{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T23:15:42Z","timestamp":1791674142547,"version":"4.3.4"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T00:00:00Z","timestamp":1544572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2009-0083533"],"award-info":[{"award-number":["2009-0083533"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006395","name":"Alabama Commission on Higher Education","doi-asserted-by":"publisher","award":["17-5(Ph-II)\/2MD4-051\/HEC\/IS\/2017"],"award-info":[{"award-number":["17-5(Ph-II)\/2MD4-051\/HEC\/IS\/2017"]}],"id":[{"id":"10.13039\/100006395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006395","name":"Alabama Commission on Higher Education","doi-asserted-by":"publisher","award":["357 SRGP\/HEC\/2014"],"award-info":[{"award-number":["357 SRGP\/HEC\/2014"]}],"id":[{"id":"10.13039\/100006395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002551","name":"Seoul National University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002551","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.biopha.2018.12.047","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T20:35:17Z","timestamp":1545424517000},"page":"209-223","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"special_numbering":"C","title":["Effect of 25-methoxy hispidol A isolated from Poncirus trifoliate against bacteria-induced anxiety and depression by targeting neuroinflammation, oxidative stress and apoptosis in mice"],"prefix":"10.1016","volume":"111","author":[{"given":"Bushra","family":"Shal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7950-2983","authenticated-orcid":false,"given":"Adnan","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Naveed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naseem","family":"Ullah Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Ihsan-Ul-Haq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakir","family":"D AlSharari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeong Shik","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salman","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.12.047_bib0005","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.1016\/S0924-977X(99)00027-9","article-title":"Anxiety with depression: a treatment need","volume":"9","author":"Rouillon","year":"1999","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.biopha.2018.12.047_bib0010","series-title":"The Temporal Relationship between Anxiety and Depression in Adolescence: A Longitudinal Study on Symptom-Development in Boys and Girls","author":"Gjertsen","year":"2014"},{"issue":"16","key":"10.1016\/j.biopha.2018.12.047_bib0015","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1007\/s00213-017-4634-5","article-title":"Predicting relapse with individual residual symptoms in major depressive disorder: a reanalysis of the STAR* D data","volume":"234","author":"Sakurai","year":"2017","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.biopha.2018.12.047_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2018.01.003","article-title":"Targeting cytokines in reduction of depressive symptoms: a comprehensive review","author":"Shariq","year":"2018","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"issue":"6","key":"10.1016\/j.biopha.2018.12.047_bib0025","article-title":"The comorbidity of major depression and anxiety disorders: recognition and management in primary care","volume":"3","author":"Hirschfeld","year":"2001","journal-title":"Primary Care Compan. J. Clin. Psychiatry"},{"issue":"11","key":"10.1016\/j.biopha.2018.12.047_bib0030","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.4088\/JCP.10m06419","article-title":"Early and delayed onset of response to antidepressants in individual trajectories of change during treatment of major depression: a secondary analysis of data from the genome-based therapeutic drugs for depression (GENDEP) study","volume":"72","author":"Uher","year":"2011","journal-title":"J. Clin. Psychiatry"},{"issue":"1","key":"10.1016\/j.biopha.2018.12.047_bib0035","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/YCO.0b013e32831be9ef","article-title":"Augmentation strategies for treatment-resistant depression","volume":"22","author":"Carvalho","year":"2009","journal-title":"Curr. Opin. Psychiatry"},{"issue":"6","key":"10.1016\/j.biopha.2018.12.047_bib0040","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1159\/000350094","article-title":"Molecular mechanisms of depression: perspectives on new treatment strategies","volume":"31","author":"Lang","year":"2013","journal-title":"Cell. Physiol. Biochem."},{"issue":"2","key":"10.1016\/j.biopha.2018.12.047_bib0045","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.jep.2012.12.001","article-title":"Molecular mechanism of capillarisin-mediated inhibition of MyD88\/TIRAP inflammatory signaling in in vitro and in vivo experimental models","volume":"145","author":"Khan","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2018.12.047_bib0050","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3389\/fphar.2018.00140","article-title":"Antihyperalgesic properties of honokiol in inflammatory pain models by targeting of NF-kappaB and Nrf2 signaling","volume":"9","author":"Khalid","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"7","key":"10.1016\/j.biopha.2018.12.047_bib0055","doi-asserted-by":"crossref","first-page":"3724","DOI":"10.1128\/IAI.71.7.3724-3729.2003","article-title":"Control of the oxidative burst of human neutrophils by staphylococcal leukotoxins","volume":"71","author":"Colin","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.biopha.2018.12.047_bib0060","article-title":"Anti-inflammatory, anti-rheumatic