{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:38:24Z","timestamp":1791837504472,"version":"4.3.4"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007162","name":"Guangdong Science and Technology Department","doi-asserted-by":"publisher","award":["2013B021800208"],"award-info":[{"award-number":["2013B021800208"]}],"id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.biopha.2019.108805","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T05:27:58Z","timestamp":1554096478000},"page":"108805","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Histone deacetylase 6 negatively regulated microRNA-199a-5p induces the occurrence of preeclampsia by targeting VEGFA in vitro"],"prefix":"10.1016","volume":"114","author":[{"given":"Zhixiong","family":"Mei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoqin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xialiu","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2019.108805_bib0005","first-page":"276","article-title":"Concept and connotation of oxidative stress in preeclampsia","volume":"10","author":"Al-Kuraishy","year":"2018","journal-title":"J. Lab. Phys."},{"key":"10.1016\/j.biopha.2019.108805_bib0010","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3343\/alm.2018.38.2.95","article-title":"Evaluation of sFlt-1\/PlGF ratio for predicting and improving clinical management of pre-eclampsia: experience in a specialized perinatal care center","volume":"38","author":"Caillon","year":"2018","journal-title":"Ann. Lab. Med."},{"key":"10.1016\/j.biopha.2019.108805_bib0015","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1186\/s12885-016-2916-7","article-title":"Kwong A, miR-199a-5p confers tumor-suppressive role in triple-negative breast cancer","volume":"16","author":"Chen","year":"2016","journal-title":"BMC Cancer"},{"key":"10.1016\/j.biopha.2019.108805_bib0020","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s10456-018-9648-z","article-title":"Excess vascular endothelial growth factor-A disrupts pericyte recruitment during blood vessel formation","volume":"22","author":"Darden","year":"2018","journal-title":"Angiogenesis"},{"key":"10.1016\/j.biopha.2019.108805_bib0025","doi-asserted-by":"crossref","first-page":"17871","DOI":"10.18632\/oncotarget.4934","article-title":"WISp39 and Hsp90: actin\u2019 together in cell migration","volume":"6","author":"Fotedar","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.biopha.2019.108805_bib0030","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1038\/s41596-018-0005-x","article-title":"In vitro generation of mouse polarized embryo-like structures from embryonic and trophoblast stem cells","volume":"13","author":"Harrison","year":"2018","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.biopha.2019.108805_bib0035","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.biopha.2017.08.077","article-title":"Natural killer T cells in Preeclampsia: an updated review","volume":"95","author":"Hashemi","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2019.108805_bib0040","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.tranon.2018.06.001","article-title":"Activating transcription factor 3 as a novel regulator of chemotherapy response in breast cancer","volume":"11","author":"Hasim","year":"2018","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.biopha.2019.108805_bib0045","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-024331","article-title":"Impact of pre-eclampsia on the cardiovascular health of the offspring: a cohort study protocol","volume":"8","author":"Hoodbhoy","year":"2018","journal-title":"BMJ Open"},{"key":"10.1016\/j.biopha.2019.108805_bib0050","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19092560","article-title":"The HSP90 family: structure, regulation, function, and implications in health and disease","volume":"19","author":"Hoter","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2019.108805_bib0055","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.thromres.2015.11.032","article-title":"Gestational hypertension, preeclampsia and intrauterine growth restriction induce dysregulation of cardiovascular and cerebrovascular disease associated microRNAs in maternal whole peripheral blood","volume":"137","author":"Hromadnikova","year":"2016","journal-title":"Thromb. Res."