{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T19:48:54Z","timestamp":1779911334785,"version":"3.53.1"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T00:00:00Z","timestamp":1561420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81730012"],"award-info":[{"award-number":["81730012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.biopha.2019.109176","type":"journal-article","created":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T18:35:03Z","timestamp":1562006103000},"page":"109176","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Daming capsule, a hypolipidaemic drug, lowers blood lipids by activating the AMPK signalling pathway"],"prefix":"10.1016","volume":"117","author":[{"given":"Yu","family":"Bian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaming","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hangfei","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueling","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baofeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.biopha.2019.109176_bib0005","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.tcm.2013.07.003","article-title":"Hyperlipidemia, tissue factor, coagulation, and simvastatin","volume":"24","author":"Owens","year":"2014","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.biopha.2019.109176_bib0010","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.atherosclerosissup.2015.02.029","article-title":"Practical recommendations for the management of hyperlipidemia","volume":"18","author":"Fischer","year":"2015","journal-title":"Atheroscler. Suppl."},{"issue":"3","key":"10.1016\/j.biopha.2019.109176_bib0015","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s11910-016-0621-1","article-title":"Guidelines for management of hyperlipidemia: implications for treatment of patients with stroke secondary to atherosclerotic disease","volume":"16","author":"Dandapat","year":"2016","journal-title":"Curr. Neurol. Neurosci. Rep."},{"issue":"13","key":"10.1016\/j.biopha.2019.109176_bib0020","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1021\/acs.jafc.6b00290","article-title":"Isoorientin prevents hyperlipidemia and liver injury by regulating lipid metabolism, antioxidant capability, and inflammatory cytokine release in high-fructose-fed mice","volume":"64","author":"Yuan","year":"2016","journal-title":"J. Agric. Food Chem."},{"issue":"35","key":"10.1016\/j.biopha.2019.109176_bib0025","doi-asserted-by":"crossref","first-page":"4934","DOI":"10.3748\/wjg.v18.i35.4934","article-title":"Coexistence of hyperlipidemia and acute cerebral ischemia\/reperfusion induces severe liver damage in a rat model","volume":"18","author":"Gong","year":"2012","journal-title":"World J. Gastroenterol."},{"issue":"3","key":"10.1016\/j.biopha.2019.109176_bib0030","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1096\/fj.201601022R","article-title":"Hypolipidemic effect of oleanolic acid is mediated by the miR-98-5p\/PGC-1beta axis in high-fat diet-induced hyperlipidemic mice","volume":"31","author":"Chen","year":"2017","journal-title":"FASEB J."},{"issue":"9493","key":"10.1016\/j.biopha.2019.109176_bib0035","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S0140-6736(05)67394-1","article-title":"Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins","volume":"366","author":"Baigent","year":"2005","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.biopha.2019.109176_bib0040","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.atherosclerosis.2010.02.020","article-title":"Long-term coronary heart disease risk associated with very-low-density lipoprotein cholesterol in Chinese: the results of a 15-Year Chinese Multi-Provincial Cohort Study (CMCS)","volume":"211","author":"Ren","year":"2010","journal-title":"Atherosclerosis"},{"issue":"25","key":"10.1016\/j.biopha.2019.109176_bib0045","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1161\/circ.106.25.3143","article-title":"Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report","volume":"106","year":"2002","journal-title":"Circulation"},{"issue":"25 Pt B","key":"10.1016\/j.biopha.2019.109176_bib0050","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1016\/j.jacc.2013.11.002","article-title":"2013 ACC\/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines","volume":"63","author":"Stone","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"issue":"25 Suppl 2","key":"10.1016\/j.biopha.2019.109176_bib0055","first-page":"S1","article-title":"2013 ACC\/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines","volume":"129","author":"Stone","year":"2014","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.biopha.2019.109176_bib0060","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jacl.2015.02.003","article-title":"National lipid association recommendations for patient-centered management of dyslipidemia: part 1--full report","volume":"9","author":"Jacobson","year":"2015","journal-title":"J. Clin. Lipidol."},{"issue":"4","key":"10.1016\/j.biopha.2019.109176_bib0065","doi-asserted-by":"crossref","first-page":"296","DOI":"10.5551\/jat.19737","article-title":"Diagnosis of atherosclerosis. Executive summary of the japan atherosclerosis society (JAS) guidelines for the diagnosis and prevention of atherosclerotic cardiovascular diseases in Japan-2012 version","volume":"21","author":"Teramoto","year":"2014","journal-title":"J. Atheroscler. Thromb."