{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T03:15:30Z","timestamp":1790478930944,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T00:00:00Z","timestamp":1548288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2017CFA043"],"award-info":[{"award-number":["2017CFA043"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.biopha.2019.108627","type":"journal-article","created":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T15:04:06Z","timestamp":1550761446000},"page":"108627","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["Knockdown of lncRNA PVT1 inhibits retinoblastoma progression by sponging miR-488-3p"],"prefix":"10.1016","volume":"112","author":[{"given":"Xue-Zhi","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Pei","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Jiang","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"13","key":"10.1016\/j.biopha.2019.108627_bib0005","doi-asserted-by":"crossref","first-page":"e98","DOI":"10.1158\/1078-0432.CCR-17-0652","article-title":"Retinoblastoma and neuroblastoma predisposition and surveillance","volume":"23","author":"Kamihara","year":"2017","journal-title":"Clin. Cancer Res."},{"issue":"12","key":"10.1016\/j.biopha.2019.108627_bib0010","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1038\/s41388-017-0050-x","article-title":"The management of retinoblastoma","volume":"37","author":"Fabian","year":"2018","journal-title":"Oncogene"},{"issue":"6089","key":"10.1016\/j.biopha.2019.108627_bib0015","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/323643a0","article-title":"A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma","volume":"323","author":"Friend","year":"1986","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.biopha.2019.108627_bib0020","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1002\/jcp.26070","article-title":"MicroRNAs in retinoblastoma: potential diagnostic and therapeutic biomarkers","volume":"233","author":"Golabchi","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"7200","key":"10.1016\/j.biopha.2019.108627_bib0025","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/nature06992","article-title":"Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription","volume":"454","author":"Wang","year":"2008","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.biopha.2019.108627_bib0030","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.bbrc.2017.01.134","article-title":"Long noncoding RNA BDNF-AS is a potential biomarker and regulates cancer development in human retinoblastoma","volume":"497","author":"Shang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.biopha.2019.108627_bib0035","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s12038-016-9636-7","article-title":"Long non-coding RNA HOTAIR regulates proliferation and invasion via activating notch signalling pathway in retinoblastoma","volume":"41","author":"Dong","year":"2016","journal-title":"J. Biosci."},{"issue":"2","key":"10.1016\/j.biopha.2019.108627_bib0040","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1007\/s13277-015-4564-y","article-title":"Decreased expression of MEG3 contributes to retinoblastoma progression and affects retinoblastoma cell growth by regulating the activity of Wnt\/beta-catenin pathway","volume":"37","author":"Gao","year":"2016","journal-title":"Tumour Biol."},{"issue":"3","key":"10.1016\/j.biopha.2019.108627_bib0045","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20180384","article-title":"LncRNA AFAP1-AS1 is a prognostic biomarker and serves as oncogenic role in retinoblastoma","volume":"38","author":"Hao","year":"2018","journal-title":"Biosci. Rep."},{"issue":"9","key":"10.1016\/j.biopha.2019.108627_bib0050","doi-asserted-by":"crossref","first-page":"7205","DOI":"10.1007\/s13277-015-3413-3","article-title":"Long non-coding RNA BANCR regulates growth and metastasis and is associated with poor prognosis in retinoblastoma","volume":"36","author":"Su","year":"2015","journal-title":"Tumour Biol."},{"issue":"4","key":"10.1016\/j.biopha.2019.108627_bib0055","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1002\/jcb.26521","article-title":"Long non-coding RNA H19 suppresses retinoblastoma progression via counteracting miR-17-92 cluster","volume":"119","author":"Zhang","year":"2018","journal-title":"J. Cell. Biochem."},{"issue":"49","key":"10.1016\/j.biopha.2019.108627_bib0060","doi-asserted-by":"crossref","first-page":"85353","DOI":"10.18632\/oncotarget.19743","article-title":"lncRNA PVT1 and its splicing variant function as competing endogenous RNA to regulate clear cell renal cell carcinoma progression","volume":"8","author":"Yang","year":"2017","journal-title":"Oncotarget"},{"issue":"11","key":"10.1016\/j.biopha.2019.108627_bib0065","first-page":"5025","article-title":"LncRNA PVT1 overexpression is a poor prognostic biomarker and regulates migration and invasion in small cell lung cancer","volume":"8","author":"Huang","year":"2016","journal-title":"Am. J. Transl. Res."