{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:08:35Z","timestamp":1787314115228,"version":"build-2736575974"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T00:00:00Z","timestamp":1557273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundations of China","doi-asserted-by":"crossref","award":["81703895"],"award-info":[{"award-number":["81703895"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.biopha.2019.108971","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T06:15:39Z","timestamp":1557900939000},"page":"108971","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["Sini decoction ameliorates sepsis-induced acute lung injury via regulating ACE2-Ang (1-7)-Mas axis and inhibiting the MAPK signaling pathway"],"prefix":"10.1016","volume":"115","author":[{"given":"Qiuhua","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanqiu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingqi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengjie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2019.108971_bib0005","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for Sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.biopha.2019.108971_bib0010","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1007\/s00134-015-3764-7","article-title":"Phenotypic clusters within sepsis-associated multiple organ dysfunction syndrome","volume":"41","author":"Knox","year":"2015","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.biopha.2019.108971_bib0015","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.freeradbiomed.2018.02.028","article-title":"PICK1 deficiency exacerbates sepsis-associated acute lung injury and impairs glutathione synthesis via reduction of xCT","volume":"118","author":"Qian","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biopha.2019.108971_bib0020","doi-asserted-by":"crossref","first-page":"L744","DOI":"10.1152\/ajplung.00368.2009","article-title":"Zinc modulates the innate immune response in vivo to polymicrobial sepsis through regulation of NF-kappaB","volume":"298","author":"Bao","year":"2010","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.biopha.2019.108971_bib0025","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1056\/NEJMcibr1007320","article-title":"Sepsis and endothelial permeability","volume":"363","author":"Lee","year":"2010","journal-title":"N. Engl. J. Med."},{"issue":"Suppl. 1","key":"10.1016\/j.biopha.2019.108971_bib0030","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1513\/AnnalsATS.201407-340MG","article-title":"Mechanisms and clinical consequences of acute lung injury","volume":"12","author":"Fanelli","year":"2015","journal-title":"Ann. Am. Thorac. Soc."},{"key":"10.1016\/j.biopha.2019.108971_bib0035","doi-asserted-by":"crossref","first-page":"L665","DOI":"10.1152\/ajplung.00232.2013","article-title":"Novel concepts of acute lung injury and alveolar-capillary barrier dysfunction","volume":"305","author":"Herold","year":"2013","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.biopha.2019.108971_bib0040","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.jep.2013.07.022","article-title":"A novel concept for detoxification: complexation between aconitine and liquiritin in a Chinese herbal formula (\u2019Sini Tang\u2019)","volume":"149","author":"Peter","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2019.108971_bib0045","first-page":"184","article-title":"Effect of Sini decoction on function of hypothalamic-pituitary-adrenal axis in patients with sepsis","volume":"26","author":"Huang","year":"2014","journal-title":"Zhonghua wei zhong bing ji jiu yi xue"},{"key":"10.1016\/j.biopha.2019.108971_bib0050","first-page":"43","article-title":"The effect of sini decoction on inflammatory cytokines in septic shock patients","volume":"12","author":"Mujuan","year":"2013","journal-title":"Trad. Chin. Med. J."},{"key":"10.1016\/j.biopha.2019.108971_bib0055","first-page":"1","article-title":"Anti-inflammatory effects of the chinese herbal formula sini tang in myocardial infarction rats","volume":"2014","author":"Liu","year":"2014","journal-title":"Evid. Complement. Alternat. Med."},{"key":"10.1016\/j.biopha.2019.108971_bib0060","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1155\/2018\/5186158","article-title":"Sini decoction improves adrenal function and the short-term outcome of septic rats through downregulation of adrenal toll-like receptor 4 expression","volume":"2018","author":"Lai","year":"2018","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.biopha.2019.108971_bib0065","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.lfs.2018.07.013","article-title":"Sini decoction alleviates E. coli induced acute lung injury in mice via equilibrating ACE-AngII-AT1R and ACE2-Ang-(1-7)-Mas axis","author":"Liu","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.biopha.2019.108971_bib0070","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1042\/CS20180121","article-title":"Intratubular and intracellular renin-angiotensin system in the kidney: a unifying perspective in blood pressure control","volume":"132","author":"Li","year":"2018","journal-title":"Clin. Sci. (Lond., Engl.: 1979)"},{"key":"10.1016\/j.biopha.2019.108971_bib0075","doi-asserted-by":"crossref","first-page":"253","DOI":"10.7150\/ijbs.23489","article-title":"Instillation of particulate matter 2.5 induced acute lung injury and attenuated the injury recovery in ACE2 knockout