{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:29:12Z","timestamp":1793042952975,"version":"4.5.0"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T00:00:00Z","timestamp":1562630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570344"],"award-info":[{"award-number":["81570344"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004032","name":"Jilin University","doi-asserted-by":"publisher","award":["2015203"],"award-info":[{"award-number":["2015203"]}],"id":[{"id":"10.13039\/501100004032","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004032","name":"Jilin University","doi-asserted-by":"publisher","award":["2015225"],"award-info":[{"award-number":["2015225"]}],"id":[{"id":"10.13039\/501100004032","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.biopha.2019.109217","type":"journal-article","created":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T18:28:16Z","timestamp":1562869696000},"page":"109217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"special_numbering":"C","title":["The role of NLRP3 inflammasome activation in radiation damage"],"prefix":"10.1016","volume":"118","author":[{"given":"Jinlong","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heru","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingbin","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2019.109217_bib0005","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1080\/09553002.2018.1440092","article-title":"Mechanisms of inflammatory responses to radiation and normal tissues toxicity: clinical implications","volume":"94","author":"Najafi","year":"2018","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.biopha.2019.109217_bib0010","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4252\/wjsc.v5.i3.68","article-title":"Fifteen years of preclinical and clinical experiences about biotherapy treatment of lesions induced by accidental irradiation and radiotherapy","volume":"5","author":"Chapel","year":"2013","journal-title":"World J. Stem Cells"},{"key":"10.1016\/j.biopha.2019.109217_bib0015","first-page":"1206","article-title":"NLRP3 inflammasome induces pyroptosis in lung tissues of radiation-induced lung injury in mice","volume":"33","author":"Han","year":"2017","journal-title":"Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi"},{"key":"10.1016\/j.biopha.2019.109217_bib0020","doi-asserted-by":"crossref","DOI":"10.3390\/toxins8050131","article-title":"Regulatory T cells contribute to the inhibition of radiation-induced acute lung inflammation via bee venom phospholipase a(2) in mice","volume":"8","author":"Shin","year":"2016","journal-title":"Toxins"},{"key":"10.1016\/j.biopha.2019.109217_bib0025","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.etap.2015.02.019","article-title":"The inflammasome accelerates radiation-induced lung inflammation and fibrosis in mice","volume":"39","author":"Sohn","year":"2015","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.biopha.2019.109217_bib0030","doi-asserted-by":"crossref","first-page":"e2579","DOI":"10.1038\/cddis.2016.460","article-title":"NLRP3 inflammasome activation mediates radiation-induced pyroptosis in bone marrow-derived macrophages","volume":"8","author":"Liu","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.biopha.2019.109217_bib0035","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.it.2005.06.004","article-title":"NLRs join TLRs as innate sensors of pathogens","volume":"26","author":"Martinon","year":"2005","journal-title":"Trends Immunol."},{"key":"10.1016\/j.biopha.2019.109217_bib0040","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.redox.2015.01.008","article-title":"NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases","volume":"4","author":"Abderrazak","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.biopha.2019.109217_bib0045","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nri2936","article-title":"Emerging inflammasome effector mechanisms","volume":"11","author":"Lamkanfi","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.biopha.2019.109217_bib0050","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.cell.2014.04.007","article-title":"Mechanisms and functions of inflammasomes","volume":"157","author":"Lamkanfi","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2019.109217_bib0055","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2019.109217_bib0060","doi-asserted-by":"crossref","first-page":"982","DOI":"10.15252\/embr.201438463","article-title":"Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming","volume":"15","author":"Allam","year":"2014","journal-title":"EMBO Rep."