{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:57:52Z","timestamp":1773925072678,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T00:00:00Z","timestamp":1559088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009601","name":"Beijing Municipal Administration of Hospitals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81541155"],"award-info":[{"award-number":["81541155"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7152064"],"award-info":[{"award-number":["7152064"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.biopha.2019.109048","type":"journal-article","created":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T23:05:52Z","timestamp":1559948752000},"page":"109048","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["An acellular tissue matrix-based drug carriers with dual chemo-agents for colon cancer growth suppression"],"prefix":"10.1016","volume":"117","author":[{"given":"Changfu","family":"Qin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingmo","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoshan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuefei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.biopha.2019.109048_bib0005","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1158\/1940-6207.CAPR-14-0469","article-title":"Cancer prevention research in China","volume":"8","author":"Yu","year":"2015","journal-title":"Cancer Prev. Res. Phila. (Phila)"},{"issue":"7","key":"10.1016\/j.biopha.2019.109048_bib0010","doi-asserted-by":"crossref","first-page":"211","DOI":"10.4251\/wjgo.v6.i7.211","article-title":"Advances and new perspectives in the treatment of metastatic colon cancer","volume":"6","author":"Recondo","year":"2014","journal-title":"World J. Gastrointest. Oncol."},{"issue":"8","key":"10.1016\/j.biopha.2019.109048_bib0015","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.biopha.2014.10.019","article-title":"Colon cancer: cancer stem cells markers, drug resistance and treatment","volume":"68","author":"Kozovska","year":"2014","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.biopha.2019.109048_bib0020","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s12272-013-0276-2","article-title":"Cancer multidrug resistance: mechanisms involved and strategies for circumvention using a drug delivery system","volume":"37","author":"Kibria","year":"2014","journal-title":"Arch. Pharm. Res."},{"issue":"10","key":"10.1016\/j.biopha.2019.109048_bib0025","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1097\/CAD.0b013e32834a4554","article-title":"Targeting of nanoparticles in cancer: drug delivery and diagnostics","volume":"22","author":"Talekar","year":"2011","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.biopha.2019.109048_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2017.04.008","article-title":"Chitosan-modified PLGA nanoparticles tagged with 5TR1 aptamer for in vivo tumor-targeted drug delivery","volume":"400","author":"Taghavi","year":"2017","journal-title":"Cancer Lett."},{"issue":"12","key":"10.1016\/j.biopha.2019.109048_bib0035","doi-asserted-by":"crossref","first-page":"6661","DOI":"10.1021\/am509204u","article-title":"Polymeric nanomedicine for tumor-targeted combination therapy to elicit synergistic genotoxicity against prostate cancer","volume":"7","author":"Yang","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"8","key":"10.1016\/j.biopha.2019.109048_bib0040","first-page":"563","article-title":"Biopolymeric alginate-chitosan nanoparticles as drug delivery carriers for cancer therapy","volume":"69","author":"Bhunchu","year":"2014","journal-title":"Pharmazie"},{"key":"10.1016\/j.biopha.2019.109048_bib0045","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.addr.2015.10.023","article-title":"Dual delivery of biological therapeutics for multimodal and synergistic cancer therapies","volume":"98","author":"Jang","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"9","key":"10.1016\/j.biopha.2019.109048_bib0050","first-page":"1982","article-title":"Rapamycin enhances apoptosis and increases sensitivity to cisplatin in vitro","volume":"55","author":"Shi","year":"1995","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.biopha.2019.109048_bib0055","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.cell.2017.02.004","article-title":"mTOR signaling in growth, metabolism, and disease","volume":"168","author":"Saxton","year":"2017","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.biopha.2019.109048_bib0060","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nrc1074","article-title":"5-fluorouracil: mechanisms of action and clinical strategies","volume":"3","author":"Longley","year":"2003","journal-title":"Nat. Rev. Cancer"},{"issue":"3","key":"10.1016\/j.biopha.2019.109048_bib0065","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.cmet.2014.01.001","article-title":"Rapamycin: one drug, many effects","volume":"19","author":"Li","year":"2014","journal-title":"Cell Metab."