{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:33:48Z","timestamp":1791999228462,"version":"4.4.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T00:00:00Z","timestamp":1544572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81673656"],"award-info":[{"award-number":["81673656"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81102861"],"award-info":[{"award-number":["81102861"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81374048"],"award-info":[{"award-number":["81374048"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Chinese Medicine Science Foundation of Zhejiang Province, China","award":["2015ZA062"],"award-info":[{"award-number":["2015ZA062"]}]},{"name":"Zhejiang Provincial Natural Science Foundation, China","award":["LYY18H280001"],"award-info":[{"award-number":["LYY18H280001"]}]},{"name":"Zhejiang Provincial Natural Science Foundation, China","award":["LY18H280002"],"award-info":[{"award-number":["LY18H280002"]}]},{"name":"the Scientific Research Projects Zhejiang Province Association of Chinese Integrative Medicine, China","award":["2016LYK011"],"award-info":[{"award-number":["2016LYK011"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.biopha.2018.12.050","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T23:20:25Z","timestamp":1545261625000},"page":"162-168","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":94,"special_numbering":"C","title":["The flavonoid-rich fraction from rhizomes of Smilax glabra Roxb. ameliorates renal oxidative stress and inflammation in uric acid nephropathy rats through promoting uric acid excretion"],"prefix":"10.1016","volume":"111","author":[{"given":"Siwei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuejuan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinfen","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7902-5002","authenticated-orcid":false,"given":"Daozong","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.biopha.2018.12.050_bib0005","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/SMJ.0000000000000082","article-title":"Hyperuricemia, gout, and related comorbidities: cause and effect on a two-way street","volume":"107","author":"Karis","year":"2014","journal-title":"South. Med. J."},{"key":"10.1016\/j.biopha.2018.12.050_bib0010","doi-asserted-by":"crossref","first-page":"43614","DOI":"10.1038\/srep43614","article-title":"Effects of multiple genetic loci on the pathogenesis from serum urate to gout","volume":"7","author":"Dong","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2018.12.050_bib0015","first-page":"S68","article-title":"[Hyperuricemia and Gout]","volume":"33","author":"Delbarba","year":"2016","journal-title":"G. Ital. Nefrol."},{"issue":"11-12","key":"10.1016\/j.biopha.2018.12.050_bib0020","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.lfs.2012.08.013","article-title":"Anti-inflammatory and immunomodulatory effects of iridoid glycosides from Paederia scandens (LOUR.) MERRILL (Rubiaceae) on uric acid nephropathy rats","volume":"91","author":"Zhu","year":"2012","journal-title":"Life Sci."},{"issue":"5","key":"10.1016\/j.biopha.2018.12.050_bib0025","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.semnephrol.2011.08.011","article-title":"Uric acid as a mediator of diabetic nephropathy","volume":"31","author":"Jalal","year":"2011","journal-title":"Semin. Nephrol."},{"issue":"2","key":"10.1016\/j.biopha.2018.12.050_bib0030","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s10157-004-0292-0","article-title":"Crystal-induced inflammation of the kidneys: results from human studies, animal models, and tissue-culture studies","volume":"8","author":"Khan","year":"2004","journal-title":"Clin. Exp. Nephrol."},{"issue":"2","key":"10.1016\/j.biopha.2018.12.050_bib0035","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s11926-012-0240-z","article-title":"Regulation of uric acid excretion by the kidney","volume":"14","author":"Lipkowitz","year":"2012","journal-title":"Curr. Rheumatol. Rep."},{"issue":"3","key":"10.1016\/j.biopha.2018.12.050_bib0040","doi-asserted-by":"crossref","first-page":"214","DOI":"10.3724\/SP.J.1009.2013.00214","article-title":"Wuling San ameliorates urate under-excretion and renal dysfunction in hyperuricemic mice","volume":"11","author":"Ding","year":"2014","journal-title":"Chin. J. Nat. Med."},{"issue":"2","key":"10.1016\/j.biopha.2018.12.050_bib0045","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1152\/physiolgenomics.00207.2007","article-title":"Multiple organic anion transporters contribute to net renal excretion of uric acid","volume":"33","author":"Eraly","year":"2008","journal-title":"Physiol. Genomics"},{"issue":"1","key":"10.1016\/j.biopha.2018.12.050_bib0050","doi-asserted-by":"crossref","first-page":"F165","DOI":"10.1152\/ajprenal.90257.2008","article-title":"Kidney-specific expression of human organic cation transporter 2 (OCT2\/SLC22A2) is regulated by DNA methylation","volume":"295","author":"Aoki","year":"2008","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.biopha.2018.12.050_bib0055","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.1038\/srep03755","article-title":"ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload","volume":"4","author":"Matsuo","year":"2014","journal-title":"Sci. Rep."