{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T17:44:55Z","timestamp":1789062295672,"version":"build-2803163510"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600280"],"award-info":[{"award-number":["81600280"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.biopha.2019.108660","type":"journal-article","created":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T08:07:04Z","timestamp":1554710824000},"page":"108660","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["ACE inhibitor suppresses cardiac remodeling after myocardial infarction by regulating dendritic cells and AT2 receptor-mediated mechanism in mice"],"prefix":"10.1016","volume":"114","author":[{"given":"Yuanji","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunzeng","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbo","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2019.108660_bib0005","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/32588","article-title":"Dendritic cells and the control of immunity","volume":"392","author":"Banchereau","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2019.108660_bib0010","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/ni.1894","article-title":"Programming dendritic cells to induce T(H)2 and tolerogenic responses","volume":"11","author":"Pulendran","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.biopha.2019.108660_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.molimm.2018.07.007","article-title":"Dendritic cells in sepsis: potential immunoregulatory cells with therapeutic potential","author":"Kumar","year":"2018","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.biopha.2019.108660_bib0020","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1016\/j.celrep.2017.02.079","article-title":"Myocardial infarction primes autoreactive T cells through activation of dendritic cells","volume":"18","author":"Van der Borght","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.biopha.2019.108660_bib0025","doi-asserted-by":"crossref","first-page":"5691","DOI":"10.4049\/jimmunol.181.8.5691","article-title":"Differential effects of GM-CSF and G-CSF on infiltration of dendritic cells during early left ventricular remodeling after myocardial infarction","volume":"181","author":"Naito","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.biopha.2019.108660_bib0030","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1161\/CIRCULATIONAHA.109.865956","article-title":"Survival and cardiac remodeling after myocardial infarction are critically dependent on the host innate immune interleukin-1 receptor-associated kinase-4 signaling: a regulator of bone marrow-derived dendritic cells","volume":"120","author":"Maekawa","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2019.108660_bib0035","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1006\/bbrc.2001.5215","article-title":"Expression of renin\u2013angiotensin system genes in immature and mature dendritic cells identified using human cDNA microarray","volume":"285","author":"Lapteva","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2019.108660_bib0040","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S0006-291X(02)00855-0","article-title":"Activation and suppression of renin\u2013angiotensin system in human dendritic cells","volume":"296","author":"Lapteva","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2019.108660_bib0045","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1126\/science.1175202","article-title":"Identification of splenic reservoir monocytes and their deployment to inflammatory sites","volume":"325","author":"Swirski","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.biopha.2019.108660_bib0050","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1161\/CIRCRESAHA.110.227454","article-title":"Angiotensin-converting enzyme inhibition prevents the release of monocytes from their splenic reservoir in mice with myocardial infarction","volume":"107","author":"Leuschner","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.biopha.2019.108660_bib0055","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1046\/j.1523-1755.2002.00365.x","article-title":"Angiotensin II activates nuclear transcription factor-kappaB through AT1 and AT2 receptors","volume":"61","author":"Wolf","year":"2002","journal-title":"Kidney Int."},{"key":"10.1016\/j.biopha.2019.108660_bib0060","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10557-017-6717-2","article-title":"Inhibition of the renin\u2013angiotensin system post myocardial infarction prevents inflammation-associated acute cardiac rupture","volume":"31","author":"Gao","year":"2017","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.biopha.2019.108660_bib0065","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.amjmed.2008.02.038","article-title":"Angiotensin receptor blockers: current status and future prospects","volume":"121","author":"Ram","year":"2008","journal-title":"Am. J. Med."},{"key":"10.1016\/j.biopha.2019.108660_bib0070","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ejphar.2008.12.049","article-title":"Angiotensin II increases collagen I expression via transforming growth factor-beta1 and extracellular signal-regulated kinase in cardiac fibroblasts","volume":"606","author":"Gao","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2019.108660_bib0075","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3317\/jraas.2000.024","volume":"1","author":"Xu","year":"2000","journal-title":"J. Renin Angiotensin Aldosterone Syst."},{"key":"10.1016\/j.biopha.2019.108660_bib0080","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.pharmthera.2008.08.009","article-title":"AT2 receptors: functional relevance in cardiovascular disease","volume":"120","author":"Jones","year":"2008","journal-title":"Pharmaol. Ther."},{"key":"10.1016\/j.biopha.2019.108660_bib0085","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/s11906-013-0416-6","article-title":"AT(2) receptor and tissue injury: therapeutic implications","volume":"16","author":"Namsolleck","year":"2014","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.biopha.2019.108660_bib0090","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0022-3565(24)37201-5","article-title":"Differential distribution of angiotensin AT2 receptors in the normal and failing human heart","volume":"284","author":"Wharton","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.biopha.2019.108660_bib0095","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1023\/A:1015709617405","article-title":"Pathophysiologic and therapeutic importance of tissue ACE: a consensus report","volume":"16","author":"Dzau","year":"2002","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.biopha.2019.108660_bib0100","doi-asserted-by":"crossref","first-page":"F150","DOI":"10.1152\/ajprenal.00477.2009","article-title":"Intrarenal mouse renin\u2013angiotensin system during ANG II-induced hypertension and ACE inhibition","volume":"298","author":"Gonzalez-Villalobos","year":"2010","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.biopha.2019.108660_bib0105","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1161\/HYPERTENSIONAHA.108.124511","article-title":"Angiotensin-converting enzyme-derived angiotensin II formation during angiotensin II-induced hypertension","volume":"53","author":"Gonzalez-Villalobos","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.biopha.2019.108660_bib0110","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1536\/ihj.51.359","article-title":"Year-long antihypertensive therapy with candesartan completely prevents development of cardiovascular organ injuries in spontaneously hypertensive rats","volume":"51","author":"Ishimitsu","year":"2010","journal-title":"Int. Heart J."