},{"issue":"2","key":"10.1016\/j.biopha.2019.109176_bib0070","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1096\/fj.11-194019","article-title":"Sustained activation of PPARalpha by endogenous ligands increases hepatic fatty acid oxidation and prevents obesity in ob\/ob mice","volume":"26","author":"Huang","year":"2012","journal-title":"FASEB J."},{"issue":"9","key":"10.1016\/j.biopha.2019.109176_bib0075","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1002\/jssc.201401269","volume":"38","author":"An","year":"2015","journal-title":"J. Sep. Sci."},{"issue":"7","key":"10.1016\/j.biopha.2019.109176_bib0080","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/ptr.2654","article-title":"A randomized, multicentre, open-label, parallel-group trial to compare the efficacy and safety profile of daming capsule in patients with hypercholesterolemia","volume":"23","author":"Jing","year":"2009","journal-title":"Phytother. Res."},{"issue":"8","key":"10.1016\/j.biopha.2019.109176_bib0085","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1248\/bpb.32.1354","article-title":"The protective effect of Daming capsule on heart function in streptozocin-induced diabetic rats with hyperlipidemia","volume":"32","author":"Ai","year":"2009","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.biopha.2019.109176_bib0090","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/1472-6882-10-80","article-title":"Protective effect of the daming capsule on impaired baroreflexes in STZ-induced diabetic rats with hyperlipoidemia","volume":"10","author":"Ai","year":"2010","journal-title":"BMC Complement. Altern. Med."},{"issue":"26","key":"10.1016\/j.biopha.2019.109176_bib0095","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.2174\/138161210793176464","article-title":"The efficacy and safety of herbal medicines used in the treatment of hyperlipidemia; a systematic review","volume":"16","author":"Hasani-Ranjbar","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.biopha.2019.109176_bib0100","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1472-6882-12-21","article-title":"Daming capsule restores endothelial dysfunction induced by high-fat diet","volume":"12","author":"Zhang","year":"2012","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.biopha.2019.109176_bib0105","doi-asserted-by":"crossref","first-page":"34284","DOI":"10.1038\/srep34284","article-title":"The anti-hyperglycemic efficacy of a lipid-lowering drug Daming capsule and the underlying signaling mechanisms in a rat model of diabetes mellitus","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2019.109176_bib0110","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1186\/s12906-015-0826-x","article-title":"The anti-inflammatory and antifibrotic effects of Coreopsis tinctoria Nutt on high-glucose-fat diet and streptozotocin-induced diabetic renal damage in rats","volume":"15","author":"Yao","year":"2015","journal-title":"BMC Complement. Altern. Med."},{"issue":"10","key":"10.1016\/j.biopha.2019.109176_bib0115","first-page":"17295","article-title":"Hawthorn leaf flavonoids alleviate nonalcoholic fatty liver disease by enhancing the adiponectin\/AMPK pathway","volume":"8","author":"Li","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"issue":"2","key":"10.1016\/j.biopha.2019.109176_bib0120","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.mce.2012.06.019","article-title":"AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: implications for obesity","volume":"366","author":"O\u2019Neill","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.biopha.2019.109176_bib0125","first-page":"23","article-title":"Regulation of carbohydrate metabolism, lipid metabolism, and protein metabolism by AMPK","volume":"107","author":"Angin","year":"2016","journal-title":"Exp. Suppl."},{"issue":"4","key":"10.1016\/j.biopha.2019.109176_bib0130","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.cmet.2011.03.009","article-title":"AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice","volume":"13","author":"Li","year":"2011","journal-title":"Cell Metab."},{"issue":"5","key":"10.1016\/j.biopha.2019.109176_bib0135","doi-asserted-by":"crossref","first-page":"G1195","DOI":"10.1152\/ajpgi.00553.2006","article-title":"Regulation of Triglyceride Metabolism. II. Function of mitochondrial GPAT1 in the regulation of triacylglycerol biosynthesis and insulin action","volume":"292","author":"Gonzalez-Baro","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"1","key":"10.1016\/j.biopha.2019.109176_bib0140","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1097-2765(02)00822-5","article-title":"Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain","volume":"11","author":"Sever","year":"2003","journal-title":"Mol. Cell"},{"issue":"6","key":"10.1016\/j.biopha.2019.109176_bib0145","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.bbalip.2013.01.017","article-title":"Endoplasmic reticulum-localized hepatic lipase decreases triacylglycerol storage and VLDL secretion","volume":"1831","author":"Erickson","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"4","key":"10.1016\/j.biopha.2019.109176_bib0150","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1021\/jf802867b","article-title":"Compound K, intestinal metabolite of ginsenoside, attenuates hepatic lipid accumulation via AMPK activation in human hepatoma cells","volume":"57","author":"Kim","year":"2009","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"10.1016\/j.biopha.2019.109176_bib0155","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1055\/s-2004-822993","article-title":"Low-density lipoprotein receptor--its structure, function, and mutations","volume":"4","author":"Defesche","year":"2004","journal-title":"Semin. Vasc. Med."