and analgesic activities of 2-(5-mercapto-1,3,4-oxadiazol-2-yl)-N-propylbenzenesulphonamide (MOPBS) in rodents","author":"Rasheed","year":"2018","journal-title":"Inflammopharmacology"},{"issue":"2","key":"10.1016\/j.biopha.2018.12.047_bib0065","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a012559","article-title":"DNA base damage by reactive oxygen species, oxidizing agents, and UV radiation","volume":"5","author":"Cadet","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"10","key":"10.1016\/j.biopha.2018.12.047_bib0070","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1080\/17460441.2017.1362385","article-title":"Animal inflammation-based models of depression and their application to drug discovery","volume":"12","author":"Ma","year":"2017","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.biopha.2018.12.047_bib0075","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ejphar.2014.07.031","article-title":"Protective effect of mangiferin against lipopolysaccharide-induced depressive and anxiety-like behaviour in mice","volume":"740","author":"Jangra","year":"2014","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.biopha.2018.12.047_bib0080","first-page":"463","article-title":"Escherichia coli and Staphylococcus aureus elicit differential innate immune responses following intramammary infection","volume":"11","author":"Bannerman","year":"2004","journal-title":"Clin. Diagn. Lab. Immunol."},{"issue":"8","key":"10.1016\/j.biopha.2018.12.047_bib0085","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1176\/ajp.150.8.1189","article-title":"Interleukin-1 beta: a putative mediator of HPA axis hyperactivity in major depression?","volume":"150","author":"Maes","year":"1993","journal-title":"Am. J. Psychiatry"},{"issue":"4","key":"10.1016\/j.biopha.2018.12.047_bib0090","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0031-6997(25)06673-6","article-title":"Physiology and pharmacology of corticotropin-releasing factor","volume":"43","author":"Owens","year":"1991","journal-title":"Pharmacol. Rev"},{"issue":"1-3","key":"10.1016\/j.biopha.2018.12.047_bib0095","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.ejphar.2009.10.036","article-title":"Anti-inflammatory activity of hispidol a 25-methyl ether, a triterpenoid isolated from ponciri immaturus fructus","volume":"627","author":"Shin","year":"2010","journal-title":"Eur. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.biopha.2018.12.047_bib0100","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1016\/j.fct.2011.07.001","article-title":"25-Methoxyhispidol A, A novel triterpenoid of Poncirus trifoliata, inhibits cell growth via the modulation of EGFR\/c-Src signaling pathway in MDA-MB-231 human breast cancer cells","volume":"49","author":"Chung","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2018.12.047_bib0105","doi-asserted-by":"crossref","first-page":"S694","DOI":"10.1016\/j.euroneuro.2011.07.002","article-title":"The keys to improving depression outcomes","volume":"21","author":"Rizvi","year":"2011","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"6","key":"10.1016\/j.biopha.2018.12.047_bib0110","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1248\/cpb.56.839","article-title":"Terpenoids and coumarins isolated from the fruits of Poncirus trifoliata","volume":"56","author":"Xu","year":"2008","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"issue":"4","key":"10.1016\/j.biopha.2018.12.047_bib0115","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1007\/s10753-016-0376-5","article-title":"Lipopolysaccharide-induced behavioral alterations are alleviated by sodium phenylbutyrate via attenuation of oxidative stress and neuroinflammatory cascade","volume":"39","author":"Jangra","year":"2016","journal-title":"Inflammation"},{"issue":"4","key":"10.1016\/j.biopha.2018.12.047_bib0120","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.ymeth.2007.01.006","article-title":"Microtitre plate-based antibacterial assay incorporating resazurin as an indicator of cell growth, and its application in the in vitro antibacterial screening of phytochemicals","volume":"42","author":"Sarker","year":"2007","journal-title":"Methods"},{"key":"10.1016\/j.biopha.2018.12.047_bib0125","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ejphar.2014.09.049","article-title":"Honokiol abrogates lipopolysaccharide-induced depressive like behavior by impeding neuroinflammation and oxido-nitrosative stress in mice","volume":"744","author":"Sulakhiya","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2018.12.047_bib0130","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jpsychires.2018.02.006","article-title":"Anxiolytic effects of ascorbic acid and ketamine in mice","volume":"100","author":"Fraga","year":"2018","journal-title":"J. Psychiatr. Res."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.047_bib0135","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0166-4328(01)00231-5","article-title":"A comparison of 129S2\/SvHsd and C57BL\/6JOlaHsd mice on a test battery assessing sensorimotor, affective and cognitive behaviours: implications for the study of genetically modified mice","volume":"124","author":"Contet","year":"2001","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.biopha.2018.12.047_bib0140","article-title":"Measuring the strength of mice","volume":"76","author":"Deacon","year":"2013","journal-title":"J. Vis. Exp.: JoVE"},{"key":"10.1016\/j.biopha.2018.12.047_bib0145","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3389\/fphar.2018.00140","article-title":"Antihyperalgesic properties of honokiol in inflammatory pain models by targeting of NF-\u03baB and Nrf2 