{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T08:52:52Z","timestamp":1778748772313,"version":"3.51.4"},"update-to":[{"DOI":"10.1016\/j.biopha.2019.108689","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000}}],"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T00:00:00Z","timestamp":1550102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570723"],"award-info":[{"award-number":["81570723"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571696"],"award-info":[{"award-number":["81571696"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673423"],"award-info":[{"award-number":["81673423"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1704168"],"award-info":[{"award-number":["U1704168"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1704175"],"award-info":[{"award-number":["U1704175"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1804197U 81874312"],"award-info":[{"award-number":["U1804197U 81874312"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["162300410216"],"award-info":[{"award-number":["162300410216"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["17IRTSTHN022"],"award-info":[{"award-number":["17IRTSTHN022"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["182300410332"],"award-info":[{"award-number":["182300410332"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["18HASTIT047"],"award-info":[{"award-number":["18HASTIT047"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["19420051000"],"award-info":[{"award-number":["19420051000"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["2017GGJS108"],"award-info":[{"award-number":["2017GGJS108"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["2018GGJS102"],"award-info":[{"award-number":["2018GGJS102"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011841","name":"Xinxiang Medical University","doi-asserted-by":"publisher","award":["2016PN-KFKT-02"],"award-info":[{"award-number":["2016PN-KFKT-02"]}],"id":[{"id":"10.13039\/501100011841","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011841","name":"Xinxiang Medical University","doi-asserted-by":"publisher","award":["2017CXY-2-6"],"award-info":[{"award-number":["2017CXY-2-6"]}],"id":[{"id":"10.13039\/501100011841","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011841","name":"Xinxiang Medical University","doi-asserted-by":"publisher","award":["XYBSKYZZ201626"],"award-info":[{"award-number":["XYBSKYZZ201626"]}],"id":[{"id":"10.13039\/501100011841","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011841","name":"Xinxiang Medical University","doi-asserted-by":"publisher","award":["XYBSKYZZ505319"],"award-info":[{"award-number":["XYBSKYZZ505319"]}],"id":[{"id":"10.13039\/501100011841","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.biopha.2019.108689","type":"journal-article","created":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T18:14:32Z","timestamp":1550859272000},"page":"108689","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["RETRACTED: Experimental study of blood pressure and its impact on spontaneous hypertension in rats with Xin Mai Jia"],"prefix":"10.1016","volume":"112","author":[{"given":"Yun","family":"Jing","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jierong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingxiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaling","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2019.108689_bib0005","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1001\/jama.290.22.2945","article-title":"Creactive protein and therisk of developing hypertension","volume":"290","author":"Sesso","year":"2003","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.biopha.2019.108689_bib0010","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1086\/510918","article-title":"Multiple genes for essential-hypertension susceptibility on chromosome 1q","volume":"80","author":"Chang","year":"2007","journal-title":"Am. J. Hum. Genet."},{"issue":"3","key":"10.1016\/j.biopha.2019.108689_bib0015","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2174\/138920306777452330","article-title":"Development of inhibitors of the asperity protease rennin for the treatment of hypertension","volume":"7","author":"Scott","year":"2006","journal-title":"Curr. Protein Pept. Sci."},{"issue":"3","key":"10.1016\/j.biopha.2019.108689_bib0020","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1074\/jbc.271.3.1507","article-title":"Polar residues in the transmembrane domains of the type 1 angiotensin II receptor are required for binding and coupling. Reconstitution of the binding site by co-expression of two deficient mutants","volume":"271","author":"Monnot","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.biopha.2019.108689_bib0025","first-page":"6018","article-title":"Effect of Xin Mai Jia on atherosclerosis in rats","volume":"14","author":"Li","year":"2015","journal-title":"Genet. Med. Res."