{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:39:19Z","timestamp":1792179559430,"version":"4.4.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,12,8]],"date-time":"2018-12-08T00:00:00Z","timestamp":1544227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.biopha.2018.12.036","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T15:29:03Z","timestamp":1544801343000},"page":"869-877","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Dipeptidyl peptidase-4 inhibition protects the liver of insulin-resistant female rats against triglyceride accumulation by suppressing uric acid"],"prefix":"10.1016","volume":"110","author":[{"given":"Tolulope Eniola","family":"Omolekulo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olugbenga Samuel","family":"Michael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7735-7441","authenticated-orcid":false,"given":"Lawrence Aderemi","family":"Olatunji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.12.036_bib0005","first-page":"585","article-title":"Pathophysiology and pharmacological treatment of insulin resistance","volume":"21","author":"Matthaei","year":"2000","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.biopha.2018.12.036_bib0010","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1136\/pgmj.2004.025601","article-title":"Pathophysiology of dyslipidaemia in the metabolic syndrome","volume":"81","author":"Kolovou","year":"2005","journal-title":"Postgrad. Med. J."},{"key":"10.1016\/j.biopha.2018.12.036_bib0015","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.peptides.2011.05.024","article-title":"Adrenomedullin protects against fructose-induced insulin resistance and myocardial hypertrophy in rats","volume":"32","author":"Zhang","year":"2011","journal-title":"Peptides"},{"key":"10.1016\/j.biopha.2018.12.036_bib0020","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/hep.20734","article-title":"Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study","volume":"42","author":"Bedogni","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.biopha.2018.12.036_bib0025","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.arcmed.2005.01.005","article-title":"Regulation of plasma triglycerides in insulin resistance and diabetes","volume":"36","author":"Ginsberg","year":"2005","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.biopha.2018.12.036_bib0030","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1161\/CIRCRESAHA.116.305665","article-title":"DPP4 in cardiometabolic disease recent insights from the laboratory and clinical trials of DPP4 inhibition","volume":"116","author":"Zhong","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.biopha.2018.12.036_bib0035","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.bbrc.2017.02.071","article-title":"Dipeptidyl peptidase-4 impairs insulin signaling and promotes lipid accumulation in hepatocytes","volume":"485","author":"Rufinatscha","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2018.12.036_bib0040","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/1753-0407.12237","article-title":"Circulating dipeptidyl peptidase-4 activity correlates with measures of hepatocyte apoptosis and fibrosis in non-alcoholic fatty liver disease in type 2 diabetes mellitus and obesity: a dual cohort cross-sectional study","volume":"7","author":"Williams","year":"2015","journal-title":"J. Diabetes"},{"key":"10.1016\/j.biopha.2018.12.036_bib0045","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.3748\/wjg.v19.i15.2298","article-title":"Dipeptidyl peptidase-4: a key player in chronic liver disease","volume":"19","author":"Itou","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.biopha.2018.12.036_bib0050","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s00404-009-1148-3","article-title":"Serum adenosine deaminase activity in gestational diabetes mellitus and normal pregnancy","volume":"281","author":"Mokhtari","year":"2010","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.biopha.2018.12.036_bib0055","doi-asserted-by":"crossref","first-page":"C1183","DOI":"10.1152\/ajpcell.00075.2008","article-title":"Uric acid decreases NO production and increases arginase activity in cultured pulmonary artery endothelial cells","volume":"295","author":"Zharikov","year":"2008","journal-title":"Am. J. Phys. Cell Physiol."},{"key":"10.1016\/j.biopha.2018.12.036_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhep.2015.01.019","article-title":"Xanthine oxidase in nonalcoholic fatty liver disease and hyperuricemia: one stone hits two birds","author":"Xu","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.biopha.2018.12.036_bib0065","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/j.ajog.2011.06.056","article-title":"The state of hormonal contraception today: established and emerging non-contraceptive health benefits","volume":"205","author":"Maguire","year":"2011","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.biopha.2018.12.036_bib0070","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.pathophys.2011.09.001","article-title":"Combined estrogen-progestogen but not progestogen-only oral contraceptive alters glucose tolerance and plasma lipid profile in female rats","volume":"19","author":"Olatunji","year":"2012","journal-title":"Pathophysiology"},{"key":"10.1016\/j.biopha.2018.12.036_bib0075","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3109\/13813455.2016.1151892","article-title":"Improvement of oral contraceptive-induced glucose dysregulation and dyslipidemia by valproic acid is independent of circulating corticosterone","volume":"122","author":"Olatunji","year":"2016","journal-title":"Arch. Physiol. Biochem."