{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:47:07Z","timestamp":1786985227836,"version":"build-2736575974"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8150030603"],"award-info":[{"award-number":["8150030603"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701018"],"award-info":[{"award-number":["81701018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.biopha.2019.108803","type":"journal-article","created":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T12:21:01Z","timestamp":1554207661000},"page":"108803","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Effect of tumor necrosis factor \u03b1 on ability of SHED to promote osteoclastogenesis during physiological root resorption"],"prefix":"10.1016","volume":"114","author":[{"given":"Chen","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.biopha.2019.108803_bib0005","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/BF00303076","article-title":"Odontoclastic resorption of the superficial nonmineralized layer of predentine in the shedding of human deciduous teeth","volume":"277","author":"Sahara","year":"1994","journal-title":"Cell Tissue Res."},{"issue":"1","key":"10.1016\/j.biopha.2019.108803_bib0010","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.biopha.2017.05.083","article-title":"rhBMP 2-loaded calcium phosphate cements combined with allogenic bone marrow mesenchymal stem cells for bone formation","volume":"92","author":"Luo","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.biopha.2019.108803_bib0015","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1600-0722.2012.00950.x","article-title":"Root resorption of primary molars without successor teeth. An experimental study in the beagle dog","volume":"120","author":"Lin","year":"2012","journal-title":"Eur. J. Oral Sci."},{"issue":"1","key":"10.1016\/j.biopha.2019.108803_bib0020","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.tripleo.2007.06.026","article-title":"The role of dental pulp cells in resorption of deciduous teeth","volume":"105","author":"Yildirim","year":"2008","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"issue":"1","key":"10.1016\/j.biopha.2019.108803_bib0025","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0003-9969(03)00173-0","article-title":"Immunocompetent cells in the pulp of human deciduous teeth","volume":"49","author":"Angelova","year":"2004","journal-title":"Arch. Oral Biol."},{"issue":"3","key":"10.1016\/j.biopha.2019.108803_bib0030","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1679\/aohc.55.273","article-title":"Odontoclastic resorption at the pulpal surface of coronal dentin prior to the shedding of human deciduous teeth","volume":"55","author":"Sahara","year":"1992","journal-title":"Arch. Histol. Cytol."},{"issue":"2","key":"10.1016\/j.biopha.2019.108803_bib0035","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1034\/j.1600-0765.2001.10602.x","article-title":"Cell proliferation and cell death in periodontal ligaments during orthodontic tooth movement","volume":"37","author":"Mabuchi","year":"2002","journal-title":"J. Periodontal. Res."},{"issue":"10","key":"10.1016\/j.biopha.2019.108803_bib0040","doi-asserted-by":"crossref","first-page":"5807","DOI":"10.1073\/pnas.0937635100","article-title":"SHED: stem cells from human exfoliated deciduous teeth","volume":"100","author":"Miura","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.biopha.2019.108803_bib0045","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1177\/00220345630420021401","article-title":"Experimental investigation of factors causing resorption of deciduous teeth","volume":"42","author":"Obersztyn","year":"1963","journal-title":"J. Dent. Res."},{"issue":"1","key":"10.1016\/j.biopha.2019.108803_bib0050","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/jcp.24122","article-title":"Deciduous dental pulp stem cells are involved in osteoclastogenesis during physiologic root resorption","volume":"228","author":"Zhu","year":"2013","journal-title":"J. Cell. Physiol."},{"issue":"3","key":"10.1016\/j.biopha.2019.108803_bib0055","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/wsbm.1331","article-title":"Signaling via the NFkappaB system","volume":"8","author":"Mitchell","year":"2016","journal-title":"Wiley Interdiscip. Rev. Syst. Biol. Med."},{"issue":"24","key":"10.1016\/j.biopha.2019.108803_bib0060","doi-asserted-by":"crossref","first-page":"3482","DOI":"10.1101\/gad.11.24.3482","article-title":"Requirement for NF-kappaB in osteoclast and B-cell development","volume":"11","author":"Franzoso","year":"1997","journal-title":"Genes Dev."