{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:57:01Z","timestamp":1791601021916,"version":"4.3.4"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T00:00:00Z","timestamp":1565136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["155290"],"award-info":[{"award-number":["155290"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["IFC 2016-2282"],"award-info":[{"award-number":["IFC 2016-2282"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["154542"],"award-info":[{"award-number":["154542"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["464723"],"award-info":[{"award-number":["464723"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004881","name":"Instituto Mexicano del Seguro Social","doi-asserted-by":"publisher","award":["99187271"],"award-info":[{"award-number":["99187271"]}],"id":[{"id":"10.13039\/501100004881","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005739","name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005739","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.biopha.2019.109349","type":"journal-article","created":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T17:55:39Z","timestamp":1566928539000},"page":"109349","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["A Malva parviflora\u00b4s fraction prevents the deleterious effects resulting from neuroinflammation"],"prefix":"10.1016","volume":"118","author":[{"given":"Cristina E.","family":"Ram\u00edrez-Serrano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Jim\u00e9nez-Ferrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maribel","family":"Herrera-Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Zamilpa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Vargas-Villa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Jair","family":"Ram\u00edrez-Carreto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anah\u00ed","family":"Chavarr\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Tortoriello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Pedraza-Alva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonor","family":"P\u00e9rez-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2019.109349_bib0005","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.micinf.2015.04.004","article-title":"Infection, systemic inflammation, and Alzheimer\u2019s disease","volume":"17","author":"Lim","year":"2015","journal-title":"Microbes Infect."},{"key":"10.1016\/j.biopha.2019.109349_bib0010","first-page":"125","article-title":"Inflammatory risk factors and pathologies promoting Alzheimer\u2019s disease progression: is RAGE the key?","volume":"30","author":"Matrone","year":"2015","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.biopha.2019.109349_bib0015","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1586\/14737175.7.7.887","article-title":"Environmental and dietary risk factors in Alzheimer\u2019s disease","volume":"7","author":"Dosunmu","year":"2007","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.biopha.2019.109349_bib0020","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1212\/01.wnl.0000311269.57716.63","article-title":"Protective effects of NSAIDs on the development of Alzheimer disease","volume":"70","author":"Vlad","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.biopha.2019.109349_bib0025","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.jalz.2010.12.014","article-title":"Extended results of the Alzheimer\u2019s disease anti-inflammatory prevention trial","volume":"7","author":"Breitner","year":"2011","journal-title":"Alzheimers Dement."},{"issue":"Suppl 2","key":"10.1016\/j.biopha.2019.109349_bib0030","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1365-2036.2004.02037.x","article-title":"Gastrointestinal side-effects of traditional non-steroidal anti-inflammatory drugs and new formulations","volume":"20","author":"Lazzaroni","year":"2004","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.biopha.2019.109349_bib0035","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1136\/bmj.332.7553.1302","article-title":"Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials","volume":"332","author":"Kearney","year":"2006","journal-title":"Bmj"},{"key":"10.1016\/j.biopha.2019.109349_bib0040","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bbi.2019.04.022","article-title":"From traditional remedies to cutting-edge medicine: using ancient mesoamerican knowledge to address complex disorders relevant to psychoneuroimmunology","volume":"79","author":"Pedraza-Alva","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.biopha.2019.109349_bib0045","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1039\/c2fo10153j","article-title":"Evaluation of hypoglycemic activity of the leaves of Malva parviflora in streptozotocin-induced diabetic rats","volume":"3","author":"Perez Gutierrez","year":"2012","journal-title":"Food Funct."