},{"key":"10.1016\/j.biopha.2019.108805_bib0060","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.ijcard.2017.07.045","article-title":"Profiling of cardiovascular and cerebrovascular disease associated microRNA expression in umbilical cord blood in gestational hypertension, preeclampsia and fetal growth restriction","volume":"249","author":"Hromadnikova","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.biopha.2019.108805_bib0065","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1161\/HYPERTENSIONAHA.117.09548","article-title":"Activating transcription factor 3 is reduced in preeclamptic placentas and negatively regulates sFlt-1 (Soluble fms-like tyrosine kinase 1), soluble endoglin, and proinflammatory cytokines in placenta","volume":"70","author":"Kaitu\u2019u-Lino","year":"2017","journal-title":"Hypertension"},{"key":"10.1016\/j.biopha.2019.108805_bib0070","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/cdd.2016.124","article-title":"Correction: strong antitumor synergy between DNA crosslinking and HSP90 inhibition causes massive premitotic DNA fragmentation in ovarian cancer cells","volume":"24","author":"Kramer","year":"2018","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.biopha.2019.108805_bib0075","doi-asserted-by":"crossref","first-page":"350","DOI":"10.14503\/THIJ-17-6359","article-title":"Hypertension and pregnancy","volume":"44","author":"Lai","year":"2017","journal-title":"Tex. Heart Inst. J."},{"key":"10.1016\/j.biopha.2019.108805_bib0080","doi-asserted-by":"crossref","first-page":"940","DOI":"10.7150\/jca.17496","article-title":"Mutual Regulation of MiR-199a-5p and HIF-1\u03b1 modulates the Warburg effect in hepatocellular carcinoma","volume":"8","author":"Li","year":"2017","journal-title":"J. Cancer"},{"key":"10.1016\/j.biopha.2019.108805_bib0085","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1128\/MCB.00345-16","article-title":"Activated transcription factor 3 in association with histone deacetylase 6 negatively regulates MicroRNA 199a2 transcription by chromatin remodeling and reduces Endothelin-1 expression","volume":"36","author":"Li","year":"2016","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.biopha.2019.108805_bib0090","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.biopha.2018.08.122","article-title":"The silencing of ApoC3 suppresses oxidative stress and inflammatory responses in placenta cells from mice with preeclampsia via inhibition of the NF-\u03baB signaling pathway","volume":"107","author":"Li","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2019.108805_bib0095","first-page":"4543","article-title":"miRNA-199a-5p suppresses proliferation and invasion by directly targeting NF-\u03baB1 in human ovarian cancer cells","volume":"16","author":"Liu","year":"2018","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.biopha.2019.108805_bib0100","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/nm731","article-title":"Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1","volume":"8","author":"Luttun","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.biopha.2019.108805_bib0105","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1002\/jcp.27291","article-title":"Roles of microRNAs in preeclampsia","volume":"234","author":"Lv","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"3 Suppl","key":"10.1016\/j.biopha.2019.108805_bib0110","first-page":"1059","article-title":"The expression of ATF3, MMP-2 and maspin in tissue chip of glioma","volume":"28","author":"Ma","year":"2015","journal-title":"Pak. J. Pharm. Sci."},{"key":"10.1016\/j.biopha.2019.108805_bib0115","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1016\/j.celrep.2017.02.030","article-title":"MAP3K4 controls the chromatin modifier HDAC6 during trophoblast stem cell epithelial-to-mesenchymal transition","volume":"18","author":"Mobley","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.biopha.2019.108805_bib0120","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1517\/14728222.2015.1057569","article-title":"MiR-199a-5p and miR-375 affect colon cancer cell sensitivity to cetuximab by targeting PHLPP1","volume":"19","author":"Mussnich","year":"2015","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.biopha.2019.108805_bib0125","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.3389\/fphys.2018.01091","article-title":"The role of placental hormones in mediating maternal adaptations to support pregnancy and lactation","volume":"9","author":"Napso","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.biopha.2019.108805_bib0130","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1182\/blood-2002-05-1516","article-title":"A critical role of placental growth factor in the induction of inflammation and edema formation","volume":"101","author":"Oura","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.biopha.2019.108805_bib0135","doi-asserted-by":"crossref","first-page":"256","DOI":"10.5603\/GP.a2018.0044","article-title":"Proteinuria in preeclampsia: is it important?","volume":"89","author":"\u00d6zkara","year":"2018","journal-title":"Ginekol. Pol."