{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T02:32:35Z","timestamp":1780626755169,"version":"3.54.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,12,8]],"date-time":"2018-12-08T00:00:00Z","timestamp":1544227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.biopha.2018.12.043","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T20:11:18Z","timestamp":1545250278000},"page":"142-150","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Fangchinoline supplementation attenuates inflammatory markers in experimental rheumatoid arthritis-induced rats"],"prefix":"10.1016","volume":"111","author":[{"given":"Lu","family":"Shan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Hang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwu","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.12.043_bib0005","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1034\/j.1600-065x.2001.1840117.x","article-title":"Arthritis induced in rats with nonimmunogenic adjuvants as models for rheumatoid arthritis","volume":"184","author":"Holmdahl","year":"2001","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.biopha.2018.12.043_bib0010","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s00296-006-0197-1","article-title":"Effects of glucosamine administration on patients with rheumatoid arthritis","volume":"27","author":"Nakamura","year":"2007","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.biopha.2018.12.043_bib0015","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1159\/000139330","article-title":"Effect of high lipid diet and allopurinol on the development of experimentally induced arthritis in rats","volume":"51","author":"Yossif","year":"1995","journal-title":"Pharmacology"},{"key":"10.1016\/j.biopha.2018.12.043_bib0020","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1590\/S0074-02762005000900002","article-title":"Nitric oxide as a regulator of inflammatory processes","volume":"100","author":"Wallace","year":"2005","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.biopha.2018.12.043_bib0025","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1002\/1529-0131(199906)42:6<1119::AID-ANR8>3.0.CO;2-3","article-title":"Hemoglobin protects from streptococcal cell wall-induced arthritis","volume":"42","author":"McCartney-Francis","year":"1999","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.biopha.2018.12.043_bib0030","first-page":"1245","article-title":"Diagnosis and management of rheumatoid arthritis","volume":"84","author":"Wasserman","year":"2011","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.biopha.2018.12.043_bib0035","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1002\/ptr.4936","article-title":"Fangchinoline induces G1 arrest in breast cancer cells through cell-cycle regulation","volume":"27","author":"Xing","year":"2013","journal-title":"Phytother. Res."},{"key":"10.1016\/j.biopha.2018.12.043_bib0040","first-page":"5307","article-title":"Fangchinoline inhibits migration and causes apoptosis of human breast cancer MDA-MB-231 cells","volume":"14","author":"Wang","year":"2017","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.biopha.2018.12.043_bib0045","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0378-8741(99)00141-5","article-title":"Anti-inflammatory effects of fangchinoline and tetrandrine","volume":"69","author":"Choi","year":"2000","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2018.12.043_bib0050","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1248\/bpb.26.313","article-title":"Anti-hyperglycemic effect of fangchinoline isolated from Stephania tetrandra Radix in streptozotocin-diabetic mice","volume":"26","author":"Tsutsumi","year":"2003","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.biopha.2018.12.043_bib0055","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1078\/09447110260571599","article-title":"Therapeutic efficacy of Stephania tetrandra S. Moore for treatment of neovascularization of retinal capillary (retinopathy) in diabetes--in vitro study","volume":"9","author":"Liang","year":"2002","journal-title":"Phytomedicine."},{"key":"10.1016\/j.biopha.2018.12.043_bib0060","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1159\/000481698","article-title":"Fangchinoline induces apoptosis, autophagy and energetic impairment in bladder cancer","volume":"43","author":"Fan","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.biopha.2018.12.043_bib0065","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/j.1476-5381.2011.01349.x","article-title":"Fangchinoline induces autophagic cell death via p53\/sestrin2\/AMPK signalling in human hepatocellular carcinoma cells","volume":"164","author":"Wang","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.biopha.2018.12.043_bib0070","article-title":"Fangchinoline protects against renal injury in diabetic nephropathy by modulating the MAPK signaling pathway","author":"Jiang","year":"2018","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.biopha.2018.12.043_bib0075","article-title":"Animal models of rheumatoid arthritis (I): pristane-induced arthritis in the rat","volume":"11","author":"Tuncel","year":"2016"},{"key":"10.1016\/j.biopha.2018.12.043_bib0080","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.joad.2016.08.028","article-title":"Aluminium-induced acute neurotoxicity in rats: treatment with aqueous extract of arthrophytum (Hammada scoparia)","volume":"5","author":"Kaddour","year":"2016","journal-title":"J. Acute Dis."