},{"issue":"1","key":"10.1016\/j.biopha.2019.108803_bib0065","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/cr.2010.159","article-title":"Role of NF-kappaB in the skeleton","volume":"21","author":"Novack","year":"2011","journal-title":"Cell Res."},{"issue":"10","key":"10.1016\/j.biopha.2019.108803_bib0070","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nri910","article-title":"NF-kappaB regulation in the immune system","volume":"2","author":"Li","year":"2002","journal-title":"Nat. Rev. Immunol."},{"issue":"49","key":"10.1016\/j.biopha.2019.108803_bib0075","doi-asserted-by":"crossref","first-page":"6910","DOI":"10.1038\/sj.onc.1203238","article-title":"Control of apoptosis by Rel\/NF-kappaB transcription factors","volume":"18","author":"Barkett","year":"1999","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.biopha.2019.108803_bib0080","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.2741\/2954","article-title":"Atherosclerosis as a disease of failed endogenous repair","volume":"13","author":"Zenovich","year":"2008","journal-title":"Front Biosci"},{"issue":"25","key":"10.1016\/j.biopha.2019.108803_bib0085","doi-asserted-by":"crossref","first-page":"13625","DOI":"10.1073\/pnas.240309797","article-title":"Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo","volume":"97","author":"Gronthos","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"3","key":"10.1016\/j.biopha.2019.108803_bib0090","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1177\/00220345010800030801","article-title":"Dual regulation of osteoclast differentiation by periodontal ligament cells through RANKL stimulation and OPG inhibition","volume":"80","author":"Kanzaki","year":"2001","journal-title":"J. Dent. Res."},{"issue":"7","key":"10.1016\/j.biopha.2019.108803_bib0095","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1177\/0022034509340008","article-title":"Dental pulp and periodontal ligament cells support osteoclastic differentiation","volume":"88","author":"Uchiyama","year":"2009","journal-title":"J. Dent. Res."},{"issue":"1","key":"10.1016\/j.biopha.2019.108803_bib0100","article-title":"Phenotypic and proteomic characteristics of human dental pulp derived mesenchymal stem cells from a natal, an exfoliated deciduous, and an impacted third molar tooth","volume":"2014","author":"Akpinar","year":"2014","journal-title":"Stem Cells Int."},{"issue":"2","key":"10.1016\/j.biopha.2019.108803_bib0105","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1046\/j.1365-2141.1999.01715.x","article-title":"Propagation and senescence of human marrow stromal cells in culture: a simple colony-forming assay identifies samples with the greatest potential to propagate and differentiate","volume":"107","author":"Digirolamo","year":"1999","journal-title":"Br. J. Haematol."},{"issue":"1","key":"10.1016\/j.biopha.2019.108803_bib0110","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3892\/mmr.2016.5214","article-title":"Isolation, characterization and multi-lineage differentiation of stem cells from human exfoliated deciduous teeth","volume":"14","author":"Zhang","year":"2016","journal-title":"Mol. Med. Rep."},{"issue":"1","key":"10.1016\/j.biopha.2019.108803_bib0115","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1172\/JCI116179","article-title":"Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors","volume":"91","author":"Tanaka","year":"1993","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.biopha.2019.108803_bib0120","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/978-1-61779-367-7_23","article-title":"Human osteoclast culture and phenotypic characterization","volume":"806","author":"Agrawal","year":"2012","journal-title":"Methods Mol. Biol."},{"issue":"5","key":"10.1016\/j.biopha.2019.108803_bib0125","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1084\/jem.178.5.1733","article-title":"Macrophage colony-stimulating factor stimulates survival and chemotactic behavior in isolated osteoclasts","volume":"178","author":"Fuller","year":"1993","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.biopha.2019.108803_bib0130","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/978-1-59745-104-8_2","article-title":"Osteoclast culture and resorption assays","volume":"455","author":"Bradley","year":"2008","journal-title":"Methods Mol. Biol."