{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T01:44:17Z","timestamp":1781228657605,"version":"3.54.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,1,5]],"date-time":"2019-01-05T00:00:00Z","timestamp":1546646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473697"],"award-info":[{"award-number":["81473697"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873327"],"award-info":[{"award-number":["81873327"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573996"],"award-info":[{"award-number":["81573996"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"science and technology plan project of Guangdong province","award":["2016A020226028"],"award-info":[{"award-number":["2016A020226028"]}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2017A030313698"],"award-info":[{"award-number":["2017A030313698"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Special Construction Project of Dominant Disease (ONFH) of Chinese Medicine in Guangdong Province"},{"name":"Inheritance Studio Construction Project of Prestigious TCM Doctors (He Wei) in Guangdong Province"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.biopha.2019.01.013","type":"journal-article","created":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T00:25:42Z","timestamp":1547511942000},"page":"1213-1220","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Plasma C-terminal cross-linking telopeptide of type II collagen as a biomarker in advanced stages of femoral head osteonecrosis"],"prefix":"10.1016","volume":"111","author":[{"given":"Mincong","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shui-Di","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Xiang","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Qiu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Yuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Chun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Xian","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu-Shi","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2019.01.013_bib0005","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.transproceed.2007.02.031","article-title":"Avascular osteonecrosis after renal transplantation","volume":"39","author":"Hedri","year":"2007","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.biopha.2019.01.013_bib0010","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1002\/art.20128","article-title":"Musculoskeletal abnormalities of the forearm in patients with juvenile idiopathic arthritis relate mainly to bone geometry","volume":"50","author":"Roth","year":"2004","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.biopha.2019.01.013_bib0015","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/alcalc\/agg106","article-title":"Investigation of alcohol metabolizing enzyme genes in Chinese alcoholics with avascular necrosis of hip joint, pancreatitis and cirrhosis of the liver","volume":"38","author":"Chao","year":"2003","journal-title":"Alcohol Alcohol."},{"key":"10.1016\/j.biopha.2019.01.013_bib0020","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/01.blo.0000127921.13253.e3","article-title":"Genetic background of osteonecrosis: associated with thrombophilic mutations?","author":"Zalavras","year":"2004","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.biopha.2019.01.013_bib0025","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00264-007-0320-2","article-title":"Avascular necrosis of the femoral head: inter- and intraobserver variations of Ficat and ARCO classifications","volume":"32","author":"Schmitt-Sody","year":"2008","journal-title":"Int. Orthop."},{"key":"10.1016\/j.biopha.2019.01.013_bib0030","first-page":"6","article-title":"ARCO committee on terminology and staging (report from the Nijmegen meeting)","volume":"3","author":"JWM","year":"1991","journal-title":"ARCO News Lett"},{"key":"10.1016\/j.biopha.2019.01.013_bib0035","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1172\/JCI117156","article-title":"Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassay","volume":"93","author":"Hollander","year":"1994","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.biopha.2019.01.013_bib0040","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1172\/JCI119316","article-title":"Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage","volume":"99","author":"Billinghurst","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.biopha.2019.01.013_bib0045","article-title":"Activation of the renin-angiotensin system in mice aggravates mechanical loading-induced knee osteoarthritis","volume":"62","author":"Yamagishi","year":"2018","journal-title":"Eur. J. Histochem."},{"issue":"Suppl. 3","key":"10.1016\/j.biopha.2019.01.013_bib0050","first-page":"16","article-title":"Systematic analysis of classification systems for osteonecrosis of the femoral head","volume":"88","author":"Mont","year":"2006","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.biopha.2019.01.013_bib0055","series-title":"Sample Size Calculations in Clinical Research","author":"Chow","year":"2008"},{"key":"10.1016\/j.biopha.2019.01.013_bib0060","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1146\/annurev.bi.64.070195.002155","article-title":"Collagens: molecular biology, diseases, and potentials for therapy","volume":"64","author":"Prockop","year":"1995","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.biopha.2019.01.013_bib0065","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S8756-3282(01)00504-X","article-title":"Collagen type II C-telopeptide fragments as an index of cartilage degradation","volume":"29","author":"Christgau","year":"2001","journal-title":"Bone"},{"key":"10.1016\/j.biopha.2019.01.013_bib0070","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.gene.2016.03.019","article-title":"Development and application of a new Silent reporter system to quantitate the activity of enhancer elements in the type II Collagen Gene","volume":"585","author":"Ito","year":"2016","journal-title":"Gene"},{"key":"10.1016\/j.biopha.2019.01.013_bib0075","first-page":"222","article-title":"Osteoarthritis in 2007","volume":"65","author":"Krasnokutsky","year":"2007","journal-title":"Bulletin of the NYU Hospital for Joint Diseases"},{"key":"10.1016\/j.biopha.2019.01.013_bib0080","first-page":"1765","article-title":"Procollagen II C-propeptide in joint fluid: changes in concentration with age, time after knee injury, and osteoarthritis","volume":"23","author":"Lohmander","year":"1996","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.biopha.2019.01.013_bib0085","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/03009740601154186","article-title":"Serum cartilage oligomeric matrix protein (COMP) levels in knee osteoarthritis in a Brazilian population: clinical and radiological correlation","volume":"36","author":"Fernandes","year":"2007","journal-title":"Scand. J. Rheumatol."