},{"key":"10.1016\/j.biopha.2019.108689_bib0030","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.3892\/etm.2015.2774","article-title":"Effects and mechanism of Xin Mai Jia in a rabbit model of atherosclerosis","volume":"10","author":"Zhao","year":"2015","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.biopha.2019.108689_bib0035","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3892\/etm.2014.1700","article-title":"Protective effect of Xin Mai Jia ultrafiltration extract on human umbilical vein endothelial cell injury induced by hydrogen peroxide and the effect on the NO\u2011cGMP signaling pathway","volume":"8","author":"Yin","year":"2014","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.biopha.2019.108689_bib0040","first-page":"1","article-title":"Traditional Chinese medicine xin-mai-jia recouples endothelial nitric oxide synthase to prevent atherosclerosis in vivo","volume":"3","author":"Yin","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2019.108689_bib0045","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jep.2010.09.013","article-title":"Antihypertensive effect of total flavone extracts from Puerariae Radix","volume":"133","author":"Cai","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2019.108689_bib0050","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1248\/bpb.30.1278","article-title":"The effects of chronic treatment with Morus bombycis KOIDZUMI in spontaneously hypertensive rats","volume":"30","author":"Oh","year":"2007","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.biopha.2019.108689_bib0055","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1161\/CIRCULATIONAHA.116.017949","article-title":"Inhibition of aberrant MicroRNA-133a expression in endothelial cells by statin prevents endothelial dysfunction by targeting GTP cyclohydrolase 1 in vivo","volume":"134","author":"Li","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2019.108689_bib0060","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1111\/jcmm.12645","article-title":"Berberine via suppression of transient receptor potential vanilloid 4 channel improves vascular stiffness in mice","volume":"19","author":"Wang","year":"2015","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.biopha.2019.108689_bib0065","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.lfs.2015.06.010","article-title":"Salvianolic acid A inhibits endothelial dysfunction and vascular remodeling in spontaneously hypertensive rats","volume":"144","author":"Teng","year":"2016","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.biopha.2019.108689_bib0070","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1476-5381.2009.00525.x","article-title":"NS309 restores EDHF-type relaxation in mesenteric small arteries from type 2 diabetic ZDF rats","volume":"159","author":"Brondum","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.biopha.2019.108689_bib0075","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3892\/etm.2013.1365","article-title":"Protective effect of the ultra-filtration extract from Xin Mai Jia on human aortic smooth muscle cell injury induced by hydrogen peroxide","volume":"7","author":"WAN","year":"2014","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.biopha.2019.108689_bib0080","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1161\/ATVBAHA.114.304363","article-title":"Plasma membrane calcium ATPase isoform 4 inhibits vascular endothelial growth factor-mediated angiogenesis through interaction with calcineurin","volume":"34","author":"Baggott","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"2","key":"10.1016\/j.biopha.2019.108689_bib0085","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1111\/jcmm.13360","article-title":"Irisin inhibits high glucose-induced endothelial-to-mesenchymal transition and exerts a dose-dependent bidirectional effect on diabetic cardiomyopathy","volume":"22","author":"Liu","year":"2018","journal-title":"J. Cell. Mol. Med."},{"issue":"5","key":"10.1016\/j.biopha.2019.108689_bib0090","first-page":"357","article-title":"Clinical significance of the assessment of endothelial function","volume":"5","author":"Taddei","year":"2004","journal-title":"Ital. Heart J. Suppl."},{"issue":"8","key":"10.1016\/j.biopha.2019.108689_bib0095","first-page":"853","article-title":"Calcitonin gene-related peptide and hypertension","volume":"20","author":"Deng","year":"2004","journal-title":"China Pharmacol. Bull."},{"issue":"6","key":"10.1016\/j.biopha.2019.108689_bib0100","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s11739-010-0405-6","article-title":"Anti-hypertensive drugs and left ventricular hypertrophy: a clinical update","volume":"5","author":"Milan","year":"2010","journal-title":"Intern. Emerg. Med."},{"issue":"2","key":"10.1016\/j.biopha.2019.108689_bib0105","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/jhh.2014.40","article-title":"The associations of adipokines with selected markers of the renin -angiotensinogen -aldosterone system: the multi-ethnic study of atherosclerosis","volume":"29","author":"Allison","year":"2015","journal-title":"J. Hum. Hypertens."