10.1016\/j.biopha.2018.12.018_bib0115","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1159\/000477181","article-title":"Role of immune cells in acute kidney injury and repair","volume":"137","author":"Lee","year":"2017","journal-title":"Nephron"},{"issue":"3","key":"10.1016\/j.biopha.2018.12.018_bib0120","first-page":"165","article-title":"Cytokines in acute kidney injury (AKI)","volume":"76","author":"Lee","year":"2011","journal-title":"Clin. Nephrol."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.018_bib0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-018-03753-4","article-title":"Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury","volume":"9","author":"Lazzeri","year":"2018","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.biopha.2018.12.018_bib0130","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1152\/ajprenal.00691.2011","article-title":"Persistent oxidative stress following renal ischemia-reperfusion injury increases ANG II hemodynamic and fibrotic activity","volume":"302","author":"Basile","year":"2012","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"3","key":"10.1016\/j.biopha.2018.12.018_bib0135","doi-asserted-by":"crossref","first-page":"142","DOI":"10.12968\/coan.2015.20.3.142","article-title":"Pathophysiology of acute kidney injury","volume":"20","author":"Bird","year":"2015","journal-title":"Comp. Anim."},{"issue":"3","key":"10.1016\/j.biopha.2018.12.018_bib0140","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1124\/pr.59.3.3","article-title":"The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease","volume":"59","author":"Kobori","year":"2007","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.biopha.2018.12.018_bib0145","series-title":"The Renin-Angiotensin System and Progression of Renal Diseases","first-page":"16","article-title":"Signal transduction pathways of angiotensin II in the kidney","author":"Bernstein","year":"2001"},{"issue":"1","key":"10.1016\/j.biopha.2018.12.018_bib0150","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1755-1536-4-25","article-title":"Elevation of the antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline: a blood pressure-independent beneficial effect of angiotensin I-converting enzyme inhibitors","volume":"4","author":"Kanasaki","year":"2011","journal-title":"Fibrogenesis Tissue Repair."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.018_bib0155","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00424-012-1120-0","article-title":"ACE2, angiotensin-(1-7), and mas: the other side of the coin","volume":"465","author":"Bader","year":"2013","journal-title":"Pflugers Arch.: Eur. J. Physiol."},{"issue":"3","key":"10.1016\/j.biopha.2018.12.018_bib0160","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s11906-010-0105-7","article-title":"Angiotensin-converting enzyme 2: central regulator for cardiovascular function","volume":"12","author":"Xia","year":"2010","journal-title":"Curr. Hypertens. Rep."},{"issue":"3","key":"10.1016\/j.biopha.2018.12.018_bib0165","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3317\/jraas.2006.027","article-title":"Cognitive effects attributed to angiotensin II may result from its conversion to angiotensin IV","volume":"7","author":"Braszko","year":"2006","journal-title":"J. Renin Angiotensin Aldosterone Syst."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.018_bib0170","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1476-5381.2011.01402.x","article-title":"Identification and development of specific inhibitors for insulin-regulated aminopeptidase as a new class of cognitive enhancers","volume":"164","author":"Albiston","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.biopha.2018.12.018_bib0175","article-title":"Angiotensinogen M235T gene polymorphism is a genetic determinant of cerebrovascular and cardiopulmonary morbidity in adolescents with sickle disease","author":"ElAlfy","year":"2018","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"10.1016\/j.biopha.2018.12.018_bib0180","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.diabres.2018.05.015","article-title":"Associations between angiotensinogen M235T polymorphisms and the risk of diabetic nephropathy: a meta-analysis","volume":"142","author":"Zhou","year":"2018","journal-title":"Diab. Res. Clin. Pract."},{"issue":"6","key":"10.1016\/j.biopha.2018.12.018_bib0185","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1093\/ckj\/sfx087","article-title":"Angiotensinogen as a biomarker of acute kidney injury","volume":"10","author":"Ba Aqeel","year":"2017","journal-title":"Clin. Kidney J."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.018_bib0190","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/ajprenal.00477.2006","article-title":"Activated protein C ameliorates LPS-induced acute kidney injury and downregulates renal INOS and angiotensin 2","volume":"293","author":"Gupta","year":"2007","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.018_bib0195","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1371\/journal.pone.0084131","article-title":"Diagnostic value of urinary kidney injury molecule 1 for acute kidney injury: a meta-analysis","volume":"9","author":"Shao","year":"2014","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.biopha.2018.12.018_bib0200","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1097\/01.ASN.0000088027.54400.C6","article-title":"Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury","volume":"14","author":"Mishra","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"issue":"3","key":"10.1016\/j.biopha.2018.12.018_bib0205","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1053\/j.ajkd.2003.10.040","article-title":"Urinary interleukin-18 is a marker of human acute tubular necrosis1","volume":"43","author":"Parikh","year":"2004","journal-title":"Am. J. Kidney Dis."},{"issue":"3","key":"10.1016\/j.biopha.2018.12.018_bib0210","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1111\/j.1523-1755.2004.00861.x","article-title":"Early detection of acute renal failure by serum cystatin C","volume":"66","author":"Herget-Rosenthal","year":"2004","journal-title":"Kidney Int."},{"issue":"4","key":"10.1016\/j.biopha.2018.12.018_bib0215","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/sj.ki.5002721","article-title":"Liver fatty acid-binding protein as a biomarker of acute kidney injury after cardiac surgery","volume":"73","author":"Portilla","year":"2008","journal-title":"Kidney Int."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.018_bib0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/cc12503","article-title":"Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury","volume":"17","author":"Kashani","year":"2013","journal-title":"Crit. Care"},{"issue":"2","key":"10.1016\/j.biopha.2018.12.018_bib0225","doi-asserted-by":"crossref","first-page":"184","DOI":"10.2215\/CJN.06280612","article-title":"Urinary angiotensinogen and risk of severe AKI","volume":"8","author":"Alge","year":"2013","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.018_bib0230","first-page":"1","article-title":"Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury","volume":"17","author":"Kashani","year":"2013","journal-title":"Crit. Care (Lond., Engl.)"