{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T19:55:31Z","timestamp":1793908531979,"version":"4.8.0"},"reference-count":140,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T00:00:00Z","timestamp":1565740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81603549"],"award-info":[{"award-number":["81603549"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010876","name":"Shanghai University of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["A1-N19205010302"],"award-info":[{"award-number":["A1-N19205010302"]}],"id":[{"id":"10.13039\/501100010876","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.biopha.2019.109362","type":"journal-article","created":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T23:46:39Z","timestamp":1566603999000},"page":"109362","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":129,"special_numbering":"C","title":["Sodium tanshinone IIA sulfonate: A review of pharmacological activity and pharmacokinetics"],"prefix":"10.1016","volume":"118","author":[{"given":"Zhong-Yan","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai-Rong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Lin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Yi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2019.109362_bib0005","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.taap.2018.04.037","article-title":"Sodium tanshinone IIA sulfonate promotes endothelial integrity via regulating VE-cadherin dynamics and RhoA\/ROCK-mediated cellular contractility and prevents atorvastatin-induced intracerebral hemorrhage in zebrafish","volume":"350","author":"Zhou","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2019.109362_bib0010","first-page":"017","article-title":"Tanshinone IIA sulfonate protects against cigarette smoke-induced COPD and down-regulation of CFTR in mice","volume":"8","author":"Li","year":"2018","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.biopha.2019.109362_bib0015","first-page":"1287","article-title":"Adverse reactions of tanshinone II(A) sodium sulfonate injection in treating 18 cases: an analysis of clinical features","volume":"33","author":"Liu","year":"2013","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi"},{"issue":"6","key":"10.1016\/j.biopha.2019.109362_bib0020","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/aps.2017.191","article-title":"Different network pharmacology mechanisms of Danshen-based Fangjis in the treatment of stable angina","volume":"39","author":"Zhang","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"issue":"15","key":"10.1016\/j.biopha.2019.109362_bib0025","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.012776","article-title":"Traditional Chinese medicine use in the treatment of acute heart failure in Western Medicine Hospitals in China: analysis from the China PEACE retrospective heart failure study","volume":"8","author":"Yu","year":"2019","journal-title":"J. Am. Heart Assoc."},{"issue":"10","key":"10.1016\/j.biopha.2019.109362_bib0030","first-page":"6","article-title":"Tanshinone IIA: a promising natural cardioprotective agent","volume":"716459","author":"Shang","year":"2012","journal-title":"Evid. Complement. Alternat. Med."},{"issue":"10","key":"10.1016\/j.biopha.2019.109362_bib0035","doi-asserted-by":"crossref","first-page":"13621","DOI":"10.3390\/ijms131013621","article-title":"Tanshinones: sources, pharmacokinetics and anti-cancer activities","volume":"13","author":"Zhang","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2019.109362_bib0040","first-page":"121","article-title":"Recent insights into the biological activities and drug delivery systems of tanshinones","volume":"11","author":"Cai","year":"2016","journal-title":"Int. J. Nanomed."},{"issue":"4","key":"10.1016\/j.biopha.2019.109362_bib0045","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1159\/000430299","article-title":"Induction of heme oxygenase-1 by sodium 9-hydroxyltanshinone IIA sulfonate derivative contributes to inhibit LPS-mediated inflammatory response in macrophages","volume":"36","author":"Liu","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"issue":"1","key":"10.1016\/j.biopha.2019.109362_bib0050","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1517\/13543776.2013.736494","article-title":"Tanshinone derivatives: a patent review (January 2006 - September 2012)","volume":"23","author":"Tian","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"issue":"2","key":"10.1016\/j.biopha.2019.109362_bib0055","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s11655-017-2424-x","article-title":"Sodium tanshinone II a sulfonate injection as adjuvant treatment for unstable angina pectoris: a meta-analysis of 17 randomized controlled trials","volume":"24","author":"Tan","year":"2018","journal-title":"Chin. J. Integr. Med."},{"issue":"3","key":"10.1016\/j.biopha.2019.109362_bib0060","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1124\/jpet.114.214569","article-title":"Tanshinone II A sulfonate, but not tanshinone II A, acts as potent negative allosteric modulator of the human purinergic receptor P2X7","volume":"350","author":"Kaiser","year":"2014","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.biopha.2019.109362_bib0065","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/716459","article-title":"Tanshinone IIA: a promising natural cardioprotective agent","volume":"2012","author":"Shang","year":"2012","journal-title":"Evid. Based Complement. Altern. Med."},{"issue":"10","key":"10.1016\/j.biopha.2019.109362_bib0070","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1038\/aps.2012.84","article-title":"Tanshinone IIA protects rabbits against LPS-induced disseminated intravascular coagulation (DIC)","volume":"33","author":"Wu","year":"2012","journal-title":"Acta Pharmacol. Sin."},{"issue":"1","key":"10.1016\/j.biopha.2019.109362_bib0075","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jss.2016.04.066","article-title":"Tanshinone IIA attenuates epithelial-mesenchymal transition to inhibit the tracheal narrowing","volume":"206","author":"Duan","year":"2016","journal-title":"J. Surg. Res."