},{"key":"10.1016\/j.biopha.2019.109217_bib0065","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jaad.2005.08.054","article-title":"Radiation dermatitis: clinical presentation, pathophysiology, and treatment 2006","volume":"54","author":"Hymes","year":"2006","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.biopha.2019.109217_bib0070","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.immuni.2007.03.008","article-title":"Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of toll-like receptor signaling","volume":"26","author":"Kanneganti","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.biopha.2019.109217_bib0075","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/ni.1636","article-title":"The NALP3 inflammasome is involved in the innate immune response to amyloid-beta","volume":"9","author":"Halle","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.biopha.2019.109217_bib0080","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/ni.1631","article-title":"Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization","volume":"9","author":"Hornung","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.biopha.2019.109217_bib0085","doi-asserted-by":"crossref","first-page":"e6510","DOI":"10.1371\/journal.pone.0006510","article-title":"Malarial hemozoin is a Nalp3 inflammasome activating danger signal","volume":"4","author":"Dostert","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2019.109217_bib0090","doi-asserted-by":"crossref","first-page":"9035","DOI":"10.1073\/pnas.0803933105","article-title":"The Nalp3 inflammasome is essential for the development of silicosis","volume":"105","author":"Cassel","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biopha.2019.109217_bib0095","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1074\/jbc.M608083200","article-title":"ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages","volume":"282","author":"Cruz","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2019.109217_bib0100","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1126\/science.1156995","article-title":"Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica","volume":"320","author":"Dostert","year":"2008","journal-title":"Science (New York, NY)"},{"key":"10.1016\/j.biopha.2019.109217_bib0105","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1667\/RR1948.1","article-title":"Novel synthetic SOD\/catalase mimetics can mitigate capillary endothelial cell apoptosis caused by ionizing radiation","volume":"173","author":"Vorotnikova","year":"2010","journal-title":"Radiat. Res."},{"key":"10.1016\/j.biopha.2019.109217_bib0110","first-page":"149","article-title":"Radiation-induced reactive oxygen species formation prior to oxidative DNA damage in human peripheral T cells","volume":"11","author":"Ogawa","year":"2003","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.biopha.2019.109217_bib0115","doi-asserted-by":"crossref","first-page":"5885","DOI":"10.1038\/sj.onc.1206701","article-title":"MAPK pathways in radiation responses","volume":"22","author":"Dent","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.biopha.2019.109217_bib0120","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0300-483X(00)00302-4","article-title":"NF-kappaB activation in response to toxical and therapeutical agents: role in inflammation and cancer treatment","volume":"153","author":"Bours","year":"2000","journal-title":"Toxicology"},{"key":"10.1016\/j.biopha.2019.109217_bib0125","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/jpi.12191","article-title":"Melatonin blunts the mitochondrial\/NLRP3 connection and protects against radiation-induced oral mucositis","volume":"58","author":"Ortiz","year":"2015","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.biopha.2019.109217_bib0130","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1600-065X.2011.01043.x","article-title":"Sensing damage by the NLRP3 inflammasome","volume":"243","author":"Leemans","year":"2011","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.biopha.2019.109217_bib0135","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nrd3800","article-title":"Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases","volume":"11","author":"Dinarello","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.biopha.2019.109217_bib0140","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1002\/eji.201141550","article-title":"A clinical perspective of IL-1beta as the gatekeeper of inflammation","volume":"41","author":"Dinarello","year":"2011","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.biopha.2019.109217_bib0145","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev.immunol.25.022106.141627","article-title":"Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (*)","volume":"27","author":"Masters","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.biopha.2019.109217_bib0150","doi-asserted-by":"crossref","first-page":"C1100","DOI":"10.1152\/ajpcell.00494.2003","article-title":"Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release","volume":"286","author":"Kahlenberg","year":"2004","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.biopha.2019.109217_bib0155","doi-asserted-by":"crossref","first-page":"9745","DOI":"10.1073\/pnas.0308558101","article-title":"Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: implications for inflammatory processes","volume":"101","author":"Andrei","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biopha.2019.109217_bib0160","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1146\/annurev.immunol.021908.132612","article-title":"Immunological and inflammatory functions of the interleukin-1 family","volume":"27","author":"Dinarello","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.biopha.2019.109217_bib0165","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S1359-6101(00)00015-0","article-title":"Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu","volume":"12","author":"Nakanishi","year":"2001","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.biopha.2019.109217_bib0170","doi-asserted-by":"crossref","first-page":"11340","DOI":"10.1073\/pnas.152337799","article-title":"IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE\/stat6 