{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T16:37:17Z","timestamp":1778690237156,"version":"3.51.4"},"reference-count":105,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T00:00:00Z","timestamp":1549411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373518"],"award-info":[{"award-number":["81373518"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773979"],"award-info":[{"award-number":["81773979"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.biopha.2019.108676","type":"journal-article","created":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T15:07:25Z","timestamp":1550761645000},"page":"108676","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"special_numbering":"C","title":["Preventive and therapeutic role of Tanshinone \u2161A in hepatology"],"prefix":"10.1016","volume":"112","author":[{"given":"Miao-Juan","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben-Sheng","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Na","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Bing","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5867-1478","authenticated-orcid":false,"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2019.108676_bib0005","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1002\/hep.27406","article-title":"The global burden of liver disease: the major impact of China","volume":"60","author":"Wang","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.biopha.2019.108676_bib0010","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.fitote.2011.01.011","article-title":"Inhibitory effect of tanshinones on rat CYP3A2 and CYP2C11 activity and its structure-activity relationship","volume":"82","author":"Wang","year":"2011","journal-title":"Fitoterapia"},{"key":"10.1016\/j.biopha.2019.108676_bib0015","first-page":"842824","article-title":"Meta-analysis of the clinical value of danshen injection and huangqi injection in liver cirrhosis","volume":"2013","author":"Zhu","year":"2013","journal-title":"Evid. Complement. Alternat. Med."},{"key":"10.1016\/j.biopha.2019.108676_bib0020","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/med.20077","article-title":"New developments in the chemistry and biology of the bioactive constituents of Tanshen","volume":"27","author":"Wang","year":"2007","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.biopha.2019.108676_bib0025","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1177\/0091270005282630","article-title":"Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use","volume":"45","author":"Zhou","year":"2005","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.biopha.2019.108676_bib0030","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.atherosclerosis.2011.06.041","article-title":"Cardiovascular actions and therapeutic potential of tanshinone IIA","volume":"220","author":"Gao","year":"2012","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.biopha.2019.108676_bib0035","first-page":"1065","article-title":"A successful case of tanshinone II A treatment for relapsed acute promyelocytic leukemia after maintainance therapy of all-trans retinoic acid and arsenic trioxide","volume":"41","author":"Yang","year":"2010","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"key":"10.1016\/j.biopha.2019.108676_bib0040","first-page":"965","article-title":"Complete remission of acute promyelocytic leukemia resisting all-trans retinoic acid of one case treated by tanshinone II A","volume":"37","author":"Yang","year":"2006","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"key":"10.1016\/j.biopha.2019.108676_bib0045","first-page":"1794","article-title":"Sodium tanshinone IIA silate as an add-on therapy in patients with unstable angina pectoris","volume":"6","author":"Zhang","year":"2014","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.biopha.2019.108676_bib0050","first-page":"756519","article-title":"The effect of sodium tanshinone IIA sulfate and simvastatin on elevated serum levels of inflammatory markers in patients with coronary heart disease: a study protocol for a randomized controlled trial","volume":"2013","author":"Shang","year":"2013","journal-title":"Evid. Complement. Alternat. Med."},{"key":"10.1016\/j.biopha.2019.108676_bib0055","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/s12975-017-0526-6","article-title":"Sodium tanshinone IIA sulfonate enhances effectiveness Rt-PA treatment in acute ischemic stroke patients associated with ameliorating blood-brain barrier damage","volume":"8","author":"Ji","year":"2017","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.biopha.2019.108676_bib0060","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ijcard.2008.03.020","article-title":"Sulfotanshinone Sodium Injection could decrease fibrinogen level and improve clinical outcomes in patients with unstable angina