{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T17:45:42Z","timestamp":1783446342746,"version":"3.55.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,2,24]],"date-time":"2019-02-24T00:00:00Z","timestamp":1550966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002836","name":"Chang Gung University","doi-asserted-by":"publisher","award":["CMRPG8G0381"],"award-info":[{"award-number":["CMRPG8G0381"]}],"id":[{"id":"10.13039\/501100002836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.biopha.2019.108737","type":"journal-article","created":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T14:00:30Z","timestamp":1551967230000},"page":"108737","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Short-interval exposure to ambient fine particulate matter (PM2.5) exacerbates the susceptibility of pulmonary damage in setting of lung ischemia-reperfusion injury in rodent: Pharmacomodulation of melatonin"],"prefix":"10.1016","volume":"113","author":[{"given":"Fan-Yen","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mel S.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher Glenn","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Ruei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Hsiang","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Hong","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhih-Hong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Sheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia C.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hon-Kan","family":"Yip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2019.108737_bib0005","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1161\/CIRCULATIONAHA.106.636977","article-title":"Ischemic heart disease events triggered by short-term exposure to fine particulate air pollution","volume":"114","author":"Pope","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2019.108737_bib0010","first-page":"629","article-title":"Relationship between ambient fine particles and ventricular repolarization changes and heart rate variability of elderly people with heart disease in Beijing, China","volume":"26","author":"Xu","year":"2013","journal-title":"Biomed. Environ. Sci."},{"key":"10.1016\/j.biopha.2019.108737_bib0015","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1001\/jama.295.10.1127","article-title":"Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases","volume":"295","author":"Dominici","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.biopha.2019.108737_bib0020","article-title":"Acute effects of particulate air pollution on the incidence of coronary heart disease in Shanghai, China","volume":"11","author":"Ye","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2019.108737_bib0025","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1093\/aje\/kwr046","article-title":"Short-term association between ambient air pollution and risk of hospitalization for acute myocardial infarction: results of the cardiovascular risk and air pollution in Tuscany (RISCAT) study","volume":"174","author":"Nuvolone","year":"2011","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.biopha.2019.108737_bib0030","doi-asserted-by":"crossref","first-page":"4826","DOI":"10.1016\/j.scitotenv.2009.05.022","article-title":"The association between fine particulate air pollution and hospital emergency room visits for cardiovascular diseases in Beijing, China","volume":"407","author":"Guo","year":"2009","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.biopha.2019.108737_bib0035","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.ijheh.2015.05.002","article-title":"Associations between short-term exposure to particulate matter and ultrafine particles and myocardial infarction in Augsburg, Germany","volume":"218","author":"Wolf","year":"2015","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"10.1016\/j.biopha.2019.108737_bib0040","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.envres.2012.08.005","article-title":"Estimates of global mortality attributable to particulate air pollution using satellite imagery","volume":"120","author":"Evans","year":"2013","journal-title":"Environ. Res."},{"key":"10.1016\/j.biopha.2019.108737_bib0045","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1289\/ehp.11173","article-title":"Children are likely to suffer most from our fossil fuel addiction","volume":"116","author":"Perera","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.biopha.2019.108737_bib0050","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1161\/CIRCRESAHA.110.237560","article-title":"Chronic fine particulate matter exposure induces systemic vascular dysfunction via NADPH oxidase and TLR4 pathways","volume":"108","author":"Kampfrath","year":"2011","journal-title":"Circ. Res."},{"key":"10.1016\/j.biopha.2019.108737_bib0055","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/1471-2458-11-115","article-title":"The relationship of air pollution and surrogate markers of endothelial dysfunction in a population-based sample of children","volume":"11","author":"Poursafa","year":"2011","journal-title":"BMC Public Health"},{"key":"10.1016\/j.biopha.2019.108737_bib0060","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/jpi.12264","article-title":"Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis","volume":"59","author":"Fernandez","year":"2015","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.biopha.2019.108737_bib0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-079X.2011.00916.x","article-title":"Melatonin as a natural ally against oxidative stress: a physicochemical examination","volume":"51","author":"Galano","year":"2011","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.biopha.2019.108737_bib0070","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/jpi.12010","article-title":"On the free radical scavenging activities of melatonin\u2019s metabolites, AFMK and AMK","volume":"54","author":"Galano","year":"2013","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.biopha.2019.108737_bib0075","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/jpi.12162","article-title":"Melatonin: a well-documented antioxidant with conditional pro-oxidant actions","volume":"57","author":"Zhang","year":"2014","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.biopha.2019.108737_bib0080","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1600-079X.2011.00858.x","article-title":"Melatonin protects liver against ischemia and reperfusion injury through inhibition of toll-like receptor signaling