{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:18:04Z","timestamp":1780085884341,"version":"3.54.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T00:00:00Z","timestamp":1564531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004156","name":"Mahidol University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013238","name":"Faculty of Medicine Siriraj Hospital, Mahidol University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013238","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.biopha.2019.109319","type":"journal-article","created":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T11:59:34Z","timestamp":1565351974000},"page":"109319","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Clerodendrum petasites S. Moore: The therapeutic potential of phytochemicals, hispidulin, vanillic acid, verbascoside, and apigenin"],"prefix":"10.1016","volume":"118","author":[{"given":"James M.","family":"Brimson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nattawat","family":"Onlamoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tewin","family":"Tencomnao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Premrutai","family":"Thitilertdecha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2019.109319_bib0005","series-title":"The International Plant Names Index (IPNI)","article-title":"Clerodendrum petasites S. Moore","year":"2005"},{"key":"10.1016\/j.biopha.2019.109319_bib0010","series-title":"Chemical Constituents from the Twigs of Garcinia hombroniana, the leaves of Garcinia prainiana and the Roots of Clerodendrum petasites S. Moore [MSc. Thesis]","author":"Klaiklay","year":"2009"},{"key":"10.1016\/j.biopha.2019.109319_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5530\/pj.2011.21.1","article-title":"Pharmacognostic specification of five root species in Thai traditional medicine remedy: ben-Cha-Lo-Ka-Wi-Chian","volume":"3","author":"Singharachai","year":"2011","journal-title":"Phcog J."},{"key":"10.1016\/j.biopha.2019.109319_bib0020","series-title":"The Explanation of Traditional Recipes","author":"Pichaensoonthon","year":"2005"},{"key":"10.1016\/j.biopha.2019.109319_bib0025","series-title":"National List of Essential Medicines: Ha-rak Food and Drug Administration in Thailand","year":"2019"},{"key":"10.1016\/j.biopha.2019.109319_bib0030","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0378-8741(01)00320-8","article-title":"Isolation of a bronchodilator flavonoid from the Thai medicinal plant Clerodendrum petasites","volume":"78","author":"Hazekamp","year":"2001","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2019.109319_bib0035","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0378-8741(02)00368-9","article-title":"Anti-inflammatory and antipyretic properties of Clerodendrum petasites S. Moore","volume":"85","author":"Panthong","year":"2003","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2019.109319_bib0040","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0378-8741(86)90001-2","article-title":"Ethnobotanical review of medicinal plants from Thai traditional books, Part I: plants with anti-inflammatory, anti-asthmatic and antihypertensive properties","volume":"18","author":"Panthong","year":"1986","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2019.109319_bib0045","unstructured":"Thai Traditional Medical Textbook: Paet-Ta-Ya-Saat-Song-Kror, conservative ed, Bangkok, Thailand, The Rehabilitation Foundation for Thai Traditional Medicine and Ayurved Thamrong School, 2007."},{"key":"10.1016\/j.biopha.2019.109319_bib0050","first-page":"142","article-title":"Clerodendrum and heathcare: an overview","volume":"1","author":"Shrivastava","year":"2007","journal-title":"Med. Aromatic Plant Sci. Biotechnol."},{"key":"10.1016\/j.biopha.2019.109319_bib0055","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.jep.2014.04.021","article-title":"Characterisation of polyphenolic compounds in Clerodendrum petasites S. Moore and their potential for topical delivery through the skin","volume":"154","author":"Thitilertdecha","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2019.109319_bib0060","first-page":"35","article-title":"High-performance liquid chromatographic determination of arbutin in skin-whitening creams and medicinal plant extracts","volume":"58","author":"Thongchai","year":"2007","journal-title":"J. Cosmet. Sci."