},{"issue":"10","key":"10.1016\/j.biopha.2019.109362_bib0080","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1097\/CAD.0000000000000144","article-title":"Novel mechanisms involving chemically modified tetracycline 3 cytotoxicity","volume":"25","author":"Zhao","year":"2014","journal-title":"Anticancer Drugs"},{"issue":"10","key":"10.1016\/j.biopha.2019.109362_bib0085","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1016\/j.jasms.2008.06.005","article-title":"Effect of tanshinone IIA on the noncovalent interaction between warfarin and human serum albumin studied by electrospray ionization mass spectrometry","volume":"19","author":"Liu","year":"2008","journal-title":"J. Am. Soc. Mass Spectrom."},{"issue":"10","key":"10.1016\/j.biopha.2019.109362_bib0090","first-page":"24","article-title":"Effect of supplementation of tanshinone IIA and sodium tanshinone IIA sulfonate on the anticancer effect of epirubicin: an in vitro study","volume":"841564","author":"Chan","year":"2011","journal-title":"Evid. Complement. Alternat. Med."},{"issue":"14","key":"10.1016\/j.biopha.2019.109362_bib0095","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1002\/rcm.3080","article-title":"Profiling the metabolic difference of seven tanshinones using high-performance liquid chromatography\/multi-stage mass spectrometry with data-dependent acquisition","volume":"21","author":"Sun","year":"2007","journal-title":"Rapid Commun. Mass Spectrom."},{"issue":"11","key":"10.1016\/j.biopha.2019.109362_bib0100","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1002\/bmc.871","article-title":"Determination of sodium tanshinone IIA sulfonate in plasma by liquid chromatography-electrospray ionisation-tandem mass spectrometry","volume":"21","author":"Hao","year":"2007","journal-title":"Biomed. Chromatogr."},{"issue":"12","key":"10.1016\/j.biopha.2019.109362_bib0105","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.3109\/00498254.2016.1152417","article-title":"Sodium tanshinone IIA sulfonate and its interactions with human CYP450s","volume":"46","author":"Chen","year":"2016","journal-title":"Xenobiotica"},{"issue":"6","key":"10.1016\/j.biopha.2019.109362_bib0110","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s10557-015-6625-2","article-title":"Rationale and design of sodium tanshinone IIA sulfonate in left ventricular remodeling secondary to acute myocardial infarction (STAMP-REMODELING) trial: a randomized controlled study","volume":"29","author":"Mao","year":"2015","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.biopha.2019.109362_bib0115","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ijcard.2014.12.166","article-title":"Sodium tanshinone IIA sulfonate for reduction of periprocedural myocardial injury during percutaneous coronary intervention (STAMP trial): rationale and design","volume":"182","author":"Mao","year":"2015","journal-title":"Int. J. Cardiol."},{"issue":"1","key":"10.1016\/j.biopha.2019.109362_bib0120","first-page":"351","article-title":"Protective effects of sodium tanshinone IIA sulfonate on cardiac function after myocardial infarction in mice","volume":"11","author":"Wu","year":"2019","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.biopha.2019.109362_bib0125","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ijcard.2015.05.152","article-title":"Sodium tanshinone IIA sulfonate ameliorates ischemia-induced myocardial inflammation and lipid accumulation in Beagle dogs through NLRP3 inflammasome","volume":"196","author":"Hu","year":"2015","journal-title":"Int. J. Cardiol."},{"issue":"1","key":"10.1016\/j.biopha.2019.109362_bib0130","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0006-2952(02)01447-8","article-title":"Sodium tanshinone IIA sulfonate mediates electron transfer reaction in rat heart mitochondria","volume":"65","author":"Zhou","year":"2003","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.biopha.2019.109362_bib0135","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.atherosclerosis.2014.05.924","article-title":"The cardioprotective effect of sodium tanshinone IIA sulfonate and the optimizing of therapeutic time window in myocardial ischemia\/reperfusion injury in rats","volume":"235","author":"Wei","year":"2014","journal-title":"Atherosclerosis"},{"issue":"11","key":"10.1016\/j.biopha.2019.109362_bib0140","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1038\/aps.2013.91","article-title":"Sodium tanshinone IIA sulfonate protects rat myocardium against ischemia-reperfusion injury via activation of PI3K\/Akt\/FOXO3A\/Bim pathway","volume":"34","author":"Zhang","year":"2013","journal-title":"Acta Pharmacol. Sin."},{"issue":"12","key":"10.1016\/j.biopha.2019.109362_bib0145","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1016\/0006-2952(93)90624-6","article-title":"Effect of sodium tanshinone IIA sulfonate in the rabbit myocardium and on human cardiomyocytes and vascular endothelial cells","volume":"46","author":"Wu","year":"1993","journal-title":"Biochem. Pharmacol."},{"issue":"4","key":"10.1016\/j.biopha.2019.109362_bib0150","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1097\/FJC.0b013e3181671439","article-title":"Sodium tanshinone IIA sulfonate protects cardiomyocytes against oxidative stress-mediated apoptosis through inhibiting JNK activation","volume":"51","author":"Yang","year":"2008","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2019.109362_bib0155","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.atherosclerosis.2013.07.005","article-title":"Regulation of antioxidant system, lipids and fatty acid beta-oxidation contributes to the cardioprotective effect of sodium tanshinone IIA sulphonate in isoproterenol-induced myocardial infarction in rats","volume":"230","author":"Wei","year":"2013","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.biopha.2019.109362_bib0160","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.lfs.2015.10.018","article-title":"Sodium tanshinone IIA sulfonate ameliorates experimental coronary no-reflow phenomenon through down-regulation of FGL2","volume":"142","author":"Long","year":"2015","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.biopha.2019.109362_bib0165","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s11655-008-0123-3","article-title":"Effect of sodium tanshinone II A sulfonate on phosphorylation of extracellular signal-regulated kinase 1\/2 in angiotensin II-induced hypertrophy of myocardial cells","volume":"14","author":"Li","year":"2008","journal-title":"Chin. J. Integr. Med."