{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:14:32Z","timestamp":1787505272168,"version":"build-2736575974"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007566","name":"City, University of London","doi-asserted-by":"publisher","award":["15-9-2-75-nsh"],"award-info":[{"award-number":["15-9-2-75-nsh"]}],"id":[{"id":"10.13039\/100007566","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31571829"],"award-info":[{"award-number":["31571829"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004295","name":"Shandong University of Science and Technology","doi-asserted-by":"publisher","award":["15-4-13-zdzx-hy"],"award-info":[{"award-number":["15-4-13-zdzx-hy"]}],"id":[{"id":"10.13039\/501100004295","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004295","name":"Shandong University of Science and Technology","doi-asserted-by":"publisher","award":["2014GGH215001"],"award-info":[{"award-number":["2014GGH215001"]}],"id":[{"id":"10.13039\/501100004295","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.biopha.2019.109280","type":"journal-article","created":{"date-parts":[[2019,11,9]],"date-time":"2019-11-09T00:27:06Z","timestamp":1573259226000},"page":"109280","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Effects and mechanisms of PSS-loaded nanoparticles on coronary microcirculation dysfunction in streptozotocin-induced diabetic cardiomyopathy rats"],"prefix":"10.1016","volume":"121","author":[{"given":"Yongjun","family":"Mao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengli","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huashi","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.biopha.2019.109280_bib0005","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1161\/CIRCRESAHA.117.311586","article-title":"Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity","volume":"122","author":"Jia","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.biopha.2019.109280_bib0010","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1161\/CIRCULATIONAHA.106.679597","article-title":"DPhil, diabetic cardiomyopathy revisited","volume":"115","author":"Boudina","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2019.109280_bib0015","first-page":"1","article-title":"Thymoquinone attenuates cardiomyopathy in streptozotocin-treated diabetic rats","author":"Atta","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.biopha.2019.109280_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/8095926","article-title":"Adipokines: potential therapeutic targets for vascular dysfunction in type II diabetes mellitus and obesity","author":"Mostafa Wanees Ahmed El husseny","year":"2017","journal-title":"J. Diabetes Res."},{"issue":"17","key":"10.1016\/j.biopha.2019.109280_bib0025","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1093\/eurheartj\/eht513","article-title":"Coronary microvascular dysfunction: an update","volume":"35","author":"Crea","year":"2014","journal-title":"Eur. Heart J."},{"issue":"1","key":"10.1016\/j.biopha.2019.109280_bib0030","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12968-017-0397-8","article-title":"Adenosine stress CMR T1-mapping detects early microvascular dysfunction in patients with type 2 diabetes mellitus without obstructive coronary artery disease","volume":"19","author":"Levelt","year":"2017","journal-title":"J. Cardiovasc. Magn. Reson."},{"issue":"15","key":"10.1016\/j.biopha.2019.109280_bib0035","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1161\/CIRCULATIONAHA.112.120402","article-title":"Association between coronary vascular dysfunction and cardiac mortality in patients with and without diabetes mellitus","volume":"126","author":"Murthy","year":"2012","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.biopha.2019.109280_bib0040","doi-asserted-by":"crossref","first-page":"377","DOI":"10.4330\/wjc.v2.i11.377","article-title":"Coronary microvascular dysfunction in diabetes mellitus: a review","volume":"2","author":"Picchi","year":"2010","journal-title":"World J. Cardiol."},{"key":"10.1016\/j.biopha.2019.109280_bib0045","first-page":"1","article-title":"Development of an enteric nanoparticle of marine sulfated polysaccharide propylene glycol alginate sodium sulfate for oral administration: formulation design, pharmacokinetics and efficacy","author":"Li","year":"2018","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.biopha.2019.109280_bib0050","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ejmech.2016.02.063","article-title":"Anticoagulant and antithrombotic activities of low-molecular-weight propylene glycol alginate sodium sulfate (PSS)","volume":"114","author":"Xin","year":"2016","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"10.1016\/j.biopha.2019.109280_bib0055","doi-asserted-by":"crossref","first-page":"15175","DOI":"10.1038\/s41598-017-15521-3","article-title":"The liver protection of propylene glycol alginate sodium sulfate preconditioning against ischemia reperfusion injury: focusing MAPK pathway activity","volume":"7","author":"Xu","year":"2017","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.biopha.2019.109280_bib0060","doi-asserted-by":"crossref","DOI":"10.3390\/md15020045","article-title":"Propylene glycol alginate sodium sulfate alleviates cerulein-induced acute pancreatitis by modulating the MEK\/ERK pathway in mice","volume":"15","author":"Zhang","year":"2017","journal-title":"Mar. Drugs"},{"issue":"3","key":"10.1016\/j.biopha.2019.109280_bib0065","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1177\/1076029614551822","article-title":"Efficacy of heparinoid PSS in treating cardiovascular diseases and Beyond\u2014a review of 27 years clinical experiences in China","volume":"22","author":"Zeng","year":"2016","journal-title":"Clin. Appl. Thromb. Hemost."