},{"key":"10.1016\/j.biopha.2019.109319_bib0065","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jpba.2018.09.035","article-title":"Scrophularia lucida L. as a valuable source of bioactive compounds for pharmaceutical applications: In vitro antioxidant, anti-inflammatory, enzyme inhibitory properties, in silico studies, and HPLC profiles","volume":"162","author":"Zengin","year":"2019","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.biopha.2019.109319_bib0070","doi-asserted-by":"crossref","first-page":"304","DOI":"10.3389\/fphar.2018.00304","article-title":"Chemical composition of Scrophularia lucida and the effects on tumor invasiveness in vitro","volume":"9","author":"Lewenhofer","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.biopha.2019.109319_bib0075","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jpba.2019.05.041","article-title":"Chemical profiling, antioxidant, enzyme inhibitory and molecular modelling studies on the leaves and stem bark extracts of three African medicinal plants","volume":"174","author":"Bibi Sadeer","year":"2019","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.biopha.2019.109319_bib0080","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature01322","article-title":"Inflammation and cancer","volume":"420","author":"Coussens","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2019.109319_bib0085","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ijpharm.2014.11.004","article-title":"Topical formulation and dermal delivery of active phenolic compounds in the Thai medicinal plant - Clerodendrum petasites S. Moore","volume":"478","author":"Thitilertdecha","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.biopha.2019.109319_bib0090","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3109\/08923973.2010.547500","article-title":"Vanillic acid inhibits inflammatory mediators by suppressing NF-kappaB in lipopolysaccharide-stimulated mouse peritoneal macrophages","volume":"33","author":"Kim","year":"2011","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.biopha.2019.109319_bib0095","doi-asserted-by":"crossref","first-page":"7208","DOI":"10.3390\/molecules15107208","article-title":"The beneficial effect of vanillic acid on ulcerative colitis","volume":"15","author":"Kim","year":"2010","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2019.109319_bib0100","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1111\/jcmm.12524","article-title":"Verbascoside down-regulates some pro-inflammatory signal transduction pathways by increasing the activity of tyrosine phosphatase SHP-1 in the U937 cell line","volume":"19","author":"Pesce","year":"2015","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.biopha.2019.109319_bib0105","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.taap.2015.04.004","article-title":"Effects of acteoside on lipopolysaccharide-induced inflammation in acute lung injury via regulation of NF-kappaB pathway in vivo and in vitro","volume":"285","author":"Jing","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.biopha.2019.109319_bib0110","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1007\/s11095-008-9661-9","article-title":"Cancer is a preventable disease that requires major lifestyle changes","volume":"25","author":"Anand","year":"2008","journal-title":"Pharm. Res."},{"key":"10.1016\/j.biopha.2019.109319_bib0115","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1046\/j.1365-2796.2001.00839.x","article-title":"The role of gene-environment interaction in the aetiology of human cancer: examples from cancers of the large bowel, lung and breast","volume":"249","author":"Mucci","year":"2001","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.biopha.2019.109319_bib0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/01635580903191585","article-title":"Natural phenolic compounds from medicinal herbs and dietary plants: potential use for cancer prevention","volume":"62","author":"Huang","year":"2010","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.biopha.2019.109319_bib0125","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/cdd.2008.12","article-title":"Biology of HIF-1a","volume":"15","author":"Weidemann","year":"2008","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.biopha.2019.109319_bib0130","first-page":"1047","article-title":"Hispidulin prevents hypoxia-induced epithelial-mesenchymal transition in human colon carcinoma cells","volume":"5","author":"Xie","year":"2015","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.biopha.2019.109319_bib0135","doi-asserted-by":"crossref","first-page":"9511","DOI":"10.1021\/jf1019533","article-title":"Hispidulin potently inhibits human glioblastoma multiforme cells through activation of AMP-activated protein kinase (AMPK)","volume":"58","author":"Lin","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.biopha.2019.109319_bib0140","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1349-7006.2010.01778.x","article-title":"Hispidulin, a small flavonoid molecule, suppresses the angiogenesis and growth of human pancreatic cancer by targeting vascular endothelial growth factor receptor 2-mediated PI3K\/Akt\/mTOR signaling pathway","volume":"102","author":"He","year":"2011","journal-title":"Cancer Sci."