{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T12:49:28Z","timestamp":1776430168668,"version":"3.51.2"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010854","name":"Jiangsu Provincial Commission of Health and Family Planning","doi-asserted-by":"publisher","award":["H2017086"],"award-info":[{"award-number":["H2017086"]}],"id":[{"id":"10.13039\/501100010854","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013280","name":"Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013280","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81702422"],"award-info":[{"award-number":["81702422"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010023","name":"Natural Science Research of Jiangsu Higher Education Institutions of China","doi-asserted-by":"publisher","award":["17KJB320024"],"award-info":[{"award-number":["17KJB320024"]}],"id":[{"id":"10.13039\/501100010023","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.biopha.2019.109266","type":"journal-article","created":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T06:34:09Z","timestamp":1565246049000},"page":"109266","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Overexpression of SNORA21 suppresses tumorgenesis of gallbladder cancer in vitro and in vivo"],"prefix":"10.1016","volume":"118","author":[{"given":"Yiyu","family":"Qin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anxing","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.biopha.2019.109266_bib0005","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S1479-666X(08)80073-X","article-title":"Gallbladder cancer--a comprehensive review","volume":"6","author":"Lai","year":"2008","journal-title":"Surgeon"},{"issue":"8","key":"10.1016\/j.biopha.2019.109266_bib0010","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/ng.3030","article-title":"Whole-exome and targeted gene sequencing of gallbladder carcinoma identifies recurrent mutations in the ErbB pathway","volume":"46","author":"Li","year":"2014","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.biopha.2019.109266_bib0015","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.canlet.2009.02.020","article-title":"Identification of metastasis-associated proteins involved in gallbladder carcinoma metastasis by proteomic analysis and functional exploration of chloride intracellular channel 1","volume":"281","author":"Wang","year":"2009","journal-title":"Cancer Lett."},{"issue":"4 Pt B","key":"10.1016\/j.biopha.2019.109266_bib0020","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/j.bbadis.2017.07.027","article-title":"Current controversies in cholangiocarcinoma","volume":"1864","author":"Hoyos","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"issue":"1","key":"10.1016\/j.biopha.2019.109266_bib0025","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1475-2867-13-64","article-title":"Curcumin induces apoptosis in gallbladder carcinoma cell line GBC-SD cells","volume":"13","author":"Liu","year":"2013","journal-title":"Cancer Cell Int."},{"issue":"2","key":"10.1016\/j.biopha.2019.109266_bib0030","article-title":"Roles of non-coding RNAs in normal human brain development, brain tumor, and neuropsychiatric disorders","volume":"5","author":"Nie","year":"2019","journal-title":"Noncoding RNA"},{"issue":"1","key":"10.1016\/j.biopha.2019.109266_bib0035","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s13277-014-2818-8","article-title":"Small nucleolar RNAs functioning and potential roles in cancer","volume":"36","author":"Thorenoor","year":"2015","journal-title":"Tumour Biol."},{"issue":"22","key":"10.1016\/j.biopha.2019.109266_bib0040","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1038\/onc.2011.449","article-title":"Small nucleolar RNA 42 acts as an oncogene in lung tumorigenesis","volume":"31","author":"Mei","year":"2012","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.biopha.2019.109266_bib0045","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1136\/gutjnl-2015-309359","article-title":"Clinical significance of SNORA42 as an oncogene and a prognostic biomarker in colorectal cancer","volume":"66","author":"Okugawa","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.biopha.2019.109266_bib0050","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/1476-4598-13-216","article-title":"Small nucleolar RNA 113-1 suppresses tumorigenesis in hepatocellular carcinoma","volume":"13","author":"Xu","year":"2014","journal-title":"Mol. Cancer"},{"issue":"3","key":"10.1016\/j.biopha.2019.109266_bib0055","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.1093\/nar\/gni027","article-title":"A sequence-based identification of the genes detected by probesets on the Affymetrix U133 plus 2.0 array","volume":"33","author":"Harbig","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.biopha.2019.109266_bib0060","first-page":"332","article-title":"Establishing of human primary gallbladder cancer cell line GBC-SD","volume":"38","author":"W.Z","year":"2000","journal-title":"Acta Academiae medicinae Shandong"},{"issue":"4","key":"10.1016\/j.biopha.2019.109266_bib0065","first-page":"574","article-title":"Establishment of a cell line (G-415) from a human gallbladder carcinoma","volume":"71","author":"Koyama","year":"1980","journal-title":"Gan"},{"key":"10.1016\/j.biopha.2019.109266_bib0070","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1186\/s12885-016-2719-x","article-title":"Increased long noncoding RNA SNHG20 predicts poor prognosis in colorectal cancer","volume":"16","author":"Li","year":"2016","journal-title":"BMC Cancer"},{"key":"10.1016\/j.biopha.2019.109266_bib0075","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13046-015-0170-5","article-title":"Small nucleolar RNA 78 promotes the tumorigenesis in non-small cell lung