},{"issue":"6","key":"10.1016\/j.biopha.2019.109280_bib0070","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1111\/jphp.12902","article-title":"Development of an enteric nanoparticle of marine sulfated polysaccharide propylene glycol alginate sodium sulfate for oral administration: formulation design, pharmacokinetics and efficacy","volume":"70","author":"Li","year":"2018","journal-title":"J. Pharm. Pharmacol."},{"issue":"7","key":"10.1016\/j.biopha.2019.109280_bib0075","doi-asserted-by":"crossref","first-page":"936","DOI":"10.2337\/diab.37.7.936","article-title":"Beneficial effects of verapamil in diabetic cardiomyopathy","volume":"37","author":"Afzal","year":"1988","journal-title":"Diabetes"},{"key":"10.1016\/j.biopha.2019.109280_bib0080","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1475-2840-10-4","article-title":"Cardioprotective effects of tanshinone IIA pretreatment via kinin B2 receptor-Akt-GSK-3beta dependent pathway in experimental diabetic cardiomyopathy","volume":"10","author":"Sun","year":"2011","journal-title":"Cardiovasc. Diabetol."},{"issue":"4","key":"10.1016\/j.biopha.2019.109280_bib0085","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.3390\/md11041113","article-title":"An HPLC method for microanalysis and pharmacokinetics of marine sulfated polysaccharide PSS-loaded poly lactic-co-glycolic acid (PLGA) nanoparticles in rat plasma","volume":"11","author":"Li","year":"2013","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.biopha.2019.109280_bib0090","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.neuroscience.2017.08.032","article-title":"NRG-1beta exerts neuroprotective effects against ischemia reperfusion-induced injury in rats through the JNK signaling pathway","volume":"362","author":"Ji","year":"2017","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.biopha.2019.109280_bib0095","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/gerona\/glu210","article-title":"Increased age-related cardiac dysfunction in bradykinin B2 receptor-deficient mice","volume":"71","author":"Feng","year":"2016","journal-title":"J. Gerontol. A: Biol. Sci. Med. Sci."},{"issue":"3","key":"10.1016\/j.biopha.2019.109280_bib0100","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/MOH.0000000000000416","article-title":"Endothelial cell protein C receptor-dependent signaling","volume":"25","author":"Pendurthi","year":"2018","journal-title":"Curr. Opin. Hematol."},{"issue":"Pt A","key":"10.1016\/j.biopha.2019.109280_bib0105","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jconrel.2015.10.031","article-title":"Amphiphilic drugs as surfactants to fabricate excipient-free stable nanodispersions of hydrophobic drugs for cancer chemotherapy","volume":"220","author":"Hu","year":"2015","journal-title":"J. Control. Release"},{"issue":"7","key":"10.1016\/j.biopha.2019.109280_bib0110","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1007\/s10554-017-1136-9","article-title":"Targeting the dominant mechanism of coronary microvascular dysfunction with intracoronary physiology tests","volume":"33","author":"Mejia-Renteria","year":"2017","journal-title":"Int. J. Cardiovasc. Imaging"},{"issue":"1","key":"10.1016\/j.biopha.2019.109280_bib0115","doi-asserted-by":"crossref","DOI":"10.1111\/micc.12340","article-title":"Current perspectives in coronary microvascular dysfunction","volume":"24","author":"Shome","year":"2017","journal-title":"Microcirculation."},{"issue":"16","key":"10.1016\/j.biopha.2019.109280_bib0120","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1001\/jama.291.16.1978","article-title":"Biomarkers of endothelial dysfunction and risk of type 2 diabetes mellitus","volume":"291","author":"Meigs","year":"2004","journal-title":"JAMA."},{"issue":"11","key":"10.1016\/j.biopha.2019.109280_bib0125","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.tips.2016.08.001","article-title":"Epoxyeicosatrienoic acid as therapy for diabetic and ischemic cardiomyopathy","volume":"37","author":"Romashko","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"issue":"3","key":"10.1016\/j.biopha.2019.109280_bib0130","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1006\/bbrc.1999.0846","article-title":"The endothelial cell protein C receptor (EPCR) functions as a primary receptor for protein C activation on endothelial cells in arteries, veins, and capillaries","volume":"259","author":"Ye","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.biopha.2019.109280_bib0135","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/iub.1344","article-title":"Inflammation in arterial diseases","volume":"67","author":"Carbone","year":"2015","journal-title":"IUBMB Life"},{"key":"10.1016\/j.biopha.2019.109280_bib0140","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jnutbio.2015.12.020","article-title":"Purple rice anthocyanin extract protects cardiac function in STZ-induced diabetes rat hearts by inhibiting cardiac hypertrophy and fibrosis","volume":"31","author":"Chen","year":"2016","journal-title":"J. Nutr. Biochem."