{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:58:23Z","timestamp":1783490303152,"version":"3.55.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T00:00:00Z","timestamp":1567123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20160761"],"award-info":[{"award-number":["BK20160761"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81603328"],"award-info":[{"award-number":["81603328"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81774150"],"award-info":[{"award-number":["81774150"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973506"],"award-info":[{"award-number":["81973506"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573719"],"award-info":[{"award-number":["81573719"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2016M600456"],"award-info":[{"award-number":["2016M600456"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2017T100425"],"award-info":[{"award-number":["2017T100425"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.biopha.2019.109418","type":"journal-article","created":{"date-parts":[[2019,9,7]],"date-time":"2019-09-07T11:08:16Z","timestamp":1567854496000},"page":"109418","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["YiQiFuMai powder injection ameliorates chronic heart failure through cross-talk between adipose tissue and cardiomyocytes via up-regulation of circulating adipokine omentin"],"prefix":"10.1016","volume":"119","author":[{"given":"Fang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Zhi","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Yang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Ping","family":"Kou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2019.109418_bib0005","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.jacc.2014.12.044","article-title":"Status of cardiovascular health in Chinese adults","volume":"65","author":"Jiang","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.biopha.2019.109418_bib0010","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ijcard.2014.10.087","article-title":"Heart failure and cognitive dysfunction","volume":"178","author":"Ampadu","year":"2015","journal-title":"Int J Cardio"},{"key":"10.1016\/j.biopha.2019.109418_bib0015","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/S0140-6736(14)61889-4","article-title":"The war against heart failure: the lancet lecture","volume":"385","author":"Braunwald","year":"2015","journal-title":"Lancet"},{"issue":"82","key":"10.1016\/j.biopha.2019.109418_bib0020","first-page":"E1","volume":"2012","author":"Ischemic","year":"2013","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"10.1016\/j.biopha.2019.109418_bib0025","doi-asserted-by":"crossref","first-page":"E146","DOI":"10.1161\/CIR.0000000000000485","article-title":"Heart disease and stroke statistics\u20142017 update a report from the american heart association","volume":"135","author":"Benjamin","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2019.109418_bib0030","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.metabol.2013.09.017","article-title":"Cross-talk between the heart and adipose tissue in cachectic heart failure patients with respect to alterations in body composition: a prospective study","volume":"63","author":"Christensen","year":"2014","journal-title":"Metabolism Clin & Exp"},{"key":"10.1016\/j.biopha.2019.109418_bib0035","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/j.jacc.2016.06.072","article-title":"The adipokine-cardiovascular-Lifestyle network: translation to clinical practice","volume":"68","author":"Mechanick","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.biopha.2019.109418_bib0040","doi-asserted-by":"crossref","first-page":"e837","DOI":"10.1161\/CIRCULATIONAHA.111.077602","article-title":"Ectopic fat depots and cardiovascular disease","volume":"124","author":"Britton","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2019.109418_bib0045","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.coph.2016.01.004","article-title":"Epicardial fat: a new cardiovascular therapeutic target","volume":"27","author":"Iacobellis","year":"2016","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.biopha.2019.109418_bib0050","doi-asserted-by":"crossref","DOI":"10.1152\/ajpendo.00572.2004","article-title":"Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action","volume":"290","author":"Yang","year":"2006","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2019.109418_bib0055","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3109\/1354750X.2011.622789","article-title":"Serum omentin-1 levels are inversely associated with the presence and severity of coronary artery disease in patients with metabolic syndrome","volume":"16","author":"Shang","year":"2011","journal-title":"Biomarkers"},{"key":"10.1016\/j.biopha.2019.109418_bib0060","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1016\/j.jacc.2014.03.032","article-title":"Omentin prevents myocardial ischemic injury through amp-activated protein kinase- and akt-dependent