pectoris","volume":"135","author":"Yan","year":"2009","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.biopha.2019.108676_bib0065","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.intimp.2015.06.032","article-title":"Tanshinone IIA represses inflammatory response and reduces radiculopathic pain by inhibiting IRAK-1 and NF-kappaB\/p38\/JNK signaling","volume":"28","author":"Li","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.biopha.2019.108676_bib0070","article-title":"An NQO1-initiated and p53-independent apoptotic pathway determines the anti-tumor effect of tanshinone IIA against non-small cell lung cancer","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2019.108676_bib0075","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jep.2012.10.044","article-title":"Hydrogen peroxide-mediated oxidative stress and collagen synthesis in cardiac fibroblasts: blockade by tanshinone IIA","volume":"145","author":"Wang","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2019.108676_bib0080","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.jep.2014.07.010","article-title":"Tanshinone IIA, a major component of Salvia milthorriza Bunge, inhibits platelet activation via Erk-2 signaling pathway","volume":"155","author":"Maione","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2019.108676_bib0085","first-page":"415","article-title":"Protective effects of tanshinone IIA on injured primary cultured rat hepatocytes induced by CCl4","volume":"26","author":"Liu","year":"2003","journal-title":"Zhong Yao Cai"},{"key":"10.1016\/j.biopha.2019.108676_bib0090","first-page":"588","article-title":"Protective effect of tanshinone IIA on acute hepatic injury in mice","volume":"24","author":"Liu","year":"2001","journal-title":"Zhong Yao Cai"},{"key":"10.1016\/j.biopha.2019.108676_bib0095","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1016\/j.fct.2009.08.007","article-title":"Preventive effects of a purified extract isolated from Salvia miltiorrhiza enriched with tanshinone I, tanshinone IIA and cryptotanshinone on hepatocyte injury in vitro and in vivo","volume":"47","author":"Park","year":"2009","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2019.108676_bib0100","first-page":"631","article-title":"Protective effect of tanshinones against liver injury in mice loaded with restraint stress","volume":"41","author":"Xu","year":"2006","journal-title":"Yao Xue Xue Bao"},{"key":"10.1016\/j.biopha.2019.108676_bib0105","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s12272-001-1209-2","article-title":"Effects of tanshinone IIA on the hepatotoxicity and gene expression involved in alcoholic liver disease","volume":"31","author":"Yin","year":"2008","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.biopha.2019.108676_bib0110","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3109\/08923970903120997","article-title":"Tanshinone IIA protects against immune-mediated liver injury through activation of T-cell subsets and regulation of cytokines","volume":"32","author":"Qin","year":"2010","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.biopha.2019.108676_bib0115","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/0891-5849(95)02211-2","article-title":"Effect of natural antioxidant tanshinone II-A on DNA damage by lipid peroxidation in liver cells","volume":"20","author":"Cao","year":"1996","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biopha.2019.108676_bib0120","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.phymed.2016.02.022","article-title":"Tanshinone IIA protects against acetaminophen-induced hepatotoxicity via activating the Nrf2 pathway","volume":"23","author":"Wang","year":"2016","journal-title":"Phytomedicine"},{"key":"10.1016\/j.biopha.2019.108676_bib0125","first-page":"1397","article-title":"Tanshinone IIA protects against triptolide-induced liver injury via Nrf2\/ARE activation","volume":"48","author":"Guan","year":"2013","journal-title":"Yao Xue Xue Bao"},{"key":"10.1016\/j.biopha.2019.108676_bib0130","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1016\/j.fct.2007.04.005","article-title":"PF2401-SF, standardized fraction of Salvia miltiorrhiza and its constituents, tanshinone I, tanshinone IIA, and cryptotanshinone, protect primary cultured rat hepatocytes from bile acid-induced apoptosis by inhibiting JNK phosphorylation","volume":"45","author":"Park","year":"2007","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2019.108676_bib0135","doi-asserted-by":"crossref","first-page":"484","DOI":"10.3109\/13880200903179699","article-title":"Tanshinone IIA protects rat primary hepatocytes against carbon tetrachloride toxicity via inhibiting mitochondria permeability transition","volume":"48","author":"Zhu","year":"2010","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.biopha.2019.108676_bib0140","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.3109\/13880209.2014.889720","article-title":"Salvia miltiorrhiza compounds protect the liver from acute injury by regulation of p38 and NFkappaB signaling in