},{"issue":"9","key":"10.1016\/j.biopha.2019.109280_bib0145","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nri.2017.52","article-title":"The non-canonical NF-kappaB pathway in immunity and inflammation","volume":"17","author":"Sun","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.biopha.2019.109280_bib0150","doi-asserted-by":"crossref","first-page":"17714","DOI":"10.1038\/srep17714","article-title":"Plasminogen activator inhibitor-1 and type 2 diabetes: a systematic review and meta-analysis of observational studies","volume":"6","author":"Yarmolinsky","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2019.109280_bib0155","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/858293","article-title":"Functional stability of plasminogen activator inhibitor-1","volume":"2014","author":"Yasar Yildiz","year":"2014","journal-title":"Sci. World J."},{"issue":"9","key":"10.1016\/j.biopha.2019.109280_bib0160","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s00011-017-1057-z","article-title":"Reduced monocyte adhesion to aortae of diabetic plasminogen activator inhibitor-1 knockout mice","volume":"66","author":"Zhao","year":"2017","journal-title":"Inflamm. Res."},{"issue":"1","key":"10.1016\/j.biopha.2019.109280_bib0165","doi-asserted-by":"crossref","first-page":"49","DOI":"10.11613\/BM.2012.006","article-title":"Inflammation and haemostasis","volume":"22","author":"Margetic","year":"2012","journal-title":"Biochem Med. (Zagreb)"},{"issue":"3","key":"10.1016\/j.biopha.2019.109280_bib0170","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1253\/circj.71.348","article-title":"Elevated plasma plasminogen activator inhibitor type-1 is an independent predictor of coronary microvascular dysfunction in hypertension","volume":"71","author":"Naya","year":"2007","journal-title":"Circ. J."},{"issue":"3","key":"10.1016\/j.biopha.2019.109280_bib0175","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1139\/Y10-018","article-title":"Oxidative stress and diabetic cardiovascular disorders: roles of mitochondria and NADPH oxidase","volume":"88","author":"Shen","year":"2010","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"4","key":"10.1016\/j.biopha.2019.109280_bib0180","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.jdiacomp.2015.12.018","article-title":"Diabetes mellitus: the linkage between oxidative stress, inflammation, hypercoagulability and vascular complications","volume":"30","author":"Domingueti","year":"2016","journal-title":"J. Diabetes Complicat."},{"issue":"1","key":"10.1016\/j.biopha.2019.109280_bib0185","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jcjd.2014.03.002","article-title":"The investigation of the oxidative stress-related parameters in type 2 diabetes mellitus","volume":"39","author":"Aouacheri","year":"2015","journal-title":"Can. J. Diabetes"},{"issue":"9","key":"10.1016\/j.biopha.2019.109280_bib0190","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1161\/CIRCRESAHA.110.223545","article-title":"Oxidative stress and diabetic complications","volume":"107","author":"Giacco","year":"2010","journal-title":"Circ. Res."},{"issue":"10","key":"10.1016\/j.biopha.2019.109280_bib0195","doi-asserted-by":"crossref","first-page":"25234","DOI":"10.3390\/ijms161025234","article-title":"Diabetic cardiovascular disease induced by oxidative stress","volume":"16","author":"Kayama","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2019.109280_bib0200","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.pharmthera.2016.11.013","article-title":"Cardiac oxidative stress in diabetes: mechanisms and therapeutic potential","volume":"172","author":"Faria","year":"2017","journal-title":"Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.biopha.2019.109280_bib0205","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1139\/cjpp-2015-0073","article-title":"Mangiferin suppressed advanced glycation end products (AGEs) through NF-kappaB deactivation and displayed anti-inflammatory effects in streptozotocin and high fat diet-diabetic cardiomyopathy rats","volume":"94","author":"Hou","year":"2016","journal-title":"Can. J. Physiol. Pharmacol."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219308133?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219308133?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:09:37Z","timestamp":1778242177000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332219308133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":41,"alternative-id":["S0753332219308133"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109280","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects and mechanisms of PSS-loaded nanoparticles on coronary microcirculation dysfunction in streptozotocin-induced diabetic cardiomyopathy rats","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109280","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"109280"}}