},{"issue":"8","key":"10.1016\/j.biopha.2018.12.018_bib0235","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1164\/rccm.201401-0077OC","article-title":"Validation of cell-cycle arrest biomarkers for acute kidney injury using clinical adjudication","volume":"189","author":"Bihorac","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"2","key":"10.1016\/j.biopha.2018.12.018_bib0240","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1046\/j.1523-1755.2002.00155.x","article-title":"Urinary excretion of angiotensinogen reflects intrarenal angiotensinogen production","volume":"61","author":"Kobori","year":"2002","journal-title":"Kidney Int."},{"key":"10.1016\/j.biopha.2018.12.018_bib0245","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1113\/jphysiol.2003.049890","article-title":"Renin: origin, secretion and synthesis","volume":"552","author":"Persson","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.biopha.2018.12.018_bib0250","series-title":"Handbook of Hormones","article-title":"Subchapter 29A - renin","author":"Wong","year":"2016"},{"issue":"6","key":"10.1016\/j.biopha.2018.12.018_bib0255","first-page":"809","article-title":"Aliskiren\u2014an orally active renin inhibitor. Review of pharmacology, pharmacodynamics, kinetics, and clinical potential in the treatment of hypertension","volume":"3","author":"Allikmets","year":"2007","journal-title":"Vasc. Health Risk. Manag."},{"issue":"4","key":"10.1016\/j.biopha.2018.12.018_bib0260","article-title":"Effect of renin inhibition on adipokines in diabetic rats","volume":"27","author":"Hassanin","year":"2014","journal-title":"Pak. J. Pharm. Sci."},{"issue":"3","key":"10.1016\/j.biopha.2018.12.018_bib0265","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.pcad.2016.10.002","article-title":"Renin angiotensin aldosterone system inhibitors in hypertension: is there evidence for benefit independent of blood pressure reduction?","volume":"59","author":"Bavishi","year":"2016","journal-title":"Prog. Cardiovasc. Dis."},{"issue":"10","key":"10.1016\/j.biopha.2018.12.018_bib0270","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1093\/eurheartj\/ehq522","article-title":"Effect of the direct renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with systolic dysfunction","volume":"32","author":"Solomon","year":"2011","journal-title":"Eur. Heart J."},{"issue":"4","key":"10.1016\/j.biopha.2018.12.018_bib0275","first-page":"129","article-title":"A retrospective Aliskiren and Losartan study in non-diabetic chronic kidney disease","volume":"2","author":"Woo","year":"2013","journal-title":"World J. Nephrol."},{"issue":"2","key":"10.1016\/j.biopha.2018.12.018_bib0280","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.juro.2011.03.122","article-title":"Aliskiren ameliorates renal inflammation and fibrosis induced by unilateral ureteral obstruction in mice","volume":"186","author":"Choi","year":"2011","journal-title":"J. Urol."},{"issue":"3","key":"10.1016\/j.biopha.2018.12.018_bib0285","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s11255-011-9991-0","article-title":"Beneficial effect of aliskiren combined with olmesartan in reducing urinary protein excretion in patients with chronic kidney disease","volume":"44","author":"Moriyama","year":"2012","journal-title":"Int. Urol. Nephrol."},{"issue":"6","key":"10.1016\/j.biopha.2018.12.018_bib0290","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1007\/s11255-011-0110-z","article-title":"Effect of aliskiren on proteinuria in non-diabetic chronic kidney disease: a double-blind, crossover, randomised, controlled trial","volume":"44","author":"Lizakowski","year":"2012","journal-title":"Int. Urol. Nephrol."},{"key":"10.1016\/j.biopha.2018.12.018_bib0295","doi-asserted-by":"crossref","first-page":"e42","DOI":"10.1136\/bmj.e42","article-title":"The effect of combination treatment with aliskiren and blockers of the renin-angiotensin system on hyperkalaemia and acute kidney injury: systematic review and meta-analysis","volume":"344","author":"Harel","year":"2012","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.biopha.2018.12.018_bib0300","doi-asserted-by":"crossref","first-page":"e609","DOI":"10.1016\/S1569-9056(13)61092-1","article-title":"609 renoprotective effects of aliskiren following ischemia reperfusion injury","volume":"12","author":"Hammad","year":"2013","journal-title":"Eur. Urol. Suppl."},{"issue":"2","key":"10.1016\/j.biopha.2018.12.018_bib0305","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10557-012-6380-6","article-title":"Renin inhibitors and cardiovascular and renal protection: an endless quest?","volume":"27","author":"Azizi","year":"2013","journal-title":"Cardiovasc. Drug Ther."},{"issue":"2","key":"10.1016\/j.biopha.2018.12.018_bib0310","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3109\/0886022X.2014.991327","article-title":"Renoprotective effect of aliskiren on renal ischemia\/reperfusion injury in rats: electron microscopy and molecular study","volume":"37","author":"Ziypak","year":"2015","journal-title":"Ren. Fail."},{"key":"10.1016\/j.biopha.2018.12.018_bib0315","first-page":"332","article-title":"Peptidyl-dipeptidase A\/angiotensin I-converting enzyme","volume":"vol. 1","author":"Corvol","year":"2004"},{"issue":"19","key":"10.1016\/j.biopha.2018.12.018_bib0320","doi-asserted-by":"crossref","first-page":"13398","DOI":"10.1016\/S0021-9258(18)42224-7","article-title":"The two homologous domains of human angiotensin I-converting enzyme interact differently with competitive inhibitors","volume":"267","author":"Wei","year":"1992","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.biopha.2018.12.018_bib0325","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1161\/01.RES.0000223145.74217.e7","article-title":"ACE polymorphisms","volume":"98","author":"Sayed-Tabatabaei","year":"2006","journal-title":"Cir. Res."},{"issue":"3","key":"10.1016\/j.biopha.2018.12.018_bib0330","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.tig.2004.01.004","article-title":"Human genetics, animal models and computer simulations for studying hypertension","volume":"20","author":"Takahashi","year":"2004","journal-title":"Trends Genet."