Kupffer cells","volume":"52","author":"Yue","year":"2014","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.biopha.2019.108676_bib0145","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.biopha.2017.03.022","article-title":"Pre-conditioning with tanshinone IIA attenuates the ischemia\/reperfusion injury caused by liver grafts via regulation of HMGB1 in rat Kupffer cells","volume":"89","author":"Li","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2019.108676_bib0150","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.2741\/e461","article-title":"Tanshinone IIA pretreatment attenuates hepatic ischemia-reperfusion","volume":"4","author":"Qi","year":"2012","journal-title":"Front. Biosci. (Elite Ed)"},{"key":"10.1016\/j.biopha.2019.108676_bib0155","first-page":"142","article-title":"Similarities in the sequence of early histological changes induced in the liver of the rat by ethionine, 2-acetylamino-fluorene, and 3\u2019-methyl-4-dimethylaminoazobenzene","volume":"16","author":"Farber","year":"1956","journal-title":"Cancer Res."},{"key":"10.1016\/j.biopha.2019.108676_bib0160","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.3892\/mmr.2015.4696","article-title":"Tanshinone IIA promotes the proliferation of WB-F344 hepatic oval cells via Wnt\/beta-catenin signaling","volume":"13","author":"Ze","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.biopha.2019.108676_bib0165","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.jep.2015.01.047","article-title":"Tanshinone IIA exerts protective effects in a LCA-induced cholestatic liver model associated with participation of pregnane X receptor","volume":"164","author":"Zhang","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2019.108676_bib0170","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1046\/j.1440-1746.2002.02846.x","article-title":"Fatty liver in non-alcoholic non-overweight Japanese adults: incidence and clinical characteristics","volume":"17","author":"Omagari","year":"2002","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.biopha.2019.108676_bib0175","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3109\/00365527709181339","article-title":"Liver histology in a\u2019 normal\u2019 population--examinations of 503 consecutive fatal traffic casualties","volume":"12","author":"Hilden","year":"1977","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.biopha.2019.108676_bib0180","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.3748\/wjg.v9.i5.1106","article-title":"Prevalence of nonalcoholic fatty liver among administrative officers in Shanghai: an epidemiological survey","volume":"9","author":"Shen","year":"2003","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.biopha.2019.108676_bib0185","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18030620","article-title":"A biomedical investigation of the hepatoprotective effect of Radix salviae miltiorrhizae and network pharmacology-based prediction of the active compounds and molecular targets","volume":"18","author":"Hong","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2019.108676_bib0190","first-page":"4639","article-title":"Effect of tanshinone IIA on oxidative stress and apoptosis in a rat model of fatty liver","volume":"14","author":"Yang","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.biopha.2019.108676_bib0195","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.abb.2016.01.001","article-title":"Tanshinone IIA affects the HDL subfractions distribution not serum lipid levels: involving in intake and efflux of cholesterol","volume":"592","author":"Jia","year":"2016","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.biopha.2019.108676_bib0200","doi-asserted-by":"crossref","first-page":"4627","DOI":"10.3892\/mmr.2016.5133","article-title":"Effects of Tanshinone IIA on the modulation of miR33a and the SREBP2\/Pcsk9 signaling pathway in hyperlipidemic rats","volume":"13","author":"Jia","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.biopha.2019.108676_bib0205","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.biopha.2018.12.019","article-title":"Sodium tanshinone IIA sulfonate ameliorates hepatic steatosis by inhibiting lipogenesis and inflammation","volume":"111","author":"Li","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2019.108676_bib0210","first-page":"459","article-title":"Update on the pathophysiology of liver fibrosis, Expert Rev","volume":"4","author":"Pinzani","year":"2010","journal-title":"Gastroenterol. Hepatol."