{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T17:26:54Z","timestamp":1793899614996,"version":"4.8.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T00:00:00Z","timestamp":1558396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin City","doi-asserted-by":"publisher","award":["18JCQNJC11100"],"award-info":[{"award-number":["18JCQNJC11100"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin City","doi-asserted-by":"publisher","award":["18JCQNJC13400"],"award-info":[{"award-number":["18JCQNJC13400"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010041","name":"Tianjin Science and Technology Committee","doi-asserted-by":"publisher","award":["15ZXLCSY00030"],"award-info":[{"award-number":["15ZXLCSY00030"]}],"id":[{"id":"10.13039\/501100010041","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.biopha.2019.109012","type":"journal-article","created":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T06:03:37Z","timestamp":1558937017000},"page":"109012","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["Treatment with 3,4-dihydroxyphenylethyl alcohol glycoside ameliorates sepsis-induced ALI in mice by reducing inflammation and regulating M1 polarization"],"prefix":"10.1016","volume":"116","author":[{"given":"Yuzhen","family":"Zhuo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dihua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shukun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanqiu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ximo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.biopha.2019.109012_bib0005","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4161\/viru.27372","article-title":"Epidemiology of severe sepsis","volume":"5","author":"Mayr","year":"2014","journal-title":"Virulence"},{"key":"10.1016\/j.biopha.2019.109012_bib0010","doi-asserted-by":"crossref","first-page":"16045","DOI":"10.1038\/nrdp.2016.45","article-title":"Sepsis and septic shock","volume":"2","author":"Hotchkiss","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"16","key":"10.1016\/j.biopha.2019.109012_bib0015","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJMoa050333","article-title":"Incidence and outcomes of acute lung injury","volume":"353","author":"Rubenfeld","year":"2005","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.biopha.2019.109012_bib0020","first-page":"1","article-title":"Inflammatory processes during acute respiratory distress syndrome:a complex system","volume":"24","author":"Reiss","year":"2018","journal-title":"Curr. Opin. Crit. Care"},{"issue":"3","key":"10.1016\/j.biopha.2019.109012_bib0025","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/cc11144","article-title":"Clinical review: early treatment of acute lung injury-paradigm shift toward prevention and treatment prior to respiratory failure","volume":"16","author":"Levitt","year":"2012","journal-title":"Crit. Care"},{"key":"10.1016\/j.biopha.2019.109012_bib0030","unstructured":"Editorial Board of ZhongHua BenCao of State Administration of Traditional Chinese Medicine, in \u00b4ZhongHua BenCao\u00b4 1st edn, Shanghai Science and Technology Press, Shanghai, 1999, vol. 8, p. 338."},{"key":"10.1016\/j.biopha.2019.109012_bib0035","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.intimp.2017.09.012","article-title":"Protective role of liriodendrin in mice with dextran sulphate sodium-induced ulcerative colitis","volume":"52","author":"Zhang","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.biopha.2019.109012_bib0040","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/8509858","article-title":"Simultaneous determination of four active ingredients in Sargentodoxa cuneata by HPLC coupled with evaporative light scattering detection","volume":"2016","author":"Li","year":"2016","journal-title":"Int. J. Anal. Chem."},{"issue":"4","key":"10.1016\/j.biopha.2019.109012_bib0045","doi-asserted-by":"crossref","first-page":"104","DOI":"10.5897\/JMPR2014.5658","article-title":"Anti-in\ufb02ammatory and immunoregulatory properties of fractions from Sargentodoxa cuneata ethanol extract","volume":"9","author":"Ma","year":"2015","journal-title":"J. Med. Plants Res."},{"key":"10.1016\/j.biopha.2019.109012_bib0050","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.lwt.2007.03.011","article-title":"Antioxidant properties in vitro and total phenolic contents in methanol extracts from medicinal plants","volume":"41","author":"Li","year":"2008","journal-title":"LWT-Food Sci. Technol."