},{"issue":"11","key":"10.1016\/j.biopha.2019.108803_bib0135","doi-asserted-by":"crossref","first-page":"5119","DOI":"10.1016\/j.bbagen.2013.07.027","article-title":"GSK3beta is a checkpoint for TNF-alpha-mediated impaired osteogenic differentiation of mesenchymal stem cells in inflammatory microenvironments","volume":"1830","author":"Kong","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"4","key":"10.1016\/j.biopha.2019.108803_bib0140","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1177\/0022034509334070","article-title":"TNF-alpha promotes an odontoblastic phenotype in dental pulp cells","volume":"88","author":"Paula-Silva","year":"2009","journal-title":"J. Dent. Res."},{"issue":"13","key":"10.1016\/j.biopha.2019.108803_bib0145","doi-asserted-by":"crossref","first-page":"9792","DOI":"10.1074\/jbc.M109.082305","article-title":"Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome","volume":"285","author":"Juliana","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.biopha.2019.108803_bib0150","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.leukres.2005.05.004","article-title":"Inhibition of NF-kappaB activity by BAY 11-7082 increases apoptosis in multidrug resistant leukemic T-cell lines","volume":"29","author":"Garcia","year":"2005","journal-title":"Leuk. Res."},{"issue":"1","key":"10.1016\/j.biopha.2019.108803_bib0155","first-page":"102","article-title":"A study of root resorption of deciduous teeth in dogs. Influence of successional tooth germ and occlusal force","volume":"29","author":"Ishikura","year":"1991","journal-title":"Shoni Shikagaku Zasshi"},{"issue":"7","key":"10.1016\/j.biopha.2019.108803_bib0160","article-title":"Carvedilol decrease IL-1beta and TNF-alpha, inhibits MMP-2, MMP-9, COX-2, and RANKL expression, and up-regulates OPG in a rat model of periodontitis","volume":"8","author":"de Araujo","year":"2013","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.biopha.2019.108803_bib0165","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nri2171","article-title":"Evolving functions of endothelial cells in inflammation","volume":"7","author":"Pober","year":"2007","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.biopha.2019.108803_bib0170","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1172\/JCI200523394","article-title":"IL-1 mediates TNF-induced osteoclastogenesis","volume":"115","author":"Wei","year":"2005","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.biopha.2019.108803_bib0175","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.abb.2008.03.018","article-title":"Functions of RANKL\/RANK\/OPG in bone modeling and remodeling","volume":"473","author":"Boyce","year":"2008","journal-title":"Arch Bicochem Biophys"},{"issue":"6","key":"10.1016\/j.biopha.2019.108803_bib0180","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.it.2004.03.008","article-title":"The two NF-kappaB activation pathways and their role in innate and adaptive immunity","volume":"25","author":"Bonizzi","year":"2004","journal-title":"Trends Immunol."},{"issue":"1-2","key":"10.1016\/j.biopha.2019.108803_bib0185","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jneuroim.2004.04.013","article-title":"CpG oligodeoxynucleotides induce expression of proinflammatory cytokines and chemokines in astrocytes: the role of c-Jun N-terminal kinase in CpG ODN-mediated NF-kappaB activation","volume":"153","author":"Lee","year":"2004","journal-title":"J. Neuroimmunol."},{"issue":"2","key":"10.1016\/j.biopha.2019.108803_bib0190","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0092-8674(00)80406-7","article-title":"The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation","volume":"91","author":"Zandi","year":"1997","journal-title":"Cell"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219300952?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219300952?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T11:29:19Z","timestamp":1781522959000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332219300952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":38,"alternative-id":["S0753332219300952"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.108803","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of tumor necrosis factor \u03b1 on ability of SHED to promote osteoclastogenesis during physiological root resorption","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.108803","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"108803"}}