{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T11:55:16Z","timestamp":1776081316732,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T00:00:00Z","timestamp":1550620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81602379"],"award-info":[{"award-number":["81602379"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2016A030313196"],"award-info":[{"award-number":["2016A030313196"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["[2013]163"],"award-info":[{"award-number":["[2013]163"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.biopha.2019.108719","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T18:23:21Z","timestamp":1551291801000},"page":"108719","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"special_numbering":"C","title":["LncRNA ADAMTS9-AS2 promotes tongue squamous cell carcinoma proliferation, migration and EMT via the miR-600\/EZH2 axis"],"prefix":"10.1016","volume":"112","author":[{"given":"Yingru","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianxi","family":"Mai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liujuan","family":"Sha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mubarak","family":"Mashrah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoyu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaobin","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.biopha.2019.108719_bib0005","first-page":"87","article-title":"Global cancer statistics, 2012","volume":"65","author":"Torre","year":"2015","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.biopha.2019.108719_bib0010","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.biopha.2017.09.149","article-title":"Targeting of cell cycle and let-7a\/STAT3 pathway by niclosamide inhibits proliferation, migration and invasion in oral squamous cell carcinoma cells","volume":"96","author":"Li","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2019.108719_bib0015","doi-asserted-by":"crossref","first-page":"126","DOI":"10.2174\/1874210601206010126","article-title":"Current aspects on oral squamous cell carcinoma","volume":"6","author":"Markopoulos","year":"2012","journal-title":"Open Dent. J."},{"key":"10.1016\/j.biopha.2019.108719_bib0020","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.biopha.2018.05.025","article-title":"MiR-92a regulates oral squamous cell carcinoma (TSCC) cell growth by targeting FOXP1 expression","volume":"104","author":"Guo","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"6","key":"10.1016\/j.biopha.2019.108719_bib0025","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.oraloncology.2010.02.015","article-title":"Living with oral cancer: epidemiology with particular reference to prevalence and life-style changes that influence survival","volume":"46","author":"Warnakulasuriya","year":"2010","journal-title":"Oral Oncol."},{"issue":"6","key":"10.1016\/j.biopha.2019.108719_bib0030","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1016\/j.ymthe.2018.04.002","article-title":"Chemotherapy-induced long non-coding RNA 1 promotes metastasis and chemo-resistance of TSCC via the Wnt\/beta-Catenin signaling pathway","volume":"26","author":"Lin","year":"2018","journal-title":"Mol. Ther."},{"issue":"12","key":"10.1016\/j.biopha.2019.108719_bib0035","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1016\/j.ymthe.2018.08.018","article-title":"Upregulation of lncRNA ADAMTS9-AS2 promotes salivary adenoid cystic carcinoma metastasis via PI3K\/Akt and MEK\/Erk signaling","volume":"26","author":"Xie","year":"2018","journal-title":"Mol. Ther."},{"issue":"4","key":"10.1016\/j.biopha.2019.108719_bib0040","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.ccell.2016.03.010","article-title":"Long noncoding RNAs in cancer pathways","volume":"29","author":"Schmitt","year":"2016","journal-title":"Cancer Cell"},{"issue":"2","key":"10.1016\/j.biopha.2019.108719_bib0045","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1172\/JCI96218","article-title":"Long noncoding RNA BLACAT2 promotes bladder cancer-associated lymphangiogenesis and lymphatic metastasis","volume":"128","author":"He","year":"2018","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.biopha.2019.108719_bib0050","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.ccr.2014.03.010","article-title":"A long noncoding RNA activated by TGF-beta promotes the invasion-metastasis cascade in hepatocellular carcinoma","volume":"25","author":"Yuan","year":"2014","journal-title":"Cancer Cell"},{"issue":"7","key":"10.1016\/j.biopha.2019.108719_bib0055","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/s41419-018-0793-5","article-title":"LncRNA KCNQ1OT1 regulates proliferation and cisplatin resistance in tongue cancer via miR-211-5p mediated Ezrin\/Fak\/Src signaling","volume":"9","author":"Zhang","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.biopha.2019.108719_bib0060","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.omtn.2018.09.023","article-title":"Targeting long noncoding RNA in glioma: a pathway