{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:15:12Z","timestamp":1791501312242,"version":"4.3.4"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,2,9]],"date-time":"2019-02-09T00:00:00Z","timestamp":1549670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.biopha.2019.108678","type":"journal-article","created":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T19:37:16Z","timestamp":1550605036000},"page":"108678","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"special_numbering":"C","title":["Allium tuberosum alleviates diabetic nephropathy by supressing hyperglycemia-induced oxidative stress and in\ufb02ammation in high fat diet\/streptozotocin treated rats"],"prefix":"10.1016","volume":"112","author":[{"given":"Ziyuan","family":"Ni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Opeyemi Joshua","family":"Olatunji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2019.108678_bib0005","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1152\/physrev.00045.2011","article-title":"Mechanisms of diabetic complications","volume":"93","author":"Forbes","year":"2013","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.biopha.2019.108678_bib0010","doi-asserted-by":"crossref","first-page":"9141","DOI":"10.1039\/C6RA26970B","article-title":"Advantages of the polysaccharides from Gracilaria lemaneiformis over metformin in antidiabetic effects on streptozotocin-induced diabetic mice","volume":"7","author":"Wen","year":"2017","journal-title":"RSC Adv."},{"key":"10.1016\/j.biopha.2019.108678_bib0015","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2337\/diaclin.26.2.77","article-title":"Microvascular and macrovascular complications of diabetes","volume":"26","author":"Michael","year":"2008","journal-title":"Clin. Diabetes"},{"key":"10.1016\/j.biopha.2019.108678_bib0020","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.2337\/dci15-0012","article-title":"Update on prevention of cardiovascular disease in adults with type 2 diabetes mellitus in light of recent evidence: a scientific statement from the American Heart Association and the American Diabetes Association","volume":"38","author":"Fox","year":"2015","journal-title":"Diabetes Care"},{"key":"10.1016\/j.biopha.2019.108678_bib0025","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1016\/S0140-6736(17)30058-2","article-title":"Type 2 diabetes","volume":"389","author":"Chatterjee","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.biopha.2019.108678_bib0030","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1053\/jarr.2001.21711","article-title":"Diabetic nephropathy and end-stage renal failure: the Norwegian story","volume":"8","author":"Bergrem","year":"2001","journal-title":"Adv. Ren. Replace. Ther."},{"key":"10.1016\/j.biopha.2019.108678_bib0035","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1056\/NEJMoa0706245","article-title":"E\ufb00 ;ect of a multifactorial intervention on mortality in type 2 diabetes","volume":"358","author":"Gaede","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biopha.2019.108678_bib0040","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.bbadis.2013.01.023","article-title":"3,5-Diiodo-L-thyronine ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats","volume":"1832","author":"Shang","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.biopha.2019.108678_bib0045","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1900\/RDS.2015.12.87","article-title":"Diabetic kidney disease: a syndrome rather than a single disease","volume":"12","author":"Piccoli","year":"2015","journal-title":"Rev. Diabet. Stud."},{"key":"10.1016\/j.biopha.2019.108678_bib0050","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.biopha.2017.10.084","article-title":"6-Shogaol ameliorates diabetic nephropathy through anti-inflammatory, hyperlipidemic, anti-oxidative activity in db\/db mice","volume":"97","author":"Xu","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2019.108678_bib0055","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1210\/er.2003-0019","article-title":"Oxidative stress in the pathogenesis of diabetic neuropathy","volume":"25","author":"Vincent","year":"2004","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.biopha.2019.108678_bib0060","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.cbi.2018.02.001","article-title":"Crocin mediated amelioration of oxidative burden and inflammatory cascade suppresses diabetic nephropathy progression in diabetic rats","volume":"284","author":"Abou-Hany","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.biopha.2019.108678_bib0065","doi-asserted-by":"crossref","first-page":"8301","DOI":"10.1073\/pnas.122228799","article-title":"3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase\/p21 signaling pathway: implications for diabetic nephropathy","volume":"99","author":"Danesh","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biopha.2019.108678_bib0070","doi-asserted-by":"crossref","first-page":"F807","DOI":"10.1152\/ajprenal.00266.2015","article-title":"Twenty years after ACEIs and ARBs: emerging treatment strategies for diabetic nephropathy","volume":"309","author":"Johnson","year":"2015","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.biopha.2019.108678_bib0075","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1097\/01.ASN.0000146423.71226.0C","article-title":"Continuum of renoprotection with losartan at all stages of type 2 diabetic nephropathy: a post hoc analysis of the RENAAL trial results","volume":"15","author":"Remuzzi","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.biopha.2019.108678_bib0080","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.foodchem.2016.05.144","article-title":"A new kinetic model of ultrasound\u2010assisted extraction of polysaccharides from Chinese chive","volume":"212","author":"Zhang","year":"2016","journal-title":"Food Chem."