{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T03:37:20Z","timestamp":1794281840779,"version":"4.9.0"},"reference-count":114,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T00:00:00Z","timestamp":1546214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Department of Biotechnology (DBT), Govt. of India","award":["MAP\/2015\/58"],"award-info":[{"award-number":["MAP\/2015\/58"]}],"id":[{"id":"https:\/\/ror.org\/03tjsyq23","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Indo-Brazil","award":["DBT\/IC-2\/Indo-Brazil\/2016-19\/01"],"award-info":[{"award-number":["DBT\/IC-2\/Indo-Brazil\/2016-19\/01"]}]},{"name":"DST-Science and Engineering Board Early Career Research Award","award":["ECR\/2016\/000007"],"award-info":[{"award-number":["ECR\/2016\/000007"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.biopha.2018.12.146","type":"journal-article","created":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T18:49:08Z","timestamp":1546627748000},"page":"802-812","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":747,"special_numbering":"C","title":["Therapeutic applications of selenium nanoparticles"],"prefix":"10.1016","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0749-4555","authenticated-orcid":false,"given":"Amit","family":"Khurana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sravani","family":"Tekula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Aslam","family":"Saifi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooladanda","family":"Venkatesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandraiah","family":"Godugu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.biopha.2018.12.146_bib0005","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/nnano.2007.387","article-title":"Nanocarriers as an emerging platform for cancer therapy","volume":"2","author":"Peer","year":"2007","journal-title":"Nat. Nanotechnol."},{"issue":"6","key":"10.1016\/j.biopha.2018.12.146_bib0010","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0167-7799(97)01036-6","article-title":"Biomedical applications of nanotechnology\u2014implications for drug targeting and gene therapy","volume":"15","author":"Davis","year":"1997","journal-title":"Trends Biotechnol."},{"issue":"5","key":"10.1016\/j.biopha.2018.12.146_bib0015","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1021\/nn800072t","article-title":"Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery","volume":"2","author":"Liong","year":"2008","journal-title":"ACS Nano"},{"issue":"5","key":"10.1016\/j.biopha.2018.12.146_bib0020","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0169-409X(02)00044-3","article-title":"Nanoparticles in cancer therapy and diagnosis","volume":"54","author":"Brigger","year":"2002","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.biopha.2018.12.146_bib0025","doi-asserted-by":"crossref","DOI":"10.1038\/srep29197","article-title":"Cationic lipid-nanoceria hybrids, a novel nonviral vector-mediated gene delivery into mammalian cells: investigation of the cellular uptake mechanism","volume":"6","author":"Das","year":"2016","journal-title":"Sci. Rep."},{"issue":"5601","key":"10.1016\/j.biopha.2018.12.146_bib0030","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1126\/science.1077229","article-title":"Shape-controlled synthesis of gold and silver nanoparticles","volume":"298","author":"Sun","year":"2002","journal-title":"Science"},{"issue":"5582","key":"10.1016\/j.biopha.2018.12.146_bib0035","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1126\/science.1060928","article-title":"Carbon nanotubes--the route toward applications","volume":"297","author":"Baughman","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.biopha.2018.12.146_bib0040","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jtemb.2018.01.016","article-title":"Nanoceria ameliorates doxorubicin induced cardiotoxicity: possible mitigation via reduction of oxidative stress and inflammation","volume":"47","author":"Sangomla","year":"2018","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.biopha.2018.12.146_bib0045","first-page":"1","article-title":"Protective effect of Nanoceria on cisplatin-induced nephrotoxicity by amelioration of oxidative stress and pro-inflammatory mechanisms","author":"Saifi","year":"2018","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.biopha.2018.12.146_bib0050","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.jtemb.2018.07.011","article-title":"Cardioprotective effects of nanoceria in a murine model of cardiac remodeling","volume":"50","author":"Kumari","year":"2018","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"3","key":"10.1016\/j.biopha.2018.12.146_bib0055","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1096\/fj.04-2747rev","article-title":"Nanomedicine: current status and future prospects","volume":"19","author":"Moghimi","year":"2005","journal-title":"Faseb J."