mechanisms","volume":"63","author":"Kataoka","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.biopha.2019.109418_bib0065","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.yjmcc.2014.11.019","article-title":"Omentin functions to attenuate cardiac hypertrophic response","volume":"79","author":"Ohashi","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.biopha.2019.109418_bib0070","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.bbrc.2015.01.032","article-title":"Adipocytokine, omentin inhibits doxorubicininduced H9c2 cardiomyoblasts apoptosis through the inhibition of mitochondrial reactive oxygen species","volume":"457","author":"Kazama","year":"2015","journal-title":"Biochem Bioph Res Commun"},{"key":"10.1016\/j.biopha.2019.109418_bib0075","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1038\/hr.2011.130","article-title":"Association of a fat-derived plasma protein omentin with carotid artery intima-media thickness in apparently healthy men","volume":"34","author":"Takahashi","year":"2011","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.biopha.2019.109418_bib0080","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.diabres.2010.01.013","article-title":"Changes of serum omentin-1 levels in normal subjects and in patients with impaired glucose regulation and with newly diagnosed and untreated type 2 diabetes","volume":"88","author":"Pan","year":"2010","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.biopha.2019.109418_bib0085","first-page":"2418","article-title":"Therapeutic effect of YiQiFuMai in patients with chronic congestive heart failure","volume":"22","author":"Xu","year":"2009","journal-title":"Med. Inform. (Lond)"},{"key":"10.1016\/j.biopha.2019.109418_bib0090","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jep.2013.04.019","article-title":"Cardioprotective effects of the YiQiFuMai injection and isolated compounds on attenuating chronic heart failure via NF-kappab inactivation and cytokine suppression","volume":"148","author":"Xing","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2019.109418_bib0095","first-page":"401","article-title":"Protective effect of the extract of Yi-Qi-Fu-Mai preparation on hypoxia-induced heart injury in mice","volume":"14","author":"Feng","year":"2016","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.biopha.2019.109418_bib0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/rej.2015.1801","article-title":"YiQiFuMai Powder Injection Attenuates Ischemia\/Reperfusion-Induced Myocardial Apoptosis Through AMPK Activation","volume":"19","author":"Li","year":"2016","journal-title":"Rejuv Res"},{"key":"10.1016\/j.biopha.2019.109418_bib0105","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jep.2017.02.032","article-title":"YiQiFuMai Powder Injection attenuates coronary artery ligation-induced myocardial remodeling and heart failure through modulating MAPKs signaling pathway","volume":"202","author":"Pang","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2019.109418_bib0110","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.ddmod.2006.10.002","article-title":"Surgical models of hypertrophy and heart failure: myocardial infarction and transverse aortic constriction","volume":"3","author":"Lygate","year":"2006","journal-title":"Drug Discov. Today Dis. Models"},{"key":"10.1016\/j.biopha.2019.109418_bib0115","doi-asserted-by":"crossref","first-page":"37114","DOI":"10.1038\/srep37114","article-title":"Cardioprotection by combination of three compounds from ShengMai preparations in mice with myocardial ischemia\/reperfusion injury through AMPK activation-mediated mitochondrial fission","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.biopha.2019.109418_bib0120","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.amjcard.2013.12.007","article-title":"Effect of digoxin on shocks in cardiac resynchronization therapy-defibrillator patients with coronary artery disease","volume":"113","author":"Adelstein","year":"2014","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.biopha.2019.109418_bib0125","doi-asserted-by":"crossref","first-page":"g2866","DOI":"10.1136\/bmj.g2866","article-title":"Influence of healthy candidate bias in assessing clinical effectiveness for implantable cardioverter-defibrillators: cohort study of older patients with heart failure","volume":"348","author":"Setoguchi","year":"2014","journal-title":"BMJ"},{"key":"10.1016\/j.biopha.2019.109418_bib0130","first-page":"1","article-title":"Evaluation of myocardial function according to early diastolic intraventricular pressure difference in fetuses","volume":"9","author":"Takemoto","year":"2017","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"10.1016\/j.biopha.2019.109418_bib0135","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/1050-1738(91)90037-F","article-title":"Metabolic and diagnostic significance of creatine kinase isoenzymes","volume":"1","author":"Homburg","year":"1991","journal-title":"Trends Cardiovasc. Med."