{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T22:31:56Z","timestamp":1794609116310,"version":"4.9.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T00:00:00Z","timestamp":1562025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673668"],"award-info":[{"award-number":["81673668"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2014A030304059"],"award-info":[{"award-number":["2014A030304059"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2017A030313657"],"award-info":[{"award-number":["2017A030313657"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.biopha.2019.109195","type":"journal-article","created":{"date-parts":[[2019,7,27]],"date-time":"2019-07-27T17:16:10Z","timestamp":1564247770000},"page":"109195","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":173,"special_numbering":"C","title":["Curcumin attenuates potassium oxonate-induced hyperuricemia and kidney inflammation in mice"],"prefix":"10.1016","volume":"118","author":[{"given":"Yonger","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cantao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuni","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaozhen","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.biopha.2019.109195_bib0005","doi-asserted-by":"crossref","first-page":"656","DOI":"10.2741\/3950","article-title":"Uric acid, hyperuricemia and vascular diseases","volume":"17","author":"Jin","year":"2012","journal-title":"Front Biosci."},{"key":"10.1016\/j.biopha.2019.109195_bib0010","first-page":"1","article-title":"Prevalence of hyperuricemia and gout in mainland China from 2000 to 2014: a systematic review and meta-analysis","volume":"2015","author":"Liu","year":"2015","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.biopha.2019.109195_bib0015","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ijcard.2015.08.109","article-title":"Regulation of uric acid metabolism and excretion","volume":"213","author":"Maiuolo","year":"2016","journal-title":"Int. J. Cardiol."},{"issue":"1","key":"10.1016\/j.biopha.2019.109195_bib0020","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1124\/pr.58.1.6","article-title":"Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol","volume":"58","author":"Pacher","year":"2006","journal-title":"Pharmacol. Rev."},{"issue":"2","key":"10.1016\/j.biopha.2019.109195_bib0025","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s11926-012-0240-z","article-title":"Regulation of uric acid excretion by the kidney","volume":"14","author":"Lipkowitz","year":"2012","journal-title":"Curr. Rheumatol. Rep."},{"issue":"7329","key":"10.1016\/j.biopha.2019.109195_bib0030","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.biopha.2019.109195_bib0035","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1097\/01.mnh.0000444814.49755.90","article-title":"The emerging role of the inflammasome in kidney diseases","volume":"23","author":"Chang","year":"2014","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"issue":"5","key":"10.1016\/j.biopha.2019.109195_bib0040","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.3892\/ijmm.2015.2148","article-title":"Soluble uric acid increases NLRP3 inflammasome and interleukin-1\u03b2 expression in human primary renal proximal tubule epithelial cells through the toll-like receptor 4-mediated pathway","volume":"35","author":"Xiao","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.biopha.2019.109195_bib0045","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.cbi.2017.10.012","article-title":"Salidroside alleviates high glucose-induced oxidative stress and extracellular matrix accumulation in rat glomerular mesangial cells by the TXNIP-NLRP3 inflammasome pathway","volume":"278","author":"Wang","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.biopha.2019.109195_bib0050","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3389\/fphys.2018.00114","article-title":"Oxidative stress and NLRP3-inflammasome activity as significant drivers of diabetic cardiovascular complications: therapeutic implications","volume":"9","author":"Sharma","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.biopha.2019.109195_bib0055","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.molimm.2018.09.004","article-title":"Curcumin alleviates DSS-induced colitis via inhibiting NLRP3 inflammsome activation and IL-1\u03b2 production","volume":"104","author":"Gong","year":"2018","journal-title":"Mol. Immunol."},{"issue":"4","key":"10.1016\/j.biopha.2019.109195_bib0060","doi-asserted-by":"crossref","first-page":"6718","DOI":"10.1002\/jcb.27969","article-title":"Curcumin ameliorates monosodium urate-induced gouty arthritis through Nod-like receptor 3 inflammasome mediation via inhibiting nuclear factor-kappa B signaling","volume":"120","author":"Li","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.biopha.2019.109195_bib0065","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.fct.2018.12.002","article-title":"Mechanistic insights of hepatoprotective effects of curcumin: therapeutic updates and future prospects","volume":"124","author":"Khan","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2019.109195_bib0070","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/2418671","article-title":"Recent advances of curcumin in the prevention and treatment of renal fibrosis","volume":"2017","author":"Sun","year":"2017","journal-title":"Biomed Res. Int."