},{"issue":"1915","key":"10.1016\/j.biopha.2018.12.146_bib0060","first-page":"1333","article-title":"Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles","volume":"368","author":"Sperling","year":"2010","journal-title":"Philos. Trans. R. Soc. Lond. A: Math. Phys. Eng. Sci."},{"issue":"5","key":"10.1016\/j.biopha.2018.12.146_bib0065","first-page":"16","article-title":"Berzelius\u2019 discovery of selenium","volume":"33","author":"Trofast","year":"2011","journal-title":"Chem. Int."},{"issue":"3","key":"10.1016\/j.biopha.2018.12.146_bib0070","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1021\/ed009p474","article-title":"The discovery of the elements. VI. Tellurium and selenium","volume":"9","author":"Weeks","year":"1932","journal-title":"J. Chem. Educ."},{"issue":"9225","key":"10.1016\/j.biopha.2018.12.146_bib0075","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0140-6736(00)02490-9","article-title":"The importance of selenium to human health","volume":"356","author":"Rayman","year":"2000","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.biopha.2018.12.146_bib0080","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1016\/j.bbagen.2014.10.008","article-title":"Selenium compounds as therapeutic agents in cancer","volume":"1850","author":"Fernandes","year":"2015","journal-title":"Biochim. Biophys. Acta (BBA)-Gen. Subj."},{"key":"10.1016\/j.biopha.2018.12.146_bib0085","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.nut.2016.05.001","article-title":"Selenium nanoparticles as a nutritional supplement","volume":"33","author":"Skalickova","year":"2017","journal-title":"Nutrition"},{"issue":"11","key":"10.1016\/j.biopha.2018.12.146_bib0090","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/j.bbagen.2009.02.014","article-title":"Protection against reactive oxygen species by selenoproteins","volume":"1790","author":"Steinbrenner","year":"2009","journal-title":"Biochim. Biophys. Acta (BBA)-Gen. Subj."},{"issue":"2b","key":"10.1016\/j.biopha.2018.12.146_bib0095","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1079\/PHN2001143","article-title":"Selenium, selenoproteins and human health: a review","volume":"4","author":"Brown","year":"2001","journal-title":"Public Health Nutr."},{"issue":"9","key":"10.1016\/j.biopha.2018.12.146_bib0100","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1093\/carcin\/20.9.1657","article-title":"Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase","volume":"20","author":"Ganther","year":"1999","journal-title":"Carcinogenesis"},{"issue":"4","key":"10.1016\/j.biopha.2018.12.146_bib0105","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1079\/PNS2005467","article-title":"Selenium in cancer prevention: a review of the evidence and mechanism of action","volume":"64","author":"Rayman","year":"2005","journal-title":"Proc. Nutr. Soc."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.146_bib0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jnutbio.2007.02.005","article-title":"Selenium as an anticancer nutrient: roles in cell proliferation and tumor cell invasion","volume":"19","author":"Zeng","year":"2008","journal-title":"J. Nutr. Biochem."},{"issue":"01","key":"10.1016\/j.biopha.2018.12.146_bib0115","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1079\/BJN20031015","article-title":"Selenium and its relationship to cancer: an update","volume":"91","author":"Whanger","year":"2004","journal-title":"Br. J. Nutr."},{"issue":"2","key":"10.1016\/j.biopha.2018.12.146_bib0120","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.mehy.2006.01.058","article-title":"Cancer chemoprevention: selenium as a prooxidant, not an antioxidant","volume":"67","author":"Drake","year":"2006","journal-title":"Med. Hypotheses"},{"issue":"10","key":"10.1016\/j.biopha.2018.12.146_bib0125","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1166\/jbn.2014.1985","article-title":"Surface functionalized selenium nanoparticles for biomedical applications","volume":"10","author":"Chaudhary","year":"2014","journal-title":"J. Biomed. Nanotechnol."},{"issue":"6","key":"10.1016\/j.biopha.2018.12.146_bib0130","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1007\/s00253-016-7300-7","article-title":"Biogenic selenium nanoparticles: current status and future prospects","volume":"100","author":"Wadhwani","year":"2016","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.biopha.2018.12.146_bib0135","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.pmatsci.2016.07.001","article-title":"Selenium nanomaterials: an overview of recent developments in synthesis, properties and potential applications","volume":"83","author":"Chaudhary","year":"2016","journal-title":"Prog. Mater. Sci."