{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T11:17:47Z","timestamp":1778757467080,"version":"3.51.4"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T00:00:00Z","timestamp":1569974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012540","name":"Guangdong Province Introduction of Innovative R&D Team","doi-asserted-by":"publisher","award":["2016KCXTD019"],"award-info":[{"award-number":["2016KCXTD019"]}],"id":[{"id":"10.13039\/100012540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["ID 81773118"],"award-info":[{"award-number":["ID 81773118"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31471290"],"award-info":[{"award-number":["31471290"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31771578"],"award-info":[{"award-number":["31771578"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","award":["ID A2017345"],"award-info":[{"award-number":["ID A2017345"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.biopha.2019.109534","type":"journal-article","created":{"date-parts":[[2019,11,24]],"date-time":"2019-11-24T05:05:38Z","timestamp":1574571938000},"page":"109534","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Gastric precancerous lesions present in ApcMin\/+ mice"],"prefix":"10.1016","volume":"121","author":[{"given":"Sheng","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianbiao","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guifeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingyun","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangchao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2019.109534_bib0005","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.biopha.2019.109534_bib0010","first-page":"26","article-title":"Epidemiology of gastric cancer: global trends, risk factors and prevention","volume":"14","author":"Rawla","year":"2019","journal-title":"Prz. Gastroenterol."},{"issue":"2","key":"10.1016\/j.biopha.2019.109534_bib0015","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.gtc.2013.01.002","article-title":"Gastric cancer: overview","volume":"42","author":"Correa","year":"2013","journal-title":"Gastroenterol. Clin. North Am."},{"issue":"1","key":"10.1016\/j.biopha.2019.109534_bib0020","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1751-2980.2011.00550.x","article-title":"The gastric precancerous cascade","volume":"13","author":"Correa","year":"2012","journal-title":"J. Dig. Dis."},{"issue":"1","key":"10.1016\/j.biopha.2019.109534_bib0025","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s12876-017-0708-4","article-title":"Adenocarcinoma risk in gastric atrophy and intestinal metaplasia: a systematic review","volume":"17","author":"Spence","year":"2017","journal-title":"BMC Gastroenterol."},{"issue":"4","key":"10.1016\/j.biopha.2019.109534_bib0030","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1136\/gutjnl-2017-314498","article-title":"Surveillance of premalignant gastric lesions: a multicentre prospective cohort study from low incidence regions","volume":"68","author":"den Hollander","year":"2019","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.biopha.2019.109534_bib0035","doi-asserted-by":"crossref","DOI":"10.1111\/hel.12548","article-title":"High-risk symptoms do not predict gastric cancer precursors","volume":"24","author":"Da","year":"2019","journal-title":"Helicobacter"},{"key":"10.1016\/j.biopha.2019.109534_bib0040","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2147\/CMAR.S149619","article-title":"Gastric cancer: epidemiology, prevention, classification, and treatment","volume":"10","author":"Sitarz","year":"2018","journal-title":"Cancer Manage. Res."},{"issue":"7","key":"10.1016\/j.biopha.2019.109534_bib0045","doi-asserted-by":"crossref","first-page":"10827","DOI":"10.1002\/jcp.27908","article-title":"Dynamic changes of Sonic Hedgehog signaling pathway in gastric mucosa of rats with MNNG-induced gastric precancerous lesions","volume":"234","author":"Cai","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"12","key":"10.1016\/j.biopha.2019.109534_bib0050","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1016\/j.prp.2018.10.022","article-title":"The application of transgenic and gene knockout mice in the study of gastric precancerouslesions","volume":"214","author":"Liu","year":"2018","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.biopha.2019.109534_bib0055","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ctrv.2017.11.002","article-title":"Targeting the Wnt\/\u03b2-catenin pathway in cancer: update on effectors and inhibitors","volume":"62","author":"Krishnamurthy","year":"2018","journal-title":"Cancer Treat. Rev."},{"issue":"1","key":"10.1016\/j.biopha.2019.109534_bib0060","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s12943-018-0874-1","article-title":"LINC01133 as ceRNA inhibits gastric cancer progression by sponging miR-106a-3p to regulate APC expression and the Wnt\/\u03b2-catenin pathway","volume":"17","author":"Yang","year":"2018","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.biopha.2019.109534_bib0065","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s12876-018-0841-8","article-title":"Variables affecting penetrance of gastric and duodenal phenotype in familial adenomatous polyposis patients","volume":"18","author":"Sample","year":"2018","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.biopha.2019.109534_bib0070","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1126\/science.2296722","article-title":"A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse","volume":"247","author":"Moser","year":"1990","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.biopha.2019.109534_bib0075","doi-asserted-by":"crossref","first-page":"4079","DOI":"10.1158\/0008-5472.CAN-06-4025","article-title":"Development of gastric tumors in Apc(Min\/+) mice by the activation of the beta-catenin\/Tcf signaling pathway","volume":"67","author":"Tomita","year":"2007","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.biopha.2019.109534_bib0080","doi-asserted-by":"crossref","first-page":"679","DOI":"10.7150\/ijbs.11589","article-title":"P-selectin-mediated adhesion between platelets and tumor cells promotes intestinal tumorigenesis in apc(Min\/+) mice","volume":"11","author":"Qi","year":"2015","journal-title":"Int. J. Biol. Sci."