},{"issue":"4","key":"10.1016\/j.biopha.2018.12.018_bib0335","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1172\/JCI114844","article-title":"An insertion\/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels","volume":"86","author":"Rigat","year":"1990","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.biopha.2018.12.018_bib0340","doi-asserted-by":"crossref","first-page":"384","DOI":"10.2337\/diab.43.3.384","article-title":"Relationships between angiotensin I converting enzyme gene polymorphism, plasma levels, and diabetic retinal and renal complications","volume":"43","author":"Marre","year":"1994","journal-title":"Diabetes"},{"issue":"7","key":"10.1016\/j.biopha.2018.12.018_bib0345","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1172\/JCI119321","article-title":"Contribution of genetic polymorphism in the renin-angiotensin system to the development of renal complications in insulin-dependent diabetes: Genetique de la Nephropathie Diabetique (GENEDIAB) study group","volume":"99","author":"Marre","year":"1997","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.biopha.2018.12.018_bib0350","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1046\/j.1472-8206.2003.00188.x","article-title":"The preventive effect of captopril or enalapril on reperfusion injury of the kidney of rats is independent of angiotensin II AT1 receptors","volume":"17","author":"Pazoki\u2010Toroudi","year":"2003","journal-title":"Fundam. Clin. Pharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.018_bib0355","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/s12882-015-0190-6","article-title":"Genetic predisposition to acute kidney injury-a systematic review","volume":"16","author":"Vilander","year":"2015","journal-title":"BMC Nephrol."},{"issue":"4","key":"10.1016\/j.biopha.2018.12.018_bib0360","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1046\/j.1523-1755.2001.0590041458.x","article-title":"Intrarenal angiotensin and bradykinin peptide levels in the remnant kidney model of renal insufficiency","volume":"59","author":"Mackie","year":"2001","journal-title":"Kidney Int."},{"issue":"4","key":"10.1016\/j.biopha.2018.12.018_bib0365","first-page":"241","article-title":"The mechanism of preventive effect of captopril on renal ischemia reperfusion injury is independent of ATP dependent potassium channels","volume":"12","author":"Habibey","year":"2008","journal-title":"Iran Biomed. J."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.018_bib0370","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1093\/ndt\/gfr256","article-title":"Effect of captopril treatment on recuperation from ischemia\/reperfusion-induced acute renal injury","volume":"27","author":"Efrati","year":"2011","journal-title":"Nephrol. Dial. Transpl."},{"issue":"2","key":"10.1016\/j.biopha.2018.12.018_bib0375","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1472-8206.2011.00974.x","article-title":"Captopril and telmisartan treatments attenuate cadmium-induced testicular toxicity in rats","volume":"27","author":"Fouad","year":"2013","journal-title":"Fund. Clin. Pharmacol."},{"issue":"2","key":"10.1016\/j.biopha.2018.12.018_bib0380","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/1440-1681.12511","article-title":"Effects of captopril, telmisartan and bardoxolone methyl (CDDO-Me) in ischemia-reperfusion-induced acute kidney injury in rats: an experimental comparative study","volume":"43","author":"Kocak","year":"2016","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"8","key":"10.1016\/j.biopha.2018.12.018_bib0385","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.freeradbiomed.2006.07.011","article-title":"Early activation of bradykinin B2 receptor aggravates reactive oxygen species generation and renal damage in ischemia\/reperfusion injury","volume":"41","author":"Chiang","year":"2006","journal-title":"Free Radic. Biol. Med."},{"issue":"18","key":"10.1016\/j.biopha.2018.12.018_bib0390","doi-asserted-by":"crossref","first-page":"7576","DOI":"10.1073\/pnas.0701617104","article-title":"Bradykinin B1 and B2 receptors both have protective roles in renal ischemia\/reperfusion injury","volume":"104","author":"Kakoki","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.biopha.2018.12.018_bib0395","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1038\/ki.1992.426","article-title":"Prostaglandins protect kidneys against ischemic and toxic injury by a cellular effect","volume":"42","author":"Paller","year":"1992","journal-title":"Kidney Int."},{"issue":"11","key":"10.1016\/j.biopha.2018.12.018_bib0400","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1007\/s00134-016-4670-3","article-title":"Prevention of cardiac surgery-associated AKI by implementing the KDIGO guidelines in high risk patients identified by biomarkers: the PrevAKI randomized controlled trial","volume":"43","author":"Meersch","year":"2017","journal-title":"Intensive Care Med."},{"issue":"3","key":"10.1016\/j.biopha.2018.12.018_bib0405","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0031-6997(24)01458-3","article-title":"International union of pharmacology. XXIII. The angiotensin II receptors","volume":"52","author":"De Gasparo","year":"2000","journal-title":"Pharmacol. Rev."},{"issue":"6","key":"10.1016\/j.biopha.2018.12.018_bib0410","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1161\/01.HYP.0000101968.09376.79","article-title":"Role of superoxide in modulating the renal effects of angiotensin II","volume":"42","author":"Lopez","year":"2003","journal-title":"Hypertension"},{"issue":"7","key":"10.1016\/j.biopha.2018.12.018_bib0415","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1371\/journal.pone.0039739","article-title":"Angiotensin II-induced mitochondrial Nox4 is a major endogenous source of oxidative stress in kidney tubular cells","volume":"7","author":"Kim","year":"2012","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.biopha.2018.12.018_bib0420","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1258\/ebm.2012.012041","article-title":"Endoplasmic reticulum stress and C\/EBP homologous protein-induced Bax translocation are involved in angiotensin II-induced apoptosis in cultured neonatal rat cardiomyocytes","volume":"237","author":"Zou","year":"2012","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.biopha.2018.12.018_bib0425","first-page":"29","article-title":"Inhibition of RAS in diabetic nephropathy","volume":"8","author":"Yacoub","year":"2015","journal-title":"Int. J. Nephrol. Renovasc. Dis."},{"issue":"11","key":"10.1016\/j.biopha.2018.12.018_bib0430","doi-asserted-by":"crossref","first-page":"1","DOI":"10.14814\/phy2.13309","article-title":"Sodium balance, circadian BP rhythm, heart rate variability, and intrarenal renin-angiotensin-aldosterone and dopaminergic systems in acute phase of ARB therapy","volume":"5","author":"Isobe-Sasaki","year":"2017","journal-title":"Physiol. Rep."},{"issue":"12","key":"10.1016\/j.biopha.2018.12.018_bib0435","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1089\/ars.2016.6664","article-title":"Diabetes and kidney disease: role of oxidative stress","volume":"25","author":"Jha","year":"2016","journal-title":"Antioxid. Redox Signal."},{"issue":"Suppl. 1","key":"10.1016\/j.biopha.2018.12.018_bib0440","first-page":"1","article-title":"Epidermal growth factor as a prognostic biomarker in chronic kidney diseases","volume":"4","author":"Isaka","year":"2016","journal-title":"Ann. Trans. Med."