{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:34:08Z","timestamp":1792100048448,"version":"4.4.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,2,25]],"date-time":"2019-02-25T00:00:00Z","timestamp":1551052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473697"],"award-info":[{"award-number":["81473697"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573996"],"award-info":[{"award-number":["81573996"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81574002"],"award-info":[{"award-number":["81574002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873327"],"award-info":[{"award-number":["81873327"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2017A030313698"],"award-info":[{"award-number":["2017A030313698"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.biopha.2019.108746","type":"journal-article","created":{"date-parts":[[2019,3,2]],"date-time":"2019-03-02T11:48:00Z","timestamp":1551527280000},"page":"108746","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":177,"special_numbering":"C","title":["Polydatin promotes the osteogenic differentiation of human bone mesenchymal stem cells by activating the BMP2-Wnt\/\u03b2-catenin signaling pathway"],"prefix":"10.1016","volume":"112","author":[{"given":"Xiao-Jun","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Shan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Cong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Xiang","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-ming","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu-Shi","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.biopha.2019.108746_bib0005","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s11420-016-9505-9","article-title":"Treatment of pre-collapse stages of osteonecrosis of the femoral head: a systematic review of randomized control trials","volume":"12","author":"Villa","year":"2016","journal-title":"HSS J."},{"key":"10.1016\/j.biopha.2019.108746_bib0010","first-page":"1","article-title":"Early diagnosis and treatment of steroid-induced osteonecrosis of the femoral head","author":"Fu","year":"2018","journal-title":"Int. Orthop."},{"issue":"17","key":"10.1016\/j.biopha.2019.108746_bib0015","first-page":"2637","article-title":"Research progress of epidemiology about nontraumatic osteonecrosis of the femoral head","volume":"15","author":"Liu","year":"2009","journal-title":"Med. Recap."},{"issue":"447","key":"10.1016\/j.biopha.2019.108746_bib0020","article-title":"Clinical analysis of osteonecrosis of femoral head","volume":"16","author":"Liu","year":"2007","journal-title":"Chin. J. Conva. Med."},{"issue":"21","key":"10.1016\/j.biopha.2019.108746_bib0025","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.4103\/0366-6999.168017","article-title":"Prevalence of nontraumatic osteonecrosis of the femoral head and its associated risk factors in the Chinese population: results from a nationally representative survey","volume":"128","author":"Zhao","year":"2015","journal-title":"Chin. Med. J."},{"issue":"3","key":"10.1016\/j.biopha.2019.108746_bib0030","doi-asserted-by":"crossref","first-page":"459","DOI":"10.2106\/00004623-199503000-00018","article-title":"Current concepts review. Non-traumatic avascular necrosis of the femoral head","volume":"77","author":"Mont","year":"1995","journal-title":"JBJS"},{"issue":"4","key":"10.1016\/j.biopha.2019.108746_bib0035","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/jor.20078","article-title":"Alterations in the differentiation ability of mesenchymal stem cells in patients with nontraumatic osteonecrosis of the femoral head: comparative analysis according to the risk factor","volume":"24","author":"Lee","year":"2006","journal-title":"J. Orthop. Res."},{"issue":"1","key":"10.1016\/j.biopha.2019.108746_bib0040","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1517\/14712598.2016.1093108","article-title":"Therapeutic application of mesenchymal stem cells in osteoarthritis","volume":"16","author":"Ruiz","year":"2015","journal-title":"Expert Opin. Biol. Ther."},{"issue":"21","key":"10.1016\/j.biopha.2019.108746_bib0045","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1089\/scd.2014.0203","article-title":"A systematic review of the safety and efficacy of mesenchymal stem cells for disc degeneration: insights and future directions for regenerative therapeutics","volume":"23","author":"Yim","year":"2014","journal-title":"Stem Cells Dev."},{"issue":"21","key":"10.1016\/j.biopha.2019.108746_bib0050","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1089\/scd.2014.0203","article-title":"A systematic review of the safety and efficacy of mesenchymal stem cells for disc degeneration: insights and future directions for regenerative therapeutics","volume":"23","author":"Yim","year":"2014","journal-title":"Stem Cells Dev."},{"issue":"1","key":"10.1016\/j.biopha.2019.108746_bib0055","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s10238-012-0218-1","article-title":"Therapeutic application of mesenchymal stem cells in bone and joint diseases","volume":"14","author":"Liu","year":"2014","journal-title":"Clin. Exp. Med."