{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T03:51:55Z","timestamp":1771473115358,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,1,7]],"date-time":"2019-01-07T00:00:00Z","timestamp":1546819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Medical Research Center Program"},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Science and ICT","award":["NRF-2017R1A5A2014768"],"award-info":[{"award-number":["NRF-2017R1A5A2014768"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.biopha.2019.01.017","type":"journal-article","created":{"date-parts":[[2019,1,18]],"date-time":"2019-01-18T02:17:32Z","timestamp":1547777852000},"page":"1359-1366","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Anti-neuroinflammatory effect of Iresine celosia on lipopolysaccharide-stimulated microglial cells and mouse"],"prefix":"10.1016","volume":"111","author":[{"given":"Namkwon","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy Cruz","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae Sik","family":"Jang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Kil","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myung Sook","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2019.01.017_bib0005","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s00204-015-1472-2","article-title":"Compromised MAPK signaling in human diseases: an update","volume":"89","author":"Kim","year":"2015","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.biopha.2019.01.017_bib0010","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nrd.2015.14","article-title":"Central nervous system myeloid cells as drug targets: current status and translational challenges","volume":"15","author":"Biber","year":"2016","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.biopha.2019.01.017_bib0015","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1002\/jnr.20180","article-title":"Redox regulation of glial inflammatory response to lipopolysaccharide and interferongamma","volume":"77","author":"Pawate","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.biopha.2019.01.017_bib0020","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pneurobio.2005.06.004","article-title":"Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism","volume":"76","author":"Block","year":"2005","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.biopha.2019.01.017_bib0025","series-title":"Historia natural de Nueva Espa\u00f1a","author":"Hern\u00e1ndez","year":"1959"},{"key":"10.1016\/j.biopha.2019.01.017_bib0030","series-title":"Plantas medicinales utilizadas en el estado de Morelos","author":"Monroy-Ort\u00edz","year":"2007"},{"key":"10.1016\/j.biopha.2019.01.017_bib0035","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1177\/2051415817698289","article-title":"A pilot study of clinical results of Odyliresin (Iresine celosia) in symptomatic benign prostatic hyperplasia","volume":"10","author":"Porru","year":"2017","journal-title":"J. Clin. Urol."},{"key":"10.1016\/j.biopha.2019.01.017_bib0040","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.colsurfb.2012.04.006","article-title":"The green synthesis, characterization and evaluation of the biological activities of silver nanoparticles synthesized from Iresine herbstii leaf aqueous extracts","volume":"98","author":"Dipankar","year":"2012","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.biopha.2019.01.017_bib0045","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0165-5728(90)90073-V","article-title":"Immortalization of murine microglial cells by a v-raf\/v-myc carrying retrovirus","volume":"27","author":"Blasi","year":"1990","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.biopha.2019.01.017_bib0050","doi-asserted-by":"crossref","first-page":"210","DOI":"10.4062\/biomolther.2018.008","article-title":"Synthetic 3\u2019,4\u2019-dihydroxyflavone exerts anti-neuroinflammatory effects in BV2 microglia and a mouse model","volume":"26","author":"Kim","year":"2018","journal-title":"Biomol. Ther. (Seoul)"},{"key":"10.1016\/j.biopha.2019.01.017_bib0055","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/tox.22463","article-title":"Effects of Rhei Undulati Rhizoma on lipopolysaccharide-induced neuroinflammation in vitro and in vivo","volume":"33","author":"Hwang","year":"2018","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.biopha.2019.01.017_bib0060","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.freeradbiomed.2014.04.014","article-title":"Inducible nitric oxide synthase is key to peroxynitrite-mediated, LPS-induced protein radical formation in murine microglial BV2 cells","volume":"73","author":"Kumar","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biopha.2019.01.017_bib0065","doi-asserted-by":"crossref","DOI":"10.3390\/nu9101057","article-title":"Coptidis rhizoma prevents heat stress-induced brain damage and cognitive impairment in mice","volume":"9","author":"Moon","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.biopha.2019.01.017_bib0070","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/sj.mp.4002148","article-title":"Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice","volume":"14","author":"O\u2019Connor","year":"2009","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.biopha.2019.01.017_bib0075","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/1742-2094-8-100","article-title":"Peripheral anti-inflammatory effects explain the ginsenosides paradox between poor brain distribution and anti-depression efficacy","volume":"8","author":"Kang","year":"2011","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.biopha.2019.01.017_bib0080","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1111\/j.1749-6632.1969.tb12983.x","article-title":"Open-field behavior in the rat: what does it mean?","volume":"159","author":"Denenberg","year":"1969","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.biopha.2019.01.017_bib0085","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1016\/j.fct.2010.05.002","article-title":"Cassiae semen, a seed of Cassia obtusifolia, has neuroprotective effects in Parkinson\u2019s disease models","volume":"48","author":"Ju","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2019.01.017_bib0090","series-title":"Paxinos and Franklin\u2019s the Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2013"},{"key":"10.1016\/j.biopha.2019.01.017_bib0095","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/mrc.1550","article-title":"1H and 13C assignments of three new drimenes from Iresine diffusa Humb. & Bonpl. ex Willd","volume":"43","author":"Rios","year":"2005","journal-title":"Magn. Reson. Chem."