},{"key":"10.1016\/j.biopha.2019.109012_bib0055","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.fitote.2015.01.008","article-title":"Antimicrobial and cytotoxic phenolics and phenolic glycosides from Sargentodoxa cuneata","volume":"101","author":"Zeng","year":"2015","journal-title":"Fitoterapia"},{"issue":"8","key":"10.1016\/j.biopha.2019.109012_bib0060","doi-asserted-by":"crossref","first-page":"991","DOI":"10.3390\/molecules21080991","article-title":"Phenylethanoid glycosides: research advances in their phytochemistry, pharmacological activity and pharmacokinetics","volume":"21","author":"Xue","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2019.109012_bib0065","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.biopha.2018.05.072","article-title":"Echinacoside alleviated LPS-induced cell apoptosis and in ammation in rat intestine epithelial cells by inhibiting the mTOR\/STAT3 pathway","volume":"104","author":"Li","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.biopha.2019.109012_bib0070","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19041135","article-title":"Neuroprotective effects of four phenylethanoid glycosides on H\u2082O\u2082-induced apoptosis on PC12 cells via the Nrf2\/ARE pathway","volume":"19","author":"Li","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2019.109012_bib0075","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1016\/j.fct.2012.01.019","article-title":"Cytotoxic and antioxidative activities of Plantago lagopus L. and characterization of its bioactive compounds","volume":"50","author":"Harput","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2019.109012_bib0080","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jep.2015.07.019","article-title":"Anti-influenza virus effects of crude phenylethanoid glycosides isolated from Ligustrum purpurascens via inducing endogenous interferon-\u03b3","volume":"179","author":"Hu","year":"2015","journal-title":"J. Ethnopharmacol."},{"issue":"9-10","key":"10.1016\/j.biopha.2019.109012_bib0085","first-page":"710","article-title":"New phenylethanoid glycosides from Cistanche phelypaea and their activity as inhibitors of monoacylglycerol lipase (MAGL)","volume":"84","author":"Beladjila","year":"2018","journal-title":"Planta Med."},{"key":"10.1016\/j.biopha.2019.109012_bib0090","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/978-3-319-54090-0_12","article-title":"Macrophage dysfunction in respiratory disease","volume":"62","author":"Belchamber","year":"2017","journal-title":"Results Probl. Cell Differ."},{"key":"10.1016\/j.biopha.2019.109012_bib0095","first-page":"750","article-title":"Transcriptional regulation of macrophage polarization: enabling diversity with identity. Nature reviews","volume":"11","author":"Lawrence","year":"2011","journal-title":"Immunology"},{"issue":"2011","key":"10.1016\/j.biopha.2019.109012_bib0100","first-page":"723","article-title":"Protective and pathogenic functions of macrophage subsets. Nature reviews","volume":"11","author":"Murray","year":"2011","journal-title":"Immunology"},{"issue":"5","key":"10.1016\/j.biopha.2019.109012_bib0105","doi-asserted-by":"crossref","first-page":"e2763","DOI":"10.1038\/cddis.2017.102","article-title":"Ubiquitylation of MFHAS1 by the ubiquitin ligase praja2 promotes M1 macrophage polarization by activating JNK and p38 pathways","volume":"8","author":"Zhong","year":"2017","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.biopha.2019.109012_bib0110","first-page":"4449","article-title":"Effect of bone marrow mesenchymal stem cells on the polarization of macrophages","author":"Zheng","year":"2018","journal-title":"Mol. Med. Rep."},{"issue":"3","key":"10.1016\/j.biopha.2019.109012_bib0115","doi-asserted-by":"crossref","first-page":"253","DOI":"10.7150\/ijbs.23489","article-title":"Instillation of particulate matter 2.5 induced acute lung injury and attenuated the injury recovery in ACE2 knockout mice","volume":"4","author":"Lin","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.biopha.2019.109012_bib0120","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.intimp.2016.04.004","article-title":"Salidroside attenuates inflammatory response via suppressing JAK2-STAT3 pathway activation and preventing STAT3 transfer into nucleus","volume":"35","author":"Qi","year":"2016","journal-title":"Int. Immunopharmacol."