signaling","volume":"9","author":"Khalid","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.biopha.2018.12.047_bib0150","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s002130050834","article-title":"The in vivo effects of olanzapine and other antipsychotic agents on receptor occupancy and antagonism of dopamine D1, D2, D3, 5HT2A and muscarinic receptors","volume":"141","author":"Zhang","year":"1999","journal-title":"Psychopharmacology (Berl)"},{"issue":"7","key":"10.1016\/j.biopha.2018.12.047_bib0155","first-page":"368","article-title":"Antidepressant and anxiolytic properties of the methanolic extract of Momordica charantia Linn (Cucurbitaceae) and its mechanism of action","volume":"64","author":"Ishola","year":"2014","journal-title":"Drug Res. (Stuttg)"},{"issue":"1","key":"10.1016\/j.biopha.2018.12.047_bib0160","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.advms.2017.07.005","article-title":"Antidepressant-like activity of methyl jasmonate involves modulation of monoaminergic pathways in mice","volume":"63","author":"Umukoro","year":"2018","journal-title":"Adv. Med. Sci."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.047_bib0165","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"issue":"5","key":"10.1016\/j.biopha.2018.12.047_bib0170","first-page":"882","article-title":"Improved method for determination of blood glutathione","volume":"61","author":"Beutler","year":"1963","journal-title":"J. Lab. Clin. Med."},{"issue":"4","key":"10.1016\/j.biopha.2018.12.047_bib0175","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.pbb.2007.10.009","article-title":"Protective effect of curcumin, the active principle of turmeric (Curcuma longa) in haloperidol-induced orofacial dyskinesia and associated behavioural, biochemical and neurochemical changes in rat brain","volume":"88","author":"Bishnoi","year":"2008","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.biopha.2018.12.047_bib0180","series-title":"62] Glutathione Transferases from Human Liver, in Methods in Enzymology","first-page":"499","author":"Warholm","year":"1985"},{"issue":"70","key":"10.1016\/j.biopha.2018.12.047_bib0185","article-title":"Assaying DNA damage in hippocampal neurons using the comet assay","author":"Au-Nowsheen","year":"2012","journal-title":"JoVE"},{"issue":"1","key":"10.1016\/j.biopha.2018.12.047_bib0190","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s10565-008-9072-z","article-title":"Comet assay: a reliable tool for the assessment of DNA damage in different models","volume":"25","author":"Dhawan","year":"2009","journal-title":"Cell Biol. Toxicol."},{"issue":"3","key":"10.1016\/j.biopha.2018.12.047_bib0195","first-page":"313","article-title":"Indomethacin induced hepatic alterations in mono-oxygenase system and faecal Clostridium perfringens enterotoxin in the rat","volume":"31","author":"Fracasso","year":"1990","journal-title":"Inflamm. Res."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.047_bib0200","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0014-2999(99)00790-6","article-title":"Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice","volume":"387","author":"Ribeiro","year":"2000","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.biopha.2018.12.047_bib0205","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s10787-011-0111-7","article-title":"New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates\u2014Nrf2 activators and GSK-3 inhibitors","volume":"20","author":"Maes","year":"2012","journal-title":"Inflammopharmacology"},{"issue":"1","key":"10.1016\/j.biopha.2018.12.047_bib0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0033291709005558","article-title":"Not fade away: the HPA axis and depression","volume":"40","author":"Cowen","year":"2010","journal-title":"Psychol. Med."},{"issue":"2","key":"10.1016\/j.biopha.2018.12.047_bib0215","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.neubiorev.2011.12.005","article-title":"Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression","volume":"36","author":"Leonard","year":"2012","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.biopha.2018.12.047_bib0220","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.intimp.2018.05.034","article-title":"Attenuation of inflammatory pain by puerarin in animal model of inflammation through inhibition of pro-inflammatory mediators","volume":"61","author":"Ullah","year":"2018","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.047_bib0225","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.jad.2011.08.023","article-title":"IgM-mediated autoimmune responses directed against multiple neoepitopes in depression: new pathways that underpin the inflammatory and neuroprogressive pathophysiology","volume":"135","author":"Maes","year":"2011","journal-title":"J. Affect. Disord."},{"issue":"8","key":"10.1016\/j.biopha.2018.12.047_bib0230","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.bbi.2008.06.005","article-title":"Evidence that oxidative stress is linked to anxiety-related behaviour in mice","volume":"22","author":"Rammal","year":"2008","journal-title":"Brain Behav. Immun."},{"issue":"4","key":"10.1016\/j.biopha.2018.12.047_bib0235","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1742-7843.2011.00824.x","article-title":"Lipopolysaccharide\u2010induced sickness behaviour evaluated in different models of anxiety and innate fear in rats","volume":"110","author":"Bassi","year":"2012","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"11","key":"10.1016\/j.biopha.2018.12.047_bib0240","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1016\/j.neurobiolaging.2007.04.012","article-title":"Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide","volume":"29","author":"Huang","year":"2008","journal-title":"Neurobiol. Aging"},{"issue":"10","key":"10.1016\/j.biopha.2018.12.047_bib0245","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/j.jpsychires.2013.06.008","article-title":"Effects of doxycycline on depressive-like behavior in mice after lipopolysaccharide (LPS) administration","volume":"47","author":"Mello","year":"2013","journal-title":"J. Psychiatr. Res."