{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T11:54:10Z","timestamp":1776081250534,"version":"3.50.1"},"update-to":[{"DOI":"10.1016\/j.biopha.2019.108729","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000}}],"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T00:00:00Z","timestamp":1550793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.biopha.2019.108729","type":"journal-article","created":{"date-parts":[[2019,3,2]],"date-time":"2019-03-02T00:49:08Z","timestamp":1551487748000},"page":"108729","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["RETRACTED: Arbutin attenuates hydrogen peroxide-induced oxidative injury through regulation of microRNA-29a in retinal ganglion cells"],"prefix":"10.1016","volume":"112","author":[{"given":"Wenbo","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingyu","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenzhan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"751","key":"10.1016\/j.biopha.2019.108729_bib0005","first-page":"e1","article-title":"Poor prognosis and challenging treatment of optic nerve malignant gliomas: literature review and case report series","volume":"97","author":"Alireza","year":"2017","journal-title":"World Neurosurg."},{"key":"10.1016\/j.biopha.2019.108729_bib0010","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s11427-016-5022-9","article-title":"Pressure balance and imbalance in the optic nerve chamber: the Beijing Intracranial and Intraocular Pressure (iCOP) Study","volume":"59","author":"Hou","year":"2016","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.biopha.2019.108729_bib0015","article-title":"Optic nerve injury-associated blunt cerebrovascular injury: three case reports","volume":"96","author":"Li","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.biopha.2019.108729_bib0020","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.neuroscience.2016.03.041","article-title":"Protective effect of magnesium acetyltaurate against endothelin-induced retinal and optic nerve injury","volume":"325","author":"Arfuzir","year":"2016","journal-title":"Neuroscience."},{"key":"10.1016\/j.biopha.2019.108729_bib0025","first-page":"253","article-title":"Absence of galectin-3 promotes neuroprotection in retinal ganglion cells after optic nerve injury","volume":"32","author":"Abreu","year":"2017","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.biopha.2019.108729_bib0030","doi-asserted-by":"crossref","first-page":"e569","DOI":"10.1097\/IJG.0000000000000395","article-title":"The optic nerve head in primary open-angle Glaucoma eyes with high myopia: characteristics and association with visual field defects","volume":"25","author":"Chen","year":"2016","journal-title":"J. Glaucoma"},{"key":"10.1016\/j.biopha.2019.108729_bib0035","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.drudis.2010.02.007","article-title":"Strategies for optic nerve rescue and regeneration in glaucoma and other optic neuropathies","volume":"15","author":"Dahlmann-Noor","year":"2010","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.biopha.2019.108729_bib0040","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.expneurol.2012.03.021","article-title":"The mechanism of axonal degeneration after perikaryal excitotoxic injury to the retina","volume":"236","author":"Bull","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.biopha.2019.108729_bib0045","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.archoralbio.2015.05.007","article-title":"The impact of antioxidant agents complimentary to periodontal therapy on oxidative stress and periodontal outcomes: a systematic review","volume":"60","author":"Muniz","year":"2015","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.biopha.2019.108729_bib0050","doi-asserted-by":"crossref","first-page":"198","DOI":"10.5114\/ceji.2014.43723","article-title":"Immune mechanisms and the role of oxidative stress in intrahepatic cholestasis of pregnancy","volume":"39","author":"Ozler","year":"2014","journal-title":"Cent.-Eur. J. Immunol."},{"key":"10.1016\/j.biopha.2019.108729_bib0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0193250","article-title":"Proteomic analysis of the human retina reveals region-specific susceptibilities to metabolic- and oxidative stress-related diseases","volume":"13","author":"Velez","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2019.108729_bib0060","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2174\/1389557516666151120114605","article-title":"The role oxidative stress in the pathogenesis of eye diseases: current status and a dual role of physical activity","volume":"16","author":"Kruk","year":"2015","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.biopha.2019.108729_bib0065","doi-asserted-by":"crossref","DOI":"10.1038\/srep25792","article-title":"Association between systemic oxidative stress and visual field damage in open-angle glaucoma","volume":"6","author":"Tanito","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2019.108729_bib0070","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3736\/jintegrmed2013037","article-title":"Research advances on the usage of traditional Chinese medicine for neuroprotection in glaucoma","volume":"11","author":"Mi","year":"2013","journal-title":"J. Integr. Med."