},{"key":"10.1016\/j.biopha.2019.108676_bib0215","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1152\/physrev.00013.2007","article-title":"Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver","volume":"88","author":"Friedman","year":"2008","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.biopha.2019.108676_bib0220","first-page":"G1059","article-title":"TGF-beta1 in liver fibrosis: an inducible transgenic mouse model to study liver fibrogenesis","volume":"276","author":"Kanzler","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.biopha.2019.108676_bib0225","first-page":"31","article-title":"Effect of tanshinone IIA on CCl4-induced liver fibrosis in rats","volume":"25","author":"Liu","year":"2002","journal-title":"Zhong Yao Cai"},{"key":"10.1016\/j.biopha.2019.108676_bib0230","doi-asserted-by":"crossref","first-page":"8189","DOI":"10.3390\/molecules19068189","article-title":"Standardized Salvia miltiorrhiza extract suppresses hepatic stellate cell activation and attenuates steatohepatitis induced by a methionine-choline deficient diet in mice","volume":"19","author":"Lee","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2019.108676_bib0235","first-page":"1012","article-title":"Effect of tanshinone II on hepatic fibrosis in mice","volume":"29","author":"Sun","year":"2009","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"key":"10.1016\/j.biopha.2019.108676_bib0240","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s12272-014-0425-2","article-title":"Anti-fibrotic effect of PF2401-SF, a standardized fraction of Salvia miltiorrhiza, in thioacetamide-induced experimental rats liver fibrosis","volume":"38","author":"Parajuli","year":"2015","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.biopha.2019.108676_bib0245","first-page":"734987","article-title":"Explore the molecular mechanism of apoptosis induced by tanshinone IIA on activated rat hepatic stellate cells","volume":"2012","author":"Pan","year":"2012","journal-title":"Evid. Complement. Alternat. Med."},{"key":"10.1016\/j.biopha.2019.108676_bib0250","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1742-7843.2009.00465.x","article-title":"Tanshinone II A induces apoptosis and S phase cell cycle arrest in activated rat hepatic stellate cells","volume":"106","author":"Che","year":"2010","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.biopha.2019.108676_bib0255","first-page":"69","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.biopha.2019.108676_bib0260","first-page":"87","article-title":"Global cancer statistics, 2012","volume":"65","author":"Torre","year":"2015","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.biopha.2019.108676_bib0265","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1039\/C0MB00343C","article-title":"Nano-LC-MS\/MS based proteomics of hepatocellular carcinoma cells compared to Chang liver cells and tanshinone IIA induction","volume":"7","author":"Long","year":"2011","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.biopha.2019.108676_bib0270","first-page":"99","article-title":"Inhibition of cell growth and induction of apoptosis in human hepatoma cell line HepG2 by tanshione IIA","volume":"32","author":"Zhong","year":"2007","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban"},{"key":"10.1016\/j.biopha.2019.108676_bib0275","first-page":"166","article-title":"Growth inhibition and apoptosis induction in human hepatoma cells by tanshinone II A","volume":"23","author":"Tang","year":"2003","journal-title":"J. Huazhong Univ. Sci. Technol. Med. Sci."},{"key":"10.1016\/j.biopha.2019.108676_bib0280","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s11418-011-0576-0","article-title":"Tanshinone IIA activates calcium-dependent apoptosis signaling pathway in human hepatoma cells","volume":"66","author":"Dai","year":"2012","journal-title":"J. Nat. Med."},{"key":"10.1016\/j.biopha.2019.108676_bib0285","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ejphar.2016.11.046","article-title":"Tanshinone IIA induced cell death via miR30b-p53-PTPN11\/SHP2 signaling pathway in human hepatocellular carcinoma cells","volume":"796","author":"Ren","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2019.108676_bib0290","first-page":"379","article-title":"Tanshinone IIA inhibits Hep-J5 cells by increasing calreticulin, caspase 12 and GADD153 protein expression","volume":"26","author":"Cheng","year":"2010","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.biopha.2019.108676_bib0295","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.3748\/wjg.v10.i14.2024","article-title":"Growth inhibition and apoptosis induction of tanshinone II-A on human hepatocellular carcinoma cells","volume":"10","author":"Yuan","year":"2004","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.biopha.2019.108676_bib0300","first-page":"2694","article-title":"The Chinese medicine, Jianpi Huayu Decoction, inhibits the epithelial mesenchymal transition via the regulation of the Smad3\/Smad7 cascade","volume":"9","author":"Zhong","year":"2017","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.biopha.2019.108676_bib0305","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1177\/030089160909500623","article-title":"Tanshinone II-A inhibits invasion and metastasis of human hepatocellular carcinoma cells in vitro and in vivo","volume":"95","author":"Yuxian","year":"2009","journal-title":"Tumori."