{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T17:27:28Z","timestamp":1793899648194,"version":"4.8.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T00:00:00Z","timestamp":1557705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["15-25396A"],"award-info":[{"award-number":["15-25396A"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004240","name":"Akademie V\u011bd \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["RVO 67985823"],"award-info":[{"award-number":["RVO 67985823"]}],"id":[{"id":"10.13039\/501100004240","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["19-18260J J"],"award-info":[{"award-number":["19-18260J J"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.biopha.2019.108996","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T01:09:31Z","timestamp":1558660171000},"page":"108996","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Role of angiotensin II in chronic blood pressure control of heterozygous Ren-2 transgenic rats: Peripheral vasoconstriction versus central sympathoexcitation"],"prefix":"10.1016","volume":"116","author":[{"given":"Lenka","family":"\u0158ez\u00e1\u010dov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvie","family":"Hojn\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libor","family":"Kopkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"Rauchov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Kadlecov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Zicha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Van\u011b\u010dkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6 Pt 1","key":"10.1016\/j.biopha.2019.108996_bib0005","first-page":"E919","article-title":"Physiological characterization of the hypertensive transgenic rat TGR(mREN2)27","volume":"270","author":"Lee","year":"1996","journal-title":"Am. J. Physiol."},{"issue":"3","key":"10.1016\/j.biopha.2019.108996_bib0010","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/01.hjh.0000209988.51606.c7","article-title":"Effects of changes in sodium balance on plasma and kidney angiotensin II levels in anesthetized and conscious Ren-2 transgenic rats","volume":"24","author":"Huskov\u00e1","year":"2006","journal-title":"J. Hypertens."},{"issue":"3","key":"10.1016\/j.biopha.2019.108996_bib0015","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1172\/JCI116292","article-title":"Increased adrenal renin in transgenic hypertensive rats, TGR(mREN2)27, and its regulation by cAMP, angiotensin II, and calcium","volume":"91","author":"Peters","year":"1993","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.biopha.2019.108996_bib0020","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/0196-9781(94)90051-5","article-title":"Increased expression of angiotensin peptides in the brain of transgenic hypertensive rats","volume":"15","author":"Senanayake","year":"1994","journal-title":"Peptides"},{"issue":"7","key":"10.1016\/j.biopha.2019.108996_bib0025","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/S0895-7061(99)00021-7","article-title":"Different effects of antihypertensive agents on cardiac and vascular hypertrophy in the transgenic rat line TGR(mRen2)27","volume":"12","author":"Brosnan","year":"1999","journal-title":"Am. J. Hypertens."},{"issue":"2","key":"10.1016\/j.biopha.2019.108996_bib0030","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1161\/01.HYP.31.2.692","article-title":"Additive effects of enalapril and losartan in (mREN-2)27 transgenic rats","volume":"31","author":"Richer","year":"1998","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.biopha.2019.108996_bib0035","doi-asserted-by":"crossref","first-page":"F758","DOI":"10.1152\/ajprenal.00259.2010","article-title":"Persistent antihypertensive effect of aliskiren is accompanied by reduced proteinuria and normalization of glomerular area in Ren-2 transgenic rats","volume":"299","author":"Raku\u0161an","year":"2010","journal-title":"Am. J. Physiol. Renal Physiol."},{"issue":"6 pt 2","key":"10.1016\/j.biopha.2019.108996_bib0040","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1161\/01.HYP.19.6.681","article-title":"Role of tissue renin in the pathophysiology of hypertension in TGR(mREN2)27 rats","volume":"19","author":"Bader","year":"1992","journal-title":"Hypertension"},{"key":"10.1016\/j.biopha.2019.108996_bib0045","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.lfs.2016.01.020","article-title":"Moderate additive effects of endothelin receptor A blockade in Ren-2 transgenic rats subjected to various types of RAS blockade","volume":"159","author":"Van\u011b\u010dkov\u00e1","year":"2016","journal-title":"Life Sci."},{"issue":"7","key":"10.1016\/j.biopha.2019.108996_bib0050","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/hr.2012.29","article-title":"The effects of repeated delivery of angiotensin II AT1 receptor antisense on distinct vasoactive systems in Ren-2 transgenic rats: young vs. Adult animals","volume":"35","author":"Van\u011b\u010dkov\u00e1","year":"2012","journal-title":"Hypertens. Res."