{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T17:26:50Z","timestamp":1793899610702,"version":"4.8.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T00:00:00Z","timestamp":1556150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004695","name":"Inyuvesi Yakwazulu-Natali","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004695","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.biopha.2019.108925","type":"journal-article","created":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T05:00:56Z","timestamp":1558155656000},"page":"108925","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["The effects of Momordica balsamina methanolic extract on haematological function in streptozotocin-induced diabetic rats: Effects on selected markers"],"prefix":"10.1016","volume":"116","author":[{"given":"A.","family":"Ludidi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.C.","family":"Baloyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Khathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.H.","family":"Sibiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.S.","family":"Ngubane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2019.108925_bib0005","doi-asserted-by":"crossref","first-page":"64","DOI":"10.2337\/dc12-s064","article-title":"Diagnosis and classification of diabetes mellitus","volume":"35","author":"Association AD","year":"2012","journal-title":"Diabetes Care"},{"key":"10.1016\/j.biopha.2019.108925_bib0010","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.2337\/diacare.26.4.1164","article-title":"Unrecognized anemia in patients with diabetes","volume":"26","author":"Thomas","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.biopha.2019.108925_bib0015","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1007\/s12010-015-1793-x","article-title":"Advanced glycation-modified human serum albumin evokes alterations in membrane and eryptosis in erythrocytes","volume":"177","author":"Awasthi","year":"2015","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.biopha.2019.108925_bib0020","doi-asserted-by":"crossref","first-page":"662","DOI":"10.4239\/wjd.v6.i4.662","article-title":"Advanced glycation end-product expression is upregulated in the gastrointestinal tract of type 2 diabetic rats","volume":"6","author":"Chen","year":"2015","journal-title":"World J. Diabetes"},{"key":"10.1016\/j.biopha.2019.108925_bib0025","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.pharep.2014.09.012","article-title":"Ability of natural astaxanthin from shrimp by-products to attenuate liver oxidative stress in diabetic rats","volume":"67","author":"Sila","year":"2015","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.biopha.2019.108925_bib0030","doi-asserted-by":"crossref","first-page":"550","DOI":"10.5530\/jyp.2017.9.105","article-title":"Beneficial effects of Tephrosia purpurea ethanolic seed extract on lipids and membrane bound enzymes in experimental diabetic rats","volume":"9","author":"Pamu","year":"2017","journal-title":"J. Young Pharm."},{"key":"10.1016\/j.biopha.2019.108925_bib0035","doi-asserted-by":"crossref","first-page":"332","DOI":"10.3389\/fphys.2018.00332","article-title":"On the effects of reactive oxygen species and nitric oxide on red blood cell deformability","volume":"9","author":"Diederich","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.biopha.2019.108925_bib0040","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/ptr.1380","article-title":"Protective effects of selected medicinal plants against protein degradation, lipid peroxidation and deformability loss of oxidatively stressed human erythrocytes","volume":"18","author":"Suboh","year":"2004","journal-title":"Phytother. Res."},{"key":"10.1016\/j.biopha.2019.108925_bib0045","first-page":"200","article-title":"Changes of blood rheological properties in patients with metabolic syndrome","volume":"4","author":"Shilov","year":"2008","journal-title":"Russ. Med. J."},{"key":"10.1016\/j.biopha.2019.108925_bib0050","first-page":"116","article-title":"Effect of aqueous leaf extract of heinsia crinata on haematological and some biochemical indices of toxicity in streptozotocin induced diabetic rats","volume":"2","author":"Miikue-Yobe","year":"2015","journal-title":"Int. J. Sci. Res. Innov. Technol."},{"key":"10.1016\/j.biopha.2019.108925_bib0055","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1159\/000443081","article-title":"Phosphatidylserine exposure in human red blood cells depending on cell age","volume":"38","author":"Wesseling","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.biopha.2019.108925_bib0060","first-page":"22","article-title":"Abnormalities of elastic and transporting properties of red blood cells under development of apoptosis","volume":"4","author":"Mindukshev","year":"2010","journal-title":"Biochem. Mosc. Suppl. Ser. A Membr. Cell Biol."},{"key":"10.1016\/j.biopha.2019.108925_bib0065","article-title":"Erythropoietin eliminates increased bone marrow adiposity and alters bone features in obese mice","author":"Suresh","year":"2017","journal-title":"Am. Soc. Hematol."