},{"issue":"8","key":"10.1016\/j.biopha.2019.109195_bib0075","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1093\/ndt\/gfv067","article-title":"Interstitial eosinophilic aggregates in diabetic nephropathy: allergy or not?","volume":"30","author":"Dai","year":"2015","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.biopha.2019.109195_bib0080","doi-asserted-by":"crossref","DOI":"10.2337\/dc18-2173","article-title":"Uric acid is an independent risk factor for decline in kidney function","author":"Pilemann-Lyberg","year":"2019","journal-title":"Diabetes Care"},{"issue":"6","key":"10.1016\/j.biopha.2019.109195_bib0085","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1093\/ndt\/gfv024","article-title":"Hyperuricemia-induced inflammasome and kidney diseases","volume":"31","author":"Isaka","year":"2016","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.biopha.2019.109195_bib0090","first-page":"1","article-title":"Cardiovascular disease in gout and the protective effect of treatments including urate-lowering therapy","author":"Gupta","year":"2019","journal-title":"Drugs"},{"issue":"7","key":"10.1016\/j.biopha.2019.109195_bib0095","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1136\/gutjnl-2015-310297","article-title":"Titanium dioxide nanoparticles exacerbate dss-induced colitis: role of the NLRP3 inflammasome","volume":"66","author":"Ruiz","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.biopha.2019.109195_bib0100","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/ncomms1756","article-title":"Decreased extra-renal urate excretion is a common cause of hyperuricemia","volume":"3","author":"Ichida","year":"2012","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.biopha.2019.109195_bib0105","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/acr.20065","article-title":"Hyperuricemia and coronary heart disease: a systematic review and meta-analysis","volume":"62","author":"Kim","year":"2010","journal-title":"Arthritis Care Res."},{"issue":"1","key":"10.1016\/j.biopha.2019.109195_bib0110","doi-asserted-by":"crossref","first-page":"R4","DOI":"10.1186\/ar3552","article-title":"Association between being african-american, serum urate levels and the risk of developing hyperuricemia: findings from the coronary artery risk development in young adult cohort","volume":"14","author":"Gaffo","year":"2012","journal-title":"Arthritis Res. Ther."},{"issue":"1","key":"10.1016\/j.biopha.2019.109195_bib0115","doi-asserted-by":"crossref","first-page":"13646","DOI":"10.1038\/s41598-018-32006-z","article-title":"Bacillus velezensis A2 fermentation exerts a protective effect on renal injury induced by zearalenone in mice","volume":"8","author":"Wang","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2019.109195_bib0120","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.bios.2018.08.074","article-title":"Layer-by-layer electrochemical biosensors configuring xanthine oxidase and carbon nanotubes\/graphene complexes for hypoxanthine and uric acid in human serum solutions","volume":"121","author":"Si","year":"2018","journal-title":"Biosens. Bioelectron."},{"issue":"3","key":"10.1016\/j.biopha.2019.109195_bib0125","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.jep.2005.08.040","article-title":"Effects of cassia oil on serum and hepatic uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver","volume":"103","author":"Zhao","year":"2006","journal-title":"J. Ethnopharmacol."},{"issue":"12","key":"10.1016\/j.biopha.2019.109195_bib0130","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/gm118","article-title":"What lies behind serum urate concentration? Insights from genetic and genomic studies","volume":"1","author":"Ichida","year":"2009","journal-title":"Genome Med."},{"issue":"2","key":"10.1016\/j.biopha.2019.109195_bib0135","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s11926-012-0240-z","article-title":"Regulation of uric acid excretion by the kidney","volume":"14","author":"Lipkowitz","year":"2012","journal-title":"Curr. Rheumatol. Rep."},{"issue":"8","key":"10.1016\/j.biopha.2019.109195_bib0140","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.4049\/jimmunol.1700796","article-title":"Targeting peroxiredoxin 1 by a curcumin analogue, AI-44, inhibits NLRP3 inflammasome activation and attenuates lipopolysaccharide-induced sepsis in mice","volume":"201","author":"Wen","year":"2018","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.biopha.2019.109195_bib0145","doi-asserted-by":"crossref","first-page":"39551","DOI":"10.1038\/srep39551","article-title":"Suppression of NLRP3 inflammasome activation ameliorates chronic kidney disease-induced cardiac fibrosis and diastolic dysfunction","volume":"6","author":"Bugyei-Twum","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.biopha.2019.109195_bib0150","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00018-010-0450-3","article-title":"Involvement of xanthine oxidase and hypoxia-inducible factor 1 in Toll-like receptor 7\/8-mediated activation of caspase 1 and interleukin-1\u03b2","volume":"68","author":"Nicholas","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"issue":"9","key":"10.1016\/j.biopha.2019.109195_bib0155","doi-asserted-by":"crossref","first-page":"F993","DOI":"10.1152\/ajprenal.00637.2014","article-title":"Hyperuricemia-induced NLRP3 activation of macrophages contributes to the progression of diabetic nephropathy","volume":"308","author":"Kim","year":"2015","journal-title":"Am. J. Physiol. Renal Physiol."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S075333221932462X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S075333221932462X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T11:58:58Z","timestamp":1776427138000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S075333221932462X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":31,"alternative-id":["S075333221932462X"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109195","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Curcumin attenuates potassium oxonate-induced hyperuricemia and kidney inflammation in mice","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109195","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"109195"}}