},{"key":"10.1016\/j.biopha.2019.01.013_bib0090","doi-asserted-by":"crossref","first-page":"6629","DOI":"10.1074\/jbc.M112.364729","article-title":"Mutations in the catalytic domain of human matrix metalloproteinase-1 (MMP-1) that allow for regulated activity through the use of Ca2+","volume":"288","author":"Paladini","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2019.01.013_bib0095","doi-asserted-by":"crossref","first-page":"4481","DOI":"10.1016\/S0021-9258(18)53634-6","article-title":"Recombinant Chinese hamster ovary cell matrix metalloprotease-3 (MMP-3, stromelysin-1). Role of calcium in promatrix metalloprotease-3 (pro-MMP-3, prostromelysin-1) activation and thermostability of the low mass catalytic domain of MMP-3","volume":"268","author":"Housley","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2019.01.013_bib0100","doi-asserted-by":"crossref","first-page":"14162","DOI":"10.1016\/S0021-9258(17)43838-5","article-title":"The collagen substrate specificity of rat uterus collagenase","volume":"258","author":"Welgus","year":"1983","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2019.01.013_bib0105","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cca.2005.09.020","article-title":"Review: collagen markers in early arthritic diseases","volume":"365","author":"Elsaid","year":"2006","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.biopha.2019.01.013_bib0110","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1002\/art.21977","article-title":"Diurnal variation of serum and urine biomarkers in patients with radiographic knee osteoarthritis","volume":"54","author":"Kong","year":"2006","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.biopha.2019.01.013_bib0115","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.bios.2014.08.016","article-title":"Detection of CTX-II in serum and urine to diagnose osteoarthritis by using a fluoro-microbeads guiding chip","volume":"67","author":"Park","year":"2015","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.biopha.2019.01.013_bib0120","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.orthres.2004.12.006","article-title":"Cartilage degeneration in post-collapse cases of osteonecrosis of the human femoral head: altered mechanical properties in tension, compression, and shear","volume":"23","author":"Magnussen","year":"2005","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.biopha.2019.01.013_bib0125","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/jor.20995","article-title":"Low-intensity pulsed ultrasound (LIPUS) increases the articular cartilage type II collagen in a rat osteoarthritis model","volume":"28","author":"Naito","year":"2010","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.biopha.2019.01.013_bib0130","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1136\/ard.2005.042895","article-title":"Urinary CTX-II and glucosyl-galactosyl-pyridinoline are associated with the presence and severity of radiographic knee osteoarthritis in men","volume":"65","author":"Jordan","year":"2006","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.biopha.2019.01.013_bib0135","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1136\/ard.60.6.619","article-title":"Cross sectional evaluation of biochemical markers of bone, cartilage, and synovial tissue metabolism in patients with knee osteoarthritis: relations with disease activity and joint damage","volume":"60","author":"Garnero","year":"2001","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.biopha.2019.01.013_bib0140","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1002\/art.10576","article-title":"Uncoupling of type II collagen synthesis and degradation predicts progression of joint damage in patients with knee osteoarthritis","volume":"46","author":"Garnero","year":"2002","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.biopha.2019.01.013_bib0145","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1007\/s00198-015-3029-x","article-title":"RANKL and OPG gene polymorphisms: associations with vertebral fractures and bone mineral density in premenopausal systemic lupus erythematosus","volume":"26","author":"Bonfa","year":"2015","journal-title":"Osteoporos. Int."},{"issue":"48","key":"10.1016\/j.biopha.2019.01.013_bib0150","first-page":"S213","article-title":"Associations between medical co-morbidities and putative biomarkers of osteoarthritis","volume":"2003","author":"Jordan","year":"2003","journal-title":"ACR Abstract"},{"key":"10.1016\/j.biopha.2019.01.013_bib0155","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1002\/art.11326","article-title":"The release of crosslinked peptides from type II collagen into human synovial fluid is increased soon after joint injury and in osteoarthritis","volume":"48","author":"Lohmander","year":"2003","journal-title":"Arthritis Rheum."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218381538?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218381538?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T11:45:04Z","timestamp":1760096704000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218381538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":31,"alternative-id":["S0753332218381538"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.01.013","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasma C-terminal cross-linking telopeptide of type II collagen as a biomarker in advanced stages of femoral head osteonecrosis","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.01.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}