{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T20:20:28Z","timestamp":1789158028725,"version":"build-2803163510"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T00:00:00Z","timestamp":1555977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010883","name":"Traditional Chinese Medicine Bureau of Guangdong Province","doi-asserted-by":"publisher","award":["20181133"],"award-info":[{"award-number":["20181133"]}],"id":[{"id":"10.13039\/501100010883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2014A020212642"],"award-info":[{"award-number":["2014A020212642"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2018B030322012"],"award-info":[{"award-number":["2018B030322012"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81774216"],"award-info":[{"award-number":["81774216"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.biopha.2019.108904","type":"journal-article","created":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T18:34:56Z","timestamp":1556908496000},"page":"108904","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Sanqi oral solution ameliorates renal damage and restores podocyte injury in experimental membranous nephropathy via suppression of NF\u03baB"],"prefix":"10.1016","volume":"115","author":[{"given":"Ruimin","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aibin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2019.108904_bib0005","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1093\/ndt\/gfq665","article-title":"The incidence of primary glomerulonephritis worldwide: a systematic review of the literature","volume":"26","author":"McGrogan","year":"2011","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.biopha.2019.108904_bib0010","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.kint.2016.09.048","article-title":"Membranous nephropathy: integrating basic science into improved clinical management","volume":"91","author":"Cattran","year":"2017","journal-title":"Kidney Int."},{"key":"10.1016\/j.biopha.2019.108904_bib0015","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1159\/000348638","article-title":"Changing spectrum of biopsy-proven primary glomerular diseases over the past 15 years: a single-center study in China","volume":"181","author":"Pan","year":"2013","journal-title":"Contrib. Nephrol."},{"key":"10.1016\/j.biopha.2019.108904_bib0020","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1681\/ASN.2016010093","article-title":"Long-term exposure to air pollution and increased risk of membranous nephropathy in China","volume":"27","author":"Xu","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.biopha.2019.108904_bib0025","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/ndt\/gfr220","article-title":"Idiopathic membranous nephropathy and nephrotic syndrome: outcome in the era of evidence-based therapy","volume":"27","author":"McQuarrie","year":"2012","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.biopha.2019.108904_bib0030","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1016\/S0140-6736(15)60731-0","article-title":"Pathophysiological advances in membranous nephropathy: time for a shift in patient\u2019s care","volume":"385","author":"Ronco","year":"2015","journal-title":"Lancet."},{"key":"10.1016\/j.biopha.2019.108904_bib0035","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/S0272-6386(04)00868-6","article-title":"The treatment of idiopathic membranous nephropathy: a dilemma or a conundrum?","volume":"44","author":"Glassock","year":"2004","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.biopha.2019.108904_bib0040","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1681\/ASN.2005010028","article-title":"Management of membranous nephropathy: when and what for treatment","volume":"16","author":"Cattran","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.biopha.2019.108904_bib0045","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1053\/j.ajkd.2005.08.020","article-title":"Idiopathic membranous nephropathy: outline and rationale of a treatment strategy","volume":"46","author":"du Buf-Vereijken","year":"2005","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.biopha.2019.108904_bib0050","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1053\/j.ajkd.2013.06.002","article-title":"KDOQI US commentary on the 2012 KDIGO clinical practice guideline for glomerulonephritis","volume":"62","author":"Beck","year":"2013","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.biopha.2019.108904_bib0055","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1172\/JCI110469","article-title":"Induction of membranous nephropathy in rabbits by administration of an exogenous cationic antigen","volume":"69","author":"Border","year":"1982","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.biopha.2019.108904_bib0060","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1111\/j.1523-1755.2005.00328.x","article-title":"Nephrin and podocin dissociate at the onset of proteinuria in experimental membranous nephropathy","volume":"67","author":"Nakatsue","year":"2005","journal-title":"Kidney Int."},{"key":"10.1016\/j.biopha.2019.108904_bib0065","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s12882-016-0390-8","article-title":"Alteration of histone H3K4 methylation in glomerular podocytes associated with proteinuria in patients with membranous nephropathy","volume":"17","author":"Fujino","year":"2016","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.biopha.2019.108904_bib0070","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1056\/NEJMoa1013792","article-title":"Early-childhood membranous nephropathy due to cationic bovine serum albumin","volume":"364","author":"Hanna","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biopha.2019.108904_bib0075","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.semnephrol.2013.08.004","article-title":"The role of complement in membranous nephropathy","volume":"33","author":"Ma","year":"2013","journal-title":"Semin. Nephrol."