perspective","volume":"13","author":"Li","year":"2018","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.biopha.2019.108719_bib0065","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.biopha.2018.06.081","article-title":"Long non-coding RNA HOTTIP is upregulated in renal cell carcinoma and regulates cell growth and apoptosis by epigenetically silencing of LATS2","volume":"105","author":"Peng","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2019.108719_bib0070","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.biopha.2018.02.099","article-title":"Long non-coding RNA as potential biomarkers in non-small-cell lung cancer: what do we know so far?","volume":"101","author":"Osielska","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"8","key":"10.1016\/j.biopha.2019.108719_bib0075","doi-asserted-by":"crossref","first-page":"7935","DOI":"10.1007\/s13277-014-1949-2","article-title":"A new tumor suppressor LncRNA ADAMTS9-AS2 is regulated by DNMT1 and inhibits migration of glioma cells","volume":"35","author":"Yao","year":"2014","journal-title":"Tumour Biol."},{"key":"10.1016\/j.biopha.2019.108719_bib0080","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.biopha.2018.06.146","article-title":"Down-regulation of lncRNA ADAMTS9-AS2 contributes to gastric cancer development via activation of PI3K\/Akt pathway","volume":"107","author":"Cao","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2019.108719_bib0085","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1002\/iub.1752","article-title":"Upregulated lncRNA ADAMTS9-AS2 suppresses progression of lung cancer through inhibition of miR-223-3p and promotion of TGFBR3","volume":"70","author":"Liu","year":"2018","journal-title":"IUBMB Life"},{"key":"10.1016\/j.biopha.2019.108719_bib0090","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/j.ijbiomac.2018.09.179","article-title":"LncRNA ADAMTS9-AS2 regulates ovarian cancer progression by targeting miR-182-5p\/FOXF2 signaling pathway","volume":"120","author":"Wang","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.biopha.2019.108719_bib0095","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1158\/1078-0432.CCR-18-1656","article-title":"Long noncoding RNA LBCS inhibits self-renewal and chemoresistance of bladder cancer stem cells through epigenetic silencing of SOX2","volume":"25(4","author":"Chen","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.biopha.2019.108719_bib0100","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/s41388-018-0432-8","article-title":"Long noncoding RNA PVT1-214 promotes proliferation and invasion of colorectal cancer by stabilizing Lin28 and interacting with miR-128","volume":"38 (2","author":"He","year":"2019","journal-title":"Oncogene"},{"issue":"7483","key":"10.1016\/j.biopha.2019.108719_bib0105","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nature12986","article-title":"The multilayered complexity of ceRNA crosstalk and competition","volume":"505","author":"Tay","year":"2014","journal-title":"Nature"},{"issue":"19","key":"10.1016\/j.biopha.2019.108719_bib0110","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1016\/j.jmb.2012.11.024","article-title":"Posttranscriptional gene regulation by long noncoding RNA","volume":"425","author":"Yoon","year":"2013","journal-title":"J. Mol. Biol."},{"issue":"37","key":"10.1016\/j.biopha.2019.108719_bib0115","doi-asserted-by":"crossref","first-page":"10322","DOI":"10.1073\/pnas.1600008113","article-title":"SHAPE reveals transcript-wide interactions, complex structural domains, and protein interactions across the Xist lncRNA in living cells","volume":"113","author":"Smola","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"10.1016\/j.biopha.2019.108719_bib0120","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1016\/j.celrep.2017.02.016","article-title":"miR-600 acts as a bimodal switch that regulates breast Cancer stem cell fate through WNT signaling","volume":"18","author":"El","year":"2017","journal-title":"Cell Rep."},{"issue":"3","key":"10.1016\/j.biopha.2019.108719_bib0125","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.3892\/ol.2017.5654","article-title":"miR-600 inhibits cell proliferation, migration and invasion by targeting p53 in mutant p53-expressing human colorectal cancer cell lines","volume":"13","author":"Zhang","year":"2017","journal-title":"Oncol. Lett."},{"issue":"1","key":"10.1016\/j.biopha.2019.108719_bib0130","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s13046-018-0771-x","article-title":"LncRNA TUG1 promoted KIAA1199 expression via miR-600 to accelerate cell metastasis and epithelial-mesenchymal transition in colorectal cancer","volume":"37","author":"Sun","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.biopha.2019.108719_bib0135","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.biopha.2018.03.085","article-title":"Hsa_circ_0071589 promotes carcinogenesis via the miR-600\/EZH2 axis in colorectal cancer","volume":"102","author":"Yong","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.biopha.2019.108719_bib0140","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/nm.4036","article-title":"Targeting EZH2 in cancer","volume":"22","author":"Kim","year":"2016","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.biopha.2019.108719_bib0145","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/CCO.0000000000000390","article-title":"Targeting EZH2 in cancer therapy","volume":"29","author":"Yamagishi","year":"2017","journal-title":"Curr. Opin. Oncol."