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.018_bib0445","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1152\/ajprenal.1998.274.1.F79","article-title":"Role of AT1 angiotensin II receptors in renal ischemic injury","volume":"274","author":"Kontogiannis","year":"1998","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.018_bib0450","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.peptides.2012.04.024","article-title":"Role of angiotensin-converting enzyme (ACE and ACE2) imbalance on tourniquet-induced remote kidney injury in a mouse hindlimb ischemia-reperfusion model","volume":"36","author":"Yang","year":"2012","journal-title":"Peptides"},{"issue":"2","key":"10.1016\/j.biopha.2018.12.018_bib0455","doi-asserted-by":"crossref","first-page":"256","DOI":"10.2215\/CJN.01040905","volume":"1","author":"Chrysostomou","year":"2006","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"2","key":"10.1016\/j.biopha.2018.12.018_bib0460","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1159\/000077396","article-title":"Aldosterone antagonism ameliorates proteinuria and nephrosclerosis independent of glomerular dynamics in L-NAME\/SHR model","volume":"24","author":"Zhou","year":"2004","journal-title":"Am. J. Nephrol."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.018_bib0465","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1254\/jphs.10R07CR","article-title":"Pathophysiological roles of aldosterone and mineralocorticoid receptor in the kidney","volume":"115","author":"Rafiq","year":"2011","journal-title":"J. Pharmacol. Sci."},{"issue":"8","key":"10.1016\/j.biopha.2018.12.018_bib0470","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.1093\/ndt\/gfs014","article-title":"Recovery from ischemic acute kidney injury by spironolactone administration","volume":"27","author":"Sanchez-Pozos","year":"2012","journal-title":"Nephrol. Dial. Transplant."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.018_bib0475","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/ki.2012.352","article-title":"Spironolactone prevents chronic kidney disease caused by ischemic acute kidney injury","volume":"83","author":"Barrera Chimal","year":"2013","journal-title":"Kidney Int."},{"issue":"6323","key":"10.1016\/j.biopha.2018.12.018_bib0480","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/351233a0","article-title":"Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor","volume":"351","author":"Murphy","year":"1991","journal-title":"Nature"},{"issue":"6323","key":"10.1016\/j.biopha.2018.12.018_bib0485","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/351230a0","article-title":"Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptor","volume":"351","author":"Sasaki","year":"1991","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.biopha.2018.12.018_bib0490","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1042\/CS20060342","article-title":"Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology","volume":"112","author":"Higuchi","year":"2007","journal-title":"Clin. Sci."},{"issue":"5","key":"10.1016\/j.biopha.2018.12.018_bib0495","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1161\/01.RES.86.5.494","article-title":"NAD (P) H oxidase: role in cardiovascular biology and disease","volume":"86","author":"Griendling","year":"2000","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.018_bib0500","first-page":"1","article-title":"Angiotensin II affects inflammation mechanisms via AMPK-related signalling pathways in HL-1 atrial myocytes","volume":"7","author":"Kim","year":"2017","journal-title":"Sci. Rep."},{"issue":"171","key":"10.1016\/j.biopha.2018.12.018_bib0505","first-page":"1","article-title":"The renin-angiotensin-aldosterone system in renal and cardiovascular disease and the effects of its pharmacological blockade","volume":"3","author":"Macia Heras","year":"2012","journal-title":"J. Diabetes Metab."},{"issue":"9","key":"10.1016\/j.biopha.2018.12.018_bib0510","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1161\/CIRCRESAHA.110.229393","article-title":"A novel role for calpain in the endothelial dysfunction induced by activation of angiotensin II type 1 receptor SignalingNovelty and significance","volume":"108","author":"Scalia","year":"2011","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.biopha.2018.12.018_bib0515","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0031-6997(24)01471-6","article-title":"Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells","volume":"52","author":"Touyz","year":"2000","journal-title":"Pharmacol. Rev."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.018_bib0520","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1159\/000210574","article-title":"Effects of losartan pretreatment in an experimental model of ischemic acute kidney injury","volume":"112","author":"Molinas","year":"2009","journal-title":"Nephron Exp. Nephrol."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.018_bib0525","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000371748","article-title":"Variation in risk and mortality of acute kidney injury in critically ill patients: a multicenter study","volume":"41","author":"Srisawat","year":"2015","journal-title":"Am. J. Nephrol."},{"issue":"4","key":"10.1016\/j.biopha.2018.12.018_bib0530","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/ki.2015.200","article-title":"Th-17 cell activation in response to high salt following acute kidney injury is associated with progressive fibrosis and attenuated by AT-1R antagonism","volume":"88","author":"Mehrotra","year":"2015","journal-title":"Kidney Int."},{"issue":"4","key":"10.1016\/j.biopha.2018.12.018_bib0535","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1152\/ajpregu.00298.2009","article-title":"T lymphocytes mediate hypertension and kidney damage in Dahl salt-sensitive rats","volume":"298","author":"De Miguel","year":"2010","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"2","key":"10.1016\/j.biopha.2018.12.018_bib0540","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/ki.2015.320","article-title":"AT1 receptor antagonism before ischemia prevents the transition of acute kidney injury to chronic kidney disease","volume":"89","author":"Rodriguez Romo","year":"2016","journal-title":"Kidney Int."