},{"key":"10.1016\/j.biopha.2019.108676_bib0310","doi-asserted-by":"crossref","first-page":"6665","DOI":"10.1158\/0008-5472.CAN-06-3643","article-title":"Cytochrome p450 epoxygenase promotes human cancer metastasis","volume":"67","author":"Jiang","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.biopha.2019.108676_bib0315","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.ejphar.2015.07.047","article-title":"Inhibition of cytochrome P450 2J2 by tanshinone IIA induces apoptotic cell death in hepatocellular carcinoma HepG2 cells","volume":"764","author":"Jeon","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2019.108676_bib0320","doi-asserted-by":"crossref","first-page":"16065","DOI":"10.1038\/cddiscovery.2016.65","article-title":"Simultaneous induction of apoptosis and necroptosis by Tanshinone IIA in human hepatocellular carcinoma HepG2 cells","volume":"2","author":"Lin","year":"2016","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.biopha.2019.108676_bib0325","first-page":"163","article-title":"Effect of Tanshinone II A on expression of EGF and EGFR in hepatocellular carcinoma cell line SMMC-7721","volume":"38","author":"Zhai","year":"2009","journal-title":"Zhejiang Da Xue Xue Bao Yi Xue Ban"},{"key":"10.1016\/j.biopha.2019.108676_bib0330","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3748\/wjg.v4.i4.317","article-title":"Reversing effect of Tanshinone on malignant phenotypes of human hepatocarcinoma cell line","volume":"4","author":"Yuan","year":"1998","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.biopha.2019.108676_bib0335","first-page":"282","article-title":"Tanshinone IIA inhibits human hepatocellular carcinoma J5 cell growth by increasing Bax and caspase 3 and decreasing CD31 expression in vivo","volume":"5","author":"Chien","year":"2012","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.biopha.2019.108676_bib0340","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1756-8722-5-69","article-title":"Tanshinone IIA inhibits metastasis after palliative resection of hepatocellular carcinoma and prolongs survival in part via vascular normalization","volume":"5","author":"Wang","year":"2012","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.biopha.2019.108676_bib0345","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1021\/np900792p","article-title":"Cytotoxic effects of tanshinones from Salvia miltiorrhiza on doxorubicin-resistant human liver cancer cells","volume":"73","author":"Lee","year":"2010","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.biopha.2019.108676_bib0350","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0254-6272(15)30029-7","article-title":"Pharmacokinetic investigation on interaction between hydrophilic lithospermic acid B and lipophilic tanshinone IIA in rats: an experi- mental study","volume":"35","author":"Xiuli","year":"2015","journal-title":"J. Tradit. Chin. Med."},{"key":"10.1016\/j.biopha.2019.108676_bib0355","first-page":"5473","article-title":"Synergistic combinations of tanshinone IIA and trans-resveratrol toward cisplatin-comparable cytotoxicity in HepG2 human hepatocellular carcinoma cells","volume":"34","author":"Chang","year":"2014","journal-title":"Anticancer Res."},{"key":"10.1016\/j.biopha.2019.108676_bib0360","first-page":"995","article-title":"Effect of tanshinone \u2161a combined with oxaliplatin on human hepatocellular carcinoma cell line SMMC-7721","volume":"42","author":"Gao","year":"2007","journal-title":"Chin. Pharm. J."},{"key":"10.1016\/j.biopha.2019.108676_bib0365","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1080\/01480540903176594","article-title":"The effect of tanshinone IIA on renal and liver functions in ovine fetuses in utero","volume":"32","author":"Zhang","year":"2009","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.biopha.2019.108676_bib0370","article-title":"Evaluation of tanshinone IIA developmental toxicity in zebrafish embryos","volume":"22","author":"Wang","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2019.108676_bib0375","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1248\/bpb.31.1469","article-title":"Pharmacokinetic interaction between tanshinones and polyphenolic extracts of salvia miltinorrhiza BUNGE after intravenous administration in rats","volume":"31","author":"Guo","year":"2008","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.biopha.2019.108676_bib0380","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.jpba.2007.04.033","article-title":"Simultaneous determination of danshensu, ferulic acid, cryptotanshinone and tanshinone IIA in rabbit plasma by HPLC and their pharmacokinetic application in danxiongfang","volume":"44","author":"Li","year":"2007","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.biopha.2019.108676_bib0385","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/00498250701767675","article-title":"Preclinical factors affecting the pharmacokinetic behaviour of