},{"issue":"7465","key":"10.1016\/j.biopha.2018.12.047_bib0250","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nature12479","article-title":"Bacteria activate sensory neurons that modulate pain and inflammation","volume":"501","author":"Chiu","year":"2013","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.biopha.2018.12.047_bib0255","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.pnpbp.2003.11.018","article-title":"Central monoamines and their role in major depression","volume":"28","author":"Elhwuegi","year":"2004","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"1-3","key":"10.1016\/j.biopha.2018.12.047_bib0260","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.ejphar.2004.07.038","article-title":"The role of monoamines in the actions of established and \"novel\" antidepressant agents: a critical review","volume":"500","author":"Millan","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2018.12.047_bib0265","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.physbeh.2016.04.052","article-title":"Involvement of D1 and D2 dopamine receptors in the antidepressant-like effects of selegiline in maternal separation model of mouse","volume":"163","author":"Amiri","year":"2016","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.biopha.2018.12.047_bib0270","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.pbb.2017.10.006","article-title":"The antidepressant-and anxiolytic-like effects of fluoxetine and clozapine in chronically isolated rats involve inhibition of hippocampal Tnf-\u03b1","volume":"163","author":"Todorovi\u0107","year":"2017","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.047_bib0275","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/syn.10212","article-title":"Role of epinephrine stimulation of CNS \u03b11\u2010adrenoceptors in motor activity in mice","volume":"49","author":"Stone","year":"2003","journal-title":"Synapse"},{"issue":"4","key":"10.1016\/j.biopha.2018.12.047_bib0280","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0006-3223(02)01728-6","article-title":"Elevated agonist binding to alpha2-adrenoceptors in the locus coeruleus in major depression","volume":"53","author":"Ordway","year":"2003","journal-title":"Biol. Psychiatry"},{"issue":"6","key":"10.1016\/j.biopha.2018.12.047_bib0285","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.euroneuro.2005.12.002","article-title":"Dopaminergic-based pharmacotherapies for depression","volume":"16","author":"Papakostas","year":"2006","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.047_bib0290","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s002130050165","article-title":"Blockade of phencyclidine-induced hyperlocomotion by olanzapine, clozapine and serotonin receptor subtype selective antagonists in mice","volume":"129","author":"Gleason","year":"1997","journal-title":"Psychopharmacology"},{"issue":"3","key":"10.1016\/j.biopha.2018.12.047_bib0295","first-page":"287","article-title":"The cytokine hypothesis of depression: inflammation, oxidative & nitrosative stress (IO&NS) and leaky gut as new targets for adjunctive treatments in depression","volume":"29","author":"Maes","year":"2008","journal-title":"Neuro Endocrinol. Lett."},{"key":"10.1016\/j.biopha.2018.12.047_bib0300","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.brainres.2010.09.049","article-title":"Fluoxetine prevents LPS-induced degeneration of nigral dopaminergic neurons by inhibiting microglia-mediated oxidative stress","volume":"1363","author":"Chung","year":"2010","journal-title":"Brain Res."},{"issue":"548","key":"10.1016\/j.biopha.2018.12.047_bib0305","article-title":"Anti-neuroinflammatory potential of natural products in attenuation of alzheimer\u2019s disease","volume":"9","author":"Shal","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.biopha.2018.12.047_bib0310","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1192\/bjp.164.3.365","article-title":"Glucocorticoids and the genesis of depressive illness a psychobiological model","volume":"164","author":"Dinan","year":"1994","journal-title":"Brit. J. Psychiatry"},{"issue":"1","key":"10.1016\/j.biopha.2018.12.047_bib0315","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00441-011-1196-4","article-title":"Immunohistological markers for proliferative events, gliogenesis, and neurogenesis within the adult hippocampus","volume":"345","author":"und Halbach","year":"2011","journal-title":"Cell Tissue Res."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218362309?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218362309?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T11:30:58Z","timestamp":1760095858000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218362309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":63,"alternative-id":["S0753332218362309"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.12.047","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of 25-methoxy hispidol A isolated from Poncirus trifoliate against bacteria-induced anxiety and depression by targeting neuroinflammation, oxidative stress and apoptosis in mice","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.12.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}