},{"issue":"4-6","key":"10.1016\/j.biopha.2018.12.050_bib0060","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1080\/15257770.2013.866679","article-title":"ABCG2 dysfunction increases the risk of renal overload hyperuricemia","volume":"33","author":"Matsuo","year":"2014","journal-title":"Nucleosides Nucleotides Nucl. Acids"},{"issue":"4-6","key":"10.1016\/j.biopha.2018.12.050_bib0065","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1080\/15257770.2013.854902","article-title":"ABCG2 dysfunction increases serum uric acid by decreased intestinal urate excretion","volume":"33","author":"Takada","year":"2014","journal-title":"Nucleosides Nucleotides Nucl. Acids"},{"issue":"2","key":"10.1016\/j.biopha.2018.12.050_bib0070","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.jep.2010.05.025","article-title":"Protective effect of Smilax glabra extract against lead-induced oxidative stress in rats","volume":"130","author":"Xia","year":"2010","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.050_bib0075","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.chroma.2005.04.072","article-title":"Purification of astilbin and isoastilbin in the extract of smilax glabra rhizome by high-speed counter-current chromatography","volume":"1077","author":"Du","year":"2005","journal-title":"J. Chromatogr. A"},{"issue":"3","key":"10.1016\/j.biopha.2018.12.050_bib0080","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S1357-2725(01)00004-8","article-title":"Isolation of a novel heterodimeric agglutinin from rhizomes of Smilax glabra, the Chinese medicinal material tufuling","volume":"33","author":"Ng","year":"2001","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"8","key":"10.1016\/j.biopha.2018.12.050_bib0085","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/S0031-9422(99)00522-1","article-title":"Phenylpropanoid glycosides from Smilax glabra","volume":"53","author":"Chen","year":"2000","journal-title":"Phytochemistry"},{"issue":"6","key":"10.1016\/j.biopha.2018.12.050_bib0090","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00232-013-9560-9","article-title":"Protective effects of the flavonoid-rich fraction from rhizomes of Smilax glabra Roxb. on carbon tetrachloride-induced hepatotoxicity in rats","volume":"246","author":"Xia","year":"2013","journal-title":"J. Membr. Biol."},{"issue":"Pt B","key":"10.1016\/j.biopha.2018.12.050_bib0095","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.fct.2016.11.004","article-title":"Carvacrol attenuates acute kidney injury induced by cisplatin through suppression of ERK and PI3K\/Akt activation","volume":"98","author":"Potocnjak","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2018.12.050_bib0100","doi-asserted-by":"crossref","first-page":"6043601","DOI":"10.1155\/2016\/6043601","article-title":"New pathogenic concepts and therapeutic approaches to oxidative stress in chronic kidney disease","volume":"2016","author":"Pedraza-Chaverri","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"issue":"8","key":"10.1016\/j.biopha.2018.12.050_bib0105","doi-asserted-by":"crossref","DOI":"10.3949\/ccjm.69.8.594","article-title":"Asymptomatic hyperuricemia: to treat or not to treat","volume":"69","author":"Dincer","year":"2002","journal-title":"Cleve. Clin. J. Med."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.050_bib0110","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s12325-014-0175-z","article-title":"A review of uric acid, crystal deposition disease, and gout","volume":"32","author":"Perez-Ruiz","year":"2015","journal-title":"Adv. Ther."},{"key":"10.1016\/j.biopha.2018.12.050_bib0115","doi-asserted-by":"crossref","first-page":"535686","DOI":"10.1155\/2015\/535686","article-title":"Renal oxidative stress induced by long-term hyperuricemia alters mitochondrial function and maintains systemic hypertension","volume":"2015","author":"Cristobal-Garcia","year":"2015","journal-title":"Oxid Med. Cell Longev."},{"issue":"5","key":"10.1016\/j.biopha.2018.12.050_bib0120","doi-asserted-by":"crossref","first-page":"167","DOI":"10.14740\/cr494w","article-title":"Effects of cilnidipine on heart rate and uric acid metabolism in patients with essential hypertension","volume":"7","author":"Das","year":"2016","journal-title":"Cardiol. Res."},{"issue":"10","key":"10.1016\/j.biopha.2018.12.050_bib0125","first-page":"2009","article-title":"[Rats hyperuricemia model established by lipid emulsion simulating irregular of diet]","volume":"40","author":"Ma","year":"2015","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"issue":"334","key":"10.1016\/j.biopha.2018.12.050_bib0130","first-page":"1","article-title":"Dietary intake of ten key nutrients for public health, United States: 1999-2000","author":"Wright","year":"2003","journal-title":"Adv. Data"},{"issue":"2","key":"10.1016\/j.biopha.2018.12.050_bib0135","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00228-010-0916-0","article-title":"Effect of ABCG2 genotypes on the pharmacokinetics of A771726, an active metabolite of prodrug leflunomide, and association of A771726 exposure with serum uric acid level","volume":"67","author":"Kim","year":"2011","journal-title":"Eur. J. Clin. Pharmacol."},{"issue":"12","key":"10.1016\/j.biopha.2018.12.050_bib0140","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1080\/15257770.2011.633953","article-title":"ABCG2 is a high-capacity urate transporter and its genetic impairment increases serum uric acid levels in humans","volume":"30","author":"Nakayama","year":"2011","journal-title":"Nucleosides Nucleotides Nucl. Acids"},{"issue":"3","key":"10.1016\/j.biopha.2018.12.050_bib0145","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.jep.2010.02.012","article-title":"Simiao pill ameliorates urate underexcretion and renal dysfunction in hyperuricemic mice","volume":"128","author":"Hu","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2018.12.050_bib0150","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.biopha.2016.07.025","article-title":"Astilbin improves potassium oxonate-induced hyperuricemia and kidney injury through regulating oxidative stress and inflammation response in mice","volume":"83","author":"Wang","year":"2016","journal-title":"Biomed. Pharmacother."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218330002?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218330002?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T11:30:28Z","timestamp":1760095828000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218330002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":30,"alternative-id":["S0753332218330002"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.12.050","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The flavonoid-rich fraction from rhizomes of Smilax glabra Roxb. ameliorates renal oxidative stress and inflammation in uric acid nephropathy rats through promoting uric acid excretion","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.12.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}