},{"key":"10.1016\/j.biopha.2019.108805_bib0140","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1158\/0008-5472.CAN-10-2345","article-title":"MicroRNAs miR-199a-5p and -3p target the Brm subunit of SWI\/SNF to generate a double-negative feedback loop in a variety of human cancers","volume":"71","author":"Sakurai","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.biopha.2019.108805_bib0145","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1002\/jbmr.2787","article-title":"Class I and IIa HDACs mediate HIF-1\u03b1 stability through PHD2-Dependent mechanism, while HDAC6, a class IIb member, promotes HIF-1\u03b1 transcriptional activity in nucleus pulposus cells of the intervertebral disc","volume":"31","author":"Schoepflin","year":"2016","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.biopha.2019.108805_bib0150","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1186\/s12885-018-4031-4","article-title":"ATF-3\/miR-590\/GOLPH3 signaling pathway regulates proliferation of breast cancer","volume":"18","author":"Song","year":"2018","journal-title":"BMC Cancer"},{"key":"10.1016\/j.biopha.2019.108805_bib0155","doi-asserted-by":"crossref","first-page":"6623","DOI":"10.1002\/jcb.26841","article-title":"Silence of HDAC6 suppressed esophageal squamous cell carcinoma proliferation and migration by disrupting chaperone function of HSP90","volume":"119","author":"Tao","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.biopha.2019.108805_bib0160","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.ajog.2009.09.016","article-title":"An automated method for the determination of the sFlt-1\/PIGF ratio in the assessment of preeclampsia","volume":"202","author":"Verlohren","year":"2010","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.biopha.2019.108805_bib0165","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.biopha.2018.08.055","article-title":"MicroRNA-454 is involved in regulating trophoblast cell proliferation, apoptosis, and invasion in preeclampsia by modulating the expression of ephrin receptor B4","volume":"107","author":"Wang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2019.108805_bib0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2012.05.003","article-title":"Examining the correlation between placental and serum placenta growth factor in preeclampsia","volume":"207","author":"Weed","year":"2012","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.biopha.2019.108805_bib0175","doi-asserted-by":"crossref","first-page":"88730","DOI":"10.18632\/oncotarget.20982","article-title":"Histone deacetylase 6 inhibition counteracts the epithelial-mesenchymal transition of peritoneal mesothelial cells and prevents peritoneal fibrosis","volume":"8","author":"Xu","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.biopha.2019.108805_bib0180","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1159\/000492995","article-title":"AMPK hyper-activation alters fatty acids metabolism and impairs invasiveness of trophoblasts in preeclampsia","volume":"49","author":"Yang","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.biopha.2019.108805_bib0185","doi-asserted-by":"crossref","DOI":"10.1111\/aji.12990","article-title":"XCL1-XCR1 pathway promotes trophoblast invasion at maternal-fetal interface by inducing MMP-2\/MMP-9 activity","volume":"80","author":"Zhang","year":"2018","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.biopha.2019.108805_bib0190","first-page":"1","article-title":"LAMA5 promotes human umbilical vein endothelial cells migration, proliferation, and angiogenesis and is decreased in preeclampsia","author":"Zhang","year":"2018","journal-title":"J. Matern. Fetal. Neonatal. Med."},{"key":"10.1016\/j.biopha.2019.108805_bib0195","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000370195","article-title":"Inhibition of lectin-like oxidized low-density lipoprotein receptor 1 protects against plasma\/hypoxia-mediated trophoblast dysfunction associated with preeclampsia","volume":"79","author":"Zhang","year":"2015","journal-title":"Gynecol. Obstet. Invest."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218383203?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218383203?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T11:30:23Z","timestamp":1781523023000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218383203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":39,"alternative-id":["S0753332218383203"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.108805","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Histone deacetylase 6 negatively regulated microRNA-199a-5p induces the occurrence of preeclampsia by targeting VEGFA in vitro","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.108805","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"108805"}}