},{"issue":"5","key":"10.1016\/j.biopha.2019.109362_bib0170","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s11596-008-0509-7","article-title":"Changes of c-fos and c-jun mRNA expression in angiotensin II-induced cardiomyocyte hypertrophy and effects of sodium tanshinone IIA sulfonate","volume":"28","author":"Zhou","year":"2008","journal-title":"J. Huazhong Univ. Sci. Technol. Med. Sci."},{"issue":"3","key":"10.1016\/j.biopha.2019.109362_bib0175","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s11655-008-0197-y","article-title":"Effect of sodium tanshinone II A sulfonate on cardiac myocyte hypertrophy and its underlying mechanism","volume":"14","author":"Feng","year":"2008","journal-title":"Chin. J. Integr. Med."},{"issue":"4","key":"10.1016\/j.biopha.2019.109362_bib0180","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0006-2952(02)01250-9","article-title":"Sodium tanshinone IIA sulfonate derived from Danshen (Salvia miltiorrhiza) attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac cells","volume":"64","author":"Takahashi","year":"2002","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2019.109362_bib0185","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/emm.2007.8","article-title":"Sodium tanshinone IIA sulfonate depresses angiotensin II-induced cardiomyocyte hypertrophy through MEK\/ERK pathway","volume":"39","author":"Yang","year":"2007","journal-title":"Exp. Mol. Med."},{"issue":"7","key":"10.1016\/j.biopha.2019.109362_bib0190","doi-asserted-by":"crossref","first-page":"508","DOI":"10.3858\/emm.2009.41.7.056","article-title":"Sodium tanshinone IIA sulfonate attenuates angiotensin II-induced collagen type I expression in cardiac fibroblasts in vitro","volume":"41","author":"Yang","year":"2009","journal-title":"Exp. Mol. Med."},{"issue":"6","key":"10.1016\/j.biopha.2019.109362_bib0195","first-page":"1093","article-title":"Effect of sodium tanshinone II (A) sulfonate on Ang II -induced atrial fibroblast collagen synthesis and TGF-beta1 activation","volume":"39","author":"Yang","year":"2014","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"issue":"6712585","key":"10.1016\/j.biopha.2019.109362_bib0200","article-title":"Sodium tanshinone IIA sulfonate prevents angiotensin II-Induced differentiation of human atrial fibroblasts into myofibroblasts","volume":"24","author":"Chen","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"4","key":"10.1016\/j.biopha.2019.109362_bib0205","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.3892\/ijmm.2015.2087","article-title":"Sodium tanshinone IIA sulfonate attenuates the transforming growth factor-beta1-induced differentiation of atrial fibroblasts into myofibroblasts in vitro","volume":"35","author":"Yang","year":"2015","journal-title":"Int. J. Mol. Med."},{"issue":"10","key":"10.1016\/j.biopha.2019.109362_bib0210","first-page":"12","article-title":"Sodium tanshinone IIA sulfonate prevents radiation-induced toxicity in H9c2 cardiomyocytes","volume":"4537974","author":"Zhang","year":"2017","journal-title":"Evid. Complement. Alternat. Med."},{"issue":"9","key":"10.1016\/j.biopha.2019.109362_bib0215","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1080\/10286020.2014.935769","article-title":"Sodium tanshinone IIA sulfonate attenuates radiation-induced fibrosis damage in cardiac fibroblasts","volume":"16","author":"Gu","year":"2014","journal-title":"J. Asian Nat. Prod. Res."},{"issue":"5","key":"10.1016\/j.biopha.2019.109362_bib0220","doi-asserted-by":"crossref","DOI":"10.1142\/S0192415X13500729","article-title":"Anti-inflammatory effects of Danshen on human vascular endothelial cells in culture","volume":"41","author":"Stumpf","year":"2013","journal-title":"Am. J. Chin. Med."},{"issue":"3","key":"10.1016\/j.biopha.2019.109362_bib0225","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1055\/s-0036-1580087","article-title":"Danshen and the cardiovascular system: new advances for an old remedy","volume":"42","author":"Maione","year":"2016","journal-title":"Semin. Thromb. Hemost."},{"issue":"2","key":"10.1016\/j.biopha.2019.109362_bib0230","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.jep.2014.07.010","article-title":"Tanshinone IIA, a major component of Salvia milthorriza Bunge, inhibits platelet activation via Erk-2 signaling pathway","volume":"155","author":"Maione","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2019.109362_bib0235","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.fitote.2014.11.024","article-title":"Molecular mechanism of tanshinone IIA and cryptotanshinone in platelet anti-aggregating effects: an integrated study of pharmacology and computational analysis","volume":"100","author":"Maione","year":"2015","journal-title":"Fitoterapia"},{"key":"10.1016\/j.biopha.2019.109362_bib0240","first-page":"1","article-title":"Cryptotanshinone and tanshinone IIA from Salvia milthorrhiza Bunge (Danshen) as a new class of potential pancreatic lipase inhibitors","volume":"20","author":"Marrelli","year":"2019","journal-title":"Nat. Prod. Res."},{"issue":"3","key":"10.1016\/j.biopha.2019.109362_bib0245","first-page":"214","article-title":"Comparison of antihemolytic effects of sodium tanshinone II-A sulfonate and propranolol in vitro (author\u2019s transl)","volume":"2","author":"Wang","year":"1981","journal-title":"Zhongguo Yao Li Xue Bao"},{"issue":"1","key":"10.1016\/j.biopha.2019.109362_bib0250","first-page":"39","article-title":"Effects of tanshinone II-A sulfonate on thrombus formation, platelet and blood coagulation in rats and mice","volume":"5","author":"Li","year":"1984","journal-title":"Zhongguo Yao Li Xue Bao"},{"issue":"1","key":"10.1016\/j.biopha.2019.109362_bib0255","first-page":"20","article-title":"Therapeutic effect of sodium tanshinone IIA sulfonate in patients with coronary heart disease. A double blind study. Shanghai Cooperative Group for the Study of Tanshinone IIA","volume":"4","year":"1984","journal-title":"J. Tradit. Chin. Med."