},{"issue":"46","key":"10.1016\/j.biopha.2018.12.146_bib0140","doi-asserted-by":"crossref","first-page":"24036","DOI":"10.1074\/jbc.M116.756155","article-title":"Selenoprotein gene nomenclature","volume":"291","author":"Gladyshev","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.146_bib0145","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/biof.5520150103","article-title":"Biological effects of a nano red elemental selenium","volume":"15","author":"Zhang","year":"2001","journal-title":"Biofactors"},{"issue":"10","key":"10.1016\/j.biopha.2018.12.146_bib0150","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/j.freeradbiomed.2007.02.013","article-title":"Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: comparison with selenomethionine in mice","volume":"42","author":"Wang","year":"2007","journal-title":"Free Radic. Biol. Med."},{"issue":"29","key":"10.1016\/j.biopha.2018.12.146_bib0155","doi-asserted-by":"crossref","first-page":"7106","DOI":"10.1016\/j.biomaterials.2013.04.067","article-title":"Selective cellular uptake and induction of apoptosis of cancer-targeted selenium nanoparticles","volume":"34","author":"Huang","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.biopha.2018.12.146_bib0160","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.cbi.2014.09.017","article-title":"Selenium nanoparticles involve HSP-70 and SIRT1 in preventing the progression of type 1 diabetic nephropathy","volume":"223","author":"Kumar","year":"2014","journal-title":"Chem. Biol. Interact."},{"issue":"2","key":"10.1016\/j.biopha.2018.12.146_bib0165","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1600-079X.2005.00231.x","article-title":"Melatonin\u2010selenium nanoparticles inhibit oxidative stress and protect against hepatic injury induced by Bacillus Calmette\u2013Gu\u00e9rin\/lipopolysaccharide in mice","volume":"39","author":"Wang","year":"2005","journal-title":"J. Pineal Res."},{"issue":"34","key":"10.1016\/j.biopha.2018.12.146_bib0170","doi-asserted-by":"crossref","first-page":"9068","DOI":"10.1016\/j.biomaterials.2011.08.001","article-title":"The reversal of cisplatin-induced nephrotoxicity by selenium nanoparticles functionalized with 11-mercapto-1-undecanol by inhibition of ROS-mediated apoptosis","volume":"32","author":"Li","year":"2011","journal-title":"Biomaterials"},{"issue":"7","key":"10.1016\/j.biopha.2018.12.146_bib0175","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S0891-5849(03)00428-3","article-title":"Free radical scavenging efficiency of Nano-Se in vitro","volume":"35","author":"Huang","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biopha.2018.12.146_bib0180","first-page":"3939","article-title":"PEG-nanolized ultrasmall selenium nanoparticles overcome drug resistance in hepatocellular carcinoma HepG2 cells through induction of mitochondria dysfunction","volume":"7","author":"Zheng","year":"2012","journal-title":"Int. J. Nanomed. Nanosurg."},{"issue":"10","key":"10.1016\/j.biopha.2018.12.146_bib0185","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1021\/mp500364a","article-title":"Cyclic peptide\u2013selenium nanoparticles as drug transporters","volume":"11","author":"Nasrolahi Shirazi","year":"2014","journal-title":"Mol. Pharm."},{"issue":"8","key":"10.1016\/j.biopha.2018.12.146_bib0190","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.yexcr.2010.02.032","article-title":"Selenoproteins\u2014what unique properties can arise with selenocysteine in place of cysteine?","volume":"316","author":"Arn\u00e9r","year":"2010","journal-title":"Exp. Cell Res."},{"issue":"3","key":"10.1016\/j.biopha.2018.12.146_bib0195","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s12011-010-8656-7","article-title":"Regulation of redox signaling by selenoproteins","volume":"134","author":"Hawkes","year":"2010","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.biopha.2018.12.146_bib0200","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.abb.2015.06.024","article-title":"Selenoproteins: antioxidant selenoenzymes and beyond","volume":"595","author":"Steinbrenner","year":"2016","journal-title":"Arch. Biochem. Biophys."},{"issue":"5963","key":"10.1016\/j.biopha.2018.12.146_bib0205","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1126\/science.1184003","article-title":"The NLRP3 inflammasome: a sensor for metabolic danger?","volume":"327","author":"Schroder","year":"2010","journal-title":"Science"},{"issue":"35","key":"10.1016\/j.biopha.2018.12.146_bib0210","doi-asserted-by":"crossref","first-page":"11864","DOI":"10.1021\/bi050815q","article-title":"Elucidation of the mechanism of selenoprotein glutathione peroxidase (GPx)-catalyzed hydrogen peroxide reduction by two glutathione molecules: a density functional study","volume":"44","author":"Prabhakar","year":"2005","journal-title":"Biochemistry"},{"issue":"11","key":"10.1016\/j.biopha.2018.12.146_bib0215","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1002\/mnfr.200700330","article-title":"The influence of selenium on immune responses","volume":"52","author":"Hoffmann","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"issue":"7","key":"10.1016\/j.biopha.2018.12.146_bib0220","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1089\/ars.2010.3275","article-title":"Selenium in human health and disease","volume":"14","author":"Fairweather-Tait","year":"2011","journal-title":"Antioxid. Redox Signal."