},{"key":"10.1016\/j.biopha.2019.109176_bib0160","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.biopha.2016.07.028","article-title":"Swertiamarin ameliorates oleic acid induced lipid accumulation and oxidative stress by attenuating gluconeogenesis and lipogenesis in hepatic steatosis","volume":"83","author":"Patel","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2019.109176_bib0165","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/978-3-642-17214-4_13","article-title":"AMP-activated protein kinase and metabolic control","volume":"203","author":"Viollet","year":"2011","journal-title":"Handb. Exp. Pharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2019.109176_bib0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0030782","article-title":"Mangiferin decreases plasma free fatty acids through promoting its catabolism in liver by activation of AMPK","volume":"7","author":"Niu","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.biopha.2019.109176_bib0175","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cmet.2004.12.003","article-title":"AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism","volume":"1","author":"Kahn","year":"2005","journal-title":"Cell Metab."},{"issue":"5","key":"10.1016\/j.biopha.2019.109176_bib0180","doi-asserted-by":"crossref","first-page":"E923","DOI":"10.1152\/ajpendo.00360.2002","article-title":"Potential mechanisms and consequences of cardiac triacylglycerol accumulation in insulin-resistant rats","volume":"284","author":"Atkinson","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.biopha.2019.109176_bib0185","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1161\/CIRCRESAHA.110.221713","article-title":"Preferential oxidation of triacylglyceride-derived fatty acids in heart is augmented by the nuclear receptor PPARalpha","volume":"107","author":"Banke","year":"2010","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.biopha.2019.109176_bib0190","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/aps.2011.165","article-title":"AVE8134, a novel potent PPARalpha agonist, improves lipid profile and glucose metabolism in dyslipidemic mice and type 2 diabetic rats","volume":"33","author":"Schafer","year":"2012","journal-title":"Acta Pharmacol. Sin."},{"issue":"5","key":"10.1016\/j.biopha.2019.109176_bib0195","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/00041433-199510000-00009","article-title":"Triglyceride lipases and atherosclerosis","volume":"6","author":"Olivecrona","year":"1995","journal-title":"Curr. Opin. Lipidol."},{"issue":"1","key":"10.1016\/j.biopha.2019.109176_bib0200","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/MOL.0b013e32834d0b33","article-title":"New wrinkles in lipoprotein lipase biology","volume":"23","author":"Davies","year":"2012","journal-title":"Curr. Opin. Lipidol."},{"issue":"2","key":"10.1016\/j.biopha.2019.109176_bib0205","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s10157-011-0549-3","article-title":"Lipoprotein lipase deficiency in chronic kidney disease is accompanied by down-regulation of endothelial GPIHBP1 expression","volume":"16","author":"Vaziri","year":"2012","journal-title":"Clin. Exp. Nephrol."},{"issue":"4","key":"10.1016\/j.biopha.2019.109176_bib0210","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1242\/dev.115.4.1035","article-title":"Perturbation of developmental gene expression in rat liver by fibric acid derivatives: lipoprotein lipase and alpha-fetoprotein as models","volume":"115","author":"Staels","year":"1992","journal-title":"Development"},{"issue":"7","key":"10.1016\/j.biopha.2019.109176_bib0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0132720","article-title":"Wedelolactone regulates lipid metabolism and improves hepatic steatosis partly by AMPK activation and up-regulation of expression of PPARalpha\/LPL and LDLR","volume":"10","author":"Zhao","year":"2015","journal-title":"PLoS One"},{"issue":"15","key":"10.1016\/j.biopha.2019.109176_bib0220","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1161\/01.CIR.97.15.1436","article-title":"Statin trials and goals of cholesterol-lowering therapy","volume":"97","author":"Grundy","year":"1998","journal-title":"Circulation"},{"issue":"21","key":"10.1016\/j.biopha.2019.109176_bib0225","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1001\/jama.282.21.2051","article-title":"An evidence-based assessment of the NCEP Adult Treatment Panel II guidelines. National Cholesterol Education Program","volume":"282","author":"Ansell","year":"1999","journal-title":"JAMA"},{"issue":"4746","key":"10.1016\/j.biopha.2019.109176_bib0230","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1126\/science.3513311","article-title":"A receptor-mediated pathway for cholesterol homeostasis","volume":"232","author":"Brown","year":"1986","journal-title":"Science"}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219320608?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219320608?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T23:11:40Z","timestamp":1778541100000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332219320608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":46,"alternative-id":["S0753332219320608"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109176","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Daming capsule, a hypolipidaemic drug, lowers blood lipids by activating the AMPK signalling pathway","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109176","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"109176"}}