{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:37:41Z","timestamp":1792521461672,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T00:00:00Z","timestamp":1563148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY17H020010"],"award-info":[{"award-number":["LY17H020010"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.biopha.2019.109227","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T09:50:08Z","timestamp":1563961808000},"page":"109227","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":143,"special_numbering":"C","title":["SIRT1 activation attenuates cardiac fibrosis by endothelial-to-mesenchymal transition"],"prefix":"10.1016","volume":"118","author":[{"given":"Zhen-Hua","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Fang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-sheng","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ping","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2019.109227_bib0005","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nrcardio.2010.165","article-title":"Epidemiology and risk profile of heart failure","volume":"8","author":"Bui","year":"2011","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.biopha.2019.109227_bib0010","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1001\/jama.2013.1363","article-title":"Association of fibrosis with mortality and sudden cardiac death in patients with nonischemic dilated cardiomyopathy","volume":"309","author":"Gulati","year":"2013","journal-title":"Jama"},{"key":"10.1016\/j.biopha.2019.109227_bib0015","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1139\/cjpp-2016-0687","article-title":"A primer on current progress in cardiac fibrosis","volume":"95","author":"Al Hattab","year":"2017","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.biopha.2019.109227_bib0020","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/nrrheum.2014.53","article-title":"Fibrosis-a lethal component of systemic sclerosis","volume":"10","author":"Ho","year":"2014","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.biopha.2019.109227_bib0025","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/j.ajpath.2012.02.004","article-title":"Recent developments in myofibroblast biology: paradigms for connective tissue remodeling","volume":"180","author":"Hinz","year":"2012","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.biopha.2019.109227_bib0030","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.exphem.2010.03.004","article-title":"Fibrocytes in health and disease","volume":"38","author":"Herzog","year":"2010","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.biopha.2019.109227_bib0035","doi-asserted-by":"crossref","first-page":"20202","DOI":"10.1074\/jbc.M110.102012","article-title":"Identification of epithelial to mesenchymal transition as a novel source of fibroblasts in intestinal fibrosis","volume":"285","author":"Flier","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2019.109227_bib0040","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/nm1613","article-title":"Endothelial-to-mesenchymal transition contributes to cardiac fibrosis","volume":"13","author":"Zeisberg","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.biopha.2019.109227_bib0045","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/path.4814","article-title":"Fine-tuning vascular fate during endothelial-mesenchymal transition","volume":"241","author":"Xiao","year":"2017","journal-title":"J. Pathol."},{"key":"10.1016\/j.biopha.2019.109227_bib0050","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nrm3758","article-title":"Molecular mechanisms of epithelial-mesenchymal transition","volume":"15","author":"Lamouille","year":"2014","journal-title":"Nat Rev Mol Cell Bio"},{"key":"10.1016\/j.biopha.2019.109227_bib0055","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.01985","article-title":"A potential link between oxidative stress and endothelial-to-Mesenchymal transition in systemic sclerosis","volume":"9","author":"Thuan","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.biopha.2019.109227_bib0060","first-page":"6485","article-title":"Roles of notch signaling pathway and endothelial-mesenchymal transition in vascular endothelial dysfunction and atherosclerosis","volume":"22","author":"Ling","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.biopha.2019.109227_bib0065","doi-asserted-by":"crossref","first-page":"492-+","DOI":"10.1038\/nature12207","article-title":"EndMT contributes to the onset and progression of cerebral cavernous malformations","volume":"498","author":"Maddaluno","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2019.109227_bib0070","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.ajpath.2011.06.001","article-title":"Role of endothelial-mesenchymal transition (EndoMT) in the pathogenesis of fibrotic disorders","volume":"179","author":"Piera-Velazquez","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.biopha.2019.109227_bib0075","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00018-013-1349-6","article-title":"The pathogenesis of cardiac fibrosis","volume":"71","author":"Kong","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.biopha.2019.109227_bib0080","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCRESAHA.109.216101","article-title":"Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction","volume":"107","author":"Dobaczewski","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.biopha.2019.109227_bib0085","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1161\/01.RES.0000187457.24338.3D","article-title":"NAD(P)H