},{"issue":"4","key":"10.1016\/j.biopha.2019.108746_bib0060","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/jor.20078","article-title":"Alterations in the differentiation ability of mesenchymal stem cells in patients with nontraumatic osteonecrosis of the femoral head: comparative analysis according to the risk factor","volume":"24","author":"Lee","year":"2010","journal-title":"J. Orthop. Res."},{"issue":"11","key":"10.1016\/j.biopha.2019.108746_bib0065","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.3899\/jrheum.130191","article-title":"Aberrant CpG islands\u2019 hypermethylation of ABCB1 in mesenchymal stem cells of patients with steroid-associated osteonecrosis","volume":"40","author":"Sun","year":"2013","journal-title":"J. Rheumatol."},{"issue":"4","key":"10.1016\/j.biopha.2019.108746_bib0070","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.arth.2015.08.017","article-title":"Decreased osteogenic activity of mesenchymal stem cells in patients with corticosteroid-induced osteonecrosis of the femoral head","volume":"31","author":"Houdek","year":"2016","journal-title":"J. Arthroplasty"},{"issue":"3","key":"10.1016\/j.biopha.2019.108746_bib0075","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1089\/154732804323099208","article-title":"The role of BMP-6, IL-6, and BMP-4 in mesenchymal stem cell-dependent bone development: effects on osteoblastic differentiation induced by parathyroid hormone and vitamin D(3)","volume":"13","author":"Sammons","year":"2004","journal-title":"Stem Cells Dev."},{"issue":"6","key":"10.1016\/j.biopha.2019.108746_bib0080","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.yexcr.2010.12.015","article-title":"Wnt signalling mediates the cross-talk between bone marrow derived pre-adipocytic and pre-osteoblastic cell populations","volume":"317","author":"Taipaleenm\u00e4ki","year":"2011","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.biopha.2019.108746_bib0085","series-title":"Focus Issue: Wnt and \u03b2-catenin Signaling in Development and Disease","author":"Gough","year":"2012"},{"issue":"23","key":"10.1016\/j.biopha.2019.108746_bib0090","doi-asserted-by":"crossref","first-page":"4352","DOI":"10.1242\/dev.136879","article-title":"Specification of osteoblast cell fate by canonical Wnt signaling requires Bmp2","volume":"143","author":"Salazar","year":"2016","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.biopha.2019.108746_bib0095","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S0006-291X(02)02951-0","article-title":"Activated beta-catenin induces osteoblast differentiation of C3H10T1\/2 cells and participates in BMP2 mediated signal transduction","volume":"301","author":"Bain","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.biopha.2019.108746_bib0100","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.cell.2007.09.027","article-title":"Integrating patterning signals: Wnt\/GSK3 regulates the duration of the BMP\/Smad1 signal","volume":"131","author":"Ikeda","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2019.108746_bib0105","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.biocel.2016.09.025","article-title":"Bone morphogenetic protein 2 promotes osteogenesis of bone marrow stromal cells in type 2 diabetic rats via the Wnt signaling pathway","volume":"80","author":"Qian","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.biopha.2019.108746_bib0110","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.phymed.2018.03.029","article-title":"The extract of Polygoni Cuspidati Rhizoma et Radix suppresses the vascular endothelial growth factor-induced angiogenesis","volume":"42","author":"Hu","year":"2018","journal-title":"Phytomedicine"},{"key":"10.1016\/j.biopha.2019.108746_bib0115","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.fct.2012.10.037","article-title":"Polydatin ameliorates renal injury by attenuating oxidative stress-related inflammatory responses in fructose-induced urate nephropathic mice","volume":"52","author":"Chen","year":"2013","journal-title":"Food Chem. Toxicol."},{"issue":"5","key":"10.1016\/j.biopha.2019.108746_bib0120","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.phymed.2015.03.014","article-title":"Comparative studies of polydatin and resveratrol on mutual transformation and antioxidative effect in vivo","volume":"22","author":"Wang","year":"2015","journal-title":"Phytomedicine"},{"issue":"12","key":"10.1016\/j.biopha.2019.108746_bib0125","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.1002\/jcb.23303","article-title":"Reactive oxygen species\u2010mediated endoplasmic reticulum stress and mitochondrial dysfunction contribute to polydatin\u2010induced apoptosis in human nasopharyngeal carcinoma CNE cells","volume":"112","author":"Liu","year":"2011","journal-title":"J. Cell. Biochem."},{"issue":"2","key":"10.1016\/j.biopha.2019.108746_bib0130","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.3892\/mmr.2016.5432","article-title":"Polydatin possesses notable antiosteoporotic activity via regulation of OPG, RANKL and betacatenin","volume":"14","author":"Zhou","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.biopha.2019.108746_bib0135","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.biopha.2016.04.059","article-title":"Polydatin induces bone marrow stromal cells migration by activation of ERK1\/2","volume":"82","author":"Chen","year":"2016","journal-title":"Biomed. Pharmacother."