under specific pathogen-free conditions","volume":"99","author":"Konishi","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biopha.2019.109217_bib0175","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nature11588","article-title":"The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP","volume":"492","author":"Lee","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2019.109217_bib0180","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1038\/ncomms2339","article-title":"Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors","volume":"3","author":"Rossol","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biopha.2019.109217_bib0185","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.it.2014.02.007","article-title":"Calcium signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasome","volume":"35","author":"Horng","year":"2014","journal-title":"Trends Immunol."},{"key":"10.1016\/j.biopha.2019.109217_bib0190","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.cell.2007.11.028","article-title":"Calcium signaling","volume":"131","author":"Clapham","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2019.109217_bib0195","doi-asserted-by":"crossref","first-page":"11282","DOI":"10.1073\/pnas.1117765109","article-title":"Critical role for calcium mobilization in activation of the NLRP3 inflammasome","volume":"109","author":"Murakami","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biopha.2019.109217_bib0200","first-page":"81","article-title":"Calcium in health and disease","volume":"13","author":"Brini","year":"2013","journal-title":"Met. Ions Life Sci."},{"key":"10.1016\/j.biopha.2019.109217_bib0205","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1111\/php.12725","article-title":"Ultraviolet radiation-induced downregulation of SERCA2 mediates activation of NLRP3 inflammasome in basal cell carcinoma","volume":"93","author":"Ahmad","year":"2017","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.biopha.2019.109217_bib0210","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1667\/RR3255.1","article-title":"Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients","volume":"180","author":"Ryan","year":"2013","journal-title":"Radiat. Res."},{"key":"10.1016\/j.biopha.2019.109217_bib0215","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.mrrev.2016.08.004","article-title":"Human epidermal stem cells: role in adverse skin reactions and carcinogenesis from radiation","volume":"770","author":"Martin","year":"2016","journal-title":"Mutat. Res."},{"key":"10.1016\/j.biopha.2019.109217_bib0220","series-title":"World Wide Wounds","article-title":"The pathophysiology of vulnerable skin","author":"Flour","year":"1991"},{"key":"10.1016\/j.biopha.2019.109217_bib0225","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1097\/01.COC.0000071418.12121.C2","article-title":"Severe radiation dermatitis is related to Staphylococcus aureus","volume":"27","author":"Hill","year":"2004","journal-title":"Am. J. Clin. Oncol."},{"key":"10.1016\/j.biopha.2019.109217_bib0230","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nchembio.1548","article-title":"Multifaceted pathways protect human skin from UV radiation","volume":"10","author":"Natarajan","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.biopha.2019.109217_bib0235","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.bbrc.2016.06.106","article-title":"Nuclear DNA damage-triggered NLRP3 inflammasome activation promotes UVB-induced inflammatory responses in human keratinocytes","volume":"477","author":"Hasegawa","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2019.109217_bib0240","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.cub.2007.05.074","article-title":"The inflammasome mediates UVB-induced activation and secretion of interleukin-1beta by keratinocytes","volume":"17","author":"Feldmeyer","year":"2007","journal-title":"Curr. Biol.: CB."},{"key":"10.1016\/j.biopha.2019.109217_bib0245","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1007\/s00520-013-1810-y","article-title":"Emerging evidence on the pathobiology of mucositis","volume":"21","author":"Al-Dasooqi","year":"2013","journal-title":"Supportive Care in Cancer"},{"key":"10.1016\/j.biopha.2019.109217_bib0250","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3892\/mco.2014.253","article-title":"Oral mucositis in cancer treatment: natural history, prevention and treatment","volume":"2","author":"Campos","year":"2014","journal-title":"Mol. Clin. Oncol."