oxidase 4 mediates transforming growth factor-beta 1-induced differentiation of cardiac fibroblasts into myofibroblasts","volume":"97","author":"Cucoranu","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.biopha.2019.109227_bib0090","article-title":"Losartan attenuates myocardial endothelial-to-Mesenchymal transition in spontaneous hypertensive rats via inhibiting TGF-beta\/Smad signaling","volume":"11","author":"Wu","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2019.109227_bib0095","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18102157","article-title":"P. Ten Dijke, TGF-beta-Induced endothelial-mesenchymal transition in fibrotic diseases","volume":"18","author":"Pardali","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2019.109227_bib0100","doi-asserted-by":"crossref","first-page":"41361","DOI":"10.1074\/jbc.M204597200","article-title":"Modulation of Smad2-mediated signaling by extracellular signal-regulated kinase","volume":"277","author":"Funaba","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2019.109227_bib0105","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nature02006","article-title":"Smad-dependent and Smad-independent pathways in TGF-beta family signalling","volume":"425","author":"Derynck","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2019.109227_bib0110","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1093\/cvr\/cvy131","article-title":"Sirtuin 1 activation attenuates cardiac fibrosis in a rodent pressure overload model by modifying Smad2\/3 transactivation","volume":"114","author":"Bugyei-Twum","year":"2018","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.biopha.2019.109227_bib0115","article-title":"Geniposide alleviates isoproterenol-induced cardiac fibrosis partially via SIRT1 activation in vivo and in vitro","volume":"9","author":"Li","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.biopha.2019.109227_bib0120","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1136\/annrheumdis-2014-205740","article-title":"Sirt1 regulates canonical TGF-beta signalling to control fibroblast activation and tissue fibrosis","volume":"75","author":"Zerr","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.biopha.2019.109227_bib0125","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1111\/jcmm.13076","article-title":"CD38 promotes angiotensin II-induced cardiac hypertrophy","volume":"21","author":"Guan","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.biopha.2019.109227_bib0130","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.lfs.2013.12.011","article-title":"Potential of resveratrol in the treatment of heart failure","volume":"95","author":"Raj","year":"2014","journal-title":"Life Sci."},{"key":"10.1016\/j.biopha.2019.109227_bib0135","doi-asserted-by":"crossref","first-page":"H894","DOI":"10.1152\/ajpheart.00333.2014","article-title":"Indispensable role of endothelial nitric oxide synthase in caloric restriction-induced cardioprotection against ischemia-reperfusion injury, American journal of physiology","volume":"308","author":"Shinmura","year":"2015","journal-title":"Heart and circulatory physiology"},{"key":"10.1016\/j.biopha.2019.109227_bib0140","doi-asserted-by":"crossref","first-page":"8375","DOI":"10.1074\/jbc.M109.090266","article-title":"Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure","volume":"285","author":"Tanno","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2019.109227_bib0145","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1111\/acel.12220","article-title":"SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass","volume":"13","author":"Mercken","year":"2014","journal-title":"Aging Cell"},{"key":"10.1016\/j.biopha.2019.109227_bib0150","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0092-8674(95)90499-9","article-title":"Mutation in the silencing gene SIR4 can delay aging in S. Cerevisiae","volume":"80","author":"Kennedy","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2019.109227_bib0155","doi-asserted-by":"crossref","first-page":"682","DOI":"10.18632\/aging.100599","article-title":"Increased expression of Drosophila Sir2 extends life span in a dose-dependent manner","volume":"5","author":"Whitaker","year":"2013","journal-title":"Aging"},{"key":"10.1016\/j.biopha.2019.109227_bib0160","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.celrep.2012.11.013","article-title":"dSir2 in the adult fat body, but not in muscles, regulates life span in a diet-dependent manner","volume":"2","author":"Banerjee","year":"2012","journal-title":"Cell Rep."