},{"key":"10.1016\/j.biopha.2018.12.043_bib0085","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jobaz.2014.01.003","article-title":"The Potential anti-inflammatory effect of lemon and hot pepper extracts on adjuvant-induced arthritis in mice","volume":"67","author":"Hend","year":"2014","journal-title":"J. Basic Appl. Zool."},{"key":"10.1016\/j.biopha.2018.12.043_bib0090","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/clinchem\/26.2.227","article-title":"Use of 3,5-dichloro-2-hydroxybenzene sulfonic acid\/4-aminophenazone chromogenic system in the direct enzymic assay of uric acid in serum and urine","volume":"26","author":"Fossati","year":"1980","journal-title":"Clin. Chem."},{"key":"10.1016\/j.biopha.2018.12.043_bib0095","first-page":"139","article-title":"Antioxidants and rheumatoid arthritis","volume":"2","author":"Mahajan","year":"2004","journal-title":"J. Indian Rheumatol. Assoc."},{"key":"10.1016\/j.biopha.2018.12.043_bib0100","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1677\/joe.0.1590027","article-title":"Plasma nitrate + nitrite level are regulated by ovarian steroids but do not correlate with trabecular bone mineral density in rats","volume":"159","author":"Van Beezooijen","year":"1988","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.biopha.2018.12.043_bib0105","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/2193-1801-2-57","article-title":"A biochemical and histopathological study in rats intoxicated with carbon tetrachloride and treated with camel milk","volume":"2","author":"Althnaian","year":"2013","journal-title":"SpringerPlus"},{"key":"10.1016\/j.biopha.2018.12.043_bib0110","doi-asserted-by":"crossref","first-page":"e1984","DOI":"10.21769\/BioProtoc.1984","article-title":"Sulforhodamine B (SRB) assay in cell culture to investigate cell proliferation","volume":"6","author":"Orellana","year":"2016","journal-title":"Bio-protocol."},{"key":"10.1016\/j.biopha.2018.12.043_bib0115","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.ijbiomac.2016.07.044","article-title":"Efficacy of carnosine on activation of caspase 3 and human renal carcinoma cell inhibition","volume":"92","author":"Muthuraman","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.biopha.2018.12.043_bib0120","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0009-2797(00)00289-1","article-title":"The role of aldose reductase in sugar cataract formation: aldose reductase plays a key role in lens epithelial cell death (apoptosis)","volume":"130-132","author":"Masatoshi","year":"2001","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.biopha.2018.12.043_bib0125","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/PAI.0b013e3181ebf4e8","article-title":"Novel immunofluorescence protocol for multimarker assessment of putative disseminating breast cancer stem cells","volume":"19","author":"Balic","year":"2011","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"key":"10.1016\/j.biopha.2018.12.043_bib0130","first-page":"15","article-title":"Role of reactive oxygen and nitrogen species in the etiopathogenesis of rheumatoid arthritis","volume":"18","author":"Bauerova","year":"1999","journal-title":"Gen. Physiol. Biophys."},{"key":"10.1016\/j.biopha.2018.12.043_bib0135","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1136\/ard.53.1.51","article-title":"Serum antioxidants and risk of rheumatoid arthritis","volume":"53","author":"Heliovaara","year":"1994","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.biopha.2018.12.043_bib0140","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s002960050097","article-title":"Oxidant\/antioxidant status of plasma samples from patients with rheumatoid arthritis","volume":"19","author":"Ozturk","year":"1999","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.biopha.2018.12.043_bib0145","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/sj.ejcn.1601601","article-title":"Copper and zinc intake and serum levels in patients with juvenile rheumatoid arthritis","volume":"57","author":"Amancio","year":"2003","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.biopha.2018.12.043_bib0150","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/BF02784402","article-title":"Trace element and magnesium levels and superoxide dismutase activity in rheumatoid arthritis","volume":"68","author":"Tuncer","year":"1999","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.biopha.2018.12.043_bib0155","first-page":"261","article-title":"Serum zinc, copper, and selenium in rheumatoid arthritis","volume":"5","author":"Honkanen","year":"1991","journal-title":"J. Trace Elem. Electrolytes Health Dis."