},{"key":"10.1016\/j.biopha.2019.108729_bib0075","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/cod.12594","article-title":"Contact dermatitis caused by arbutin contained in skin-whitening cosmetics","volume":"75","author":"Numata","year":"2016","journal-title":"Contact Derm."},{"key":"10.1016\/j.biopha.2019.108729_bib0080","first-page":"9","article-title":"Preparation and characterization of cosmeceutical liposomes loaded with avobenzone and arbutin","volume":"64","author":"Liu","year":"2013","journal-title":"J. Cosmet. Sci."},{"key":"10.1016\/j.biopha.2019.108729_bib0085","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1471-2490-14-53","article-title":"Chronic bacterial prostatitis: efficacy of short-lasting antibiotic therapy with prulifloxacin (Unidrox(R)) in association with saw palmetto extract, lactobacillus sporogens and arbutin (Lactorepens(R))","volume":"14","author":"Busetto","year":"2014","journal-title":"BMC Urol."},{"key":"10.1016\/j.biopha.2019.108729_bib0090","doi-asserted-by":"crossref","DOI":"10.17795\/jjnpp.33392","article-title":"Hepatoprotective effects of arbutin against liver damage induced by carbon tetrachloride in rats","volume":"11","author":"Mirshahvalad","year":"2016","journal-title":"Jundishapur J. Nat. Pharm. Prod."},{"key":"10.1016\/j.biopha.2019.108729_bib0095","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1084\/jem.20090831","article-title":"microRNA-29a induces aberrant self-renewal capacity in hematopoietic progenitors, biased myeloid development, and acute myeloid leukemia","volume":"207","author":"Han","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.biopha.2019.108729_bib0100","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.3892\/ijo.2013.2145","article-title":"Tumor-suppressive microRNA-29a inhibits cancer cell migration and invasion via targeting HSP47 in cervical squamous cell carcinoma","volume":"43","author":"Yamamoto","year":"2013","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.biopha.2019.108729_bib0105","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.bbrc.2018.06.048","article-title":"Zhou XZ. microRNA-29a inhibition induces Gab1 upregulation to protect OB-6 human osteoblasts from hydrogen peroxide","volume":"503","author":"Ruan","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2019.108729_bib0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0189980","article-title":"Effects of GABACR and mGluR1 antagonists on contrast response functions of Sprague-Dawley and P23H rat retinal ganglion cells","volume":"12","author":"Jensen","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2019.108729_bib0115","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.optom.2017.06.002","article-title":"Reactive oxygen species, oxidative stress, glaucoma and hyperbaric oxygen therapy","volume":"11","author":"McMonnies","year":"2018","journal-title":"J. Optom."},{"key":"10.1016\/j.biopha.2019.108729_bib0120","first-page":"678","article-title":"Implication of glutathione S-transferase M1 and T1 polymorphisms in the development of senile cataract among Egyptians","volume":"110","author":"Abdel Azeem","year":"2009","journal-title":"Bratisl. Lek. Listy"},{"key":"10.1016\/j.biopha.2019.108729_bib0125","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1046\/j.1365-2362.1997.780629.x","article-title":"Oxidative protein damage in human diabetic eye: evidence of a retinal participation","volume":"27","author":"Altomare","year":"1997","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.biopha.2019.108729_bib0130","first-page":"1467","article-title":"Resveratrol protects human lens epithelial cells against H2O2-induced oxidative stress by increasing catalase, SOD-1, and HO-1 expression","volume":"16","author":"Zheng","year":"2010","journal-title":"Mol. Vis."},{"key":"10.1016\/j.biopha.2019.108729_bib0135","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s12886-018-0766-6","article-title":"Identification of H2O2 induced oxidative stress associated microRNAs in HLE-B3 cells and their clinical relevance to the progression of age-related nuclear cataract","volume":"18","author":"Wang","year":"2018","journal-title":"BMC Ophthalmol."},{"key":"10.1016\/j.biopha.2019.108729_bib0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.peptides.2017.04.008","article-title":"Liraglutide alleviates H2O2-induced retinal ganglion cells injury by inhibiting autophagy through mitochondrial pathways","volume":"92","author":"Ma","year":"2017","journal-title":"Peptides"},{"key":"10.1016\/j.biopha.2019.108729_bib0145","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s12031-015-0522-9","article-title":"Inhibition of miR-134 protects against hydrogen peroxide-induced apoptosis in retinal ganglion cells","volume":"56","author":"Shao","year":"2015","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.biopha.2019.108729_bib0150","first-page":"2100","article-title":"Flavonoids from the stems and leaves of Scutellaria baicalensis Georgi attenuate H2O2-induced oxidative damage to rat cortical