},{"issue":"16","key":"10.1016\/j.biopha.2018.12.018_bib0545","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1161\/hc4101.096153","article-title":"Renal considerations in angiotensin converting enzyme inhibitor therapy: a statement for healthcare professionals from the Council on the Kidney in Cardiovascular Disease and the Council for High Blood Pressure Research of the American Heart Association","volume":"104","author":"Schoolwerth","year":"2001","journal-title":"Circulation"},{"issue":"9982","key":"10.1016\/j.biopha.2018.12.018_bib0550","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1016\/S0140-6736(14)62459-4","article-title":"Comparative efficacy and safety of blood pressure-lowering agents in adults with diabetes and kidney disease: a network meta-analysis","volume":"385","author":"Palmer","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.biopha.2018.12.018_bib0555","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/bmj.e8525","article-title":"Concurrent use of diuretics, angiotensin converting enzyme inhibitors, and angiotensin receptor blockers with non-steroidal anti-inflammatory drugs and risk of acute kidney injury: nested case-control study","volume":"346","author":"Lapi","year":"2013","journal-title":"BMJ"},{"issue":"2","key":"10.1016\/j.biopha.2018.12.018_bib0560","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/ki.2015.101","article-title":"Combined use of nonsteroidal anti-inflammatory drugs with diuretics and\/or renin-angiotensin system inhibitors in the community increases the risk of acute kidney injury","volume":"88","author":"Dreischulte","year":"2015","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.biopha.2018.12.018_bib0565","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.0306-5251.2004.2188.x","article-title":"Drug combinations and impaired renal function-the \u2018triple whammy\u2019","volume":"59","author":"Loboz","year":"2005","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"7","key":"10.1016\/j.biopha.2018.12.018_bib0570","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.2215\/CJN.05480610","article-title":"Predictors of acute kidney injury in septic shock patients: an observational cohort study","volume":"6","author":"Plataki","year":"2011","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"6","key":"10.1016\/j.biopha.2018.12.018_bib0575","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/jch.12795","article-title":"Acute kidney injury in elderly patients with chronic kidney disease: do angiotensin-converting enzyme inhibitors carry a risk?","volume":"18","author":"Chaumont","year":"2016","journal-title":"J. Clin. Hypertens."},{"issue":"20","key":"10.1016\/j.biopha.2018.12.018_bib0580","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1056\/NEJMoa1303154","article-title":"Combined angiotensin inhibition for the treatment of diabetic nephropathy","volume":"369","author":"Fried","year":"2013","journal-title":"N. Engl. J. Med."},{"issue":"9638","key":"10.1016\/j.biopha.2018.12.018_bib0585","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0140-6736(08)61236-2","article-title":"Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial","volume":"372","author":"Mann","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.biopha.2018.12.018_bib0590","first-page":"38","article-title":"RCPE UK consensus conference statement management of acute kidney injury: the role of fluids, e-alerts and biomarkers","volume":"43","author":"Bosomworth","year":"2013","journal-title":"J. R. Coll. Phys. Edinb."},{"key":"10.1016\/j.biopha.2018.12.018_bib0595","series-title":"Acute Kidney Injury: Prevention, Detection and Management Up to the Point of Renal Replacement Therapy","year":"2013"},{"issue":"1","key":"10.1016\/j.biopha.2018.12.018_bib0600","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1056\/NEJMra1214243","article-title":"Acute kidney injury and chronic kidney disease as interconnected syndromes","volume":"371","author":"Chawla","year":"2014","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.biopha.2018.12.018_bib0605","doi-asserted-by":"crossref","first-page":"R123","DOI":"10.1186\/cc11419","article-title":"Kidney function decline after a non-dialysis-requiring acute kidney injury is associated with higher long-term mortality in critically ill survivors","volume":"16","author":"Lai","year":"2012","journal-title":"Crit. Care (Lond., Engl.)"},{"issue":"5","key":"10.1016\/j.biopha.2018.12.018_bib0610","doi-asserted-by":"crossref","first-page":"F1078","DOI":"10.1152\/ajprenal.00017.2010","article-title":"Acute kidney injury: a springboard for progression in chronic kidney disease","volume":"298","author":"Venkatachalam","year":"2010","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"3","key":"10.1016\/j.biopha.2018.12.018_bib0615","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1681\/ASN.2014111114","article-title":"Elevated BP after AKI","volume":"27","author":"Hsu","year":"2016","journal-title":"JASN"},{"key":"10.1016\/j.biopha.2018.12.018_bib0620","doi-asserted-by":"crossref","first-page":"46518","DOI":"10.1038\/srep46518","article-title":"Renin-angiotensin system inhibitor is associated with lower risk of ensuing chronic kidney disease after functional recovery from acute kidney injury","volume":"7","author":"Chou","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2018.12.018_bib0625","first-page":"1","article-title":"Impact of angiotensin-converting enzyme inhibitors or receptor blockers on post-ICU discharge outcome in patients with acute kidney injury","author":"Gayat","year":"2018","journal-title":"Intensive Care Med."},{"issue":"12","key":"10.1016\/j.biopha.2018.12.018_bib0630","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1001\/jamainternmed.2018.4749","article-title":"Association of angiotensin-converting enzyme inhibitor or angiotensin receptor blocker use with outcomes after acute kidney injury","volume":"178","author":"Brar","year":"2018","journal-title":"JAMA Intern. Med."},{"issue":"6891","key":"10.1016\/j.biopha.2018.12.018_bib0635","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/nature00786","article-title":"Angiotensin-converting enzyme 2 is an essential regulator of heart function","volume":"417","author":"Crackower","year":"2002","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.biopha.2018.12.018_bib0640","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/01.RES.87.5.e1","article-title":"A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9","volume":"87","author":"Donoghue","year":"2000","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.biopha.2018.12.018_bib0645","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1139\/y02-021","article-title":"ACEH\/ACE2 is a novel mammalian metallocarboxypeptidase and a homologue of angiotensin-converting enzyme insensitive to ACE inhibitors","volume":"80","author":"Turner","year":"2002","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"9","key":"10.1016\/j.biopha.2018.12.018_bib0650","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0022-2828(03)00177-9","article-title":"Heart block, ventricular tachycardia, and sudden death in ACE2 transgenic mice with downregulated connexins","volume":"35","author":"Donoghue","year":"2003","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"18","key":"10.1016\/j.biopha.2018.12.018_bib0655","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1111\/bph.13946","article-title":"Diminazene aceturate prevents nephropathy by increasing glomerular ACE2 and AT2 receptor expression in a rat model of type1 diabetes","volume":"174","author":"Goru","year":"2017","journal-title":"Br. J. Pharmacol."