},{"key":"10.1016\/j.biopha.2019.109362_bib0260","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.ejphar.2017.09.047","article-title":"Tanshinone IIA Sodium sulfonate regulates antioxidant system, inflammation, and endothelial dysfunction in atherosclerosis by downregulation of CLIC1","volume":"815","author":"Zhu","year":"2017","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2019.109362_bib0265","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1139\/cjpp-2017-0023","article-title":"Sodium tanshinone IIA sulfonate prevents lipopolysaccharide-induced inflammation via suppressing nuclear factor-kappaB signaling pathway in human umbilical vein endothelial cells","volume":"96","author":"Cheng","year":"2018","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2019.109362_bib0270","first-page":"47","article-title":"Effects of tanshinone II-A sulfonate on adhesion molecule expression of endothelial cells and platelets in vitro","volume":"19","author":"Jiang","year":"1998","journal-title":"Zhongguo Yao Li Xue Bao"},{"issue":"3","key":"10.1016\/j.biopha.2019.109362_bib0275","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1097\/HCR.0000000000000402","article-title":"A review of exercise interventions in pulmonary arterial hypertension and recommendations for rehabilitation programing","volume":"39","author":"Ozemek","year":"2019","journal-title":"J. Cardiopulm. Rehabil. Prev."},{"issue":"6","key":"10.1016\/j.biopha.2019.109362_bib0280","doi-asserted-by":"crossref","first-page":"019","DOI":"10.1007\/s11906-019-0950-y","article-title":"The use of risk assessment tools and prognostic scores in managing patients with pulmonary arterial hypertension","volume":"21","author":"Kanwar","year":"2019","journal-title":"Curr. Hypertens. Rep."},{"issue":"3","key":"10.1016\/j.biopha.2019.109362_bib0285","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.jep.2009.07.020","article-title":"Effects of sodium tanshinone II A sulphonate on hypoxic pulmonary hypertension in rats in vivo and on Kv2.1 expression in pulmonary artery smooth muscle cells in vitro","volume":"125","author":"Huang","year":"2009","journal-title":"J. Ethnopharmacol."},{"issue":"5","key":"10.1016\/j.biopha.2019.109362_bib0290","first-page":"360","article-title":"Tanshinone IIA sulfonate upregulated pulmonary artery smooth muscle peroxisome proliferator-activated receptor gamma expression in monocrotaline induced pulmonary hypertension rat","volume":"37","author":"Jiang","year":"2014","journal-title":"Zhonghua Jie He He Hu Xi Za Zhi"},{"issue":"1","key":"10.1016\/j.biopha.2019.109362_bib0295","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1152\/ajpcell.00252.2015","article-title":"Sodium tanshinone IIA sulfonate inhibits hypoxia-induced enhancement of SOCE in pulmonary arterial smooth muscle cells via the PKG-PPAR-gamma signaling axis","volume":"311","author":"Jiang","year":"2016","journal-title":"Am. J. Physiol., Cell Physiol."},{"issue":"2","key":"10.1016\/j.biopha.2019.109362_bib0300","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.advms.2019.04.001","article-title":"Assessment of serum levels of DIO1 and DIO3 in patients diagnosed with COPD","volume":"64","author":"Galecka","year":"2019","journal-title":"Adv. Med. Sci."},{"issue":"8","key":"10.1016\/j.biopha.2019.109362_bib0305","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20082024","article-title":"FKBP5 rs4713916: a potential genetic predictor of interindividual different response to inhaled corticosteroids in patients with chronic obstructive pulmonary disease in a real-life setting","volume":"20","author":"Russo","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"263","key":"10.1016\/j.biopha.2019.109362_bib0310","article-title":"Sodium tanshinone IIA sulfonate decreases cigarette smoke-induced inflammation and oxidative stress via blocking the activation of MAPK\/HIF-1alpha signaling pathway","volume":"9","author":"Guan","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.biopha.2019.109362_bib0315","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0178226","article-title":"Sodium tanshinone IIA sulfonate stimulated Cl- secretion in mouse trachea","volume":"12","author":"Chen","year":"2017","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.biopha.2019.109362_bib0320","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1039\/c5tx00291e","article-title":"Sodium tanshinone IIA sulfonate suppresses pulmonary fibroblast proliferation and activation induced by silica: role of the Nrf2\/Trx pathway","volume":"5","author":"Zhu","year":"2015","journal-title":"Toxicol. Res."},{"issue":"8","key":"10.1016\/j.biopha.2019.109362_bib0325","doi-asserted-by":"crossref","first-page":"482","DOI":"10.3109\/01902148.2011.594144","article-title":"Sodium tanshinone iia sulfonate attenuates seawater aspiration-induced acute pulmonary edema by up-regulating Na(+),K(+)-ATPase activity","volume":"37","author":"Xie","year":"2011","journal-title":"Exp. Lung Res."},{"issue":"5","key":"10.1016\/j.biopha.2019.109362_bib0330","first-page":"308","article-title":"Effects of tanshionone to bleomycin induced pulmonary fibrosis of rats on histological changes and production of lipid peroxides and hydroxyproline","volume":"17","author":"Wang","year":"1994","journal-title":"Zhonghua Jie He He Hu Xi Za Zhi"},{"issue":"6","key":"10.1016\/j.biopha.2019.109362_bib0335","doi-asserted-by":"crossref","first-page":"3856","DOI":"10.4049\/jimmunol.178.6.3856","article-title":"A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1","volume":"178","author":"Li","year":"2007","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.biopha.2019.109362_bib0340","doi-asserted-by":"crossref","first-page":"011","DOI":"10.1007\/s11596-011-0470-8","article-title":"Protective effect and mechanism of sodium tanshinone II A sulfonate on microcirculatory disturbance of small intestine in rats with sepsis","volume":"31","author":"Zhu","year":"2011","journal-title":"J. Huazhong Univ. Sci. Technol. Med. Sci."},{"issue":"7","key":"10.1016\/j.biopha.2019.109362_bib0345","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1007\/s11655-011-0942-5","article-title":"Protective effect of sodium tanshinone IIA sulfonate on injury of small intestine in rats with sepsis and its mechanism","volume":"18","author":"Zhu","year":"2012","journal-title":"Chin. J. Integr. Med."