},{"key":"10.1016\/j.biopha.2019.108678_bib0085","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1021\/jf000263c","article-title":"Antimicrobial effect of extracts from Chinese chive, cinnamon, and corni fructus","volume":"49","author":"Mau","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.biopha.2019.108678_bib0090","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.jep.2009.01.018","article-title":"Aphrodisiac properties of Allium tuberosum seeds extract","volume":"122","author":"Hu","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2019.108678_bib0095","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.fct.2017.02.011","article-title":"Isolation and identification of new chemical constituents from Chinese chive (Allium tuberosum) and toxicological evaluation of raw and cooked Chinese chive","volume":"112","author":"Gao","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2019.108678_bib0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.steroids.2015.03.015","article-title":"Spirostanol steroids from the roots of Allium tuberosum","volume":"100","author":"Fang","year":"2015","journal-title":"Steriods."},{"key":"10.1016\/j.biopha.2019.108678_bib0105","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.ijbiomac.2017.08.101","article-title":"Renoprotective effect of Chinese chive polysaccharides in adenine-induced chronic renal failure","volume":"106","author":"Li","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.biopha.2019.108678_bib0110","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.jff.2017.11.037","article-title":"Underlying action mechanism of a novel antioxidant peptide derived from Allium tuberosum Rottler protein hydrolysates and its protective effects on hydrogen peroxide induced cell injury","volume":"40","author":"Chen","year":"2018","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.biopha.2019.108678_bib0115","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1186\/s12906-017-2008-5","article-title":"In vitro and in vivo aphrodisiac properties of the seed extract from Allium tuberosum on corpus cavernosum smooth muscle relaxation and sexual behavior parameters in male Wistar rats","volume":"17","author":"Tang","year":"2017","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.biopha.2019.108678_bib0120","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.foodres.2017.08.034","article-title":"Allium tuberosum: antidiabetic and hepatoprotective activities","volume":"102","author":"Tang","year":"2017","journal-title":"Food Res. Int."},{"key":"10.1016\/j.biopha.2019.108678_bib0125","doi-asserted-by":"crossref","first-page":"228","DOI":"10.15430\/JCP.2017.22.4.228","article-title":"Protective Effect of Allium tuberosum extract on vascular inflammation in tumor necrosis factor-\u03b1-induced human vascular endothelial cells","volume":"22","author":"Hur","year":"2017","journal-title":"J. Cancer Prev."},{"key":"10.1016\/j.biopha.2019.108678_bib0130","article-title":"Isolation and identification of nucleosides\/nucleotides raising testosterone and NO levels of mice serum from Chinese chive (Allium tuberosum) leaves","author":"Gu","year":"2018","journal-title":"Andrologia"},{"key":"10.1016\/j.biopha.2019.108678_bib0135","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.niox.2017.01.003","article-title":"Nitrite increases glucose-stimulated insulin secretion and islet insulin content in obese type 2 diabetic male rats","volume":"64","author":"Gheibi","year":"2017","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.biopha.2019.108678_bib0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/molecules23010105","article-title":"Phytotherapy in the management of diabetes: a review","volume":"23","author":"Governa","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2019.108678_bib0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/697010","article-title":"Diabetic kidney disease: pathophysiology and therapeutic targets","volume":"2015","author":"Toth-manikowski","year":"2015","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.biopha.2019.108678_bib0150","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s12906-018-2221-x","article-title":"Antioxidant and antiapoptotic effect of aqueous extract of Pueraria tuberosa (Roxb. Ex Willd.) DC. On streptozotocin-induced diabetic nephropathy in rats","volume":"18","author":"Shukla","year":"2018","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.biopha.2019.108678_bib0155","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.2337\/db08-0057","article-title":"Oxidative stress as a major culprit in kidney disease in diabetes","volume":"57","author":"Forbes","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.biopha.2019.108678_bib0160","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.jep.2017.01.035","article-title":"Renoprotective and antioxidative e\ufb00 ;ects of methanolic Paederia foetida leaf extract on experimental diabetic nephropathy in rats","volume":"198","author":"Borgohain","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2019.108678_bib0165","first-page":"6701","article-title":"Functional foods for health: the interrelated antioxidant and anti-Inflammatory role of fruits, vegetables, herbs, spices and cocoa in humans","volume":"22","author":"Mauro","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.biopha.2019.108678_bib0170","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.phrs.2005.05.004","article-title":"Combination of high fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening","volume":"52","author":"Srinivasan","year":"2005","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.biopha.2019.108678_bib0175","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.biopha.2017.03.010","article-title":"Animal models for assessing the impact of natural products on the aetiology and metabolic pathophysiology of Type 2 diabetes","volume":"89","author":"Asrafuzzaman","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2019.108678_bib0180","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/jdi.12235","article-title":"Modeling type 2 diabetes in rats using high fat diet and streptozotocin","volume":"5","author":"Skovso","year":"2014","journal-title":"J. Diabetes Investig."