},{"issue":"Pt. 2","key":"10.1016\/j.biopha.2018.12.018_bib0660","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/978-94-024-1079-2_69","article-title":"Effects of taurine on ACE, ACE2 and HSP70 expression of hypothalamic-pituitary-adrenal axis in stress-induced hypertensive rats","volume":"975","author":"Lv","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"issue":"6","key":"10.1016\/j.biopha.2018.12.018_bib0665","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.kint.2017.04.001","article-title":"ACE2 as therapy for glomerular disease: the devil is in the detail","volume":"91","author":"Ross","year":"2017","journal-title":"Kidney Int."},{"issue":"6","key":"10.1016\/j.biopha.2018.12.018_bib0670","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.kint.2016.12.022","article-title":"Murine recombinant angiotensin-converting enzyme 2 attenuates kidney injury in experimental Alport syndrome","volume":"91","author":"Bae","year":"2017","journal-title":"Kidney Int."},{"issue":"3\u20134","key":"10.1016\/j.biopha.2018.12.018_bib0675","doi-asserted-by":"crossref","first-page":"c144","DOI":"10.1159\/000345508","article-title":"Circulating angiotensin-converting enzyme 2 activity in kidney transplantation: a longitudinal pilot study","volume":"121","author":"Soler","year":"2012","journal-title":"Nephron Clin. Pract."},{"issue":"5","key":"10.1016\/j.biopha.2018.12.018_bib0680","doi-asserted-by":"crossref","first-page":"e37649","DOI":"10.1371\/journal.pone.0037649","article-title":"Increased urinary angiotensin-converting enzyme 2 in renal transplant patients with diabetes","volume":"7","author":"Xiao","year":"2012","journal-title":"PLoS One"},{"issue":"17","key":"10.1016\/j.biopha.2018.12.018_bib0685","doi-asserted-by":"crossref","first-page":"14838","DOI":"10.1074\/jbc.M200581200","article-title":"Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase","volume":"277","author":"Vickers","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.biopha.2018.12.018_bib0690","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1161\/HYPERTENSIONAHA.107.102764","article-title":"Endothelial dysfunction and elevated blood pressure in MAS gene-deleted mice","volume":"51","author":"Xu","year":"2008","journal-title":"Hypertension"},{"issue":"14","key":"10.1016\/j.biopha.2018.12.018_bib0695","doi-asserted-by":"crossref","first-page":"8258","DOI":"10.1073\/pnas.1432869100","article-title":"Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor mas","volume":"100","author":"Santos","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.018_bib0700","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-3565(24)37600-1","article-title":"Angiotensin 1-7 induces bradykinin-mediated relaxation in porcine coronary artery","volume":"286","author":"Gorelik","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.018_bib0705","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1152\/physrev.00023.2016","article-title":"The ACE2\/angiotensin-(1-7)\/MAS axis of the renin-angiotensin system: focus on angiotensin-(1-7)","volume":"98","author":"Santos","year":"2018","journal-title":"Physiol. Rev."},{"issue":"8","key":"10.1016\/j.biopha.2018.12.018_bib0710","doi-asserted-by":"crossref","first-page":"F812","DOI":"10.1152\/ajprenal.00655.2013","article-title":"Angiotensin 1-7 mediates renoprotection against diabetic nephropathy by reducing oxidative stress, inflammation, and lipotoxicity","volume":"306","author":"Mori","year":"2014","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"5","key":"10.1016\/j.biopha.2018.12.018_bib0715","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1113\/expphysiol.2008.042002","article-title":"Recent advances in the angiotensin-converting enzyme 2-angiotensin(1-7)-Mas axis","volume":"93","author":"Santos","year":"2008","journal-title":"Exp. Physiol."},{"issue":"3","key":"10.1016\/j.biopha.2018.12.018_bib0720","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1007\/s11906-014-0420-5","article-title":"ACE2: angiotensin II\/angiotensin-(1-7) balance in cardiac and renal injury","volume":"16","author":"Varagic","year":"2014","journal-title":"Curr. Hypertens. Rep."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.018_bib0725","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1161\/HYPERTENSIONAHA.110.152942","article-title":"Vascular relaxation, antihypertensive effect, and cardioprotection of a novel peptide agonist of the MAS receptor","volume":"56","author":"Savergnini","year":"2010","journal-title":"Hypertension"},{"issue":"6","key":"10.1016\/j.biopha.2018.12.018_bib0730","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1080\/13543776.2016.1179283","article-title":"Therapeutic uses for angiotensin-(1-7)","volume":"26","author":"Machado-Silva","year":"2016","journal-title":"Expert Opin. Ther. Patents"},{"key":"10.1016\/j.biopha.2018.12.018_bib0735","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.peptides.2013.11.006","article-title":"An orally active angiotensin-(1-7) inclusion compound and exercise training produce similar cardiovascular effects in spontaneously hypertensive rats","volume":"51","author":"Bertagnolli","year":"2014","journal-title":"Peptides"},{"issue":"3","key":"10.1016\/j.biopha.2018.12.018_bib0740","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00109-013-1087-0","article-title":"Oral administration of angiotensin-(1-7) ameliorates type 2 diabetes in rats","volume":"92","author":"Santos","year":"2014","journal-title":"J. Mol. Med. (Berlin, Germany)"},{"key":"10.1016\/j.biopha.2018.12.018_bib0745","doi-asserted-by":"crossref","first-page":"857","DOI":"10.3324\/haematol.2008.000034","article-title":"Angiotensin-(1-7) stimulates hematopoietic progenitor cells in vitro and in vivo","volume":"94","author":"Heringer-Walther","year":"2009","journal-title":"Haematology"},{"issue":"1","key":"10.1016\/j.biopha.2018.12.018_bib0750","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00280-003-0710-0","article-title":"Synergistic effects of co-administration of angiotensin 1-7 and Neupogen on hematopoietic recovery in mice","volume":"53","author":"Ellefson","year":"2004","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"2","key":"10.1016\/j.biopha.2018.12.018_bib0755","doi-asserted-by":"crossref","first-page":"135","DOI":"10.4161\/org.7.2.16285","article-title":"Kidney regeneration and resident stem cells","volume":"7","author":"Reule","year":"2011","journal-title":"Organogenesis"},{"issue":"4","key":"10.1016\/j.biopha.2018.12.018_bib0760","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ng1294-373","article-title":"Parental imprinting of the mas protooncogene in mouse","volume":"8","author":"Villar","year":"1994","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.018_bib0765","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0014-5793(94)01292-9","article-title":"Expression of the mouse and rat mas proto-oncogene in the brain and peripheral tissues","volume":"357","author":"Metzger","year":"1995","journal-title":"FEBS Lett."