tanshinone IIA, an investigational new drug isolated from Salvia miltiorrhiza for the treatment of ischaemic heart diseases","volume":"38","author":"Bi","year":"2008","journal-title":"Xenobiotica"},{"key":"10.1016\/j.biopha.2019.108676_bib0390","first-page":"368","article-title":"Determination of tanshinone IIA in rat plasma and the pharmacokinetics by RP-HPLC method","volume":"38","author":"Qiao","year":"2003","journal-title":"Yao Xue Xue Bao"},{"key":"10.1016\/j.biopha.2019.108676_bib0395","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.ejps.2007.07.007","article-title":"Effects of the coexisting diterpenoid tanshinones on the pharmacokinetics of cryptotanshinone and tanshinone IIA in rat","volume":"32","author":"Song","year":"2007","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.biopha.2019.108676_bib0400","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jchromb.2005.07.048","article-title":"Simultaneous determination of tanshinone IIA and cryptotanshinone in rat plasma by liquid chromatography-electrospray ionisation-mass spectrometry","volume":"826","author":"Li","year":"2005","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.biopha.2019.108676_bib0405","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/bmc.968","volume":"22","author":"Park","year":"2008","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.biopha.2019.108676_bib0410","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.jpba.2010.03.041","article-title":"Simultaneous determination of danshensu, rosmarinic acid, cryptotanshinone, tanshinone IIA, tanshinone I and dihydrotanshinone I by liquid chromatographic-mass spectrometry and the application to pharmacokinetics in rats","volume":"53","author":"Liu","year":"2010","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.biopha.2019.108676_bib0415","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jpba.2012.03.058","article-title":"Pharmacokinetic comparisons of single herb extract of Fufang Danshen preparation with different combinations of its constituent herbs in rats","volume":"67\u201368","author":"Yang","year":"2012","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.biopha.2019.108676_bib0420","doi-asserted-by":"crossref","first-page":"325","DOI":"10.2174\/138920007780655450","article-title":"Role of P-glycoprotein in the intestinal absorption of tanshinone IIA, a major active ingredient in the root of Salvia miltiorrhiza Bunge","volume":"8","author":"Yu","year":"2007","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.biopha.2019.108676_bib0425","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1055\/s-2006-951698","article-title":"Pharmacokinetics, absorption and tissue distribution of tanshinone IIA solid dispersion","volume":"72","author":"Hao","year":"2006","journal-title":"Planta Med."},{"key":"10.1016\/j.biopha.2019.108676_bib0430","first-page":"660","article-title":"Study of sodium tanshinone II A sulfonate tissue distribution in rat by liquid chromatography\/tandem mass spectrometry","volume":"60","author":"He","year":"2010","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.biopha.2019.108676_bib0435","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ejps.2015.03.002","article-title":"Enhanced hepatic targeting, biodistribution and antifibrotic efficacy of tanshinone IIA loaded globin nanoparticles","volume":"73","author":"Meng","year":"2015","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.biopha.2019.108676_bib0440","first-page":"4120","article-title":"Preparation and in vivo study of liposomes mediated by glycyrrhetinic acid derivative ligand 18-GA-Gly","volume":"42","author":"Jin","year":"2017","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"10.1016\/j.biopha.2019.108676_bib0445","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1080\/10611860802374303","article-title":"Novel polymeric nanoparticles containing tanshinone IIA for the treatment of hepatoma","volume":"16","author":"Li","year":"2008","journal-title":"J. Drug Target."},{"key":"10.1016\/j.biopha.2019.108676_bib0450","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1039\/C5BM00224A","article-title":"Glycyrrhetinic acid-decorated and reduction-sensitive micelles to enhance the bioavailability and anti-hepatocellular carcinoma efficacy of tanshinone IIA","volume":"4","author":"Chen","year":"2016","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.biopha.2019.108676_bib0455","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1111\/jphp.12423","article-title":"Improvement in oral bioavailability and dissolution of tanshinone IIA by preparation of solid dispersions with porous silica","volume":"67","author":"Yan","year":"2015","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.biopha.2019.108676_bib0460","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1166\/jbn.2014.1982","article-title":"Targeted delivery of tanshinone IIA-conjugated mPEG-PLGA-PLL-cRGD nanoparticles to