},{"issue":"4","key":"10.1016\/j.biopha.2019.108719_bib0150","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3727\/096504016X14749735594687","article-title":"High-level expression of RIPK4 and EZH2 contributes to lymphnode metastasis and predicts favorable prognosis in patients with cervical cancer","volume":"25","author":"Azizmohammadi","year":"2017","journal-title":"Oncol. Res."},{"issue":"9","key":"10.1016\/j.biopha.2019.108719_bib0155","doi-asserted-by":"crossref","first-page":"6508","DOI":"10.1002\/jcp.26545","article-title":"The role of enhancer of zeste homolog 2: from viral epigenetics to the carcinogenesis of hepatocellular carcinoma","volume":"233","author":"Sanna","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"2","key":"10.1016\/j.biopha.2019.108719_bib0160","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.gene.2014.01.006","article-title":"Role of EZH2 in oral squamous cell carcinoma carcinogenesis","volume":"537","author":"Zhao","year":"2014","journal-title":"Gene"},{"issue":"47","key":"10.1016\/j.biopha.2019.108719_bib0165","doi-asserted-by":"crossref","first-page":"6542","DOI":"10.1038\/onc.2017.262","article-title":"EZH2-mediated upregulation of ROS1 oncogene promotes oral cancer metastasis","volume":"36","author":"Shih","year":"2017","journal-title":"Oncogene"},{"issue":"11","key":"10.1016\/j.biopha.2019.108719_bib0170","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1158\/1940-6207.CAPR-11-0130","article-title":"EZH2 promotes malignant phenotypes and is a predictor of oral cancer development in patients with oral leukoplakia","volume":"4","author":"Cao","year":"2011","journal-title":"Cancer Prev. Res. (Phila)"},{"issue":"2","key":"10.1016\/j.biopha.2019.108719_bib0175","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/ijc.27859","article-title":"Non-coding RNAs and EZH2 interactions in cancer: long and short tales from the transcriptome","volume":"133","author":"Benetatos","year":"2013","journal-title":"Int. J. Cancer"},{"issue":"3","key":"10.1016\/j.biopha.2019.108719_bib0180","doi-asserted-by":"crossref","first-page":"209","DOI":"10.4143\/crt.2014.46.3.209","article-title":"Regulation and role of EZH2 in cancer","volume":"46","author":"Yamaguchi","year":"2014","journal-title":"Cancer Res. Treat."},{"issue":"1","key":"10.1016\/j.biopha.2019.108719_bib0185","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.molcel.2009.08.008","article-title":"Mir-214-dependent regulation of the polycomb protein Ezh2 in skeletal muscle and embryonic stem cells","volume":"36","author":"Juan","year":"2009","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.biopha.2019.108719_bib0190","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13045-018-0606-4","article-title":"MALAT1: a druggable long non-coding RNA for targeted anticancer approaches","volume":"11","author":"Amodio","year":"2018","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.biopha.2019.108719_bib0195","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.biopha.2018.05.089","article-title":"Long noncoding RNA TP73-AS1 promotes non-small cell lung cancer progression by competitively sponging miR-449a\/EZH2","volume":"104","author":"Zhang","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.biopha.2019.108719_bib0200","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/cdd.2016.95","article-title":"The degradation of EZH2 mediated by lncRNA ANCR attenuated the invasion and metastasis of breast cancer","volume":"24","author":"Li","year":"2017","journal-title":"Cell Death Differ."},{"issue":"16","key":"10.1016\/j.biopha.2019.108719_bib0205","doi-asserted-by":"crossref","first-page":"5365","DOI":"10.1158\/0008-5472.CAN-10-4379","article-title":"Long noncoding RNA, polycomb, and the ghosts haunting INK4b-ARF-INK4a expression","volume":"71","author":"Aguilo","year":"2011","journal-title":"Cancer Res."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218388425?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218388425?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T11:03:06Z","timestamp":1776078186000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218388425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":41,"alternative-id":["S0753332218388425"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.108719","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LncRNA ADAMTS9-AS2 promotes tongue squamous cell carcinoma proliferation, migration and EMT via the miR-600\/EZH2 axis","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.108719","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"108719"}}