},{"issue":"4","key":"10.1016\/j.biopha.2018.12.018_bib0770","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1177\/1470320312466519","article-title":"New therapeutic pathways in the RAS","volume":"13","author":"Bader","year":"2012","journal-title":"J. Renin Angiotensin Aldosterone Syst."},{"issue":"6","key":"10.1016\/j.biopha.2018.12.018_bib0775","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1152\/ajpheart.2001.281.6.H2337","article-title":"Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide","volume":"281","author":"Berry","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"3","key":"10.1016\/j.biopha.2018.12.018_bib0780","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0031-6997(24)01458-3","article-title":"International union of pharmacology. XXIII. The angiotensin II receptors","volume":"52","author":"de Gasparo","year":"2000","journal-title":"Pharmacol. Rev."},{"issue":"4","key":"10.1016\/j.biopha.2018.12.018_bib0785","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1124\/pr.114.010454","article-title":"International Union of basic and clinical pharmacology. XCIX. Angiotensin receptors: interpreters of pathophysiological angiotensinergic stimuli [corrected]","volume":"67","author":"Karnik","year":"2015","journal-title":"Pharmacol. Rev."},{"issue":"2","key":"10.1016\/j.biopha.2018.12.018_bib0790","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.peptides.2012.09.016","article-title":"Subcellular characteristics of functional intracellular renin-angiotensin systems","volume":"38","author":"Abadir","year":"2012","journal-title":"Peptides"},{"issue":"4","key":"10.1016\/j.biopha.2018.12.018_bib0795","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1093\/ajh\/hpw121","article-title":"AT2 receptors: potential therapeutic targets for hypertension","volume":"30","author":"Carey","year":"2017","journal-title":"Am. J. Hypertens."},{"issue":"5","key":"10.1016\/j.biopha.2018.12.018_bib0800","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1161\/01.HYP.0000159192.93968.8f","article-title":"Cardiovascular and renal regulation by the angiotensin type 2 receptor: the AT2 receptor comes of age","volume":"45","author":"Carey","year":"2005","journal-title":"Hypertension"},{"issue":"2","key":"10.1016\/j.biopha.2018.12.018_bib0805","first-page":"91","article-title":"Update on angiotensin AT2 receptors","volume":"26","author":"Carey","year":"2017","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.biopha.2018.12.018_bib0810","series-title":"Neurobiology of Body Fluid Homeostasis: Transduction and Integration","author":"De Luca","year":"2013"},{"issue":"2","key":"10.1016\/j.biopha.2018.12.018_bib0815","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1161\/HYPERTENSIONAHA.110.164202","article-title":"Angiotensin AT(2) receptor stimulation inhibits early renal inflammation in renovascular hypertension","volume":"57","author":"Matavelli","year":"2011","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.biopha.2018.12.018_bib0820","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1161\/HYPERTENSIONAHA.109.147843","article-title":"Direct angiotensin II type 2 receptor stimulation acts anti-inflammatory through epoxyeicosatrienoic acid and inhibition of nuclear factor kappaB","volume":"55","author":"Rompe","year":"2010","journal-title":"Hypertension"},{"issue":"10","key":"10.1016\/j.biopha.2018.12.018_bib0825","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1152\/ajprenal.00247.2014","article-title":"Prevention of diabetic nephropathy by compound 21, selective agonist of angiotensin type 2 receptors, in Zucker diabetic fatty rats","volume":"307","author":"Castoldi","year":"2014","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"4","key":"10.1016\/j.biopha.2018.12.018_bib0830","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1042\/CS20130515","article-title":"Angiotensin type 2 receptor (AT2R) and receptor mas: a complex liaison","volume":"128","author":"Villela","year":"2015","journal-title":"Clin. Sci."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.018_bib0835","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.bbrc.2009.11.008","article-title":"Molecular mechanisms of the antagonistic action between AT1 and AT2 receptors","volume":"391","author":"Miura","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"6551","key":"10.1016\/j.biopha.2018.12.018_bib0840","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/377748a0","article-title":"Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor","volume":"377","author":"Ichiki","year":"1995","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.biopha.2018.12.018_bib0845","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1161\/HYPERTENSIONAHA.108.128488","article-title":"Angiotensin II type 2 receptor antagonizes angiotensin II type 1 receptor-mediated cardiomyocyte autophagy","volume":"53","author":"Porrello","year":"2009","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.biopha.2018.12.018_bib0850","doi-asserted-by":"crossref","first-page":"991","DOI":"10.2337\/diabetes.54.4.991","article-title":"Deletion of the angiotensin type 2 receptor (AT2R) reduces adipose cell size and protects from diet-induced obesity and insulin resistance","volume":"54","author":"Yvan-Charvet","year":"2005","journal-title":"Diabetes"},{"issue":"11","key":"10.1016\/j.biopha.2018.12.018_bib0855","doi-asserted-by":"crossref","first-page":"e48387","DOI":"10.1371\/journal.pone.0048387","article-title":"Direct angiotensin II type 2 receptor stimulation ameliorates insulin resistance in type 2 diabetes mice with PPARgamma activation","volume":"7","author":"Ohshima","year":"2012","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.biopha.2018.12.018_bib0860","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/HJH.0b013e32834d9efe","article-title":"Insulin resistance induces a segmental difference in thoracic and abdominal aorta: differential expression of AT1 and AT2 receptors","volume":"30","author":"Karpe","year":"2012","journal-title":"J. Hypertens."},{"key":"10.1016\/j.biopha.2018.12.018_bib0865","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.peptides.2016.12.003","article-title":"Chronic blockade of the AT2 receptor with PD123319 impairs insulin signaling in C57BL\/6 mice","volume":"88","author":"Munoz","year":"2017","journal-title":"Peptides"},{"issue":"3","key":"10.1016\/j.biopha.2018.12.018_bib0870","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1046\/j.1523-1755.2000.00925.x","article-title":"Expression of apoptosis regulatory proteins in tubular epithelium stressed in culture or following acute renal failure","volume":"57","author":"Ortiz","year":"2000","journal-title":"Kidney Int."