},{"issue":"6 Pt 2","key":"10.1016\/j.biopha.2019.108996_bib0055","first-page":"R1317","article-title":"Blockade of angiotensin receptors in rat rostral ventrolateral medulla removes excitatory vasomotor tone","volume":"270","author":"Ito","year":"1996","journal-title":"Am. J. Physiol."},{"issue":"2","key":"10.1016\/j.biopha.2019.108996_bib0060","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/sj.bjp.0705262","article-title":"Brain renin-angiotensin system dysfunction in hypertension: recent advances and perspectives","volume":"139","author":"Veerasingham","year":"2003","journal-title":"Br. J. Pharmacol."},{"issue":"13","key":"10.1016\/j.biopha.2019.108996_bib0065","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1152\/physiolgenomics.00167.2010","article-title":"Long-term systemic angiotensin II type 1 receptor blockade regulates mRNA expression of dorsomedial medulla renin-angiotensin system components","volume":"43","author":"Gilliam-Davis","year":"2011","journal-title":"Physiol. Genomics"},{"issue":"5","key":"10.1016\/j.biopha.2019.108996_bib0070","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1161\/HYPERTENSIONAHA.112.196782","article-title":"Central angiotensin-(1-7) improves vagal function independent of blood pressure in hypertensive (mRen2)27 rats","volume":"60","author":"Nautiyal","year":"2012","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.biopha.2019.108996_bib0075","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1161\/01.HYP.9.4.355","article-title":"Area postrema is critical for angiotensin-induced hypertension in rats","volume":"9","author":"Fink","year":"1987","journal-title":"Hypertension"},{"issue":"3 pt 2","key":"10.1016\/j.biopha.2019.108996_bib0080","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1161\/01.HYP.27.3.591","article-title":"Role of area postrema in transgene hypertension","volume":"27","author":"Averill","year":"1996","journal-title":"Hypertension"},{"issue":"4 Pt 2","key":"10.1016\/j.biopha.2019.108996_bib0085","first-page":"H796","article-title":"Sympathetic function in spontaneously hypertensive rats after chronic administration of captopril","volume":"252","author":"Berecek","year":"1987","journal-title":"Am. J. Physiol."},{"issue":"1","key":"10.1016\/j.biopha.2019.108996_bib0090","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.brainres.2004.06.079","article-title":"Oral administration of an AT1 receptor antagonist prevents the central effects of angiotensin II in spontaneously hypertensive rats","volume":"1028","author":"Seltzer","year":"2004","journal-title":"Brain Res."},{"issue":"Suppl I","key":"10.1016\/j.biopha.2019.108996_bib0095","first-page":"I148","article-title":"Long-term captopril treatment. Angiotensin II receptors and responses","volume":"11","author":"Wilson","year":"1988","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.biopha.2019.108996_bib0100","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1161\/01.HYP.13.1.63","article-title":"Baroreflex function in lifetime-captopril-treated spontaneously hypertensive rats","volume":"13","author":"Cheng","year":"1989","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.biopha.2019.108996_bib0105","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1161\/01.HYP.37.3.981","article-title":"Prevention of hypertension by irbesartan in Dahl S rats relates to central angiotensin II type 1 receptor blockade","volume":"37","author":"Leenen","year":"2001","journal-title":"Hypertension"},{"issue":"6","key":"10.1016\/j.biopha.2019.108996_bib0110","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1161\/01.HYP.32.6.1028","article-title":"Both brain angiotensin II and \"ouabain\" contribute to sympatho-excitation and hypertension in Dahl S rats on high salt intake","volume":"32","author":"Huang","year":"1998","journal-title":"Hypertension"},{"issue":"7","key":"10.1016\/j.biopha.2019.108996_bib0115","doi-asserted-by":"crossref","first-page":"R825","DOI":"10.1152\/ajpregu.00368.2011","article-title":"Central infusion of aliskiren prevents sympathetic hyperactivity and hypertension in Dahl salt-sensitive rats on high salt intake","volume":"302","author":"Huang","year":"2012","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"2","key":"10.1016\/j.biopha.2019.108996_bib0120","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1042\/cs0890177","article-title":"Contribution of vascular nitric oxide to basal blood pressure in conscious spontaneously hypertensive rats and normotensive Wistar Kyoto rats","volume":"89","author":"Minami","year":"1995","journal-title":"Clin. Sci. (Lond.)"