pathway","volume":"50","author":"Kang","year":"2011","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.biopha.2019.108737_bib0085","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/jpi.12199","article-title":"Systemic combined melatonin-mitochondria treatment improves acute respiratory distress syndrome in the rat","volume":"58","author":"Sun","year":"2015","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.biopha.2019.108737_bib0090","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/jpi.12128","article-title":"Protective effects of melatonin in reducing oxidative stress and in preserving the fluidity of biological membranes: a review","volume":"56","author":"Garcia","year":"2014","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.biopha.2019.108737_bib0095","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/jpi.12140","article-title":"Additional benefit of combined therapy with melatonin and apoptotic adipose-derived mesenchymal stem cell against sepsis-induced kidney injury","volume":"57","author":"Chen","year":"2014","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.biopha.2019.108737_bib0100","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1177\/1535370216642528","article-title":"Enhanced protection against renal ischemia-reperfusion injury with combined melatonin and exendin-4 in a rodent model","volume":"241","author":"Chang","year":"2016","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.biopha.2019.108737_bib0105","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/jpi.12326","article-title":"Melatonin pretreatment enhances the therapeutic effects of exogenous mitochondria against hepatic ischemia-reperfusion injury in rats through suppression of mitochondrial permeability transition","volume":"61","author":"Chen","year":"2016","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.biopha.2019.108737_bib0110","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/jpi.12357","article-title":"The cardioprotective effect of melatonin and exendin-4 treatment in a rat model of cardiorenal syndrome","volume":"61","author":"Chua","year":"2016","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.biopha.2019.108737_bib0115","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12372","article-title":"Melatonin enhances survival and preserves functional integrity of stem cells: a review","volume":"62","author":"Lee","year":"2017","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.biopha.2019.108737_bib0120","first-page":"898","article-title":"Oxidative damage in the liver induced by ischemia-reperfusion: protection by melatonin","volume":"43","author":"Sewerynek","year":"1996","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.biopha.2019.108737_bib0125","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/jpi.12273","article-title":"Combined melatonin and exendin-4 therapy preserves renal ultrastructural integrity after ischemia-reperfusion injury in the male rat","volume":"59","author":"Yip","year":"2015","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.biopha.2019.108737_bib0130","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.bbadis.2017.11.023","article-title":"Melatonin protects diabetic heart against ischemia-reperfusion injury, role of membrane receptor-dependent cGMP-PKG activation","volume":"1864","author":"Yu","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.biopha.2019.108737_bib0135","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.yfrne.2018.06.004","article-title":"Exogenous melatonin as a treatment for secondary sleep disorders: a systematic review and meta-analysis","volume":"52","author":"Li","year":"2019","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.biopha.2019.108737_bib0140","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12431","article-title":"Melatonin protects against maternal obesity-associated oxidative stress and meiotic defects in oocytes via the SIRT3-SOD2-dependent pathway","volume":"63","author":"Han","year":"2017","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.biopha.2019.108737_bib0145","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12405","article-title":"Melatonin regulates PARP1 to control the senescence-associated secretory phenotype (SASP) in human fetal lung fibroblast cells","volume":"63","author":"Yu","year":"2017","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.biopha.2019.108737_bib0150","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12489","article-title":"Daily melatonin protects the endothelial lineage and functional integrity against the aging process, oxidative stress, and toxic environment and restores blood flow in critical limb ischemia area in mice","volume":"65","author":"Lee","year":"2018","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.biopha.2019.108737_bib0155","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/1479-5876-9-118","article-title":"Autologous transplantation of adipose-derived mesenchymal stem cells markedly reduced acute ischemia-reperfusion lung injury in a rodent model","volume":"9","author":"Sun","year":"2011","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.biopha.2019.108737_bib0160","first-page":"3","article-title":"Pulmonary effects of inhaled diesel exhaust in young and old mice: a pilot project","author":"Laskin","year":"2010","journal-title":"Res. Rep. Health Eff. Inst."},{"key":"10.1016\/j.biopha.2019.108737_bib0165","doi-asserted-by":"crossref","first-page":"20167","DOI":"10.1007\/s11356-015-5222-z","article-title":"Effects of ambient PM2.5 on pathological injury, inflammation, oxidative stress, metabolic enzyme activity, and expression of c-fos and c-jun in lungs of rats","volume":"22","author":"Li","year":"2015","journal-title":"Environ. Sci. Pollut. Res. Int."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219302410?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219302410?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T07:33:34Z","timestamp":1774596814000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332219302410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":33,"alternative-id":["S0753332219302410"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.108737","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Short-interval exposure to ambient fine particulate matter (PM2.5) exacerbates the susceptibility of pulmonary damage in setting of lung ischemia-reperfusion injury in rodent: Pharmacomodulation of melatonin","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.108737","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"108737"}}