},{"key":"10.1016\/j.biopha.2019.108925_bib0070","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2337\/dc14-S081","article-title":"Diagnosis and classification of diabetes mellitus","volume":"37","author":"Association AD","year":"2014","journal-title":"Diabetes Care"},{"key":"10.1016\/j.biopha.2019.108925_bib0075","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/978-3-642-38007-5_21","article-title":"New perspective for an old antidiabetic drug: metformin as anticancer agent","volume":"159","author":"Leone","year":"2014","journal-title":"Adv. Nutr. Cancer"},{"key":"10.1016\/j.biopha.2019.108925_bib0080","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1093\/ageing\/afj042","article-title":"Metformin-related vitamin B12 deficiency","volume":"35","author":"Liu","year":"2006","journal-title":"Age Ageing"},{"key":"10.1016\/j.biopha.2019.108925_bib0085","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s00394-015-0883-4","article-title":"Grapefruit juice improves glucose intolerance in streptozotocin-induced diabetes by suppressing hepatic gluconeogenesis","volume":"55","author":"Hayanga","year":"2016","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.biopha.2019.108925_bib0090","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s11418-008-0228-1","article-title":"Antihyperglycemic and antioxidative potential of Matricaria chamomilla L. in streptozotocin-induced diabetic rats","volume":"62","author":"Cemek","year":"2008","journal-title":"J. Nat. Med."},{"key":"10.1016\/j.biopha.2019.108925_bib0095","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1440-1797.2004.00247.x","article-title":"Renoprotective effect of Hemidesmus indicus, a herbal drug used in gentamicin\u2010induced renal toxicity","volume":"9","author":"Kotnis","year":"2004","journal-title":"Nephrology"},{"key":"10.1016\/j.biopha.2019.108925_bib0100","doi-asserted-by":"crossref","first-page":"190","DOI":"10.4103\/0253-7613.25806","article-title":"Effect of Hemidesmus indicus (Anantmool) extract on IgG production and adenosine deaminase activity of human lymphocytes in vitro","volume":"38","author":"Kainthla","year":"2006","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/j.biopha.2019.108925_bib0105","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1161\/01.RES.87.10.840","article-title":"Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress","volume":"87","author":"Cai","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.biopha.2019.108925_bib0110","doi-asserted-by":"crossref","first-page":"667","DOI":"10.2174\/138920109789542066","article-title":"Momordica balsamina: a medicinal and neutraceutical plant for health care management","volume":"10","author":"Thakur","year":"2009","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.biopha.2019.108925_bib0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/7341242","article-title":"The effects of Momordica balsamina methanolic extract on kidney function in STZ-induced diabetic rats: effects on selected metabolic markers","volume":"2018","author":"Siboto","year":"2018","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.biopha.2019.108925_bib0120","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S2222-1808(13)60052-3","article-title":"Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency","volume":"3","author":"Joseph","year":"2013","journal-title":"Asian Pac. J. Trop. Dis."},{"key":"10.1016\/j.biopha.2019.108925_bib0125","doi-asserted-by":"crossref","first-page":"419","DOI":"10.3109\/0886022X.2013.867799","article-title":"Musabayane C. antioxidant effects of maslinic acid in liver, hearts and kidneys of streptozotocin-induces diabetic rats: effects on kidney function","volume":"36","author":"Mkhwanazi","year":"2014","journal-title":"Ren. Fail."},{"key":"10.1016\/j.biopha.2019.108925_bib0130","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0531-5565(00)00198-4","article-title":"Alterations of antioxidant enzymes and oxidative stress markers in aging","volume":"36","author":"Kasapoglu","year":"2001","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.biopha.2019.108925_bib0135","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12933-017-0563-1","article-title":"Red blood cell distribution width as a prognostic marker in patients with heart failure and diabetes mellitus","volume":"16","author":"Xanthopoulos","year":"2017","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.biopha.2019.108925_bib0140","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3390\/ph11040103","article-title":"Oxidative stress and cardiovascular complications in chronic kidney disease, the impact of anaemia","volume":"11","author":"Nuhu","year":"2018","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.biopha.2019.108925_bib0145","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12933-017-0625-4","article-title":"Tissue-engineered smooth muscle cell and endothelial progenitor cell bi-level cell sheets prevent progression of cardiac dysfunction, microvascular dysfunction, and interstitial fibrosis in a rodent model of type 1 diabetes-induced