},{"issue":"12","key":"10.1016\/j.biopha.2019.108746_bib0140","doi-asserted-by":"crossref","first-page":"10123","DOI":"10.3390\/molecules161210123","article-title":"The dose-effect of icariin on the proliferation and osteogenic differentiation of human bone mesenchymal stem cells","volume":"16","author":"Fan","year":"2011","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2019.108746_bib0145","doi-asserted-by":"crossref","first-page":"e1819","DOI":"10.1038\/cddis.2015.185","article-title":"2,4,5-Trimethoxyldalbergiquinol promotes osteoblastic differentiation and mineralization via the BMP and Wnt\/beta-catenin pathway","volume":"6","author":"Yun","year":"2015","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.biopha.2019.108746_bib0150","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.ultrasmedbio.2015.10.021","article-title":"Effects of focused extracorporeal shock waves on bone marrow mesenchymal stem cells in patients with avascular necrosis of the femoral head","volume":"42","author":"Zhai","year":"2016","journal-title":"Ultrasound Med. Biol."},{"issue":"9","key":"10.1016\/j.biopha.2019.108746_bib0155","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.jcyt.2016.06.005","article-title":"Effects of hypoxia on osteogenic differentiation of mesenchymal stromal cells used as a cell therapy for avascular necrosis of the femoral head","volume":"18","author":"Ciapetti","year":"2016","journal-title":"Cytotherapy"},{"issue":"7","key":"10.1016\/j.biopha.2019.108746_bib0160","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1007\/s00264-018-3994-8","article-title":"The role of autophagy in steroid necrosis of the femoral head: a comprehensive research review","volume":"42","author":"Luo","year":"2018","journal-title":"Int. Orthop."},{"issue":"431","key":"10.1016\/j.biopha.2019.108746_bib0165","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/01.blo.0000150568.16133.3c","article-title":"Decreased osteogenic differentiation of mesenchymal stem cells in alcohol-induced osteonecrosis","volume":"431","author":"Suh","year":"2005","journal-title":"Clin. Orthop. Relat. Res."},{"issue":"12","key":"10.1016\/j.biopha.2019.108746_bib0170","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1038\/cdd.2015.99","article-title":"miR-216a rescues dexamethasone suppression of osteogenesis, promotes osteoblast differentiation and enhances bone formation, by regulating c-Cbl-mediated PI3K\/AKT pathway","volume":"22","author":"Li","year":"2015","journal-title":"Cell Death Differ."},{"issue":"3","key":"10.1016\/j.biopha.2019.108746_bib0175","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00256-009-0800-0","article-title":"Treating osteonecrosis with autologous bone marrow cells","volume":"39","author":"Gangji","year":"2010","journal-title":"Skeletal Radiol."},{"issue":"405","key":"10.1016\/j.biopha.2019.108746_bib0180","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/00003086-200212000-00003","article-title":"Treatment of osteonecrosis with autologous bone marrow grafting","volume":"405","author":"Hernigou","year":"2002","journal-title":"Clin. Orthop. Relat. Res."},{"issue":"1","key":"10.1016\/j.biopha.2019.108746_bib0185","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.bone.2011.11.002","article-title":"Treatment of early stage osteonecrosis of the femoral head with autologous implantation of bone marrow-derived and cultured mesenchymal stem cells","volume":"50","author":"Zhao","year":"2012","journal-title":"Bone"},{"issue":"6","key":"10.1016\/j.biopha.2019.108746_bib0190","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1016\/j.bone.2007.04.050","article-title":"Treatment of osteonecrosis of the femoral head with implantation of autologous bone-marrow cells. A pilot study","volume":"40","author":"Gangji","year":"2007","journal-title":"Bone"},{"issue":"7","key":"10.1016\/j.biopha.2019.108746_bib0195","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.2106\/00004623-199707000-00012","article-title":"Steroid-induced adipogenesis in a pluripotential cell line from bone marrow","volume":"79","author":"Cui","year":"1997","journal-title":"JBJS"},{"issue":"36","key":"10.1016\/j.biopha.2019.108746_bib0200","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000012196","article-title":"Chinese herbal medicine formulas as adjuvant therapy for osteonecrosis of the femoral head: a systematic review and meta-analysis of randomized controlled trials","volume":"97","author":"Zhang","year":"2018","journal-title":"Medicine"},{"issue":"5","key":"10.1016\/j.biopha.2019.108746_bib0205","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1007\/s10753-018-0841-4","article-title":"Novel anti-arthritic mechanisms of polydatin in complete Freund\u2019s adjuvant-induced arthritis in rats: involvement of IL-6, STAT-3, IL-17, and NF-small ka, CyrillicB","volume":"41","author":"Kamel","year":"2018","journal-title":"Inflammation"},{"issue":"7","key":"10.1016\/j.biopha.2019.108746_bib0210","doi-asserted-by":"crossref","first-page":"824","DOI":"10.4103\/0366-6999.178952","article-title":"Effect of resveratrol on preventing steroid-induced osteonecrosis in a rabbit model","volume":"129","author":"Zhai","year":"2016","journal-title":"Chin. Med. J. (Engl.)"