},{"key":"10.1016\/j.biopha.2019.109319_bib0145","doi-asserted-by":"crossref","first-page":"10020","DOI":"10.1021\/jf102304g","article-title":"Hispidulin sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by AMPK activation leading to Mcl-1 block in translation","volume":"58","author":"Yang","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.biopha.2019.109319_bib0150","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s12013-013-9762-x","article-title":"Hispidulin induces apoptosis through mitochondrial dysfunction and inhibition of P13k\/Akt signalling pathway in HepG2 cancer cells","volume":"69","author":"Gao","year":"2014","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.biopha.2019.109319_bib0155","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s12013-014-0260-6","article-title":"Hispidulin potentiates the antitumor effect of sunitinib against human renal cell carcinoma in laboratory models","volume":"71","author":"Gao","year":"2015","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.biopha.2019.109319_bib0160","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.jtcme.2016.11.003","article-title":"Medicinal importance, pharmacological activities, and analytical aspects of hispidulin: a concise report","volume":"7","author":"Patel","year":"2017","journal-title":"J. Tradit. Complement. Med."},{"key":"10.1016\/j.biopha.2019.109319_bib0165","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ejphar.2013.06.002","article-title":"Hispidulin attenuates bone resorption and osteoclastogenesis via the RANKL-induced NF-kappaB and NFATc1 pathways","volume":"715","author":"Nepal","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2019.109319_bib0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1471-4159.1984.tb09689.x","article-title":"Glutamate: a neurotransmitter in mammalian brain","volume":"42","author":"Fonnum","year":"1984","journal-title":"J. Neurochem."},{"key":"10.1016\/j.biopha.2019.109319_bib0175","first-page":"S7","article-title":"Anatomy and physiology of glutamate in the CNS","volume":"44","author":"Greenamyre","year":"1994","journal-title":"Neurology"},{"key":"10.1016\/j.biopha.2019.109319_bib0180","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/0896-6273(89)90043-3","article-title":"Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress","volume":"2","author":"Murphy","year":"1989","journal-title":"Neuron"},{"key":"10.1016\/j.biopha.2019.109319_bib0185","doi-asserted-by":"crossref","first-page":"1007s","DOI":"10.1093\/jn\/130.4.1007S","article-title":"Glutamate as a neurotransmitter in the brain: review of physiology and pathology","volume":"130","author":"Meldrum","year":"2000","journal-title":"J. Nutr."},{"key":"10.1016\/j.biopha.2019.109319_bib0190","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.neuint.2007.10.005","article-title":"Apigenin inhibits the production of NO and PGE2 in microglia and inhibits neuronal cell death in a middle cerebral artery occlusion-induced focal ischemia mice model","volume":"52","author":"Ha","year":"2008","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.biopha.2019.109319_bib0195","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.neuropharm.2014.07.012","article-title":"Neuroprotective and neurotrophic effects of apigenin and luteolin in MPTP induced parkinsonism in mice","volume":"86","author":"Patil","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.biopha.2019.109319_bib0200","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.neuro.2015.08.014","article-title":"Hesperidin inhibits glutamate release and exerts neuroprotection against excitotoxicity induced by kainic acid in the hippocampus of rats","volume":"50","author":"Chang","year":"2015","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.biopha.2019.109319_bib0205","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.taap.2012.06.015","article-title":"Hispidulin inhibits the release of glutamate in rat cerebrocortical nerve terminals","volume":"263","author":"Lin","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.biopha.2019.109319_bib0210","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/sj.bjp.0705828","article-title":"The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects","volume":"142","author":"Kavvadias","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.biopha.2019.109319_bib0215","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00210-009-0466-0","article-title":"Protective effect of verbascoside in activated C6 glioma cells: possible molecular mechanisms","volume":"381","author":"Esposito","year":"2010","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.biopha.2019.109319_bib0220","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1002\/ptr.5357","article-title":"Memory enhancement of acteoside (verbascoside) in a senescent mice model induced by a combination of D-gal and AlCl3","volume":"29","author":"Gao","year":"2015","journal-title":"Phytother. Res."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219334043?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219334043?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T12:04:48Z","timestamp":1776427488000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332219334043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":44,"alternative-id":["S0753332219334043"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109319","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clerodendrum petasites S. Moore: The therapeutic potential of phytochemicals, hispidulin, vanillic acid, verbascoside, and apigenin","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109319","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"109319"}}