},{"issue":"19","key":"10.1016\/j.biopha.2019.108627_bib0070","first-page":"3980","article-title":"Long noncoding RNA PVT1 as a novel serum biomarker for detection of cervical cancer","volume":"20","author":"Yang","year":"2016","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.biopha.2019.108627_bib0075","doi-asserted-by":"crossref","first-page":"4723","DOI":"10.1038\/s41388-018-0310-4","article-title":"LncRNA PVT1 regulates triple-negative breast cancer through KLF5\/beta-catenin signaling","volume":"37","author":"Tang","year":"2018","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.biopha.2019.108627_bib0080","doi-asserted-by":"crossref","first-page":"453","DOI":"10.3892\/mmr.2014.2213","article-title":"Inhibition of the jagged\/notch pathway inhibits retinoblastoma cell proliferation via suppressing the PI3K\/Akt, Src, p38MAPK and Wnt\/betacatenin signaling pathways","volume":"10","author":"Xiao","year":"2014","journal-title":"Mol. Med. Rep."},{"issue":"43","key":"10.1016\/j.biopha.2019.108627_bib0085","doi-asserted-by":"crossref","first-page":"70028","DOI":"10.18632\/oncotarget.12142","article-title":"Targeting notch signaling as a novel therapy for retinoblastoma","volume":"7","author":"Asnaghi","year":"2016","journal-title":"Oncotarget"},{"issue":"6","key":"10.1016\/j.biopha.2019.108627_bib0090","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/s41585-018-0005-1","article-title":"Unravelling disparate roles of NOTCH in bladder cancer","volume":"15","author":"Goriki","year":"2018","journal-title":"Nat. Rev. Urol."},{"issue":"8","key":"10.1016\/j.biopha.2019.108627_bib0095","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.5858\/133.8.1256","article-title":"Introduction of the 7th edition eyelid carcinoma classification system from the American Joint Committee on Cancer-International Union against cancer staging manual","volume":"133","author":"Ainbinder","year":"2009","journal-title":"Arch. Pathol. Lab. Med."},{"issue":"1","key":"10.1016\/j.biopha.2019.108627_bib0100","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ohc.2004.11.003","article-title":"Intraocular retinoblastoma: the case for a new group classification","volume":"18","author":"Linn Murphree","year":"2005","journal-title":"Ophthalmol. Clin. North Am."},{"issue":"4","key":"10.1016\/j.biopha.2019.108627_bib0105","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods (San Diego, Calif.)"},{"key":"10.1016\/j.biopha.2019.108627_bib0110","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.biopha.2018.05.141","article-title":"Downregulation of circular RNA hsa_circ_0001649 indicates poor prognosis for retinoblastoma and regulates cell proliferation and apoptosis via AKT\/mTOR signaling pathway","volume":"105","author":"Xing","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"5","key":"10.1016\/j.biopha.2019.108627_bib0115","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.191","article-title":"The novel long intergenic noncoding RNA UCC promotes colorectal cancer progression by sponging miR-143","volume":"8","author":"Huang","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.biopha.2019.108627_bib0120","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.2147\/OTT.S160428","article-title":"Knockdown of long noncoding RNA 00152 (LINC00152) inhibits human retinoblastoma progression","volume":"11","author":"Li","year":"2018","journal-title":"Onco Targets Ther."},{"key":"10.1016\/j.biopha.2019.108627_bib0125","doi-asserted-by":"crossref","first-page":"6986","DOI":"10.1002\/jcp.26621","article-title":"Long noncoding RNA DANCR aggravates retinoblastoma through miR-34c and miR-613 by targeting MMP-9","volume":"233","author":"Wang","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"5","key":"10.1016\/j.biopha.2019.108627_bib0130","doi-asserted-by":"crossref","first-page":"3853","DOI":"10.1002\/jcb.26464","article-title":"MALAT1 modulates the autophagy of retinoblastoma cell through miR-124-mediated stx17 regulation","volume":"119","author":"Huang","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.biopha.2019.108627_bib0135","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12943-015-0355-8","article-title":"Long noncoding RNA PVT1 indicates a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically regulating p15 and p16","volume":"14","author":"Kong","year":"2015","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.biopha.2019.108627_bib0140","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.biopha.2018.05.078","article-title":"Long noncoding RNA PVT1 enhances the viability and invasion of papillary thyroid carcinoma cells by functioning as ceRNA of microRNA-30a through mediating expression of insulin like growth factor 1 receptor","volume":"104","author":"Feng","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.biopha.2019.108627_bib0145","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s41419-018-0265-y","article-title":"Long non-coding RNA PVT1 predicts poor prognosis and induces radioresistance by regulating DNA repair and cell apoptosis in nasopharyngeal carcinoma","volume":"9","author":"He","year":"2018","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.biopha.2019.108627_bib0150","first-page":"48","article-title":"Long non-coding RNA PVT1 functions as an oncogene