},{"key":"10.1016\/j.biopha.2019.108689_bib0110","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1161\/01.HYP.0000100443.09293.4F","article-title":"Reactive oxygen species in the vasculature\uff1amolecular and cellular mechanisms","volume":"42","author":"Taniyama","year":"2003","journal-title":"Hypertension"},{"issue":"12","key":"10.1016\/j.biopha.2019.108689_bib0115","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1038\/hr.2010.187","article-title":"Mechanical stretch potentiates angiotensinII-induced proliferation in spontaneously hypertensive rat vascularsmooth muscle cells","volume":"33","author":"Liu","year":"2010","journal-title":"Hypertens. Res."},{"issue":"8","key":"10.1016\/j.biopha.2019.108689_bib0120","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.jash.2014.04.008","article-title":"Accumulation of microvascular target organ damage in newly diagnosed hypertensive patients","volume":"8","author":"Triantafyllou","year":"2014","journal-title":"J. Am. Soc. Hypertens."},{"key":"10.1016\/j.biopha.2019.108689_bib0125","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1080\/10641963.2017.1313853","article-title":"Berberine promotes ischemia-induced angiogenesis in mice heart via upregulation of microRNA-29b","volume":"39","author":"Zhu","year":"2017","journal-title":"Clin. Exp. Hypertens."},{"issue":"6","key":"10.1016\/j.biopha.2019.108689_bib0130","first-page":"787","article-title":"Treatment of resistant hypertension","volume":"57","author":"Czarina Acelajado","year":"2009","journal-title":"Minerva ardioangiol."},{"issue":"4","key":"10.1016\/j.biopha.2019.108689_bib0135","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.sjbs.2015.06.016","article-title":"Factors regulating the renal circulation in spontaneously hypertensive rats","volume":"23","author":"Ahmeda","year":"2016","journal-title":"Saudi J. Biol. Sci."},{"issue":"4","key":"10.1016\/j.biopha.2019.108689_bib0140","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/S0008-6363(01)00345-5","article-title":"Differential regulation of thrombospondin-1 and fibronectin by angiotensin II receptor subtypes in cultured endothelial cells","volume":"51","author":"Fischer","year":"2001","journal-title":"Cardiovasc. Res."},{"issue":"6 Pt2","key":"10.1016\/j.biopha.2019.108689_bib0145","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1161\/01.HYP.13.6.968","article-title":"Remodeling of cerebral arterioles in chronic hypertension","volume":"13","author":"Baumbach Heistad","year":"1989","journal-title":"Hypertension"},{"issue":"2","key":"10.1016\/j.biopha.2019.108689_bib0150","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.artres.2013.01.003","article-title":"The reality of aging viewed from the arterial wall","volume":"7","author":"Lakatta","year":"2013","journal-title":"Artery Res."},{"key":"10.1016\/j.biopha.2019.108689_bib0155","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1161\/HYPERTENSIONAHA.111.187021","article-title":"Vascular remodeling in hypertension: mechanisms and treatment","volume":"59","author":"Schiffrin","year":"2012","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.biopha.2019.108689_bib0160","first-page":"261","article-title":"Exploring ischemia-induced vascular lesions and potential pharmacological intervention strategies","volume":"20","author":"Aliev","year":"2005","journal-title":"Histol. Histopathol."},{"issue":"5","key":"10.1016\/j.biopha.2019.108689_bib0165","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1097\/00004872-200105000-00013","article-title":"Small artery remodeling is the most prevalent (earliest?) form of target organ damage in mild essential hypertension","volume":"19","author":"Park","year":"2001","journal-title":"J. Hypertens."},{"key":"10.1016\/j.biopha.2019.108689_bib0170","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0008-6363(02)00328-0","article-title":"Extracellular superoxide dismutase and cardiovascular disease","volume":"55","author":"Fukai","year":"2002","journal-title":"Cardiovasc. Res."}],"updated-by":[{"DOI":"10.1016\/j.biopha.2019.108689","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000}},{"DOI":"10.1016\/j.biopha.2026.118992","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000}},{"DOI":"10.1016\/j.biopha.2026.118992","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000}}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218383720?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218383720?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T11:09:39Z","timestamp":1776078579000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218383720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":34,"alternative-id":["S0753332218383720"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.108689","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RETRACTED: Experimental study of blood pressure and its impact on spontaneous hypertension in rats with Xin Mai Jia","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.108689","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"108689"}}