},{"issue":"3","key":"10.1016\/j.biopha.2018.12.146_bib0225","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1152\/physrev.00039.2013","article-title":"Selenoproteins: molecular pathways and physiological roles","volume":"94","author":"Labunskyy","year":"2014","journal-title":"Physiol. Rev."},{"issue":"5","key":"10.1016\/j.biopha.2018.12.146_bib0230","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1515\/hsz-2014-0280","article-title":"Enzymatic control of cysteinyl thiol switches in proteins","volume":"396","author":"Deponte","year":"2015","journal-title":"Biol. Chem."},{"key":"10.1016\/j.biopha.2018.12.146_bib0235","series-title":"Dietary Selenium and Human Health","author":"Schomburg","year":"2016"},{"key":"10.1016\/j.biopha.2018.12.146_bib0240","series-title":"Selenium-Dependent Glutathione Peroxidases During Tumor Development, Advances in Cancer Research","first-page":"109","author":"Kipp","year":"2017"},{"key":"10.1016\/j.biopha.2018.12.146_bib0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2014.04.003","article-title":"Efficacy and safety of selenium nanoparticles administered intraperitoneally for the prevention of growth of cancer cells in the peritoneal cavity","volume":"72","author":"Wang","year":"2014","journal-title":"Free Radic. Biol. Med."},{"issue":"8","key":"10.1016\/j.biopha.2018.12.146_bib0250","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3109\/15376516.2014.956912","article-title":"Molecular mechanisms of Nano-selenium in mitigating hepatocellular carcinoma induced by N-nitrosodiethylamine (NDEA) in rats","volume":"24","author":"Ahmed","year":"2014","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.biopha.2018.12.146_bib0255","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.colsurfb.2012.02.006","article-title":"Selenium nanoparticles inhibit the growth of HeLa and MDA-MB-231 cells through induction of S phase arrest","volume":"94","author":"Luo","year":"2012","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"27","key":"10.1016\/j.biopha.2018.12.146_bib0260","doi-asserted-by":"crossref","first-page":"6515","DOI":"10.1016\/j.biomaterials.2011.05.032","article-title":"The suppression of prostate LNCaP cancer cells growth by Selenium nanoparticles through Akt\/Mdm2\/AR controlled apoptosis","volume":"32","author":"Kong","year":"2011","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.biopha.2018.12.146_bib0265","first-page":"38","article-title":"Evaluation of selenium nanoparticles as a potential chemopreventive agent against lung carcinoma","volume":"2","author":"Ali","year":"2013","journal-title":"Int. J. Pharm. Biol. Sci."},{"issue":"7","key":"10.1016\/j.biopha.2018.12.146_bib0270","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.nano.2011.12.003","article-title":"ER\u03b1 signaling imparts chemotherapeutic selectivity to selenium nanoparticles in breast cancer","volume":"8","author":"Vekariya","year":"2012","journal-title":"Nanomed.: Nanotechnol. Biol. Med."},{"issue":"23","key":"10.1016\/j.biopha.2018.12.146_bib0275","doi-asserted-by":"crossref","first-page":"6296","DOI":"10.1016\/j.bmcl.2013.09.078","article-title":"Selenium nanoparticles induced membrane bio-mechanical property changes in MCF-7 cells by disturbing membrane molecules and F-actin","volume":"23","author":"Pi","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.146_bib0280","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1042\/BA20100042","article-title":"Biosynthesis and recovery of selenium nanoparticles and the effects on matrix metalloproteinase\u20102 expression","volume":"56","author":"Shakibaie","year":"2010","journal-title":"Biotechnol. Appl. Biochem."},{"key":"10.1016\/j.biopha.2018.12.146_bib0285","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jtemb.2015.05.005","article-title":"Biomedical potential of actinobacterially synthesized selenium nanoparticles with special reference to anti-biofilm, anti-oxidant, wound healing, cytotoxic and anti-viral activities","volume":"32","author":"Ramya","year":"2015","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"6","key":"10.1016\/j.biopha.2018.12.146_bib0290","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1002\/btpr.1992","article-title":"In vivo synthesis of selenium nanoparticles by Halococcus salifodinae BK18 and their anti\u2010proliferative properties against HeLa cell line","volume":"30","author":"Srivastava","year":"2014","journal-title":"Biotechnol. Prog."