},{"issue":"10","key":"10.1016\/j.biopha.2019.109362_bib0350","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/s11655-015-2083-8","article-title":"Sodium tanshinone II A sulfonate ameliorates microcirculatory disturbance of small intestine by attenuating the production of reactie oxygen species in rats with sepsis","volume":"22","author":"Zhu","year":"2016","journal-title":"Chin. J. Integr. Med."},{"issue":"11","key":"10.1016\/j.biopha.2019.109362_bib0355","first-page":"846","article-title":"Sodium tanshinone IIA sulfonate attenuates cardiac dysfunction and improves survival of rats with cecal ligation and puncture-induced sepsis","volume":"16","author":"Meng","year":"2018","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.biopha.2019.109362_bib0360","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.12659\/MSM.909996","article-title":"Sodium tanshinone IIA sulfonate improves hemodynamic parameters, cytokine release, and multi-organ damage in Endotoxemia Rabbits","volume":"24","author":"Ma","year":"2018","journal-title":"Med. Sci. Monit."},{"issue":"7","key":"10.1016\/j.biopha.2019.109362_bib0365","doi-asserted-by":"crossref","first-page":"841","DOI":"10.3109\/13880209.2013.871639","article-title":"Screening compounds of Chinese medicinal herbs anti-Marek\u2019s disease virus","volume":"52","author":"Sun","year":"2014","journal-title":"Pharm. Biol."},{"issue":"8","key":"10.1016\/j.biopha.2019.109362_bib0370","doi-asserted-by":"crossref","first-page":"793","DOI":"10.3851\/IMP2764","article-title":"Sodium tanshinone IIA sulfonate inhibits the meq, ul49 and VP22 expression of Marek\u2019s disease virus","volume":"19","author":"Sun","year":"2014","journal-title":"Antivir. Ther."},{"key":"10.1016\/j.biopha.2019.109362_bib0375","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.ijbiomac.2013.04.029","article-title":"Effects of sodium tanshinone IIA sulfonate against Marek\u2019s disease virus in experimentally infected chickens","volume":"58","author":"Zhang","year":"2013","journal-title":"Int. J. Biol. Macromol."},{"issue":"4","key":"10.1016\/j.biopha.2019.109362_bib0380","doi-asserted-by":"crossref","first-page":"701","DOI":"10.3109\/13880209.2015.1072568","article-title":"Sodium tanshinone IIA sulfonate affects Marek\u2019s disease virus replication by inhibiting gB expression","volume":"54","author":"Wang","year":"2016","journal-title":"Pharm. Biol."},{"issue":"1","key":"10.1016\/j.biopha.2019.109362_bib0385","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3851\/IMP2694","article-title":"Sodium tanshinone IIA sulfonate inhibits porcine reproductive and respiratory syndrome virus via suppressing N gene expression and blocking virus-induced apoptosis","volume":"19","author":"Sun","year":"2014","journal-title":"Antivir. Ther."},{"issue":"8","key":"10.1016\/j.biopha.2019.109362_bib0390","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1080\/10286020.2012.685727","article-title":"Anti-PRRSV effect and mechanism of sodium tanshinone IIA sulfonate in vitro","volume":"14","author":"Sun","year":"2012","journal-title":"J. Asian Nat. Prod. Res."},{"issue":"10","key":"10.1016\/j.biopha.2019.109362_bib0395","article-title":"Autophagy involved in antiviral activity of sodium tanshinone IIA sulfonate against porcine reproductive and respiratory syndrome virus infection in vitro","volume":"1","author":"Sun","year":"2018","journal-title":"Antivir. Ther."},{"key":"10.1016\/j.biopha.2019.109362_bib0400","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ejphar.2015.02.046","article-title":"Magnesium lithospermate B and rosmarinic acid, two compounds present in Salvia miltiorrhiza, have potent antiviral activity against enterovirus 71 infections","volume":"755","author":"Chung","year":"2015","journal-title":"Eur. J. Pharmacol."},{"issue":"9","key":"10.1016\/j.biopha.2019.109362_bib0405","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1002\/jcp.24552","article-title":"Tanshinone II A inhibits tat-induced HIV-1 transactivation through redox-regulated AMPK\/Nampt pathway","volume":"229","author":"Zhang","year":"2014","journal-title":"J. Cell. Physiol."},{"issue":"6","key":"10.1016\/j.biopha.2019.109362_bib0410","doi-asserted-by":"crossref","first-page":"212","DOI":"10.5582\/ddt.2013.v7.6.212","article-title":"Traditional Chinese medicine and related active compounds: a review of their role on hepatitis B virus infection","volume":"7","author":"Qi","year":"2013","journal-title":"Drug Discov. Ther."},{"issue":"1","key":"10.1016\/j.biopha.2019.109362_bib0415","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1142\/S0192415X07004709","article-title":"Antiviral effects of Salvia miltiorrhiza (Danshen) against enterovirus 71","volume":"35","author":"Wu","year":"2007","journal-title":"Am. J. Chin. Med."},{"issue":"954032","key":"10.1016\/j.biopha.2019.109362_bib0420","article-title":"Immunomodulatory effects of Danshen (Salvia miltiorrhiza) in BALB\/c mice","volume":"16","author":"Gao","year":"2012","journal-title":"ISRN Inflamm."},{"key":"10.1016\/j.biopha.2019.109362_bib0425","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jep.2016.12.051","article-title":"Apoptosis induced by the methanol extract of Salvia miltiorrhiza Bunge in non\u2013small cell lung cancer through PTEN-mediated inhibition of PI3K\/Akt pathway","volume":"200","author":"Ye","year":"2017","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.biopha.2019.109362_bib0430","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1007\/s11095-012-0670-3","article-title":"Tanshinones from Chinese medicinal Herb Danshen (Salvia miltiorrhiza bunge) suppress prostate cancer growth and androgen receptor signaling","volume":"29","author":"Zhang","year":"2012","journal-title":"Pharm. Res."},{"issue":"6","key":"10.1016\/j.biopha.2019.109362_bib0435","first-page":"534","article-title":"No promoting effects of sodium tanshinone II-A sulfonate on growth and metastasis of Lewis carcinoma","volume":"12","author":"Liu","year":"1991","journal-title":"Zhongguo Yao Li Xue Bao"},{"issue":"12","key":"10.1016\/j.biopha.2019.109362_bib0440","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.1039\/C8BM00796A","article-title":"Non-triggered sequential-release liposomes enhance anti-breast cancer efficacy of STS and celastrol-based microemulsion","volume":"6","author":"Qu","year":"2018","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.biopha.2019.109362_bib0445","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ctim.2018.11.022","article-title":"A review of complementary therapies with medicinal plants for chemotherapy-induced peripheral neuropathy","volume":"42","author":"Wu","year":"2019","journal-title":"Complement. Ther. Med."