},{"key":"10.1016\/j.biopha.2019.109217_bib0255","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2019.109217_bib0260","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nrgastro.2014.46","article-title":"Radiation enteropathy\u2013pathogenesis, treatment and prevention","volume":"11","author":"Hauer-Jensen","year":"2014","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.biopha.2019.109217_bib0265","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1056\/NEJMra000365","article-title":"Major radiation exposure\u2013what to expect and how to respond","volume":"346","author":"Mettler","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biopha.2019.109217_bib0270","first-page":"4338","article-title":"Microvascular function regulates intestinal crypt response to radiation","volume":"63","author":"Maj","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.biopha.2019.109217_bib0275","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.3748\/wjg.v13.i22.3047","article-title":"Significance of endothelial dysfunction in the pathogenesis of early and delayed radiation enteropathy","volume":"13","author":"Wang","year":"2007","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.biopha.2019.109217_bib0280","article-title":"Irradiation induced injury reduces energy metabolism in small intestine of Tibet minipigs","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2019.109217_bib0285","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ijrobp.2018.01.035","article-title":"Protective effects of flagellin a N\/C against radiation-induced NLR pyrin domain containing 3 inflammasome-dependent pyroptosis in intestinal cells","volume":"101","author":"Wu","year":"2018","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.biopha.2019.109217_bib0290","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0174474","article-title":"Melatonin protects rats from radiotherapy-induced small intestine toxicity","volume":"12","author":"Fernandez-Gil","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2019.109217_bib0295","doi-asserted-by":"crossref","first-page":"S-497","DOI":"10.1016\/S0016-5085(18)31885-7","article-title":"Su1185 - NLRP3 inflammasomes contribute to inflammation and regeneration in radiation-induced enteritis","volume":"154","author":"Ito","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biopha.2019.109217_bib0300","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.ijrobp.2009.09.070","article-title":"Stereotactic body radiation therapy for patients with lung cancer previously treated with thoracic radiation","volume":"78","author":"Kelly","year":"2010","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.biopha.2019.109217_bib0305","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1667\/RR1522.1","article-title":"Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice","volume":"173","author":"Lee","year":"2010","journal-title":"Radiat. Res."},{"key":"10.1016\/j.biopha.2019.109217_bib0310","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1053\/j.seminoncol.2005.03.009","article-title":"Non-small cell lung cancer therapy-related pulmonary toxicity: an update on radiation pneumonitis and fibrosis","volume":"32","author":"Kong","year":"2005","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.biopha.2019.109217_bib0315","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1748-717X-2-21","article-title":"Exceptionally high incidence of symptomatic grade 2-5 radiation pneumonitis after stereotactic radiation therapy for lung tumors","volume":"2","author":"Yamashita","year":"2007","journal-title":"Radiation Oncol. (Lond., Engl.)"},{"key":"10.1016\/j.biopha.2019.109217_bib0320","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1165\/rcmb.2015-0231TR","article-title":"Regulation and function of the nucleotide binding domain leucine-rich repeat-containing receptor, pyrin domain-containing-3 inflammasome in lung disease","volume":"54","author":"Lee","year":"2016","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.biopha.2019.109217_bib0325","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1128\/IAI.74.3.1471-1479.2006","article-title":"Interleukin-5 (IL-5) augments the progression of liver fibrosis by regulating IL-13 activity","volume":"74","author":"Reiman","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.biopha.2019.109217_bib0330","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1172\/JCI30595","article-title":"Infectious disease, the innate immune response, and fibrosis","volume":"117","author":"Meneghin","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.biopha.2019.109217_bib0335","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/1948985","article-title":"Mesenchymal stem cells attenuate radiation-induced brain injury by inhibiting microglia pyroptosis","volume":"2017","author":"Liao","year":"2017","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.biopha.2019.109217_bib0340","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S1470-2045(14)71207-0","volume":"16","author":"Bradley","year":"2015","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.biopha.2019.109217_bib0345","doi-asserted-by":"crossref","first-page":"e170","DOI":"10.1016\/S1470-2045(13)70569-2","article-title":"Radiotherapy for renal-cell carcinoma","volume":"15","author":"De Meerleer","year":"2014","journal-title":"Lancet Oncol."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219325259?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219325259?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T12:16:21Z","timestamp":1776428181000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332219325259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":69,"alternative-id":["S0753332219325259"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109217","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of NLRP3 inflammasome activation in radiation damage","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109217","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"109217"}}