},{"issue":"24","key":"10.1016\/j.biopha.2018.12.018_bib0875","doi-asserted-by":"crossref","first-page":"5995","DOI":"10.1021\/jm049715t","article-title":"Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist","volume":"47","author":"Wan","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.biopha.2018.12.018_bib0880","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.ejphar.2017.09.036","article-title":"AT 2 receptor agonist compound 21: a silver lining for diabetic nephropathy","volume":"815","author":"Pandey","year":"2017","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.biopha.2018.12.018_bib0885","doi-asserted-by":"crossref","first-page":"e95762","DOI":"10.1371\/journal.pone.0095762","article-title":"Direct angiotensin AT2 receptor stimulation using a novel AT2 receptor agonist, compound 21, evokes neuroprotection in conscious hypertensive rats","volume":"9","author":"McCarthy","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.biopha.2018.12.018_bib0890","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.neuropharm.2014.01.044","article-title":"The angiotensin type 2 receptor agonist compound 21 elicits cerebroprotection in endothelin-1 induced ischemic stroke","volume":"81","author":"Joseph","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.biopha.2018.12.018_bib0895","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/3981790","article-title":"Central infusion of angiotensin II type 2 receptor agonist compound 21 attenuates DOCA\/NaCl-induced hypertension in female rats","volume":"2016","author":"Dai","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"4","key":"10.1016\/j.biopha.2018.12.018_bib0900","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.bbrc.2017.04.134","article-title":"Compound 21 and Telmisartan combination mitigates type 2 diabetic nephropathy through amelioration of caspase mediated apoptosis","volume":"487","author":"Pandey","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"6","key":"10.1016\/j.biopha.2018.12.018_bib0905","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1161\/hy1201.101214","article-title":"History about the discovery of the renin-angiotensin system","volume":"38","author":"Basso","year":"2001","journal-title":"Hypertension"},{"issue":"5","key":"10.1016\/j.biopha.2018.12.018_bib0910","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1161\/01.HYP.0000017283.67962.02","article-title":"Angiotensin 1-9 and 1-7 release in human heart: role of cathepsin A","volume":"39","author":"Jackman","year":"2002","journal-title":"Hypertension"},{"issue":"6","key":"10.1016\/j.biopha.2018.12.018_bib0915","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1161\/01.CIR.95.6.1455","volume":"95","author":"Kokkonen","year":"1997","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.biopha.2018.12.018_bib0920","first-page":"317","article-title":"Angiotensin-(1-9), the product of angiotensin I conversion in platelets, enhances arterial thrombosis in rats","volume":"61","author":"Kramkowski","year":"2010","journal-title":"J. Physiol. Pharmacol."},{"issue":"12","key":"10.1016\/j.biopha.2018.12.018_bib0925","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1042\/CS20130436","article-title":"Angiotensin-(1-7) and angiotensin-(1-9): function in cardiac and vascular remodelling","volume":"126","author":"McKinney","year":"2014","journal-title":"Clin. Sci. (Lond., Engl. : 1979)"},{"key":"10.1016\/j.biopha.2018.12.018_bib0930","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.bcp.2018.08.045","article-title":"Angiotensin-(1-9) reduces cardiovascular and renal inflammation in experimental renin-independent hypertension","volume":"156","author":"Gonzalez","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biopha.2018.12.018_bib0935","first-page":"A1","article-title":"178 angiotensin-(1-9) inhibits vascular smooth muscle cell proliferation and migration in vitro and neointimal formation in vivo","author":"McKinney","year":"2015","journal-title":"Br. Cardiovasc. Soc. (BMJ Publishing Group Ltd.)"},{"issue":"4","key":"10.1016\/j.biopha.2018.12.018_bib0940","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1161\/01.HYP.0000237862.94083.45","article-title":"Enalapril attenuates downregulation of angiotensin-converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted rat","volume":"48","author":"Ocaranza","year":"2006","journal-title":"Hypertension"},{"issue":"7","key":"10.1016\/j.biopha.2018.12.018_bib0945","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms17071098","article-title":"Angiotensin a\/alamandine\/mrgd axis: another clue to understanding cardiovascular pathophysiology","volume":"17","author":"Hrenak","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2018.12.018_bib0950","article-title":"Abstract P281: alamandine-induced vasorelaxation is selectively increased in Sp-shr","author":"Leao","year":"2016","journal-title":"Am. Heart Assoc."},{"issue":"6","key":"10.1016\/j.biopha.2018.12.018_bib0955","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s11906-014-0433-0","article-title":"New components of the renin-angiotensin system: alamandine and the mas-related G protein-coupled receptor D","volume":"16","author":"Etelvino","year":"2014","journal-title":"Curr. Hypertens. Rep."},{"issue":"2","key":"10.1016\/j.biopha.2018.12.018_bib0960","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1097\/01.mnh.0000441052.44406.92","article-title":"Alamandine: a new member of the angiotensin family","volume":"23","author":"Villela","year":"2014","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.018_bib0965","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1161\/HYPERTENSIONAHA.116.07572","article-title":"G-protein-coupled receptor MrgD is a receptor for angiotensin-(1-7) involving adenylyl cyclase, cAMP, and phosphokinase A novelty and significance","volume":"68","author":"Tetzner","year":"2016","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.biopha.2018.12.018_bib0970","doi-asserted-by":"crossref","first-page":"F636","DOI":"10.1152\/ajprenal.2000.279.4.F636","article-title":"Differential actions of renal ischemic injury on the intrarenal angiotensin system","volume":"279","author":"Allred","year":"2000","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"3","key":"10.1016\/j.biopha.2018.12.018_bib0975","doi-asserted-by":"crossref","first-page":"140","DOI":"10.15171\/jrip.2016.29","article-title":"Effect of angiotensin II type 1 receptor blockade on kidney ischemia\/reperfusion; a gender-related difference","volume":"5","author":"Moslemi","year":"2016","journal-title":"J. Ren. Inj. Prev."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218361778?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218361778?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T21:20:09Z","timestamp":1764105609000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218361778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":195,"alternative-id":["S0753332218361778"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.12.018","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fiend and friend in the renin angiotensin system: An insight on acute kidney injury","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.12.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}