cancer","volume":"34","author":"Zheng","year":"2015","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"9","key":"10.1016\/j.biopha.2019.109266_bib0080","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1038\/leu.2012.111","article-title":"Specific small nucleolar RNA expression profiles in acute leukemia","volume":"26","author":"Valleron","year":"2012","journal-title":"Leukemia"},{"issue":"17","key":"10.1016\/j.biopha.2019.109266_bib0085","first-page":"5519","article-title":"The SNORA21 expression is upregulated and acts as a novel independent indicator in human gastric cancer prognosis","volume":"22","author":"Liu","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.biopha.2019.109266_bib0090","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ebiom.2017.07.009","article-title":"SNORA21 - an oncogenic small nucleolar RNA, with a prognostic biomarker potential in human colorectal cancer","volume":"22","author":"Yoshida","year":"2017","journal-title":"EBioMedicine"},{"key":"10.1016\/j.biopha.2019.109266_bib0095","first-page":"1","article-title":"Effect of turkish Propolis on miRNA expression, cell cycle, and apoptosis in human breast cancer (MCF-7) cells","author":"Misir","year":"2019","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.biopha.2019.109266_bib0100","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1101\/pdb.prot087312","article-title":"Detecting cleaved caspase-3 in apoptotic cells by flow cytometry","volume":"2016","author":"Crowley","year":"2016","journal-title":"Cold Spring Harb. Protoc."},{"key":"10.1016\/j.biopha.2019.109266_bib0105","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a035196","article-title":"Creating a new Cancer Therapeutic agent by targeting the interaction between Bcl-2 and IP3 receptors","author":"Distelhorst","year":"2019","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.biopha.2019.109266_bib0110","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.intimp.2019.04.052","article-title":"Regulating effect of baicalin on IKK\/IKB\/NF-kB signaling pathway and apoptosis-related proteins in rats with ulcerative colitis","volume":"73","author":"Shen","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.biopha.2019.109266_bib0115","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.tox.2019.02.010","article-title":"Ginsenoside Rk1 induces cell cycle arrest and apoptosis in MDA-MB-231 triple negative breast cancer cells","volume":"418","author":"Hong","year":"2019","journal-title":"Toxicology"},{"issue":"5","key":"10.1016\/j.biopha.2019.109266_bib0120","doi-asserted-by":"crossref","DOI":"10.3390\/biom9050195","article-title":"Antiproliferative effect of aminoethyl-chitooligosaccharide on human lung A549 cancer cells","volume":"9","author":"Ngo","year":"2019","journal-title":"Biomolecules"},{"issue":"5","key":"10.1016\/j.biopha.2019.109266_bib0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0217037","article-title":"Loss of parkin reduces lung tumor development by blocking p21 degradation","volume":"14","author":"Park","year":"2019","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.biopha.2019.109266_bib0130","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1293\/tox.2019-0007","article-title":"Short-term detection of gastric genotoxicity using the DNA double-strand break marker gamma-H2AX","volume":"32","author":"Okabe","year":"2019","journal-title":"J. Toxicol. Pathol."},{"issue":"5","key":"10.1016\/j.biopha.2019.109266_bib0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0126522","article-title":"Stemness of the hybrid epithelial\/mesenchymal state in breast cancer and its association with poor survival","volume":"10","author":"Grosse-Wilde","year":"2015","journal-title":"PLoS One"},{"issue":"52","key":"10.1016\/j.biopha.2019.109266_bib0140","doi-asserted-by":"crossref","first-page":"29906","DOI":"10.18632\/oncotarget.25692","article-title":"A mechanism-based computational model to capture the interconnections among epithelial-mesenchymal transition, cancer stem cells and Notch-Jagged signaling","volume":"9","author":"Bocci","year":"2018","journal-title":"Oncotarget"},{"issue":"7702","key":"10.1016\/j.biopha.2019.109266_bib0145","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/s41586-018-0040-3","article-title":"Identification of the tumour transition states occurring during EMT","volume":"556","author":"Pastushenko","year":"2018","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.biopha.2019.109266_bib0150","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1016\/j.molonc.2015.04.016","article-title":"Autophagy induction impairs migration and invasion by reversing EMT in glioblastoma cells","volume":"9","author":"Catalano","year":"2015","journal-title":"Mol. Oncol."},{"issue":"1","key":"10.1016\/j.biopha.2019.109266_bib0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13577-016-0149-3","article-title":"Small cell lung cancer, an epithelial to mesenchymal transition (EMT)-like cancer: significance of inactive Notch signaling and expression of achaete-scute complex homologue 1","volume":"30","author":"Ito","year":"2017","journal-title":"Hum. Cell"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219324904?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219324904?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T11:56:35Z","timestamp":1776426995000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332219324904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":31,"alternative-id":["S0753332219324904"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109266","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Overexpression of SNORA21 suppresses tumorgenesis of gallbladder cancer in vitro and in vivo","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109266","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"109266"}}