neurons","volume":"06","author":"Liu","year":"2011","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.biopha.2019.108729_bib0155","first-page":"2191","article-title":"Formononetin attenuates hydrogen peroxide (H2O2)-induced apoptosis and NF-kappaB activation in RGC-5 cells","volume":"18","author":"Jia","year":"2014","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.biopha.2019.108729_bib0160","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3892\/ijmm.2015.2418","article-title":"Crocin protects retinal ganglion cells against H2O2-induced damage through the mitochondrial pathway and activation of NF-kappaB","volume":"37","author":"Lv","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.biopha.2019.108729_bib0165","first-page":"1091","article-title":"Protective effect of senegenin on retinal ganglion cells in oxidative stress induced injury","volume":"28","author":"Bie","year":"2012","journal-title":"Chin. J. Pathophysiol."},{"key":"10.1016\/j.biopha.2019.108729_bib0170","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1600-0749.1998.tb00705.x","article-title":"Arbutin increases the pigmentation of cultured human melanocytes through mechanisms other than the induction of tyrosinase activity","volume":"11","author":"Nakajima","year":"1998","journal-title":"Pigment Cell Res."},{"key":"10.1016\/j.biopha.2019.108729_bib0175","first-page":"142","article-title":"The study of arbutin against the damage caused by H_2O_2 in ECV-304 cells","volume":"39","author":"Dong","year":"2005","journal-title":"J. Harbin Med. Univ."},{"key":"10.1016\/j.biopha.2019.108729_bib0180","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1523\/JNEUROSCI.1910-13.2014","article-title":"BDNF promotes axon branching of retinal ganglion cells via miRNA-132 and p250GAP","volume":"34","author":"Marler","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.biopha.2019.108729_bib0185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0010021","article-title":"Perturbations of microRNA function in mouse dicer mutants produce retinal defects and lead to aberrant axon pathfinding at the optic chiasm","volume":"5","author":"Pinter","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2019.108729_bib0190","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12867-014-0025-1","article-title":"Downregulation of microRNA-100 protects apoptosis and promotes neuronal growth in retinal ganglion cells","volume":"15","author":"Kong","year":"2014","journal-title":"BMC Mol. Biol."},{"key":"10.1016\/j.biopha.2019.108729_bib0195","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/embor.2009.9","article-title":"miR-29a suppresses tristetraprolin, which is a regulator of epithelial polarity and metastasis","volume":"10","author":"Gebeshuber","year":"2009","journal-title":"EMBO Rep."},{"key":"10.1016\/j.biopha.2019.108729_bib0200","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.fct.2013.04.055","article-title":"Lucidone protects human skin keratinocytes against free radical-induced oxidative damage and inflammation through the up-regulation of HO-1\/Nrf2 antioxidant genes and down-regulation of NF-\u03baB signaling pathway","volume":"59","author":"Kumar","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2019.108729_bib0205","first-page":"229","article-title":"Synchronous activation of ERK 1\/2, p38mapk and PKB\/Akt signaling by H2O2 in vascular smooth muscle cells: potential involvement in vascular disease (review)","volume":"11","author":"Blanc","year":"2003","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.biopha.2019.108729_bib0210","article-title":"Orexin-A protects SH-SY5Y cells against H(2)O(2)-induced oxidative damage via the PI3K\/MEK(1\/2)\/ERK(1\/2) signaling pathway","volume":"32","author":"Wang","year":"2018","journal-title":"Int. J. Immunopath. Ph."},{"key":"10.1016\/j.biopha.2019.108729_bib0215","doi-asserted-by":"crossref","first-page":"4348","DOI":"10.3390\/ijms11114348","article-title":"Myricetin protects cells against oxidative stress-induced apoptosis via regulation of PI3K\/Akt and MAPK signaling pathways","volume":"11","author":"Kang","year":"2010","journal-title":"Int. J. Mol. Sci."}],"updated-by":[{"DOI":"10.1016\/j.biopha.2021.112508","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:00:00Z","timestamp":1638921600000},"record-id":"34762"},{"DOI":"10.1016\/j.biopha.2019.108729","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000}},{"DOI":"10.1016\/j.biopha.2021.112508","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000}}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218378454?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218378454?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T11:00:37Z","timestamp":1776078037000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218378454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":43,"alternative-id":["S0753332218378454"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.108729","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RETRACTED: Arbutin attenuates hydrogen peroxide-induced oxidative injury through regulation of microRNA-29a in retinal ganglion cells","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.108729","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"108729"}}