},{"key":"10.1016\/j.biopha.2019.01.017_bib0100","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1046\/j.1365-2567.1999.00747.x","article-title":"Involvement of p38 mitogen-activated protein kinase in lipopolysaccharide-induced iNOS and COX-2 expression in J774 macrophages","volume":"97","author":"Chen","year":"1999","journal-title":"Immunology"},{"key":"10.1016\/j.biopha.2019.01.017_bib0105","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S1359-6101(02)00026-6","article-title":"Regulation of cytokine signaling and inflammation","volume":"13","author":"Hanada","year":"2002","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.biopha.2019.01.017_bib0110","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/nri2035","article-title":"MAPK phosphatases\u2013regulating the immune response","volume":"7","author":"Liu","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.biopha.2019.01.017_bib0115","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s12031-017-1007-9","article-title":"Magnesium lithospermate B suppresses lipopolysaccharide-induced neuroinflammation in BV2 microglial cells and attenuates neurodegeneration in lipopolysaccharide-injected mice","volume":"64","author":"Tai","year":"2018","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.biopha.2019.01.017_bib0120","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.biopha.2017.08.132","article-title":"Juglanin ameliorates LPS-induced neuroinflammation in animal models of Parkinson\u2019s disease and cell culture via inactivating TLR4\/NF-kappaB pathway","volume":"97","author":"Zhang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2019.01.017_bib0125","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1046\/j.1471-4159.2003.02213.x","article-title":"Microglia\/macrophage-specific protein Iba1 binds to fimbrin and enhances its actin-bundling activity","volume":"88","author":"Ohsawa","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.biopha.2019.01.017_bib0130","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/glia.20445","article-title":"S100B expression defines a state in which GFAP-expressing cells lose their neural stem cell potential and acquire a more mature developmental stage","volume":"55","author":"Raponi","year":"2007","journal-title":"Glia"},{"key":"10.1016\/j.biopha.2019.01.017_bib0135","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.bbr.2016.01.038","article-title":"Behavioral and monoamine perturbations in adult male mice with chronic inflammation induced by repeated peripheral lipopolysaccharide administration","volume":"302","author":"Krishna","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.biopha.2019.01.017_bib0140","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1365-2567.2009.03225.x","article-title":"Inflammation in neurodegenerative diseases","volume":"129","author":"Amor","year":"2010","journal-title":"Immunology"},{"key":"10.1016\/j.biopha.2019.01.017_bib0145","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMra0909142","article-title":"Alzheimer\u2019s disease","volume":"362","author":"Querfurth","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biopha.2019.01.017_bib0150","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson\u2019s disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.biopha.2019.01.017_bib0155","doi-asserted-by":"crossref","DOI":"10.3233\/JAD-179917","article-title":"Past to future: what animal models have taught us about Alzheimer\u2019s disease","author":"Martini","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.biopha.2019.01.017_bib0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneuroim.2014.07.012","article-title":"Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases","volume":"274","author":"Gonzalez","year":"2014","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.biopha.2019.01.017_bib0165","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.neuroscience.2008.07.031","article-title":"Systemic infection and inflammation in acute CNS injury and chronic neurodegeneration: underlying mechanisms","volume":"158","author":"Teeling","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.biopha.2019.01.017_bib0170","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/glia.22350","article-title":"Microglia and neurodegeneration: the role of systemic inflammation","volume":"61","author":"Cunningham","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.biopha.2019.01.017_bib0175","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0197-4580(03)00126-X","article-title":"Importance of MAPK pathways for microglial pro-inflammatory cytokine IL-1 beta production","volume":"25","author":"Kim","year":"2004","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.biopha.2019.01.017_bib0180","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.bbapap.2005.08.017","article-title":"MAPK signalling pathways as molecular targets for anti-inflammatory therapy--from molecular mechanisms to therapeutic benefits","volume":"1754","author":"Kaminska","year":"2005","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218359183?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218359183?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T11:46:44Z","timestamp":1760096804000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218359183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":36,"alternative-id":["S0753332218359183"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.01.017","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-neuroinflammatory effect of Iresine celosia on lipopolysaccharide-stimulated microglial cells and mouse","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.01.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}