in human colon cancer through miR-30d-5p\/RUNX2 axis","volume":"23","author":"Yu","year":"2018","journal-title":"J. BUON"},{"key":"10.1016\/j.biopha.2019.108627_bib0155","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.gene.2018.02.036","article-title":"Long noncoding RNA PVT1 promotes EMT via mediating microRNA-186 targeting of Twist1 in prostate cancer","volume":"654","author":"Chang","year":"2018","journal-title":"Gene"},{"key":"10.1016\/j.biopha.2019.108627_bib0160","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.gene.2018.05.065","article-title":"SP1-induced upregulation of lncRNA PANDAR predicts adverse phenotypes in retinoblastoma and regulates cell growth and apoptosis in vitro and in vivo","volume":"668","author":"Sheng","year":"2018","journal-title":"Gene"},{"issue":"7","key":"10.1016\/j.biopha.2019.108627_bib0165","doi-asserted-by":"crossref","first-page":"8691","DOI":"10.1007\/s13277-015-4645-y","article-title":"miR-488 acts as a tumor suppressor gene in gastric cancer","volume":"37","author":"Zhao","year":"2016","journal-title":"Tumour Biol. J. Int. Soc. Oncodev. Biol. Med."},{"issue":"10","key":"10.1016\/j.biopha.2019.108627_bib0170","first-page":"2070","article-title":"MiR-488 suppresses cell proliferation and invasion by targeting ADAM9 and lncRNA HULC in hepatocellular carcinoma","volume":"7","author":"Hu","year":"2017","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.biopha.2019.108627_bib0175","doi-asserted-by":"crossref","first-page":"40384","DOI":"10.1038\/srep40384","article-title":"MiR-488 inhibits proliferation and cisplatin sensibility in non-small-cell lung cancer (NSCLC) cells by activating the eIF3a-mediated NER signaling pathway","volume":"7","author":"Fang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2019.108627_bib0180","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.2147\/OTT.S156361","article-title":"miR-488 inhibits cell growth and metastasis in renal cell carcinoma by targeting HMGN5","volume":"11","author":"Wei","year":"2018","journal-title":"OncoTargets Ther."},{"issue":"4","key":"10.1016\/j.biopha.2019.108627_bib0185","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/ijc.25753","article-title":"miR 488* inhibits androgen receptor expression in prostate carcinoma cells","volume":"129","author":"Sikand","year":"2011","journal-title":"Int. J. Cancer"},{"issue":"7","key":"10.1016\/j.biopha.2019.108627_bib0190","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1089\/dna.2017.3678","article-title":"LncRNA PVT1 regulates chondrocyte apoptosis in osteoarthritis by acting as a sponge for miR-488-3p","volume":"36","author":"Li","year":"2017","journal-title":"DNA Cell Biol."},{"issue":"4","key":"10.1016\/j.biopha.2019.108627_bib0195","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1523\/JNEUROSCI.17-04-01425.1997","article-title":"The expression and function of notch pathway genes in the developing rat eye","volume":"17","author":"Bao","year":"1997","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.biopha.2019.108627_bib0200","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1158\/1078-0432.CCR-11-1946","article-title":"Upregulation of notch2 and six1 is associated with progression of early-stage lung adenocarcinoma and a more aggressive phenotype at advanced stages","volume":"18","author":"Mimae","year":"2012","journal-title":"Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.biopha.2019.108627_bib0205","doi-asserted-by":"crossref","first-page":"734","DOI":"10.3892\/mmr.2014.2747","article-title":"Interference of notch 2 inhibits the progression of gliomas and induces cell apoptosis by induction of the cell cycle at the G0\/G1 phase","volume":"11","author":"Yu","year":"2015","journal-title":"Mol. Med. Rep."},{"issue":"6","key":"10.1016\/j.biopha.2019.108627_bib0210","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.1038\/bjc.2017.471","article-title":"miR-146a-5p mediates epithelial-mesenchymal transition of oesophageal squamous cell carcinoma via targeting notch2","volume":"118","author":"Wang","year":"2018","journal-title":"Br. J. Cancer"},{"issue":"1","key":"10.1016\/j.biopha.2019.108627_bib0215","doi-asserted-by":"crossref","first-page":"5183","DOI":"10.1038\/s41598-018-23421-3","article-title":"MicroRNA-1 suppresses proliferation, migration and invasion by targeting notch2 in esophageal squamous cell carcinoma","volume":"8","author":"Liu","year":"2018","journal-title":"Sci. Rep."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218344901?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218344901?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T11:05:04Z","timestamp":1776078304000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218344901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":43,"alternative-id":["S0753332218344901"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.108627","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Knockdown of lncRNA PVT1 inhibits retinoblastoma progression by sponging miR-488-3p","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.108627","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"108627"}}