},{"key":"10.1016\/j.biopha.2019.109349_bib0050","doi-asserted-by":"crossref","first-page":"942","DOI":"10.3109\/13880209.2011.558102","article-title":"Anti-inflammatory, free radical-scavenging, and metal-chelating activities of Malva parviflora","volume":"49","author":"Bouriche","year":"2011","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.biopha.2019.109349_bib0055","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jep.2004.09.032","article-title":"Variation in antibacterial and anti-inflammatory activity of different growth forms of Malva parviflora and evidence for synergism of the anti-inflammatory compounds","volume":"96","author":"Shale","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2019.109349_bib0060","first-page":"156976","article-title":"Neuroprotective effect of ethanol extract of leaves of Malva parviflora against amyloid-beta- (Abeta-) mediated Alzheimer\u2019s disease","volume":"2014","author":"Aslam","year":"2014","journal-title":"Int. Sch. Res. Notices"},{"key":"10.1016\/j.biopha.2019.109349_bib0065","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s12974-019-1515-3","article-title":"Malva parviflora extract ameliorates the deleterious effects of a high fat diet on the cognitive deficit in a mouse model of Alzheimer\u2019s disease by restoring microglial function via a PPAR-gamma-dependent mechanism","volume":"16","author":"Medrano-Jimenez","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.biopha.2019.109349_bib0070","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1742-2094-5-37","article-title":"Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation","volume":"5","author":"Lee","year":"2008","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.biopha.2019.109349_bib0075","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3389\/fnmol.2016.00019","article-title":"Molecular mechanisms regulating LPS-Induced inflammation in the brain","volume":"9","author":"Lykhmus","year":"2016","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.biopha.2019.109349_bib0080","doi-asserted-by":"crossref","DOI":"10.3390\/molecules22060863","article-title":"Anti-inflammatory activity of a polymeric proanthocyanidin from Serjania schiedeana","volume":"22","author":"Salinas-Sanchez","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2019.109349_bib0085","doi-asserted-by":"crossref","first-page":"15624","DOI":"10.3390\/molecules191015624","article-title":"Anti-inflammatory effect of 3-O-[(6\u2032-O-palmitoyl)-beta-D-glucopyranosyl sitosterol] from Agave angustifolia on ear edema in mice","volume":"19","author":"Hernandez-Valle","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2019.109349_bib0090","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/ptr.2650070213","article-title":"Study of the antioedema activity of some seaweed and sponge extracts from the mediterranean coast in mice","volume":"7","author":"Pay\u00e1","year":"1993","journal-title":"Phytother. Res."},{"key":"10.1016\/j.biopha.2019.109349_bib0095","first-page":"129","article-title":"Models of acute inflammation in the ear","volume":"225","author":"Gabor","year":"2003","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.biopha.2019.109349_bib0100","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0165-0270(84)90007-4","article-title":"Developments of a water-maze procedure for studying spatial learning in the rat","volume":"11","author":"Morris","year":"1984","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.biopha.2019.109349_bib0105","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/jnr.24130","article-title":"Autophagy impairment by caspase-1-dependent inflammation mediates memory loss in response to beta-Amyloid peptide accumulation","volume":"96","author":"Alvarez-Arellano","year":"2018","journal-title":"J. Neurosci. Res."},{"issue":"Pt 20","key":"10.1016\/j.biopha.2019.109349_bib0110","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1242\/jcs.112.20.3497","article-title":"Overexpression of protein kinase C-alpha in the epidermis of transgenic mice results in striking alterations in phorbol ester-induced inflammation and COX-2, MIP-2 and TNF-alpha expression but not tumor promotion","volume":"112","author":"Wang","year":"1999","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.biopha.2019.109349_bib0115","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.201900092","article-title":"Isolation of ceramides from Tagetes patula L. Yellow Flowers and nematicidal activity of the fractions and pure compounds against cyst nematode, Heterodera zeae","volume":"16","author":"Bano","year":"2019","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.biopha.2019.109349_bib0120","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/mrc.855","article-title":"Complete1H and13C NMR assignments of stigma-5-en-3-O-?-Glucoside and its acetyl derivative","volume":"39","author":"Faizi","year":"2001","journal-title":"Magn. Reson. Chem."},{"key":"10.1016\/j.biopha.2019.109349_bib0125","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.jep.2013.03.033","article-title":"Effect of Siam weed extract and its bioactive component scutellarein tetramethyl ether on anti-inflammatory activity through NF-kappaB pathway","volume":"147","author":"Pandith","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2019.109349_bib0130","doi-asserted-by":"crossref","first-page":"8983","DOI":"10.1021\/jf101390q","article-title":"Evaluation of the in vivo anti-inflammatory effects of extracts from Pyrus bretschneideri Rehd","volume":"58","author":"Huang","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.biopha.2019.109349_bib0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.sajb.2015.12.003","article-title":"Bioactive constituents from roots of Salvia syriaca L.: acetylcholinesterase inhibitory activity and molecular docking studies","volume":"106","author":"Bahadori","year":"2016","journal-title":"South Afr. J. Bot."