},{"key":"10.1016\/j.biopha.2019.108660_bib0115","doi-asserted-by":"crossref","DOI":"10.1007\/s10741-018-9711-2","article-title":"Left ventricular restoration devices post myocardial infarction","author":"Hendriks","year":"2018","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.biopha.2019.108660_bib0120","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1161\/01.RES.0000130526.20854.fa","article-title":"Inflammatory cytokines and postmyocardial infarction remodeling","volume":"94","author":"Nian","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.biopha.2019.108660_bib0125","doi-asserted-by":"crossref","DOI":"10.1093\/cvr\/cvy145","article-title":"Immunomodulatory interventions in myocardial infarction and heart failure: a systematic review of clinical trials and meta-analysis of IL-1 inhibition","author":"Panahi","year":"2018","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.biopha.2019.108660_bib0130","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.4049\/jimmunol.0803172","article-title":"Ly6C(low) monocytes differentiate into dendritic cells and cross-tolerize T cells through PDL-1","volume":"182","author":"Peng","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.biopha.2019.108660_bib0135","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s003950170073","article-title":"Apoptosis in the vascular wall and atherosclerosis","volume":"96","author":"Rossig","year":"2001","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.biopha.2019.108660_bib0140","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s11906-002-0055-9","article-title":"Angiotensin and cytoskeletal proteins: role in vascular remodeling","volume":"4","author":"Wesselman","year":"2002","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.biopha.2019.108660_bib0145","doi-asserted-by":"crossref","first-page":"148798","DOI":"10.1155\/2014\/148798","article-title":"Atorvastatin represses the angiotensin 2-induced oxidative stress and inflammatory response in dendritic cells via the PI3K\/Akt\/Nrf 2 pathway","volume":"2014","author":"Ma","year":"2014","journal-title":"Oxidat. Med. Cell. Longevity"},{"key":"10.1016\/j.biopha.2019.108660_bib0150","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/imm.12255","article-title":"Ubiquitin-activating enzyme E1 inhibitor PYR41 attenuates angiotensin II-induced activation of dendritic cells via the IkappaBa\/NF-kappaB and MKP1\/ERK\/STAT1 pathways","volume":"142","author":"Chen","year":"2014","journal-title":"Immunology"},{"key":"10.1016\/j.biopha.2019.108660_bib0155","doi-asserted-by":"crossref","first-page":"11887","DOI":"10.1073\/pnas.0806335105","article-title":"The CD83 reporter mouse elucidates the activity of the CD83 promoter in B, T, and dendritic cell populations in vivo","volume":"105","author":"Lechmann","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biopha.2019.108660_bib0160","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1600-065X.2009.00782.x","article-title":"Molecular mechanism and function of CD40\/CD40L engagement in the immune system","volume":"229","author":"Elgueta","year":"2009","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.biopha.2019.108660_bib0165","doi-asserted-by":"crossref","first-page":"H727","DOI":"10.1152\/ajpheart.00938.2006","article-title":"Potentiation of the antihypertensive action of losartan by peripheral overexpression of the ANG II type 2 receptor","volume":"292","author":"Li","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.biopha.2019.108660_bib0170","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.phrs.2018.07.006","article-title":"The anti-inflammatory peptide Ac-SDKP: synthesis, role in ACE inhibition, and its therapeutic potential in hypertension and cardiovascular diseases","volume":"134","author":"Kumar","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.biopha.2019.108660_bib0175","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1177\/1470320309347791","article-title":"The past, present and future of angiotensin II type 2 receptor stimulation","volume":"11","author":"Steckelings","year":"2010","journal-title":"J. Renin Angiotensin Aldosterone Syst."},{"key":"10.1016\/j.biopha.2019.108660_bib0180","doi-asserted-by":"crossref","first-page":"H2179","DOI":"10.1152\/ajpheart.00361.2003","article-title":"Ventricular-specific expression of angiotensin II type 2 receptors causes dilated cardiomyopathy and heart failure in transgenic mice","volume":"285","author":"Yan","year":"2003","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.biopha.2019.108660_bib0185","doi-asserted-by":"crossref","first-page":"H317","DOI":"10.1152\/ajpheart.00957.2003","article-title":"Chronic ventricular myocyte-specific overexpression of angiotensin II type 2 receptor results in intrinsic myocyte contractile dysfunction","volume":"288","author":"Nakayama","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.biopha.2019.108660_bib0190","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1161\/HYPERTENSIONAHA.114.03247","article-title":"Effects of cardiac overexpression of the angiotensin II type 2 receptor on remodeling and dysfunction in mice post-myocardial infarction","volume":"63","author":"Xu","year":"2014","journal-title":"Hypertension"}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218380582?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218380582?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T11:31:32Z","timestamp":1781523092000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218380582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":38,"alternative-id":["S0753332218380582"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.108660","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ACE inhibitor suppresses cardiac remodeling after myocardial infarction by regulating dendritic cells and AT2 receptor-mediated mechanism in mice","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.108660","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"108660"}}