},{"key":"10.1016\/j.biopha.2018.12.146_bib0295","series-title":"Alginates and Their Biomedical Applications","first-page":"157","article-title":"Alginate-Based Three-Dimensional In Vitro Tumor Models: A Better Alternative to Current Two-Dimensional Cell Culture Models","author":"Khurana","year":"2018"},{"key":"10.1016\/j.biopha.2018.12.146_bib0300","first-page":"835","article-title":"Surface decoration by Spirulina polysaccharide enhances the cellular uptake and anticancer efficacy of selenium nanoparticles","volume":"7","author":"Yang","year":"2012","journal-title":"Int. J. Nanomed."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.146_bib0305","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.colsurfb.2008.07.010","article-title":"Selenium nanoparticles fabricated in Undaria pinnatifida polysaccharide solutions induce mitochondria-mediated apoptosis in A375 human melanoma cells","volume":"67","author":"Chen","year":"2008","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"41","key":"10.1016\/j.biopha.2018.12.146_bib0310","doi-asserted-by":"crossref","first-page":"9859","DOI":"10.1021\/jf403564s","article-title":"Induction of apoptosis and cell cycle arrest in A549 human lung adenocarcinoma cells by surface-capping selenium nanoparticles: an effect enhanced by polysaccharide\u2013protein complexes from Polyporus rhinocerus","volume":"61","author":"Wu","year":"2013","journal-title":"J. Agric. Food Chem."},{"issue":"19","key":"10.1016\/j.biopha.2018.12.146_bib0315","doi-asserted-by":"crossref","first-page":"9602","DOI":"10.1039\/c2jm16828f","article-title":"Surface decoration of selenium nanoparticles by mushroom polysaccharides\u2013protein complexes to achieve enhanced cellular uptake and antiproliferative activity","volume":"22","author":"Wu","year":"2012","journal-title":"J. Mater. Chem."},{"issue":"16","key":"10.1016\/j.biopha.2018.12.146_bib0320","doi-asserted-by":"crossref","first-page":"13738","DOI":"10.1021\/am5031962","article-title":"Gracilaria lemaneiformis polysaccharide as integrin-targeting surface decorator of selenium nanoparticles to achieve enhanced anticancer efficacy","volume":"6","author":"Jiang","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"16","key":"10.1016\/j.biopha.2018.12.146_bib0325","doi-asserted-by":"crossref","first-page":"8956","DOI":"10.1021\/ic301050v","article-title":"Positive surface charge enhances selective cellular uptake and anticancer efficacy of selenium nanoparticles","volume":"51","author":"Yu","year":"2012","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.biopha.2018.12.146_bib0330","article-title":"Effect of Chitosan-stabilized Selenium nanoparticles on cell cycle arrest and invasiveness in hepatocarcinoma cells revealed by quantitative proteomics","volume":"2014","author":"Lopez-Heras","year":"2014","journal-title":"J. Nanomed. Nanotechnol."},{"issue":"4","key":"10.1016\/j.biopha.2018.12.146_bib0335","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1039\/C3DT52468J","article-title":"Differential effects of amino acid surface decoration on the anticancer efficacy of selenium nanoparticles","volume":"43","author":"Feng","year":"2014","journal-title":"J. Chem. Soc. Dalton Trans."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.146_bib0340","first-page":"74","article-title":"Enhancement of cell permeabilization apoptosis-inducing activity of selenium nanoparticles by ATP surface decoration, Nanomedicine: nanotechnology","volume":"9","author":"Zhang","year":"2013","journal-title":"Biol. Med."},{"issue":"5","key":"10.1016\/j.biopha.2018.12.146_bib0345","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1016\/j.biomaterials.2013.11.007","article-title":"Inhibition of tumor growth and vasculature and fluorescence imaging using functionalized ruthenium-thiol protected selenium nanoparticles","volume":"35","author":"Sun","year":"2014","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.biopha.2018.12.146_bib0350","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1007\/s00253-012-4359-7","article-title":"Pathway of cytotoxicity induced by folic acid modified selenium nanoparticles in MCF-7 cells","volume":"97","author":"Pi","year":"2013","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"4","key":"10.1016\/j.biopha.2018.12.146_bib0355","first-page":"947","article-title":"Rational design of cancer-targeted selenium nanoparticles to antagonize multidrug resistance in cancer cells, Nanomedicine: nanotechnology","volume":"11","author":"Liu","year":"2015","journal-title":"Biol. Med."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.146_bib0360","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.colsurfb.2010.11.023","article-title":"Sialic acid surface decoration enhances cellular uptake and apoptosis-inducing activity of selenium nanoparticles","volume":"83","author":"Zheng","year":"2011","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.biopha.2018.12.146_bib0365","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.2147\/IJN.S109822","article-title":"Multifunctional selenium nanoparticles as carriers of HSP70 siRNA to induce apoptosis of HepG2 cells","volume":"11","author":"Li","year":"2016","journal-title":"Int. J. Nanomed."