},{"issue":"3","key":"10.1016\/j.biopha.2019.108996_bib0125","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1042\/cs1020269","article-title":"Altered balance of main vasopressor and vasodepressor systems in rats with genetic hypertension and hypertriglyceridaemia","volume":"102","author":"Kune\u0161","year":"2002","journal-title":"Clin. Sci. (Lond)"},{"key":"10.1016\/j.biopha.2019.108996_bib0130","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2005"},{"issue":"3","key":"10.1016\/j.biopha.2019.108996_bib0135","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/sj.bjp.0704100","article-title":"Regional haemodynamic responses to the cannabinoid agonist, WIN 55212-2, in conscious, normotensive rats, and in hypertensive, transgenic rats","volume":"133","author":"Gardiner","year":"2001","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.biopha.2019.108996_bib0140","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1161\/HYPERTENSIONAHA.109.145722","article-title":"Proton magnetic resonance spectroscopy detection of neurotransmitters in dorsomedial medulla correlates with spontaneous baroreceptor reflex function","volume":"55","author":"Garcia-Espinosa","year":"2010","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.biopha.2019.108996_bib0145","doi-asserted-by":"crossref","first-page":"13","DOI":"10.33549\/physiolres.932717","article-title":"Nifedipine-sensitive blood pressure component in hypertensive models characterized by high activity of either sympathetic nervous system or renin-angiotensin system","volume":"63","author":"Zicha","year":"2014","journal-title":"Physiol. Res."},{"issue":"Suppl I","key":"10.1016\/j.biopha.2019.108996_bib0150","first-page":"I163","article-title":"The ventrolateral medulla. A new site of action of the renin-angiotensin system","volume":"11","author":"Andreatta","year":"1988","journal-title":"Hypertension"},{"issue":"1 Pt 2","key":"10.1016\/j.biopha.2019.108996_bib0155","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1161\/01.HYP.33.1.385","article-title":"Increased central angiotensin and osmotic responses in the Ren-2 transgenic rat","volume":"33","author":"Nishioka","year":"1999","journal-title":"Hypertension"},{"issue":"6","key":"10.1016\/j.biopha.2019.108996_bib0160","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1097\/FJC.0b013e3181734a54","article-title":"Angiotensin-(1-7) and baroreflex function in nucleus tractus solitarii of (mRen2)27 transgenic rats","volume":"51","author":"Diz","year":"2008","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"4","key":"10.1016\/j.biopha.2019.108996_bib0165","doi-asserted-by":"crossref","first-page":"H1540","DOI":"10.1152\/ajpheart.00593.2011","article-title":"Sex differences in baroreflex sensitivity, heart rate variability, and end organ damage in the TGR(mRen2)27 rat","volume":"301","author":"Johnson","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"1","key":"10.1016\/j.biopha.2019.108996_bib0170","first-page":"H52","article-title":"Neurohumoral contributions to chronic angiotensin-induced hypertension","volume":"250","author":"Bruner","year":"1986","journal-title":"Am. J. Physiol."},{"issue":"10","key":"10.1016\/j.biopha.2019.108996_bib0175","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1097\/00004872-199816100-00016","article-title":"Increased pressor function of central vasopressinergic system in hypertensive renin transgenic rats","volume":"16","author":"Szczepa\u0144ska-Sadowska","year":"1998","journal-title":"J. Hypertens."},{"issue":"5-6","key":"10.1016\/j.biopha.2019.108996_bib0180","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1440-1681.2005.04205.x","article-title":"Long-term regulation of arterial blood pressure by hypothalamic nuclei: some critical questions","volume":"32","author":"Dampney","year":"2005","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"9","key":"10.1016\/j.biopha.2019.108996_bib0185","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.2174\/138920111798281126","article-title":"The role of brain gaseous transmitters in the regulation of the circulatory system","volume":"12","author":"Ufnal","year":"2011","journal-title":"Curr. Pharm. Biotechnol."},{"issue":"10","key":"10.1016\/j.biopha.2019.108996_bib0190","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/hr.2013.73","article-title":"Regulation of the sympathetic nervous system by nitric oxide and oxidative stress in the rostral ventrolateral medulla","volume":"36","author":"Kishi","year":"2013","journal-title":"Hypertens. Res."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219309850?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219309850?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T16:54:38Z","timestamp":1793897678000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332219309850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":38,"alternative-id":["S0753332219309850"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.108996","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of angiotensin II in chronic blood pressure control of heterozygous Ren-2 transgenic rats: Peripheral vasoconstriction versus central sympathoexcitation","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.108996","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"108996"}}