},{"issue":"3","key":"10.1016\/j.biopha.2019.109012_bib0125","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1142\/S0192415X18500349","article-title":"Asatone prevents acute lung injury by reducing expressions of NF-\u03baB, MAPK and inflammatory cytokines","volume":"46","author":"Chang","year":"2018","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.biopha.2019.109012_bib0130","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.intimp.2018.11.005","article-title":"Obeticholic acid alleviate lipopolysaccharide-induced acute lung injury via its anti-inflammatory effects in mice","volume":"66","author":"Fei","year":"2019","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"10.1016\/j.biopha.2019.109012_bib0135","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.jgr.2017.05.005","article-title":"Ginsenosides from Korean Red Ginseng ameliorate lung inflammatory responses: inhibition of the MAPKs\/NF-\u03baB\/c-Fos pathways","volume":"42","author":"Lee","year":"2018","journal-title":"J. Ginseng Res."},{"key":"10.1016\/j.biopha.2019.109012_bib0140","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.1038\/s41598-019-38926-8","article-title":"Purification of 3, 4-dihydroxyphenylethyl alcohol glycoside from Sargentodoxa cuneata (Oliv.) Rehd. et Wils. and its protective effects against DSS-induced colitis","volume":"9","author":"Li","year":"2019","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.biopha.2019.109012_bib0145","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1007\/s10753-018-0819-2","article-title":"Resolvin D1 promotes SIRT1 expression to counteract the activation of STAT3 and NF-\u03baB in mice with septic-associated lung injury","volume":"41","author":"Zhuo","year":"2018","journal-title":"Inflammation"},{"issue":"4","key":"10.1016\/j.biopha.2019.109012_bib0150","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3760\/cma.j.issn.0366-6999.2009.04.0017","article-title":"Severity of sepsis is correlated with the elevation of serum high-mobility group box 1 in rats","volume":"122","author":"Hou","year":"2009","journal-title":"Chin. Med. J. (Engl.)"},{"issue":"1","key":"10.1016\/j.biopha.2019.109012_bib0155","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s12866-018-1227-3","article-title":"Gold nanoparticles attenuates bacterial sepsis in cecal ligation and puncture mouse model through the induction of M2 macrophage polarization","volume":"18","author":"Taratummarat","year":"2018","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.biopha.2019.109012_bib0160","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.pharmthera.2017.02.040","article-title":"Recent advances in the pathophysiology and molecular basis of sepsis-associated organ dysfunction: novel therapeutic implications and challenges","volume":"177","author":"Hattori","year":"2017","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.biopha.2019.109012_bib0165","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1097\/CCM.0b013e31827e83af","article-title":"Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012","volume":"41","author":"Dellinger","year":"2013","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.biopha.2019.109012_bib0170","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.tim.2011.01.001","article-title":"Cecal ligation and puncture:the gold standard model for polymicrobial sepsis?","volume":"19","author":"Dejager","year":"2011","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.biopha.2019.109012_bib0175","doi-asserted-by":"crossref","first-page":"i1585","DOI":"10.1136\/bmj.i1585","article-title":"Sepsis:pathophysiology and clinical management","volume":"353","author":"Gotts","year":"2016","journal-title":"BMJ"},{"key":"10.1016\/j.biopha.2019.109012_bib0180","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.bcp.2018.08.013","article-title":"Bumetanide attenuates acute lung injury by suppressing macrophage activation","volume":"156","author":"Hung","year":"2018","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2019.109012_bib0185","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1038\/s41467-017-02351-0","article-title":"Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis","volume":"8","author":"Guo","year":"2017","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.biopha.2019.109012_bib0190","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1152\/ajplung.00341.2013","article-title":"Diverse macrophage populations mediate acute lung inflammation and resolution","volume":"306","author":"Aggarwal","year":"2014","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"issue":"50","key":"10.1016\/j.biopha.2019.109012_bib0195","doi-asserted-by":"crossref","first-page":"8151","DOI":"10.1073\/pnas.1614935113","article-title":"TNF\u03b1-stimulated