},{"issue":"8","key":"10.1016\/j.biopha.2018.12.146_bib0370","doi-asserted-by":"crossref","first-page":"6578","DOI":"10.1021\/nn202452c","article-title":"Selenium nanoparticles as a carrier of 5-fluorouracil to achieve anticancer synergism","volume":"6","author":"Liu","year":"2012","journal-title":"ACS Nano"},{"issue":"31","key":"10.1016\/j.biopha.2018.12.146_bib0375","doi-asserted-by":"crossref","first-page":"8854","DOI":"10.1016\/j.biomaterials.2014.07.004","article-title":"Cytotoxicity and therapeutic effect of irinotecan combined with selenium nanoparticles","volume":"35","author":"Gao","year":"2014","journal-title":"Biomaterials"},{"issue":"7","key":"10.1016\/j.biopha.2018.12.146_bib0380","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1016\/j.bios.2008.10.030","article-title":"In vitro study on the individual and synergistic cytotoxicity of adriamycin and selenium nanoparticles against Bel7402 cells with a quartz crystal microbalance","volume":"24","author":"Tan","year":"2009","journal-title":"Biosens. Bioelectron."},{"issue":"1","key":"10.1016\/j.biopha.2018.12.146_bib0385","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1186\/s11671-015-1051-8","article-title":"Novel functionalized selenium nanoparticles for enhanced anti-hepatocarcinoma activity in vitro","volume":"10","author":"Xia","year":"2015","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.biopha.2018.12.146_bib0390","doi-asserted-by":"crossref","DOI":"10.1002\/asia.201701227","article-title":"Cancer\u2010targeted selenium nanoparticles sensitize Cancer cells to continuous \u03b3 radiation to achieve synergetic chemo\u2010radiotherapy","author":"Chan","year":"2017","journal-title":"Chemistry Asian J."},{"key":"10.1016\/j.biopha.2018.12.146_bib0395","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.colsurfb.2015.11.063","article-title":"X-ray-responsive selenium nanoparticles for enhanced cancer chemo-radiotherapy","volume":"139","author":"Yu","year":"2016","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.biopha.2018.12.146_bib0400","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.jcis.2014.06.030","article-title":"Quercetin and gallic acid mediated synthesis of bimetallic (silver and selenium) nanoparticles and their antitumor and antimicrobial potential","volume":"431","author":"Mittal","year":"2014","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.biopha.2018.12.146_bib0405","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.colsurfb.2015.01.009","article-title":"Carboxylic group-induced synthesis and characterization of selenium nanoparticles and its anti-tumor potential on Dalton\u2019s lymphoma cells","volume":"126","author":"Kumar","year":"2015","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"8","key":"10.1016\/j.biopha.2018.12.146_bib0410","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1007\/s00449-012-0867-1","article-title":"Green synthesis and characterization of selenium nanoparticles and its augmented cytotoxicity with doxorubicin on cancer cells","volume":"36","author":"Ramamurthy","year":"2013","journal-title":"Bioprocess. Biosyst. Eng."},{"issue":"11","key":"10.1016\/j.biopha.2018.12.146_bib0415","first-page":"456","article-title":"Study of transmissible gastroenteritis virus antigen-conjugated immunogenic properties of selenium nanoparticles and gold","volume":"11","author":"Staroverov","year":"2014","journal-title":"Life Sci. J."},{"key":"10.1016\/j.biopha.2018.12.146_bib0420","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.actbio.2014.08.035","article-title":"Multifunctional polyamidoamine-modified selenium nanoparticles dual-delivering siRNA and cisplatin to A549\/DDP cells for reversal multidrug resistance","volume":"11","author":"Zheng","year":"2015","journal-title":"Acta Biomater."},{"issue":"27","key":"10.1016\/j.biopha.2018.12.146_bib0425","doi-asserted-by":"crossref","first-page":"22936","DOI":"10.1039\/C5RA25109E","article-title":"PEG functionalized selenium nanoparticles as a carrier of crocin to achieve anticancer synergism","volume":"6","author":"Mary","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.biopha.2018.12.146_bib0430","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.actbio.2017.02.042","article-title":"Redox-responsive mesoporous selenium delivery of doxorubicin targets MCF-7 cells and synergistically enhances its anti-tumor activity","volume":"54","author":"Zhao","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biopha.2018.12.146_bib0435","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.ejpb.2017.05.003","article-title":"Curcumin loading potentiates the chemotherapeutic efficacy of selenium nanoparticles in HCT116 cells and Ehrlich\u2019s ascites carcinoma bearing mice","volume":"117","author":"Kumari","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"76","key":"10.1016\/j.biopha.2018.12.146_bib0440","doi-asserted-by":"crossref","first-page":"72213","DOI":"10.1039\/C6RA13291J","article-title":"pH-Assisted surface functionalization of selenium nanoparticles with curcumin to achieve enhanced cancer chemopreventive activity","volume":"6","author":"Yu","year":"2016","journal-title":"RSC Adv."