},{"key":"10.1016\/j.biopha.2019.109362_bib0450","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.biopha.2018.06.047","article-title":"Tanshinones from Salvia miltiorrhiza Bunge revert chemotherapy-induced neuropathic pain and reduce glioblastoma cells malignancy","volume":"105","author":"Di","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.biopha.2019.109362_bib0455","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1142\/S0192415X11008907","article-title":"Proteomic assessment of tanshinone IIA sodium sulfonate on doxorubicin induced nephropathy","volume":"39","author":"Liu","year":"2011","journal-title":"Am. J. Chin. Med."},{"issue":"12","key":"10.1016\/j.biopha.2019.109362_bib0460","first-page":"1016","article-title":"Effects of tanshinone- II A sulfonate on expression of nuclear factor-kappaB, vascular cell adhesion molecule-1 and hemorrheology during spinal cord ischemia reperfusion injury","volume":"25","author":"Zhang","year":"2012","journal-title":"Zhongguo Gu Shang"},{"issue":"5814749","key":"10.1016\/j.biopha.2019.109362_bib0465","article-title":"Efficacy of Danshen class injection in the treatment of acute cerebral infarction: a Bayesian network meta-analysis of randomized controlled trials","volume":"3","author":"Liu","year":"2019","journal-title":"Evid. Complement. Alternat. Med."},{"issue":"4","key":"10.1016\/j.biopha.2019.109362_bib0470","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/s12975-017-0526-6","article-title":"Sodium tanshinone IIA sulfonate enhances effectiveness Rt-PA treatment in acute ischemic stroke patients associated with ameliorating blood-brain barrier damage","volume":"8","author":"Ji","year":"2017","journal-title":"Transl. Stroke Res."},{"issue":"1\u20133","key":"10.1016\/j.biopha.2019.109362_bib0475","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ejphar.2011.01.028","article-title":"Unique action of sodium tanshinone II-A sulfonate (DS-201) on the Ca(2+) dependent BK(Ca) activation in mouse cerebral arterial smooth muscle cells","volume":"656","author":"Tan","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2019.109362_bib0480","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jss.2016.10.008","article-title":"Sodium tanshinone IIA sulfonate attenuates hemorrhagic shock-induced organ damages by nuclear factor-kappa B pathway","volume":"209","author":"Qian","year":"2017","journal-title":"J. Surg. Res."},{"issue":"3","key":"10.1016\/j.biopha.2019.109362_bib0485","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ijcard.2014.07.147","article-title":"Sodium tanshinone IIA sulfonate and sodium danshensu open the placental barrier through down-regulation of placental P-glycoprotein in mice: implications in the transplacental digoxin treatment for fetal heart failure","volume":"176","author":"Wang","year":"2014","journal-title":"Int. J. Cardiol."},{"issue":"7","key":"10.1016\/j.biopha.2019.109362_bib0490","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/jbt.21903","article-title":"Sodium tanshinone IIA sulfonate prevents hypoxic trophoblast-induced endothelial cell dysfunction via targeting HMGB1 release","volume":"31","author":"Zhao","year":"2017","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"3","key":"10.1016\/j.biopha.2019.109362_bib0495","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1152\/ajpregu.00222.2014","article-title":"Effect of sodium tanshinone IIA sulfonate treatment in a rat model of preeclampsia","volume":"308","author":"Morton","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"3","key":"10.1016\/j.biopha.2019.109362_bib0500","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0121897","article-title":"The vascular effects of sodium tanshinone IIA sulphonate in rodent and human pregnancy","volume":"10","author":"Morton","year":"2015","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.biopha.2019.109362_bib0505","first-page":"17","article-title":"Sodium tanshinone IIA sulfonate increased intestinal hemodynamics without systemic circulatory changes in healthy newborn piglets, American journal of physiology","volume":"297","author":"Liu","year":"2009","journal-title":"Heart Circ. Physiol."},{"issue":"5","key":"10.1016\/j.biopha.2019.109362_bib0510","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1248\/cpb.55.753","article-title":"Ion-pair reversed-phase HPLC method for determination of sodium tanshinone IIA sulfonate in biological samples and its pharmacokinetics and biodistribution in mice","volume":"55","author":"Mao","year":"2007","journal-title":"Chem. Pharm. Bull."},{"issue":"5","key":"10.1016\/j.biopha.2019.109362_bib0515","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1007\/s10875-008-9206-3","article-title":"Sodium tanshinone IIA sulfonate protects mice from ConA-induced hepatitis via inhibiting NF-kappaB and IFN-gamma\/STAT1 pathways","volume":"28","author":"Xu","year":"2008","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.biopha.2019.109362_bib0520","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.biopha.2018.12.019","article-title":"Sodium tanshinone IIA sulfonate ameliorates hepatic steatosis by inhibiting lipogenesis and inflammation","volume":"111","author":"Li","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.biopha.2019.109362_bib0525","first-page":"137","article-title":"Clinical efficiency of tanshinone IIA-sulfonate in treatment of liver fibrosis of advanced schistosomiasis","volume":"25","author":"Niu","year":"2013","journal-title":"Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi"},{"key":"10.1016\/j.biopha.2019.109362_bib0530","article-title":"Down regulation of pro-inflammatory pathways by tanshinone IIA and cryptotanshinone in a non-genetic mouse model of Alzheimer\u2019s disease","volume":"129","author":"Maione","year":"2017","journal-title":"Pharmacol. Res."