},{"key":"10.1016\/j.biopha.2019.108678_bib0185","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.2337\/diabetes.54.6.1615","article-title":"The pathobiology of diabetic complications \u2013 a unifying mechanism","volume":"54","author":"Brownlee","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.biopha.2019.108678_bib0190","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nrneph.2011.51","article-title":"Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy","volume":"7","author":"Navarro-Gonzalez","year":"2011","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.biopha.2019.108678_bib0195","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0168-8227(99)00044-3","article-title":"Pathogenesis of diabetic nephropathy: the role of oxidative stress and protein kinase C","volume":"45","author":"Ha","year":"1999","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.biopha.2019.108678_bib0200","doi-asserted-by":"crossref","first-page":"F49","DOI":"10.1152\/ajprenal.00032.2009","article-title":"Interplay between Akt and p38 MAPK pathways in the regulation of renal tubular cell apoptosis associated with diabetic nephropathy","volume":"298","author":"Rane","year":"2010","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.biopha.2019.108678_bib0205","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.procbio.2009.12.004","article-title":"Protective role of Punica granatum L. Peel extract against oxidative damage in experimental diabetic rats","volume":"45","author":"Althunibat","year":"2010","journal-title":"Process Biochem."},{"key":"10.1016\/j.biopha.2019.108678_bib0210","doi-asserted-by":"crossref","first-page":"4256","DOI":"10.2174\/092986710793348581","article-title":"Oxidative stress in diabetic nephropathy","volume":"17","author":"Kashihara","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.biopha.2019.108678_bib0215","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1046\/j.1523-1755.2001.00487.x","article-title":"Effect of lipid reduction on the progression of renal disease: a meta-analysis","volume":"59","author":"Fried","year":"2001","journal-title":"Kidney Int."},{"key":"10.1016\/j.biopha.2019.108678_bib0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2015.11.033","article-title":"Protective effect of thymol on high fat diet induced diabetic nephropathy in C57BL\/6J mice","volume":"245","author":"Saravanan","year":"2016","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.biopha.2019.108678_bib0225","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S2211-9477(12)70003-1","article-title":"Dyslipidemia in diabetic kidney disease","volume":"1","author":"Prakash","year":"2012","journal-title":"Clin. Queries Nephrol."},{"key":"10.1016\/j.biopha.2019.108678_bib0230","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s41100-016-0028-0","article-title":"Dyslipidemia in diabetic nephropathy","volume":"2","author":"Kawanami","year":"2016","journal-title":"Ren. Replacement Ther."},{"key":"10.1016\/j.biopha.2019.108678_bib0235","doi-asserted-by":"crossref","first-page":"164","DOI":"10.2337\/diacare.28.1.164","article-title":"Diabetic nephropathy: diagnosis, prevention, and treatment","volume":"28","author":"Gross","year":"2005","journal-title":"Diabetes Care"},{"key":"10.1016\/j.biopha.2019.108678_bib0240","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1097\/01.ASN.0000065640.77499.D7","article-title":"Extracellular matrixmetabolism indiabetic nephropathy","volume":"14","author":"Mason","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.biopha.2019.108678_bib0245","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.cytogfr.2006.09.011","article-title":"The role of TNF-\u03b1 in diabetic nephropathy: pathogenic and therapeutic implications","volume":"17","author":"Navarro","year":"2006","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.biopha.2019.108678_bib0250","first-page":"419","article-title":"Tumor necrosis factor induces glomerular damage in the rabbit","volume":"134","author":"Bertani","year":"1989","journal-title":"Am. J. Pathol."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218385123?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218385123?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T11:12:32Z","timestamp":1776078752000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218385123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":50,"alternative-id":["S0753332218385123"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.108678","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Allium tuberosum alleviates diabetic nephropathy by supressing hyperglycemia-induced oxidative stress and in\ufb02ammation in high fat diet\/streptozotocin treated rats","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.108678","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"108678"}}