},{"key":"10.1016\/j.biopha.2018.12.036_bib0080","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1177\/0091270010381497","article-title":"Sitagliptin, a dipeptidyl peptidase-4 inhibitor, does not affect the pharmacokinetics of ethinyl estradiol or norethindrone in healthy female subjects","volume":"51","author":"Migoya","year":"2011","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.biopha.2018.12.036_bib0085","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1210\/jc.2010-0288","article-title":"The product of triglycerides and glucose, a simple measure of insulin sensitivity. Comparison with the euglycemic hyperinsulinemic clamp","volume":"95","author":"Guerrero-Romero","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2018.12.036_bib0090","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0167-5699(99)01486-3","article-title":"CD26, let it cut or cut it down","volume":"20","author":"De Meester","year":"1999","journal-title":"Immunol. Today"},{"key":"10.1016\/j.biopha.2018.12.036_bib0095","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.atherosclerosis.2012.09.012","article-title":"An emerging role of dipeptidyl peptidase 4 (DPP4) beyond glucose control: potential implications in cardiovascular disease","volume":"226","author":"Zhong","year":"2013","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.biopha.2018.12.036_bib0100","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1007\/s00125-005-1749-8","article-title":"Hyperglycaemia increases dipeptidyl peptidaseIV activity in diabetes mellitus","volume":"48","author":"Mannucci","year":"2005","journal-title":"Diabetologia"},{"key":"10.1016\/j.biopha.2018.12.036_bib0105","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1210\/jc.2018-00194","article-title":"High DPP-4 concentrations in adolescents are associated with low intact GLP-1","volume":"103","author":"Stenlid","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2018.12.036_bib0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012226","article-title":"Serum dipeptidyl peptidase-4 activity in insulin resistant patients with non-alcoholic fatty liver disease: a novel liver disease biomarker","volume":"5","author":"Firneisz","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2018.12.036_bib0115","first-page":"729","article-title":"Increased hepatic expression of dipeptidyl peptidase-4 in non-alcoholic fatty liver disease and its association with insulin resistance and glucose metabolism","volume":"5","author":"Miyazaki","year":"2012","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.biopha.2018.12.036_bib0120","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1172\/JCI34275","article-title":"Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice","volume":"118","author":"Postic","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.biopha.2018.12.036_bib0125","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1159\/000282087","article-title":"Liver fat in the pathogenesis of insulin resistance and type 2 diabetes","volume":"28","author":"Yki-J\u00e4rvinen","year":"2010","journal-title":"Dig. Dis."},{"key":"10.1016\/j.biopha.2018.12.036_bib0130","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1365-2036.2011.04724.x","article-title":"Systematicc review: the epidemiology and natural history of nonalcoholic fatty liver disease and non alcoholic steatohepatitis in adults","volume":"34","author":"Vernon","year":"2011","journal-title":"Ailment Pharmacol. Ther."},{"key":"10.1016\/j.biopha.2018.12.036_bib0135","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1161\/ATVBAHA.107.159228","article-title":"Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk","volume":"28","author":"Despr\u00e9s","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.biopha.2018.12.036_bib0140","doi-asserted-by":"crossref","first-page":"831","DOI":"10.3748\/wjg.14.831","article-title":"The blind men\u2019 see\u2019 the elephant-the many faces of fatty liver disease","volume":"14","author":"Sanal","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.biopha.2018.12.036_bib0145","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s00109-009-0464-1","article-title":"Molecular mechanisms involved in NAFLD progression","volume":"87","author":"Malaguarnera","year":"2009","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.biopha.2018.12.036_bib0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0126910","article-title":"Ceramide as a mediator of non-alcoholic Fatty liver disease and associated atherosclerosis","volume":"10","author":"Kasumov","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2018.12.036_bib0155","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.metabol.2016.02.014","article-title":"Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease","volume":"65","author":"Mota","year":"2016","journal-title":"Metabolism"},{"key":"10.1016\/j.biopha.2018.12.036_bib0160","article-title":"Molecular pathways of nonalcoholic fatty liver disease development and progression","author":"Bessone","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.biopha.2018.12.036_bib0165","doi-asserted-by":"crossref","first-page":"33","DOI":"10.14712\/18059694.2018.63","article-title":"Adenosine deaminase activity in the serum of type 2 diabetic patients","volume":"47","author":"Kurtul","year":"2004","journal-title":"Acta Medica (Hradec Kralove)"},{"key":"10.1016\/j.biopha.2018.12.036_bib0170","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0021-9258(19)40200-7","article-title":"Pathways of purine metabolism in human adipocytes. Further evidence against a role of adenosine as an endogenous regulator of human fat cell function","volume":"265","author":"Kather","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2018.12.036_bib0175","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.pharep.2016.12.010","article-title":"Anti-inflammatory and antithrombotic effects of nicotine exposure in oral contraceptive-induced insulin resistance are glucocorticoid-independent","volume":"69","author":"Olatunji","year":"2017","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.biopha.2018.12.036_bib0180","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1096\/fj.13-247148","article-title":"Uric acid induces endothelial dysfunction by vascular insulin resistance associated with the impairment of nitric oxide synthesis","volume":"28","author":"Choi","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.biopha.2018.12.036_bib0185","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3109\/10715762.2012.747677","article-title":"Uric acid modulates vascular endothelial function through the down regulation of nitric oxide production","volume":"47","author":"Pape\u017e\u00edkov\u00e1","year":"2013","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.biopha.2018.12.036_bib0190","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1161\/01.CIR.0000092948.04444.C7","article-title":"Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels","volume":"108","author":"Berkowitz","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2018.12.036_bib0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabet.2015.02.006","article-title":"Contribution of mitochondria and endoplasmic reticulum dysfunction in insulin resistance: distinct or interrelated roles?","author":"Rieusset","year":"2015","journal-title":"Diabetes Metab."