},{"issue":"4","key":"10.1016\/j.biopha.2019.109534_bib0085","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1080\/15384047.2016.1276130","article-title":"Dietary selenium protects adiponectin knockout mice against chronic inflammation induced colon cancer","volume":"18","author":"Saxena","year":"2017","journal-title":"Cancer Biol. Ther."},{"issue":"3","key":"10.1016\/j.biopha.2019.109534_bib0090","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/j.1349-7006.2007.00721.x","article-title":"Targeting Slit-Roundabout signaling inhibits tumor angiogenesis in chemical-induced squamous cell carcinogenesis","volume":"99","author":"Wang","year":"2008","journal-title":"Cancer Sci."},{"issue":"8","key":"10.1016\/j.biopha.2019.109534_bib0095","doi-asserted-by":"crossref","first-page":"8640","DOI":"10.18632\/oncotarget.7082","article-title":"Irsogladine maleate, a gastric mucosal protectant, suppresses intestinal polyp development in Apc-mutant mice","volume":"7","author":"Onuma","year":"2016","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.biopha.2019.109534_bib0100","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12881-017-0427-2","article-title":"Novel APC gene mutations associated with protein alteration in diffuse type gastric cancer","volume":"18","author":"Ghatak","year":"2017","journal-title":"BMC Med. Genet."},{"issue":"2","key":"10.1016\/j.biopha.2019.109534_bib0105","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s00795-006-0352-5","article-title":"Adenomatous polyposis coli (APC) plays multiple roles in the intestinal and colorectal epithelia","volume":"40","author":"Senda","year":"2007","journal-title":"Med. Mol. Morphol."},{"issue":"10","key":"10.1016\/j.biopha.2019.109534_bib0110","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1111\/j.1440-1746.2012.07219.x","article-title":"Hypermethylation of adenomatous polyposis coli gene promoter is associated with novel Wnt signaling pathway in gastric adenomas","volume":"27","author":"Wang","year":"2012","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.biopha.2019.109534_bib0115","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3389\/fonc.2018.00275","article-title":"The use of circulating tumor DNA for prognosis of gastrointestinal cancers","volume":"8","author":"Saluja","year":"2018","journal-title":"Front. Oncol."},{"issue":"3","key":"10.1016\/j.biopha.2019.109534_bib0120","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/PAS.0000000000000785","article-title":"Duodenal neoplasms of gastric phenotype: an immunohistochemical and genetic study with a practical approach to the classification","volume":"41","author":"Hida","year":"2017","journal-title":"Am. J. Surg. Pathol."},{"issue":"3","key":"10.1016\/j.biopha.2019.109534_bib0125","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/path.4777","article-title":"Dysregulated Wnt signalling and recurrent mutations of the tumour suppressor RNF43 in early gastric carcinogenesis","volume":"240","author":"Min","year":"2016","journal-title":"J. Pathol."},{"issue":"4","key":"10.1016\/j.biopha.2019.109534_bib0130","doi-asserted-by":"crossref","first-page":"217","DOI":"10.29252\/ibj.22.4.217","article-title":"Molecular signaling in tumorigenesis of gastric cancer","volume":"22","author":"Molaei","year":"2018","journal-title":"Iran. Biomed. J."},{"issue":"1","key":"10.1016\/j.biopha.2019.109534_bib0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4161\/15384047.2014.972215","article-title":"Crosstalk between Wnt\/\u03b2-catenin and Hedgehog\/Gli signaling pathways in colon cancer and implications fortherapy","volume":"16","author":"Song","year":"2015","journal-title":"Cancer Biol. Ther."},{"issue":"9","key":"10.1016\/j.biopha.2019.109534_bib0140","doi-asserted-by":"crossref","first-page":"e2873","DOI":"10.1097\/MD.0000000000002873","article-title":"Gastric carcinomas in young (younger than 40 years) Chinese patients: clinicopathology, family history, and postresection survival","volume":"95","author":"Zhou","year":"2016","journal-title":"Medicine (Baltimore)"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219337084?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219337084?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:27:49Z","timestamp":1778754469000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332219337084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":28,"alternative-id":["S0753332219337084"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109534","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gastric precancerous lesions present in ApcMin\/+ mice","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109534","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"109534"}}