hepatocellular carcinoma","volume":"10","author":"Wang","year":"2014","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.biopha.2019.108676_bib0465","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jhep.2018.09.014","article-title":"Burden of liver diseases in the world","volume":"70","author":"Asrani","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.biopha.2019.108676_bib0470","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.fct.2009.03.038","article-title":"Tanshinone IIA sodium sulfonate protects against cardiotoxicity induced by doxorubicin in vitro and in vivo","volume":"47","author":"Jiang","year":"2009","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2019.108676_bib0475","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1142\/S0192415X11008907","article-title":"Proteomic assessment of tanshinone IIA sodium sulfonate on doxorubicin induced nephropathy","volume":"39","author":"Liu","year":"2011","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.biopha.2019.108676_bib0480","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.trsl.2007.11.005","article-title":"Tanshinone IIA protects neonatal rat cardiomyocytes from adriamycin-induced apoptosis","volume":"151","author":"Gao","year":"2008","journal-title":"Transl. Res."},{"key":"10.1016\/j.biopha.2019.108676_bib0485","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jep.2006.05.004","article-title":"Protective effect of tanshinone IIA on human umbilical vein endothelial cell injured by hydrogen peroxide and its mechanism","volume":"108","author":"Lin","year":"2006","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2019.108676_bib0490","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s11655-007-0137-2","article-title":"Protective effect of tanshinone II A on lipopolysaccharide-induced lung injury in rats","volume":"13","author":"Shi","year":"2007","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.biopha.2019.108676_bib0495","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/j.1745-7254.2006.00324.x","article-title":"Inhibition of ethanol-induced toxicity by tanshinone IIA in PC12 cells","volume":"27","author":"Meng","year":"2006","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.biopha.2019.108676_bib0500","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.neuint.2012.04.019","article-title":"The protective effects of tanshinone IIA on neurotoxicity induced by beta-amyloid protein through calpain and the p35\/Cdk5 pathway in primary cortical neurons","volume":"61","author":"Shi","year":"2012","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.biopha.2019.108676_bib0505","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.brainresbull.2012.03.007","article-title":"The protective effects of tanshinone IIA on beta-amyloid protein (1-42)-induced cytotoxicity via activation of the Bcl-xL pathway in neuron","volume":"88","author":"Qian","year":"2012","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.biopha.2019.108676_bib0510","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jep.2010.11.069","article-title":"Tanshinone IIA attenuates neuronal damage and the impairment of long-term potentiation induced by hydrogen peroxide","volume":"134","author":"Wang","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2019.108676_bib0515","doi-asserted-by":"crossref","first-page":"15427","DOI":"10.1038\/s41598-017-14692-3","article-title":"Network pharmacology exploration reveals endothelial inflammation as a common mechanism for stroke and coronary artery disease treatment of Danhong injection","volume":"7","author":"Lyu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2019.108676_bib0520","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1111\/j.1476-5381.2009.00377.x","article-title":"Tanshinone IIA protects against sudden cardiac death induced by lethal arrhythmias via repression of microRNA-1","volume":"158","author":"Shan","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.biopha.2019.108676_bib0525","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20180626","article-title":"Tanshinone IIA promotes the apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis by up-regulating lncRNA GAS5","volume":"38","author":"Li","year":"2018","journal-title":"Biosci. Rep."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218384245?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218384245?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T11:08:14Z","timestamp":1776078494000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218384245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":105,"alternative-id":["S0753332218384245"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.108676","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preventive and therapeutic role of Tanshinone \u2161A in hepatology","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.108676","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"108676"}}