cardiomyopathy","volume":"16","author":"Kawamura","year":"2017","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.biopha.2019.108925_bib0150","doi-asserted-by":"crossref","first-page":"12820","DOI":"10.1111\/cmi.12820","article-title":"Tailored environments to study motile cells and pathogens","volume":"20","author":"Muthinja","year":"2018","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.biopha.2019.108925_bib0155","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3324\/haematol.2016.151621","article-title":"Hemolytic anemia repressed hepcidin level without hepatocyte iron overload: lesson from G\u00fcnther disease model","volume":"102","author":"Millot","year":"2017","journal-title":"Haematologica"},{"key":"10.1016\/j.biopha.2019.108925_bib0160","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1080\/13685538.2017.1350156","article-title":"Reference database of hematological parameters for growing and aging rats","volume":"21","author":"Jacob Filho","year":"2018","journal-title":"Aging Male"},{"key":"10.1016\/j.biopha.2019.108925_bib0165","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1021\/ab500179h","article-title":"Design strategies and applications of circulating cell-mediated drug delivery systems","volume":"1","author":"Su","year":"2015","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.biopha.2019.108925_bib0170","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.drudis.2018.02.008","article-title":"The integrated stress response system in cardiovascular disease","volume":"23","author":"Santos-Ribeiro","year":"2018","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.biopha.2019.108925_bib0175","first-page":"4","article-title":"Momordica charantia restores compromised haematological parameters in streptozotocin-induced diabetic rats","volume":"26","author":"Komolafe","year":"2016","journal-title":"Fiziologia-Physiology"},{"key":"10.1016\/j.biopha.2019.108925_bib0180","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/ijlh.12500","article-title":"Laboratory diagnosis of anemia: are the old and new red cell parameters useful in classification and treatment, how?","volume":"38","author":"Buttarello","year":"2016","journal-title":"Int. J. Lab. Hematol."},{"issue":"June","key":"10.1016\/j.biopha.2019.108925_bib0185","article-title":"Hematological and serum biochemical analysis of streptozotocin-induced insulin dependent diabetes mellitus in male adult wistar rats","volume":"30","author":"Yakhchalian","year":"2018","journal-title":"bioRxiv"},{"key":"10.1016\/j.biopha.2019.108925_bib0190","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.dsx.2014.05.001","article-title":"Protective and therapeutic effectiveness of taurine in diabetes mellitus: a rationale for antioxidant supplementation","volume":"9","author":"Sirdah","year":"2015","journal-title":"Diabetes Metab. Syndr. Clin. Res. Rev."},{"key":"10.1016\/j.biopha.2019.108925_bib0195","first-page":"2147","article-title":"Investigation of the effects of sevoflurane and Desflurane on erythrocyte deformability in transient hyperglycemia","volume":"29","author":"Kalayc\u0131","year":"2017","journal-title":"Gazi Med. J."},{"key":"10.1016\/j.biopha.2019.108925_bib0200","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ceb.2014.09.010","article-title":"ROS-dependent signal transduction","volume":"33","author":"Reczek","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.biopha.2019.108925_bib0205","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s11010-017-3009-x","article-title":"Balsamin induces apoptosis in breast cancer cells via DNA fragmentation and cell cycle arrest","volume":"432","author":"Ajji","year":"2017","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.biopha.2019.108925_bib0210","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.apjtb.2015.09.008","article-title":"Anti-breast cancer properties and toxicity of Dillenia suffruticosa root aqueous extract in BALB\/c mice","volume":"5","author":"Yazan","year":"2015","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"10.1016\/j.biopha.2019.108925_bib0215","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.eujim.2016.02.011","article-title":"Activity of essential oils of Piper aduncum anf and Cinnamomum zeylanicum by evaluating osmotic and morphologic fragility of erythrocytes","volume":"8","author":"Barros","year":"2016","journal-title":"Eur. J. Integr. Med."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219307577?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219307577?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T16:50:23Z","timestamp":1793897423000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332219307577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":43,"alternative-id":["S0753332219307577"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.108925","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effects of Momordica balsamina methanolic extract on haematological function in streptozotocin-induced diabetic rats: Effects on selected markers","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.108925","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"108925"}}