},{"issue":"1\u20133","key":"10.1016\/j.biopha.2019.108746_bib0215","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bpc.2008.03.005","article-title":"Antioxidant properties of resveratrol and piceid on lipid peroxidation in micelles and monolamellar liposomes","volume":"135","author":"Fabris","year":"2008","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.biopha.2019.108746_bib0220","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/9394150","article-title":"Polydatin protects bone marrow stem cells against oxidative injury: involvement of Nrf 2\/ARE pathways","volume":"2016","author":"Chen","year":"2016","journal-title":"Stem Cells Int."},{"issue":"9","key":"10.1016\/j.biopha.2019.108746_bib0225","doi-asserted-by":"crossref","first-page":"944","DOI":"10.7150\/ijms.24111","article-title":"Polydatin, natural precursor of resveratrol, promotes osteogenic differentiation of mesenchymal stem cells","volume":"15","author":"Di Benedetto","year":"2018","journal-title":"Int. J. Med. Sci."},{"issue":"3","key":"10.1016\/j.biopha.2019.108746_bib0230","first-page":"2946","article-title":"Bone morphogenetic protein is required for fibroblast growth factor 2-dependent later-stage osteoblastic differentiation in cranial suture cells","volume":"8","author":"Jiang","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"issue":"5","key":"10.1016\/j.biopha.2019.108746_bib0235","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/jor.20359","article-title":"Distinct roles of bone morphogenetic proteins in osteogenic differentiation of mesenchymal stem cells","volume":"25","author":"Luu","year":"2007","journal-title":"J. Orthop. Res."},{"issue":"12","key":"10.1016\/j.biopha.2019.108746_bib0240","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1161\/CIRCRESAHA.107.153346","article-title":"Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia","volume":"101","author":"Bosch-Marce","year":"2007","journal-title":"Circ. Res."},{"issue":"5","key":"10.1016\/j.biopha.2019.108746_bib0245","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.devcel.2005.02.017","article-title":"Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation","volume":"8","author":"Glass","year":"2005","journal-title":"Dev. Cell"},{"issue":"10","key":"10.1016\/j.biopha.2019.108746_bib0250","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1359\/jbmr.2003.18.10.1842","article-title":"BMP\u20102 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop","volume":"18","author":"Rawadi","year":"2003","journal-title":"J. Bone Miner. Res."},{"issue":"1","key":"10.1016\/j.biopha.2019.108746_bib0255","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.bone.2012.09.029","article-title":"Wnt\/beta-catenin signaling activates bone morphogenetic protein 2 expression in osteoblasts","volume":"52","author":"Zhang","year":"2013","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.biopha.2019.108746_bib0260","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1074\/jbc.M602700200","article-title":"\u03b2-catenin signaling pathway is crucial for bone morphogenetic protein 2 to induce new bone formation","volume":"282","author":"Chen","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.biopha.2019.108746_bib0265","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1002\/jcb.22319","article-title":"BMP\u20102 modulates \u03b2\u2010catenin signaling through stimulation of Lrp5 expression and inhibition of \u03b2\u2010TrCP expression in osteoblasts","volume":"108","author":"Zhang","year":"2009","journal-title":"J. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.biopha.2019.108746_bib0270","doi-asserted-by":"crossref","first-page":"8455","DOI":"10.1038\/s41598-017-08190-9","article-title":"Acceleration of osteoblast differentiation by a novel osteogenic compound, DMP-PYT, through activation of both the BMP and Wnt pathways","volume":"7","author":"Bae","year":"2017","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.biopha.2019.108746_bib0275","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00441-015-2300-y","article-title":"Wnt\/beta-catenin signaling in bone marrow niche","volume":"363","author":"Ahmadzadeh","year":"2016","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.biopha.2019.108746_bib0280","series-title":"Planar Cell Polarity","first-page":"201","article-title":"Analysis of Wnt\/planar cell polarity pathway in cultured cells","author":"Endo","year":"2012"}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219301659?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219301659?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T11:02:44Z","timestamp":1776078164000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332219301659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":56,"alternative-id":["S0753332219301659"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.108746","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polydatin promotes the osteogenic differentiation of human bone mesenchymal stem cells by activating the BMP2-Wnt\/\u03b2-catenin signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.108746","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"108746"}}