},{"key":"10.1016\/j.biopha.2019.108904_bib0080","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s10238-018-0491-8","article-title":"The role of the alternative pathway of complement activation in glomerular diseases","volume":"18","author":"Lukawska","year":"2018","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.biopha.2019.108904_bib0085","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1007\/s00467-009-1439-8","article-title":"IgG subclasses and complement pathway in segmental and global membranous nephropathy","volume":"25","author":"Segawa","year":"2010","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.biopha.2019.108904_bib0090","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1681\/ASN.2005010096","article-title":"Contrasting roles of complement activation and its regulation in membranous nephropathy","volume":"16","author":"Cunningham","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.biopha.2019.108904_bib0095","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1681\/ASN.2004121098","article-title":"Cellular response to injury in membranous nephropathy","volume":"16","author":"Nangaku","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.biopha.2019.108904_bib0100","first-page":"57","article-title":"Distribution of IgG subclasses in membranous nephropathy","volume":"58","author":"Doi","year":"1984","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.biopha.2019.108904_bib0105","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/modpathol.2012.237","article-title":"IgG subclass staining in renal biopsies with membranous glomerulonephritis indicates subclass switch during disease progression","volume":"26","author":"Huang","year":"2013","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.biopha.2019.108904_bib0110","doi-asserted-by":"crossref","first-page":"c147","DOI":"10.1159\/000079174","article-title":"Glomerular deposition and urinary excretion of complement factor H in idiopathic membranous nephropathy","volume":"97","author":"Endo","year":"2004","journal-title":"Nephron Clin. Pract."},{"key":"10.1016\/j.biopha.2019.108904_bib0115","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1093\/ndt\/15.12.1956","article-title":"Abnormal expression of glomerular basement membrane laminins in membranous glomerulonephritis","volume":"15","author":"Fischer","year":"2000","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.biopha.2019.108904_bib0120","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1159\/000368458","article-title":"Pathogenesis and treatment of chronic kidney disease: a review of our recent basic and clinical data","volume":"39","author":"Tomino","year":"2014","journal-title":"Kidney Blood Press. Res."},{"key":"10.1016\/j.biopha.2019.108904_bib0125","doi-asserted-by":"crossref","first-page":"F841","DOI":"10.1152\/ajprenal.2001.281.5.F841","article-title":"Complement C5b-9 induces cyclooxygenase-2 gene transcription in glomerular epithelial cells","volume":"281","author":"Takano","year":"2001","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.biopha.2019.108904_bib0130","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jep.2010.06.020","article-title":"Effects of sodium houttuyfonate on expression of NF-\u03baB and MCP-1 in membranous glomerulonephritis","volume":"131","author":"Pan","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2019.108904_bib0135","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1159\/000452591","article-title":"Triptolide attenuates inflammatory response in membranous glomerulo-nephritis rat via downregulation of NF-kappaB signaling pathway","volume":"41","author":"Zhou","year":"2016","journal-title":"Kidney Blood Press. Res."},{"key":"10.1016\/j.biopha.2019.108904_bib0140","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1046\/j.1523-1755.2001.059003923.x","article-title":"Activation of nuclear factor-kappa B by podocytes in the autologous phase of passive Heymann nephritis","volume":"59","author":"Mudge","year":"2001","journal-title":"Kidney Int."},{"key":"10.1016\/j.biopha.2019.108904_bib0145","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s10157-016-1268-6","article-title":"Podocyte-specific NF-\u03baB inhibition ameliorates proteinuria in adriamycin-induced nephropathy in mice","volume":"21","author":"Yamashita","year":"2017","journal-title":"Clin. Exp. Nephrol."},{"key":"10.1016\/j.biopha.2019.108904_bib0150","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12950-014-0040-5","article-title":"Attenuating effect of Ginsenoside Rb1 on LPS-induced lung injury in rats","volume":"11","author":"Yuan","year":"2014","journal-title":"J. Inflamm. Lond. (Lond)"},{"key":"10.1016\/j.biopha.2019.108904_bib0155","doi-asserted-by":"crossref","first-page":"464","DOI":"10.3389\/fphar.2017.00464","article-title":"Attenuation of TNF-alpha-Induced inflammatory injury in endothelial cells by ginsenoside Rb1 via inhibiting NF-kappaB, JNK and p38 signaling pathways","volume":"8","author":"Zhou","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.biopha.2019.108904_bib0160","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.intimp.2014.07.028","article-title":"Ginsenoside Rg1 regulates innate immune responses in macrophages through differentially modulating the NF-\u03baB and PI3K\/Akt\/mTOR pathways","volume":"23","author":"Yao","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.biopha.2019.108904_bib0165","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejphar.2015.11.040","article-title":"Notoginsenoside R1 inhibits oxidized low-density lipoprotein induced inflammatory cytokines production in human endothelial EA.hy926 cells","volume":"770","author":"Su","year":"2016","journal-title":"Eur. J. Pharmacol."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218380648?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218380648?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T11:39:33Z","timestamp":1760096373000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218380648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":33,"alternative-id":["S0753332218380648"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.108904","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sanqi oral solution ameliorates renal damage and restores podocyte injury in experimental membranous nephropathy via suppression of NF\u03baB","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.108904","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"108904"}}