{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T20:03:31Z","timestamp":1778789011197,"version":"3.51.4"},"reference-count":17,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T00:00:00Z","timestamp":1563148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001560","name":"Conservation, Food and Health Foundation","doi-asserted-by":"publisher","award":["2018-4-4231"],"award-info":[{"award-number":["2018-4-4231"]}],"id":[{"id":"10.13039\/100001560","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013091","name":"Science and Technology Major Project of Guangxi","doi-asserted-by":"publisher","award":["2015ZX09501004-003-002"],"award-info":[{"award-number":["2015ZX09501004-003-002"]}],"id":[{"id":"10.13039\/501100013091","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013091","name":"Science and Technology Major Project of Guangxi","doi-asserted-by":"publisher","award":["2017ZX09201002-006"],"award-info":[{"award-number":["2017ZX09201002-006"]}],"id":[{"id":"10.13039\/501100013091","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013091","name":"Science and Technology Major Project of Guangxi","doi-asserted-by":"publisher","award":["2017ZX09201002-007"],"award-info":[{"award-number":["2017ZX09201002-007"]}],"id":[{"id":"10.13039\/501100013091","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.biopha.2019.109226","type":"journal-article","created":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:38:56Z","timestamp":1564619936000},"page":"109226","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Comparative study of the efficacy and pharmacokinetics of reduning injection and atomization inhalation"],"prefix":"10.1016","volume":"118","author":[{"given":"Guangping","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingfei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tengfei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunhang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongxiu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haijing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuguang","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongping","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.biopha.2019.109226_bib0005","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0254-6272(14)60005-4","article-title":"Reduning injection for fever, rash, and ulcers in children with mild hand, foot, and mouth disease: a randomized controlled clinical study","volume":"33","author":"Zhang","year":"2013","journal-title":"J. Tradit. Chin. Med."},{"issue":"8","key":"10.1016\/j.biopha.2019.109226_bib0010","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s11655-014-1758-x","article-title":"Anti-inflammatory effects of reduning injection on lipopolysaccharide-induced acute lung injury of rats","volume":"20","author":"Tang","year":"2014","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.biopha.2019.109226_bib0015","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/4895672","article-title":"Identification of the allergenic ingredients in reduning injection by ultrafiltration and high-performance liquid chromatography","volume":"2016","author":"Wang","year":"2016","journal-title":"J. Immunol. Res."},{"issue":"24","key":"10.1016\/j.biopha.2019.109226_bib0020","first-page":"4762","article-title":"Analysis of the allergic reaction types of Chinese medicine injection based on immunotoxicty","volume":"40","author":"Wang","year":"2015","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"issue":"24","key":"10.1016\/j.biopha.2019.109226_bib0025","first-page":"3539","article-title":"Reduning injection for community-acquired pneumonia: meta-analysis","volume":"36","author":"Gao","year":"2011","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"issue":"3","key":"10.1016\/j.biopha.2019.109226_bib0030","first-page":"505","article-title":"Physical fingerprint for quality control of Reduning injection","volume":"42","author":"Wu","year":"2017","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"issue":"6","key":"10.1016\/j.biopha.2019.109226_bib0035","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0254-6272(14)60005-4","article-title":"Reduning injection for fever, rash, and ulcers in children with mild hand, foot, and mouth disease: a randomized controlled clinical study","volume":"33","author":"Zhang","year":"2013","journal-title":"J. Tradit. Chin. Med."},{"issue":"6","key":"10.1016\/j.biopha.2019.109226_bib0040","first-page":"663","article-title":"Depyrogenation in key manufacturing processes of Reduning injection","volume":"36","author":"Li","year":"2011","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"issue":"12","key":"10.1016\/j.biopha.2019.109226_bib0045","first-page":"211","article-title":"Measurement of aerosol particles and their distribution in the respiratory tract","volume":"758\u2013760","author":"Nebulized inhalation","year":"1974","journal-title":"Zhonghua Yi Xue Za Zhi"},{"issue":"3","key":"10.1016\/j.biopha.2019.109226_bib0050","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1378\/chest.96.3.505","article-title":"Importance of evaporative water losses during standardized nebulized inhalation provocation tests","volume":"96","author":"Cockcroft","year":"1989","journal-title":"Chest"},{"key":"10.1016\/j.biopha.2019.109226_bib0055","first-page":"288","article-title":"Announcement of the state food and drug administration on the issuance of the pharmacopoeia of the People\u2019s Republic of China (2015 Edition)","volume":"04","author":"Administration CFAD","year":"2015","journal-title":"Drug Stand. China"},{"issue":"16","key":"10.1016\/j.biopha.2019.109226_bib0060","first-page":"1912","article-title":"Study on analgesic and antipyretics effect of re-du-ning injection","volume":"09","author":"Chen","year":"2014","journal-title":"Modernization Tradit. Chin. Med. Materia Medica-World Sci. Technol."},{"issue":"20","key":"10.1016\/j.biopha.2019.109226_bib0065","first-page":"172","article-title":"Effect of reduning injection on acute lung injury of rats","volume":"22","author":"Chang","year":"2014","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"issue":"43","key":"10.1016\/j.biopha.2019.109226_bib0070","doi-asserted-by":"crossref","first-page":"643","DOI":"10.4103\/0973-1296.160465","article-title":"On-line quantitative monitoring of liquid-liquid extraction of Lonicera japonica and Artemisia annua using near-infrared spectroscopy and chemometrics","volume":"11","author":"Wu","year":"2015","journal-title":"Pharmacogn. Mag."},{"key":"10.1016\/j.biopha.2019.109226_bib0075","first-page":"61","article-title":"Clinical observation on curative effects of aerobic inhalation of Redu\u2019ning on acute upper respiratory tract infection in children","volume":"34","author":"Zhang","year":"2017","journal-title":"Clin. J. Chin. Med."},{"key":"10.1016\/j.biopha.2019.109226_bib0080","first-page":"158","article-title":"Clinical effects of ultrasonic inhalation of Redu\u2019ning on acute bronchitis in children","volume":"10","author":"Li","year":"2016","journal-title":"For all Health"},{"key":"10.1016\/j.biopha.2019.109226_bib0085","first-page":"10","article-title":"Clinical effects of ultrasonic inhalation of Redu\u2019ning on acute upper respiratory tract infection and fever","volume":"03","author":"Wang","year":"2011","journal-title":"Hubei J. Tradit. Chin."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S075333221932582X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S075333221932582X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T11:56:29Z","timestamp":1776426989000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S075333221932582X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":17,"alternative-id":["S075333221932582X"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109226","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative study of the efficacy and pharmacokinetics of reduning injection and atomization inhalation","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109226","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"109226"}}