},{"key":"10.1016\/j.biopha.2019.109349_bib0140","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jsbmb.2015.04.007","article-title":"Daucosterol protects neurons against oxygen-glucose deprivation\/reperfusion-mediated injury by activating IGF1 signaling pathway","volume":"152","author":"Jiang","year":"2015","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.biopha.2019.109349_bib0145","doi-asserted-by":"crossref","first-page":"34699","DOI":"10.1039\/C7RA01111C","article-title":"Evaluation of the anti-inflammatory properties of telmesteine on inflammation-associated skin diseases","volume":"7","author":"Xu","year":"2017","journal-title":"RSC Adv."},{"key":"10.1016\/j.biopha.2019.109349_bib0150","article-title":"NF-kappaB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.biopha.2019.109349_bib0155","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0969-9961(03)00069-X","article-title":"Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic mice","volume":"14","author":"Sheng","year":"2003","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.biopha.2019.109349_bib0160","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s11062-008-9026-3","article-title":"Astrogliosis in the hippocampus and cortex and cognitive deficits in rats with streptozotocin-induced diabetes: effects of melatonin","volume":"40","author":"Baydas","year":"2008","journal-title":"Neurophysiology"},{"key":"10.1016\/j.biopha.2019.109349_bib0165","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/hipo.22219","article-title":"Neuronal and glial alterations, increased anxiety, and cognitive impairment before hippocampal amyloid deposition in PDAPP mice, model of Alzheimer\u2019s disease","volume":"24","author":"Beauquis","year":"2014","journal-title":"Hippocampus"},{"key":"10.1016\/j.biopha.2019.109349_bib0170","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2017.00428","article-title":"The calcineurin inhibitor FK506 prevents cognitive impairment by inhibiting reactive astrogliosis in pilocarpine-induced status epilepticus rats","volume":"11","author":"Liu","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.biopha.2019.109349_bib0175","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/imr.12294","article-title":"Negative regulation of the inflammasome: keeping inflammation under control","volume":"265","author":"Pedraza-Alva","year":"2015","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.biopha.2019.109349_bib0180","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.autrev.2005.10.013","article-title":"The role of cytokine mRNA stability in the pathogenesis of autoimmune disease","volume":"5","author":"Seko","year":"2006","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.biopha.2019.109349_bib0185","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1021\/np400831p","article-title":"2-phenoxychromones and prenylflavonoids from Epimedium koreanum and their inhibitory effects on LPS-Induced nitric oxide and Interleukin-1\u03b2 production","volume":"77","author":"Jin","year":"2014","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.biopha.2019.109349_bib0190","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.1747-0285.2012.01418.x","article-title":"Anti-inflammatory property of n-hexadecanoic acid: structural evidence and kinetic assessment","volume":"80","author":"Aparna","year":"2012","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.biopha.2019.109349_bib0195","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1080\/14786419.2015.1065493","article-title":"Anti-inflammatory, antioxidant and antiangiogenic activities of diosgenin isolated from traditional medicinal plant, Costus speciosus (Koen ex.Retz.) Sm","volume":"30","author":"Selim","year":"2016","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.biopha.2019.109349_bib0200","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1142\/S0192415X11009020","article-title":"Diosgenin ameliorates cognition deficit and attenuates oxidative damage in senescent mice induced by D-galactose","volume":"39","author":"Chiu","year":"2011","journal-title":"Am. J. Chin. Med."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S075333221930602X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S075333221930602X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T18:39:02Z","timestamp":1777574342000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S075333221930602X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":40,"alternative-id":["S075333221930602X"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109349","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Malva parviflora\u00b4s fraction prevents the deleterious effects resulting from neuroinflammation","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109349","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"109349"}}