},{"issue":"13","key":"10.1016\/j.biopha.2019.109362_bib0535","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1097\/WNR.0000000000000419","article-title":"Upregulation effects of Tanshinone IIA on the expressions of NeuN, Nissl body, and I\u03baB and downregulation effects on the expressions of GFAP and NF-\u03baB in the brain tissues of rat models of Alzheimer\u2019s disease","volume":"26","author":"Li","year":"2015","journal-title":"Neuroreport"},{"key":"10.1016\/j.biopha.2019.109362_bib0540","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jep.2015.01.042","article-title":"Tanshinone I selectively suppresses pro-inflammatory genes expression in activated microglia and prevents nigrostriatal dopaminergic neurodegeneration in a mouse model of Parkinson\u2019s disease","volume":"164","author":"Wang","year":"2015","journal-title":"J. Ethnopharmacol."},{"issue":"11","key":"10.1016\/j.biopha.2019.109362_bib0545","first-page":"660","article-title":"Study of sodium tanshinone II A sulfonate tissue distribution in rat by liquid chromatography\/tandem mass spectrometry","volume":"60","author":"He","year":"2010","journal-title":"Arzneimittelforschung"},{"issue":"10","key":"10.1016\/j.biopha.2019.109362_bib0550","first-page":"31","article-title":"Sodium tanshinone IIA sulfonate attenuates scopolamine-induced cognitive dysfunctions via improving cholinergic system","volume":"9852536","author":"Xu","year":"2016","journal-title":"Biomed Res. Int."},{"issue":"1","key":"10.1016\/j.biopha.2019.109362_bib0555","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.bbrc.2010.07.037","article-title":"Tanshinone IIA improves impaired nerve functions in experimental diabetic rats","volume":"399","author":"Liu","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"19","key":"10.1016\/j.biopha.2019.109362_bib0560","article-title":"Ghrelin combined with sodium tanshinone IIA sulfonate pretreatment reduces apoptosis and fractalkine expression induced by high-dose glucose in human umbilical vein endothelial cells","volume":"4","author":"Zhu","year":"2019","journal-title":"Minerva Endocrinol."},{"issue":"4","key":"10.1016\/j.biopha.2019.109362_bib0565","first-page":"5279","article-title":"The effects of sodium tanshinone IIa sulfonate pretreatment on high glucose-induced expression of fractalkine and apoptosis in human umbilical vein endothelial cells","volume":"8","author":"Li","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"issue":"3","key":"10.1016\/j.biopha.2019.109362_bib0570","first-page":"294","article-title":"Effects of sodium tanshinone II A sulfonate on proliferation of fibroblasts in scar and the mRNA and protein expressions of transforming growth factor beta 1 and alpha smooth muscle actin","volume":"29","author":"Liu","year":"2013","journal-title":"Zhonghua Shao Shang Za Zhi"},{"issue":"1","key":"10.1016\/j.biopha.2019.109362_bib0575","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.intimp.2014.07.002","article-title":"Sodium tanshinone IIA sulfonate prolongs the survival of skin allografts by inhibiting inflammatory cell infiltration and T cell proliferation","volume":"22","author":"Yu","year":"2014","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2019.109362_bib0580","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3892\/mmr.2017.6573","article-title":"Sodium tanshinone IIA sulfonate improves inflammation, aortic endothelial cell apoptosis, disseminated intravascular coagulation and multiple organ damage in a rat heat stroke model","volume":"16","author":"Chen","year":"2017","journal-title":"Mol. Med. Rep."},{"issue":"2","key":"10.1016\/j.biopha.2019.109362_bib0585","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.3892\/mmr.2017.6760","article-title":"Sodium tanshinone IIA sulfonate suppresses heat stress-induced endothelial cell apoptosis by promoting NO production through upregulating the PI3K\/AKT\/eNOS pathway","volume":"16","author":"Cheng","year":"2017","journal-title":"Mol. Med. Rep."},{"issue":"1","key":"10.1016\/j.biopha.2019.109362_bib0590","doi-asserted-by":"crossref","first-page":"018","DOI":"10.1038\/s41598-018-33552-2","article-title":"Sodium tanshinone IIA sulfonate protects ARPE-19 cells against oxidative stress by inhibiting autophagy and apoptosis","volume":"8","author":"Han","year":"2018","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.biopha.2019.109362_bib0595","first-page":"260","article-title":"Sodium tanshinone IIA sulfonate prevents postoperative peritoneal adhesions in rats by enhancing the activity of the peritoneal fibrinolytic system","volume":"36","author":"Lin","year":"2016","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"issue":"6","key":"10.1016\/j.biopha.2019.109362_bib0600","first-page":"721","article-title":"Topical application of sulfotanshinone sodium suppresses sebaceous hyperplasia in Syrian hamsters","volume":"151","author":"Gozali","year":"2016","journal-title":"G. Ital. Dermatol. Venereol."},{"issue":"6","key":"10.1016\/j.biopha.2019.109362_bib0605","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0129655","article-title":"Sodium tanshinone IIA sulfonate ameliorates bladder fibrosis in a rat model of partial bladder outlet obstruction by inhibiting the TGF-beta\/Smad pathway activation","volume":"10","author":"Jiang","year":"2015","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.biopha.2019.109362_bib0610","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.bcp.2006.05.014","article-title":"Sodium tanshinone IIA sulfonate derived from Slavia miltiorrhiza Bunge up-regulate the expression of prolactin releasing peptide (PrRP) in the medulla oblongata in ovariectomized rats","volume":"72","author":"Xiao","year":"2006","journal-title":"Biochem. Pharmacol."},{"issue":"13","key":"10.1016\/j.biopha.2019.109362_bib0615","doi-asserted-by":"crossref","first-page":"6954","DOI":"10.1073\/pnas.94.13.6954","article-title":"Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages","volume":"94","author":"Yong","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.biopha.2019.109362_bib0620","first-page":"139","article-title":"NADPH oxidase and uncoupled nitric oxide synthase are major sources of reactive oxygen species in oral squamous cell carcinoma. Potential implications for immune regulation in high oxidative stress conditions","volume":"59","author":"Czesnikiewiczguzik","year":"2008","journal-title":"J. Physiol. Pharmacol."