},{"issue":"33","key":"10.1016\/j.biopha.2018.12.146_bib0445","doi-asserted-by":"crossref","first-page":"6941","DOI":"10.1039\/C7TB01315A","article-title":"Targeted delivery of siRNA using RGDfC-conjugated functionalized selenium nanoparticles for anticancer therapy","volume":"5","author":"Xia","year":"2017","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.biopha.2018.12.146_bib0450","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.actbio.2015.11.041","article-title":"Co-delivery of Se nanoparticles and pooled SiRNAs for overcoming drug resistance mediated by P-glycoprotein and class III \u03b2-tubulin in drug-resistant breast cancers","volume":"31","author":"Zheng","year":"2016","journal-title":"Acta Biomater."},{"issue":"3","key":"10.1016\/j.biopha.2018.12.146_bib0455","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.taap.2012.11.025","article-title":"Protection of cisplatin-induced spermatotoxicity, DNA damage and chromatin abnormality by selenium nano-particles","volume":"266","author":"Rezvanfar","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.biopha.2018.12.146_bib0460","first-page":"1713","article-title":"The prospective protective effect of selenium nanoparticles against chromium-induced oxidative and cellular damage in rat thyroid","volume":"8","author":"Hassanin","year":"2013","journal-title":"Int. J. Nanomed."},{"issue":"2","key":"10.1016\/j.biopha.2018.12.146_bib0465","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.taap.2013.01.028","article-title":"Alleviating anastrozole induced bone toxicity by selenium nanoparticles in SD rats","volume":"268","author":"Vekariya","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"3","key":"10.1016\/j.biopha.2018.12.146_bib0470","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1007\/s12011-011-9266-8","article-title":"Nanoparticles of selenium as species with stronger physiological effects in sheep in comparison with sodium selenite","volume":"146","author":"Sadeghian","year":"2012","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.biopha.2018.12.146_bib0475","first-page":"1","article-title":"Neuro-and nephrotoxicity of subchronic cadmium chloride exposure and the potential chemoprotective effects of selenium nanoparticles","author":"Sadek","year":"2017","journal-title":"Metab. Brain Dis."},{"issue":"3","key":"10.1016\/j.biopha.2018.12.146_bib0480","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3109\/15376516.2010.547887","article-title":"Amelioration of experimental colitis by a novel nanoselenium\u2013silymarin mixture","volume":"21","author":"Miroliaee","year":"2011","journal-title":"Toxicol. Mech. Methods"},{"issue":"1","key":"10.1016\/j.biopha.2018.12.146_bib0485","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12951-017-0252-y","article-title":"Selenium nanoparticles decorated with Ulva lactuca polysaccharide potentially attenuate colitis by inhibiting NF-\u03baB mediated hyper inflammation","volume":"15","author":"Zhu","year":"2017","journal-title":"J. Nanobiotechnol."},{"issue":"2","key":"10.1016\/j.biopha.2018.12.146_bib0490","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1139\/cjpp-2016-0183","article-title":"Anti-inflammatory effect of selenium nanoparticles on the inflammation induced in irradiated rats","volume":"95","author":"El-Ghazaly","year":"2016","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.biopha.2018.12.146_bib0495","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.fct.2014.03.003","article-title":"Immunomodulatory of selenium nano-particles decorated by sulfated Ganoderma lucidum polysaccharides","volume":"68","author":"Wang","year":"2014","journal-title":"Food Chem. Toxicol."},{"issue":"6","key":"10.1016\/j.biopha.2018.12.146_bib0500","doi-asserted-by":"crossref","first-page":"5158","DOI":"10.1021\/acsami.6b15515","article-title":"H2O2-depleting and O2-generating selenium nanoparticles for fluorescence imaging and photodynamic treatment of proinflammatory-activated macrophages","volume":"9","author":"Lu","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"6","key":"10.1016\/j.biopha.2018.12.146_bib0505","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1111\/j.1745-7254.2005.00745.x","article-title":"Melatonin-selenium nanoparticles protects liver against immunological injury induced by bacillus Calmette-Gu\u00e9rin and lipopolysaccharide1","volume":"26","author":"Hua","year":"2005","journal-title":"Acta Pharmacol. Sin."