},{"issue":"11","key":"10.1016\/j.biopha.2019.109048_bib0070","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1002\/cncr.29254","article-title":"Phase 1b study of the mammalian target of rapamycin inhibitor sirolimus in combination with nanoparticle albumin-bound paclitaxel in patients with advanced solid tumors","volume":"121","author":"Abu-Khalaf","year":"2015","journal-title":"Cancer"},{"key":"10.1016\/j.biopha.2019.109048_bib0075","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3389\/fsurg.2015.00048","article-title":"Biological meshes for inguinal hernia repair - review of the literature","volume":"2","author":"Kockerling","year":"2015","journal-title":"Front. Surg."},{"issue":"9","key":"10.1016\/j.biopha.2019.109048_bib0080","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1111\/bph.13059","article-title":"Transdermal patches: history, development and pharmacology","volume":"172","author":"Pastore","year":"2015","journal-title":"Br. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.biopha.2019.109048_bib0085","first-page":"333","article-title":"An eligible biological allograft patch in tension-free herniorrhaphy of swine","volume":"6","author":"Deng","year":"2012","journal-title":"Biosci. Trends"},{"key":"10.1016\/j.biopha.2019.109048_bib0090","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jconrel.2016.06.015","article-title":"A 3D-printed local drug delivery patch for pancreatic cancer growth suppression","volume":"238","author":"Yi","year":"2016","journal-title":"J. Control. Release"},{"issue":"3","key":"10.1016\/j.biopha.2019.109048_bib0095","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jconrel.2010.02.022","article-title":"Prevention of in vivo lung tumor growth by prolonged local delivery of hydroxycamptothecin using poly(ester-carbonate)-collagen composites","volume":"144","author":"Wolinsky","year":"2010","journal-title":"J. Control. Release"},{"key":"10.1016\/j.biopha.2019.109048_bib0100","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/s13019-014-0163-z","article-title":"The \"cut-in patch-out\" technique for Pancoast tumor resections results in postoperative pain reduction: a case control study","volume":"9","author":"Weber","year":"2014","journal-title":"J. Cardiothorac. Surg."},{"issue":"25","key":"10.1016\/j.biopha.2019.109048_bib0105","doi-asserted-by":"crossref","first-page":"40140","DOI":"10.18632\/oncotarget.17370","article-title":"Locally-applied 5-fluorouracil-loaded slow-release patch prevents pancreatic cancer growth in an orthotopic mouse model","volume":"8","author":"Shim","year":"2017","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.biopha.2019.109048_bib0110","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2174\/1567201811666140822112516","article-title":"Nanomedicines based drug delivery systems for anti-cancer targeting and treatment","volume":"12","author":"Jain","year":"2015","journal-title":"Curr. Drug Deliv."},{"issue":"3","key":"10.1016\/j.biopha.2019.109048_bib0115","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.addr.2010.10.008","article-title":"PLGA nanoparticles containing various anticancer agents and tumour delivery by EPR effect","volume":"63","author":"Acharya","year":"2011","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"2","key":"10.1016\/j.biopha.2019.109048_bib0120","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2174\/1574892811308020003","article-title":"Targeted drug delivery for breast cancer treatment","volume":"8","author":"Jin","year":"2013","journal-title":"Recent Pat. Anticancer Drug Discov."},{"issue":"11","key":"10.1016\/j.biopha.2019.109048_bib0125","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1002\/ijc.24990","article-title":"Rapamycin enhances chemotherapy-induced cytotoxicity by inhibiting the expressions of TS and ERK in gastric cancer cells","volume":"126","author":"Shigematsu","year":"2010","journal-title":"Int. J. Cancer"},{"issue":"1","key":"10.1016\/j.biopha.2019.109048_bib0130","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.canlet.2010.07.020","article-title":"RAD001 shows activity against gastric cancer cells and overcomes 5-FU resistance by downregulating thymidylate synthase","volume":"299","author":"Lee","year":"2010","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.biopha.2019.109048_bib0135","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1177\/0885328215569614","article-title":"Albumin-based micro-composite drug carriers with dual chemo-agents for targeted breast cancer treatment","volume":"30","author":"Abedin","year":"2015","journal-title":"J. Biomater. Appl."},{"key":"10.1016\/j.biopha.2019.109048_bib0140","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.addr.2016.06.018","article-title":"Polylactic acid (PLA) controlled delivery carriers for biomedical applications","volume":"107","author":"Tyler","year":"2016","journal-title":"Adv. Drug Deliv. Rev."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219307887?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219307887?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T09:15:18Z","timestamp":1773911718000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332219307887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":28,"alternative-id":["S0753332219307887"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109048","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An acellular tissue matrix-based drug carriers with dual chemo-agents for colon cancer growth suppression","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"109048"}}