gene-6 (TSG6) activates macrophage phenotype transition to prevent inflammatory lung injury","volume":"113","author":"Mittal","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.biopha.2019.109012_bib0200","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nri3600","article-title":"Alveolar macrophages: plasticity in a tissue-specific context","volume":"14","author":"Hussell","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.biopha.2019.109012_bib0205","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.intimp.2018.07.040","article-title":"MicroRNA-146a protects against LPS-induced organ damage by inhibiting Notch1 in macrophage","volume":"63","author":"Bai","year":"2018","journal-title":"Int. Immunopharmacol."},{"issue":"7","key":"10.1016\/j.biopha.2019.109012_bib0210","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00011-017-1039-1","article-title":"Daphnetin reduces endotoxin lethality in mice and decreases LPS-induced inflammation in Raw264.7 cells via suppressing JAK\/STATs activation and ROS production","volume":"66","author":"Shen","year":"2017","journal-title":"Inflamm. Res."},{"issue":"1","key":"10.1016\/j.biopha.2019.109012_bib0215","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/ni.3618","article-title":"The signaling adaptor TRAF1 negatively regulates toll-like receptor signaling and this underlies its role in rheumatic disease","volume":"18","author":"Abdul-Sater","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.biopha.2019.109012_bib0220","doi-asserted-by":"crossref","first-page":"5321","DOI":"10.1021\/jf405113g","article-title":"Methanol extract of antrodia camphorata protects against lipopolysaccharide-induced acute lung injury by suppressing NF-\u03baB and MAPK pathways in mice","volume":"62","author":"Huang","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.biopha.2019.109012_bib0225","first-page":"575","article-title":"Organ dysfunction following hemorrhage and sepsis: mechanisms and herapeutic approaches (Review)","volume":"4","author":"Jarrar","year":"1999","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.biopha.2019.109012_bib0230","doi-asserted-by":"crossref","first-page":"S459","DOI":"10.1086\/431997","article-title":"Alterations in cell signaling in sepsis","volume":"41","author":"Abraham","year":"2005","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.biopha.2019.109012_bib0235","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/S1357-2725(02)00049-3","article-title":"Sepsis:current concepts in intracellular signaling","volume":"34","author":"Strassheim","year":"2002","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"1","key":"10.1016\/j.biopha.2019.109012_bib0240","doi-asserted-by":"crossref","first-page":"gmr7348","DOI":"10.4238\/gmr.15017348","article-title":"Interleukin-4 regulates macrophage polarization via the MAPK signaling pathway to protect against atherosclerosis","volume":"15","author":"Zhao","year":"2016","journal-title":"Genet. Mol. Res."},{"key":"10.1016\/j.biopha.2019.109012_bib0245","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.canlet.2012.06.006","article-title":"STAT3 activation by IL-6 from mesenchymal stem cells promotes the proliferation and metastasis of osteosarcoma","volume":"325","author":"Tu","year":"2012","journal-title":"Cancer Lett."},{"issue":"3","key":"10.1016\/j.biopha.2019.109012_bib0250","doi-asserted-by":"crossref","first-page":"253","DOI":"10.7150\/ijbs.23489","article-title":"Instillation of particulate matter 2.5 induced acute lung injury and attenuated the injury recovery in ACE2 knockout mice","volume":"14","author":"Lin","year":"2018","journal-title":"Int. J. Biol. Sci."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219314428?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219314428?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T16:50:06Z","timestamp":1793897406000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332219314428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":50,"alternative-id":["S0753332219314428"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109012","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treatment with 3,4-dihydroxyphenylethyl alcohol glycoside ameliorates sepsis-induced ALI in mice by reducing inflammation and regulating M1 polarization","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"109012"}}