mice","volume":"14","author":"Lin","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.biopha.2019.108971_bib0080","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.coph.2017.12.002","article-title":"Targeting the renin-angiotensin system as novel therapeutic strategy for pulmonary diseases","volume":"40","author":"Tan","year":"2018","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.biopha.2019.108971_bib0085","doi-asserted-by":"crossref","first-page":"3594","DOI":"10.1038\/ncomms4594","article-title":"Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections","volume":"5","author":"Zou","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biopha.2019.108971_bib0090","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.atherosclerosis.2010.05.020","article-title":"Angiotensin II induces C-reactive protein expression through ERK1\/2 and JNK signaling in human aortic endothelial cells","volume":"212","author":"Han","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.biopha.2019.108971_bib0095","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1681\/ASN.2007020149","article-title":"Angiotensin II-induced reactive oxygen species and the kidney","volume":"18","author":"Sachse","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.biopha.2019.108971_bib0100","doi-asserted-by":"crossref","first-page":"8209","DOI":"10.1038\/srep08209","article-title":"Angiotensin-converting enzyme 2\/angiotensin-(1-7)\/Mas axis prevents lipopolysaccharide-induced apoptosis of pulmonary microvascular endothelial cells by inhibiting JNK\/NF-kappaB pathways","volume":"5","author":"Li","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2019.108971_bib0105","first-page":"211","article-title":"MAP kinase cascades in antigen receptor signaling and physiology","volume":"393","author":"Yasuda","year":"2016","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.biopha.2019.108971_bib0110","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1538-7836.2009.03658.x","article-title":"The mitogen-activated protein kinase signaling pathways: role in megakaryocyte differentiation","volume":"8","author":"Severin","year":"2010","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.biopha.2019.108971_bib0115","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.intimp.2018.02.011","article-title":"New thiazolidinedione LPSF\/GQ-2 inhibits NFkappaB and MAPK activation in LPS-induced acute lung inflammation","volume":"57","author":"Santos","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.biopha.2019.108971_bib0120","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.bcp.2018.05.004","article-title":"Tabersonine attenuates lipopolysaccharide-induced acute lung injury via suppressing TRAF6 ubiquitination","volume":"154","author":"Zhang","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biopha.2019.108971_bib0125","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1097\/SHK.0000000000000302","article-title":"Angiotensin-converting enzyme inhibition attenuates lipopolysaccharide-induced lung injury by regulating the balance between angiotensin-converting enzyme and angiotensin-converting enzyme 2 and inhibiting mitogen-activated protein kinase activation","volume":"43","author":"Li","year":"2015","journal-title":"Shock"},{"key":"10.1016\/j.biopha.2019.108971_bib0130","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1165\/rcmb.2012-0451OC","article-title":"Angiotensin-Converting Enzyme 2\/Angiotensin-(1-7)\/Mas Axis Protects against Lung Fibrosis by Inhibiting the MAPK\/NF-\u03baB Pathway","volume":"50","author":"YingMeng","year":"2014","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.biopha.2019.108971_bib0135","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/art.25060","article-title":"Involvement of MAPKs and NF-kappaB in tumor necrosis factor alpha-induced vascular cell adhesion molecule 1 expression in human rheumatoid arthritis synovial fibroblasts","volume":"62","author":"Luo","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.biopha.2019.108971_bib0140","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1097\/SHK.0b013e31824ddc81","article-title":"Molecular hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice through reducing inflammation and apoptosis","volume":"37","author":"Xie","year":"2012","journal-title":"Shock"},{"key":"10.1016\/j.biopha.2019.108971_bib0145","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s10753-014-0003-2","article-title":"Magnolol inhibits the inflammatory response in mouse mammary epithelial cells and a mouse mastitis model","volume":"38","author":"Wei","year":"2015","journal-title":"Inflammation"},{"key":"10.1016\/j.biopha.2019.108971_bib0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2017.12.027","article-title":"Lariciresinol induces apoptosis in HepG2 cells via mitochondrial-mediated apoptosis pathway","volume":"821","author":"Ma","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2019.108971_bib0155","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1152\/physrev.00037.2012","article-title":"Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding","volume":"93","author":"Iskander","year":"2013","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.biopha.2019.108971_bib0160","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1186\/s13287-017-0734-8","article-title":"Mesenchymal stem cells decrease lung inflammation during sepsis, acting through inhibition of the MAPK pathway","volume":"8","author":"Pedrazza","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.biopha.2019.108971_bib0165","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1186\/s12931-018-0935-4","article-title":"Inflammation and lung injury in an ovine model of fluid resuscitated endotoxemic shock","volume":"19","author":"Passmore","year":"2018","journal-title":"Respir. Res."