},{"issue":"1\u20132","key":"10.1016\/j.biopha.2019.109418_bib0140","first-page":"1","article-title":"Secoisolariciresinol diglucoside attenuates cardiac hypertrophy and oxidative stress in monocrotaline-induced right heart dysfunction","volume":"432","author":"Puukila","year":"2017","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.biopha.2019.109418_bib0145","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/0002-8703(83)90357-5","article-title":"The roles of serum myoglobin, total CPK, and CK-MB mass in the acute phase of myocardial infarction","volume":"105","author":"Grenadier","year":"1983","journal-title":"Am. Heart J."},{"issue":"1","key":"10.1016\/j.biopha.2019.109418_bib0150","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00246-004-0677-6","article-title":"Cardiac troponin t: a marker in the diagnosis of acute myocarditis in children","volume":"26","author":"Soongswang","year":"2005","journal-title":"Pediatr. Cardiol."},{"key":"10.1016\/j.biopha.2019.109418_bib0155","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1161\/01.CIR.0000084543.79097.34","article-title":"Cardiac troponin I is associated with impaired haemodynamics, progressive left-ventricular dysfunction, and increased mortality rates in advanced heart failure","volume":"108","author":"Horwich","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2019.109418_bib0160","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1096\/fasebj.9.9.7601340","article-title":"The troponin complex and regulation of muscle contraction","volume":"9","author":"Farah","year":"1995","journal-title":"FASEB J."},{"key":"10.1016\/j.biopha.2019.109418_bib0165","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.atherosclerosis.2011.08.017","article-title":"Circulating omentin is associated with coronary artery disease in men","volume":"219","author":"Takahashi","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.biopha.2019.109418_bib0170","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.cca.2015.05.019","article-title":"The protective functions of omentin in cardiovascular diseases","volume":"448","author":"Tan","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.biopha.2019.109418_bib0175","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1074\/jbc.M111.261818","article-title":"Fat-derived factor omentin stimulates endothelial cell function and ischemia-induced revascularization via endothelial nitric oxide synthase-dependent mechanism","volume":"287","author":"Maruyama","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2019.109418_bib0180","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.bbrc.2010.02.053","article-title":"A novel adipokine, induces vasodilation in rat isolated blood vessels","volume":"393","author":"Yamawaki","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2019.109418_bib0185","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.hlc.2014.03.013","article-title":"Omentin, fat and heart: classical music with new instruments","volume":"23","author":"Katsi","year":"2014","journal-title":"Heart Lung Circ."},{"key":"10.1016\/j.biopha.2019.109418_bib0190","article-title":"Atheroprotective properties of human Omentin-1 in experimental atherosclerosis","volume":"110","author":"De","year":"2016","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.biopha.2019.109418_bib0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.ahj.2007.03.019","article-title":"Human epicardial adipose tissue: a review","volume":"153","author":"Sacks","year":"2007","journal-title":"Am. Heart J."},{"key":"10.1016\/j.biopha.2019.109418_bib0200","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1586\/ern.13.51","article-title":"Ginsenoside Rd for acute ischemic stroke: translating from bench to bedside","volume":"13","author":"Ye","year":"2013","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.biopha.2019.109418_bib0205","article-title":"Ginsenoside Rd attenuates myocardial ischemia\/reperfusion injury via Akt\/GSK-3beta signaling and inhibition of the mitochondria-dependent apoptotic pathway","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2019.109418_bib0210","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jgr.2014.11.003","article-title":"Inhibition of L-type Ca(2+) current by ginsenoside Rd in rat ventricular myocytes","volume":"39","author":"Lu","year":"2015","journal-title":"J. Ginseng Res."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219334729?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219334729?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T18:38:08Z","timestamp":1777574288000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332219334729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":42,"alternative-id":["S0753332219334729"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109418","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"YiQiFuMai powder injection ameliorates chronic heart failure through cross-talk between adipose tissue and cardiomyocytes via up-regulation of circulating adipokine omentin","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109418","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"109418"}}