},{"key":"10.1016\/j.biopha.2018.12.043_bib0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1081\/PRG-120002905","article-title":"Xanthine oxidase activation in mild gestational hypertension","volume":"21","author":"Nemeth","year":"2002","journal-title":"Hypertens. Pregnancy"},{"key":"10.1016\/j.biopha.2018.12.043_bib0165","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0026-895X(24)12518-7","article-title":"Anti-inflammatory effects of the partially purified extract of radix Stephaniae tetrandrae: comparative studies of its active principles tetrandrine and fangchinoline on human polymorphonuclear leukocyte functions","volume":"60","author":"Shen","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.biopha.2018.12.043_bib0170","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/BF02976638","article-title":"Protective effect of fangchinoline on cyanide-induced neurotoxicity in cultured rat cerebellar granule cells","volume":"25","author":"Cho","year":"2002","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.biopha.2018.12.043_bib0175","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3892\/ijo.2013.2159","article-title":"In vitro modulation of MMP-2 and MMP-9 in pediatric human sarcoma cell lines by cytokines, inducers and inhibitors","volume":"44","author":"Roomi","year":"2014","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.biopha.2018.12.043_bib0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biocel.2014.10.028","article-title":"Centchroman suppresses breast cancer metastasis by reversing epithelial-mesenchymal transition via downregulation of HER2\/ERK1\/2\/MMP-9 signaling","volume":"58","author":"Khan","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.biopha.2018.12.043_bib0185","doi-asserted-by":"crossref","first-page":"655","DOI":"10.3892\/ol.2016.5457","article-title":"Anti-metastatic activity of fangchinoline in human gastric cancer AGS cells","volume":"13","author":"Chen","year":"2017","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.biopha.2018.12.043_bib0190","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.3892\/etm.2013.924","article-title":"Fangchinoline induces G0\/G1 arrest by modulating the expression of CDKN1A and CCND2 in K562 human chronic myelogenous leukemia cells","volume":"5","author":"Wang","year":"2013","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.biopha.2018.12.043_bib0195","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3892\/or.2017.5678","article-title":"Fangchinoline suppresses growth and metastasis of melanoma cells by inhibiting the phosphorylation of FAK","volume":"38","author":"Shi","year":"2017","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.biopha.2018.12.043_bib0200","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1055\/s-2006-959356","article-title":"Inhibitory effects of bisbenzylisoquinoline alkaloids on induction of proinflammatory cytokines, interleukin-1 and tumor necrosis factor-alpha","volume":"61","author":"Onai","year":"1995","journal-title":"Planta Med."},{"key":"10.1016\/j.biopha.2018.12.043_bib0205","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3109\/14756360902932792","article-title":"Antioxidant activity of bisbenzylisoquinoline alkaloids from Stephania rotunda: cepharanthine and fangchinoline","volume":"25","author":"G\u00fcl\u00e7in","year":"2010","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.biopha.2018.12.043_bib0210","doi-asserted-by":"crossref","first-page":"138","DOI":"10.4041\/kjod.2012.42.3.138","article-title":"Effect of fangchinoline on root resorption during rat orthodontic tooth movement","volume":"42","author":"Bao","year":"2012","journal-title":"Korean J. Orthod."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218369786?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218369786?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T11:30:19Z","timestamp":1760095819000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218369786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":42,"alternative-id":["S0753332218369786"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.12.043","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fangchinoline supplementation attenuates inflammatory markers in experimental rheumatoid arthritis-induced rats","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.12.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}