},{"key":"10.1016\/j.biopha.2019.108971_bib0170","doi-asserted-by":"crossref","first-page":"7990","DOI":"10.4049\/jimmunol.0800377","article-title":"Myeloperoxidase deficiency attenuates lipopolysaccharide-induced acute lung inflammation and subsequent cytokine and chemokine production","volume":"182","author":"Haegens","year":"2009","journal-title":"J. Immunol. (Baltimore, Md. : 1950)"},{"key":"10.1016\/j.biopha.2019.108971_bib0175","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1142\/S0192415X0900693X","article-title":"Sini tang prevents depression-like behavior in rats exposed to chronic unpredictable stress","volume":"37","author":"Guo","year":"2009","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.biopha.2019.108971_bib0180","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1172\/JCI60331","article-title":"The acute respiratory distress syndrome","volume":"122","author":"Matthay","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.biopha.2019.108971_bib0185","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1159\/000479609","article-title":"Dexmedetomidine alleviates hyperoxia-induced acute lung injury via inhibiting NLRP3 inflammasome activation","volume":"42","author":"Zhang","year":"2017","journal-title":"Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol."},{"key":"10.1016\/j.biopha.2019.108971_bib0190","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.freeradbiomed.2014.03.034","article-title":"Stanniocalcin-1 ameliorates lipopolysaccharide-induced pulmonary oxidative stress, inflammation, and apoptosis in mice","volume":"71","author":"Tang","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biopha.2019.108971_bib0195","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0165-6147(00)01994-5","article-title":"The angiotensin-converting enzyme gene family: genomics and pharmacology","volume":"23","author":"Turner","year":"2002","journal-title":"Trends Pharmacol. Sci."},{"issue":"717-28","key":"10.1016\/j.biopha.2019.108971_bib0200","first-page":"18","article-title":"Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction","volume":"122","author":"Zhong","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2019.108971_bib0205","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12974-016-0489-7","article-title":"Angiotensin-converting enzyme 2 activator diminazene aceturate prevents lipopolysaccharide-induced inflammation by inhibiting MAPK and NF-\u03baB pathways in human retinal pigment epithelium","volume":"13","author":"Tao","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.biopha.2019.108971_bib0210","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1159\/000430393","article-title":"Angiotensin-converting enzyme 2 inhibits apoptosis of pulmonary endothelial cells during acute lung injury through suppressing MiR-4262","volume":"37","author":"Bao","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.biopha.2019.108971_bib0215","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.1210\/en.2016-1879","article-title":"Angiotensin II causes \u03b2-cell dysfunction through an ER stress-induced proinflammatory response","volume":"158","author":"Chan","year":"2017","journal-title":"Endocrinology"},{"key":"10.1016\/j.biopha.2019.108971_bib0220","doi-asserted-by":"crossref","first-page":"5569","DOI":"10.4049\/jimmunol.1000314","article-title":"Anti-inflammatory effects of the activation of the angiotensin-(1-7) receptor, MAS, in experimental models of arthritis","volume":"185","author":"da Silveira","year":"2010","journal-title":"J. Immunol. (Baltimore, Md. : 1950)"},{"key":"10.1016\/j.biopha.2019.108971_bib0225","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1056\/NEJM199704103361506","article-title":"Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases","volume":"336","author":"Barnes","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biopha.2019.108971_bib0230","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.7150\/thno.11685","article-title":"Blockade of interplay between IL-17A and endoplasmic reticulum stress attenuates LPS-Induced lung injury","volume":"5","author":"Kim","year":"2015","journal-title":"Theranostics"},{"key":"10.1016\/j.biopha.2019.108971_bib0235","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.jgr.2017.05.005","article-title":"Ginsenosides from Korean Red Ginseng ameliorate lung inflammatory responses: inhibition of the MAPKs\/NF-kappaB\/c-Fos pathways","volume":"42","author":"Lee","year":"2018","journal-title":"J. Ginseng Res."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219308200?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219308200?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T11:43:13Z","timestamp":1760096593000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332219308200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":47,"alternative-id":["S0753332219308200"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.108971","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sini decoction ameliorates sepsis-induced acute lung injury via regulating ACE2-Ang (1-7)-Mas axis and inhibiting the MAPK signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.108971","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"108971"}}