},{"key":"10.1016\/j.biopha.2019.109227_bib0165","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nrm.2016.93","article-title":"Slowing ageing by design: the rise of NAD(+) and sirtuin-activating compounds","volume":"17","author":"Bonkowski","year":"2016","journal-title":"Nat Rev Mol Cell Bio"},{"key":"10.1016\/j.biopha.2019.109227_bib0170","doi-asserted-by":"crossref","first-page":"8951","DOI":"10.1523\/JNEUROSCI.5657-12.2013","article-title":"A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration","volume":"33","author":"Graff","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.biopha.2019.109227_bib0175","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3109\/08977194.2011.595714","article-title":"TGF-beta signaling in fibrosis","volume":"29","author":"Biernacka","year":"2011","journal-title":"Growth Factors"},{"key":"10.1016\/j.biopha.2019.109227_bib0180","article-title":"Endothelial-to-mesenchymal transition in cardiovascular diseases: developmental signaling pathways gone awry","author":"S\u00e1nchez-Duffhues","year":"2017","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.biopha.2019.109227_bib0185","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00441-011-1222-6","article-title":"Regulation of endothelial cell plasticity by TGF-\u03b2","volume":"347","author":"van Meeteren","year":"2012","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.biopha.2019.109227_bib0190","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.26846","article-title":"SIRT1 inhibits TGF-beta-induced endothelial-mesenchymal transition in human endothelial cells with Smad4 deacetylation","author":"Li","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.biopha.2019.109227_bib0195","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1161\/CIRCRESAHA.116.305381","article-title":"Getting to the heart of the matter new insights into cardiac fibrosis","volume":"116","author":"Leask","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.biopha.2019.109227_bib0200","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.micinf.2015.04.002","article-title":"Adoptive transfer of CD4(+)Foxp3(+) regulatory T cells to C57BL\/6J mice during acute infection with Toxoplasma gondii down modulates the exacerbated T(h)1 immune response","volume":"17","author":"Olguin","year":"2015","journal-title":"Microbes Infect."},{"key":"10.1016\/j.biopha.2019.109227_bib0205","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1161\/CIRCULATIONAHA.112.001212","article-title":"Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of manganese superoxide dismutase via the SIRT1\/FoxO3a pathway","volume":"127","author":"Lai","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2019.109227_bib0210","doi-asserted-by":"crossref","first-page":"9705","DOI":"10.1007\/s11357-014-9705-5","article-title":"Resveratrol enhanced FOXO3 phosphorylation via synergetic activation of SIRT1 and PI3K\/Akt signaling to improve the effects of exercise in elderly rat hearts","volume":"36","author":"Lin","year":"2014","journal-title":"Age"},{"key":"10.1016\/j.biopha.2019.109227_bib0215","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.lfs.2017.07.014","article-title":"Endothelial to mesenchymal transition in the cardiovascular system","volume":"184","author":"Gong","year":"2017","journal-title":"Life Sci."},{"key":"10.1016\/j.biopha.2019.109227_bib0220","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0069452","article-title":"Resveratrol alleviates endotoxin-induced myocardial toxicity via the Nrf2 transcription factor","volume":"8","author":"Hao","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2019.109227_bib0225","doi-asserted-by":"crossref","DOI":"10.1186\/s12906-017-1915-9","article-title":"The protective effects of Resveratrol against radiation-induced intestinal injury","volume":"17","author":"Zhang","year":"2017","journal-title":"Bmc Complem Altern M"},{"key":"10.1016\/j.biopha.2019.109227_bib0230","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1055\/s-0042-124044","article-title":"Evodiamine prevents isoproterenol-induced cardiac fibrosis by regulating endothelial-to-Mesenchymal transition","volume":"83","author":"Jiang","year":"2017","journal-title":"Planta Med."},{"key":"10.1016\/j.biopha.2019.109227_bib0235","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.physbeh.2018.12.012","article-title":"Resveratrol prevents cognitive deficits by attenuating oxidative damage and inflammation in rat model of streptozotocin diabetes induced vascular dementia","volume":"201","author":"Gocmez","year":"2019","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.biopha.2019.109227_bib0240","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4103\/0253-7613.125167","article-title":"Protective effects of resveratrol against di-n buthyl phthalate induced toxicity in ductus epididymis and ductus deferens in rats","volume":"46","author":"Sahin","year":"2014","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/j.biopha.2019.109227_bib0245","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/aps.2017.50","article-title":"Resveratrol alleviates diabetic cardiomyopathy in rats by improving mitochondrial function through PGC-1 alpha deacetylation","volume":"39","author":"Fang","year":"2018","journal-title":"Acta Pharmacol. Sin."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219310212?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219310212?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T12:20:54Z","timestamp":1776428454000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332219310212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":49,"alternative-id":["S0753332219310212"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109227","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SIRT1 activation attenuates cardiac fibrosis by endothelial-to-mesenchymal transition","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109227","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"109227"}}