},{"issue":"22","key":"10.1016\/j.biopha.2019.109362_bib0625","doi-asserted-by":"crossref","first-page":"8812","DOI":"10.1016\/S0021-9258(19)40745-X","article-title":"Superoxide, hydrogen peroxide, and singlet oxygen in lipid peroxidation by a xanthine oxidase system","volume":"250","author":"Kellogg","year":"1975","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2019.109362_bib0630","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.freeradbiomed.2016.11.033","article-title":"Antioxidants and HNE in redox homeostasis","volume":"111","author":"Luczaj","year":"2017","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.biopha.2019.109362_bib0635","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-019-1842-2","article-title":"Overexpression of scavenger receptor and infiltration of macrophage in epicardial adipose tissue of patients with ischemic heart disease and diabetes","volume":"17","author":"Santiago-Fern\u00e1ndez","year":"2019","journal-title":"J. Transl. Med."},{"issue":"5","key":"10.1016\/j.biopha.2019.109362_bib0640","first-page":"403","article-title":"Effect of Panax notoginseng saponins on intercellular adhesion molecule-1 expression and neutrophil infiltration in cerebral infarction tissue of rats","volume":"28","author":"Wei","year":"2005","journal-title":"J. Chin. Med. Mater."},{"issue":"8","key":"10.1016\/j.biopha.2019.109362_bib0645","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/nrd.2018.97","article-title":"Targeting the NLRP3 inflammasome in inflammatory diseases","volume":"17","author":"Mangan","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"issue":"8","key":"10.1016\/j.biopha.2019.109362_bib0650","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1111\/bph.13829","article-title":"Sulfur-containing gaseous signal molecules, ion channels and cardiovascular diseases","volume":"175","author":"Yu","year":"2018","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.biopha.2019.109362_bib0655","first-page":"254","article-title":"Effects of sodium tanshinone II-A sulfonate on slow action potentials of dissociated single ventricular cells of adult guinea pig heart","volume":"42","author":"Liu","year":"1990","journal-title":"Sheng Li Xue Bao"},{"issue":"1","key":"10.1016\/j.biopha.2019.109362_bib0660","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1165\/rcmb.2012-0071OC","article-title":"Sodium tanshinone IIA sulfonate inhibits canonical transient receptor potential expression in pulmonary arterial smooth muscle from pulmonary hypertensive rats","volume":"48","author":"Wang","year":"2013","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.biopha.2019.109362_bib0665","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.metabol.2018.01.008","article-title":"Functional regulation of large conductance Ca(2+)-activated K(+) channels in vascular diseases","volume":"83","author":"Zhu","year":"2018","journal-title":"Metabolism"},{"issue":"1\u20133","key":"10.1016\/j.biopha.2019.109362_bib0670","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejphar.2008.09.013","article-title":"Activation of high conductance Ca(2+)-activated K(+) channels by sodium tanshinoneII-A sulfonate (DS-201) in porcine coronary artery smooth muscle cells","volume":"598","author":"Yang","year":"2008","journal-title":"Eur. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.biopha.2019.109362_bib0675","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/aps.2014.85","article-title":"Tanshinone II-A sodium sulfonate (DS-201) enhances human BKCa channel activity by selectively targeting the pore-forming alpha subunit","volume":"35","author":"Tan","year":"2014","journal-title":"Acta Pharmacol. Sin."},{"issue":"1\u20132","key":"10.1016\/j.biopha.2019.109362_bib0680","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jchromb.2005.11.045","article-title":"Ion-pair reversed-phase HPLC: assay validation of sodium tanshinone IIA sulfonate in mouse plasma","volume":"831","author":"Mao","year":"2006","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"issue":"1","key":"10.1016\/j.biopha.2019.109362_bib0685","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ijpharm.2011.03.031","article-title":"Danshen extract does not alter pharmacokinetics of docetaxel and clopidogrel, reflecting its negligible potential in P-glycoprotein- and cytochrome P4503A-mediated herb\u2013drug interactions","volume":"410","author":"Lee","year":"2011","journal-title":"Int. J. Pharm."},{"issue":"7","key":"10.1016\/j.biopha.2019.109362_bib0690","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1080\/00498250902951763","article-title":"Effect of sodium tanshinone II A sulfonate on the activity of CYP1A2 in healthy volunteers","volume":"39","author":"Chen","year":"2009","journal-title":"Xenobiotica"},{"issue":"11","key":"10.1016\/j.biopha.2019.109362_bib0695","first-page":"016","article-title":"Kinetics of cytochrome P450 enzymes for metabolism of sodium tanshinone IIA sulfonate in vitro","volume":"11","author":"Ouyang","year":"2016","journal-title":"Chin. Med."},{"issue":"3","key":"10.1016\/j.biopha.2019.109362_bib0700","first-page":"218","article-title":"Lower clearance of sodium tanshinone IIA sulfonate in coronary heart disease patients and the effect of total bilirubin: a population pharmacokinetics analysis","volume":"17","author":"Qin","year":"2019","journal-title":"Chin. J. Nat. Med."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219322413?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219322413?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T12:13:17Z","timestamp":1776427997000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332219322413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":140,"alternative-id":["S0753332219322413"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109362","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sodium tanshinone IIA sulfonate: A review of pharmacological activity and pharmacokinetics","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109362","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"109362"}}