},{"key":"10.1016\/j.biopha.2018.12.036_bib0200","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1126\/science.1082889","article-title":"Mitochondrial dysfunction in the elderly: possible role in insulin resistance","volume":"300","author":"Petersen","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.biopha.2018.12.036_bib0205","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.2337\/diabetes.53.11.2861","article-title":"A possible link between skeletal muscle mitochondrial efficiency and age-induced insulin resistance","volume":"53","author":"Iossa","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.biopha.2018.12.036_bib0210","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.2174\/1389557511009011175","article-title":"Physiological control of liver glycogen metabolism: lessons from novel glycogen phosphorylase inhibitors","volume":"10","author":"Agius","year":"2010","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.biopha.2018.12.036_bib0215","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.cld.2004.04.004","article-title":"The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease","volume":"8","author":"McCullough","year":"2004","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.biopha.2018.12.036_bib0220","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.1442-200X.1995.tb03389.x","article-title":"The relationship between serum transaminases activities and fatty liver in children with simple obesity","volume":"37","author":"Noguchi","year":"1995","journal-title":"Acta Paediatr. Jpn"},{"key":"10.1016\/j.biopha.2018.12.036_bib0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0038744","article-title":"Linagliptin improves insulin sensitivity and hepatic steatosis in diet-induced obesity","volume":"7","author":"Kern","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2018.12.036_bib0230","doi-asserted-by":"crossref","DOI":"10.1007\/s00125-018-4647-6","article-title":"The DPP-4 inhibitor vildagliptin impacts the gut microbiota and prevents disruption of intestinal homeostasis induced by a Western diet in mice","author":"Olivares","year":"2018","journal-title":"Diabetologia"},{"key":"10.1016\/j.biopha.2018.12.036_bib0235","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.peptides.2017.12.020","article-title":"Tissue expression of DPP-IV in obesity-diabetes and modulatory effects on peptide regulation of insulin secretion","volume":"100","author":"McKillop","year":"2018","journal-title":"Peptides"},{"key":"10.1016\/j.biopha.2018.12.036_bib0240","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1139\/cjpp-2016-0026","article-title":"Gemigliptin ameliorates Western-diet-induced metabolic syndrome in mice","volume":"95","author":"Choi","year":"2017","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.biopha.2018.12.036_bib0245","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1463-1326.2010.01275.x","article-title":"Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c","volume":"12","author":"Ferre","year":"2010","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.biopha.2018.12.036_bib0250","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/j.1463-1326.2011.01362.x","article-title":"Effect of sitagliptin therapy on postprandial lipoprotein levels in patients with type 2 diabetes","volume":"13","author":"Tremblay","year":"2011","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.biopha.2018.12.036_bib0255","first-page":"99","article-title":"Sitagliptin as add-on therapy in insulin deficiency: biomarkers of therapeutic efficacy respond differently in type 1 and type 2 diabetes","volume":"7","author":"Giampietro","year":"2013","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.biopha.2018.12.036_bib0260","first-page":"1522","article-title":"Non-alcoholic fatty liver disease adversely affects the glycemic control afforded by sitagliptin","volume":"59","author":"Iwasaki","year":"2012","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.biopha.2018.12.036_bib0265","first-page":"240","article-title":"Effects of sitagliptin in diabetic patients with nonalcoholic steatohepatitis","volume":"75","author":"Yilmaz","year":"2012","journal-title":"Acta Gastroenterol. Belg."},{"key":"10.1016\/j.biopha.2018.12.036_bib0270","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.2337\/db14-0804","article-title":"Dipeptidyl peptidase-4 inhibition ameliorates Western diet\u2013induced hepatic steatosis and insulin resistance through hepatic lipid remodeling and modulation of hepatic mitochondrial function","volume":"64","author":"Aroor","year":"2015","journal-title":"Diabetes"}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218367209?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218367209?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T21:25:30Z","timestamp":1764105930000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218367209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":54,"alternative-id":["S0753332218367209"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.12.036","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dipeptidyl peptidase-4 inhibition protects the liver of insulin-resistant female rats against triglyceride accumulation by suppressing uric acid","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.12.036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}