},{"issue":"12","key":"10.1016\/j.biopha.2018.12.146_bib0510","doi-asserted-by":"crossref","first-page":"10165","DOI":"10.1166\/jnn.2015.11692","article-title":"Adjuvant effect of biogenic selenium nanoparticles improves the immune responses and survival of mice receiving 4T1 cell antigens as vaccine in breast cancer murine model","volume":"15","author":"Yazdi","year":"2015","journal-title":"J. Nanosci. Nanotechnol."},{"key":"10.1016\/j.biopha.2018.12.146_bib0515","first-page":"4819","article-title":"Chitosan-decorated selenium nanoparticles as protein carriers to improve the in vivo half-life of the peptide therapeutic BAY 55-9837 for type 2 diabetes mellitus","volume":"9","author":"Rao","year":"2014","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.biopha.2018.12.146_bib0520","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.2147\/IJN.S130566","article-title":"A novel selective VPac2 agonist peptide-conjugated chitosan modified selenium nanoparticles with enhanced anti-type 2 diabetes synergy effects","volume":"12","author":"Zhao","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.biopha.2018.12.146_bib0525","article-title":"Selenium nanoparticles as versatile carriers for oral delivery of insulin: insight into the synergic antidiabetic effect and mechanism, Nanomedicine: nanotechnology","author":"Deng","year":"2017","journal-title":"Biol. Med."},{"key":"10.1016\/j.biopha.2018.12.146_bib0530","doi-asserted-by":"crossref","DOI":"10.1002\/ptr.5792","article-title":"The role of plant\u2010derived products in pancreatitis: experimental and clinical evidence","author":"Anchi","year":"2017","journal-title":"Phytother. Res."},{"key":"10.1016\/j.biopha.2018.12.146_bib0535","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2018.06.002","article-title":"First report on the pharmacokinetic profile of nimbolide, a novel anticancer agent in oral and intravenous administrated rats by LC\/MS method","author":"Baira","year":"2018","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.biopha.2018.12.146_bib0540","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.intimp.2018.07.012","article-title":"Andrographolide ameliorates silica induced pulmonary fibrosis","volume":"62","author":"Karkale","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.biopha.2018.12.146_bib0545","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1016\/j.biopha.2018.07.090","article-title":"Withaferin-A attenuates multiple low doses of Streptozotocin (MLD-STZ) induced type 1 diabetes","volume":"106","author":"Tekula","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2018.12.146_bib0550","doi-asserted-by":"crossref","DOI":"10.1002\/ptr.6152","article-title":"Isoproterenol\u2010induced cardiac ischemia and fibrosis: plant\u2010based approaches for intervention","author":"Allawadhi","year":"2018","journal-title":"Phytother. Res."},{"issue":"4","key":"10.1016\/j.biopha.2018.12.146_bib0555","doi-asserted-by":"crossref","DOI":"10.1615\/CritRevTherDrugCarrierSyst.2016015798","article-title":"Overview on therapeutic applications of microparticulate drug delivery systems","volume":"33","author":"Bale","year":"2016","journal-title":"Crit. Rev. Ther. Drug Carrier Syst."},{"key":"10.1016\/j.biopha.2018.12.146_bib0560","doi-asserted-by":"crossref","DOI":"10.1016\/j.xphs.2018.07.009","article-title":"Sustained release curcumin microparticles (CuMPs) for effective prophylactic treatment of exocrine dysfunction of pancreas: a preclinical study in cerulein induced acute pancreatitis","author":"Anchi","year":"2018","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.biopha.2018.12.146_bib0565","doi-asserted-by":"crossref","DOI":"10.1016\/j.pupt.2018.06.003","article-title":"Oropharyngeal administration of silica in Swiss mice: a robust and reproducible model of occupational pulmonary fibrosis","author":"Karkale","year":"2018","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.biopha.2018.12.146_bib0570","series-title":"Nanomaterials in Chromatography","first-page":"437","article-title":"Nanotoxicology: toxicity and risk assessment of nanomaterials","author":"Saifi","year":"2018"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218362954?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218362954?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T11:39:57Z","timestamp":1760096397000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218362954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":114,"alternative-id":["S0753332218362954"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.12.146","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic applications of selenium nanoparticles","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.12.146","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}