{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:47:08Z","timestamp":1786985228246,"version":"build-2736575974"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T00:00:00Z","timestamp":1571270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.biopha.2019.109556","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T17:18:10Z","timestamp":1571851090000},"page":"109556","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Suppression of TRPM2 reduces renal fibrosis and inflammation through blocking TGF-\u03b21-regulated JNK activation"],"prefix":"10.1016","volume":"120","author":[{"given":"Ying","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingwei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangyao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanting","family":"Da","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shasha","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiping","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunsheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10075","key":"10.1016\/j.biopha.2019.109556_bib0005","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/S0140-6736(16)32064-5","article-title":"Chronic kidney disease","volume":"389","author":"Webster","year":"2017","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.biopha.2019.109556_bib0010","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/kisup.2014.21","article-title":"Obesity, oxidative stress, and fibrosis in chronic kidney disease","volume":"4","author":"Sharma","year":"2014","journal-title":"Kidney Int. Suppl."},{"key":"10.1016\/j.biopha.2019.109556_bib0015","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.redox.2016.12.011","article-title":"Oxidative stress in cancer and fibrosis: Opportunity for therapeutic intervention with antioxidant compounds, enzymes, and nanoparticles","volume":"11","author":"Morry","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.biopha.2019.109556_bib0020","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev-physiol-022516-034227","article-title":"Mechanisms of renal fibrosis","volume":"80","author":"Humphreys","year":"2018","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.biopha.2019.109556_bib0025","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.redox.2016.12.022","article-title":"The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2\/PINK1","volume":"11","author":"Xiao","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.biopha.2019.109556_bib0030","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.redox.2017.06.002","article-title":"Dietary nitrate attenuates renal ischemia-reperfusion injuries by modulation of immune responses and reduction of oxidative stress","volume":"13","year":"2017","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.biopha.2019.109556_bib0035","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/kisup.2014.7","article-title":"Macrophages promote renal fibrosis through direct and indirect mechanisms","volume":"4","author":"Nikolic-Paterson","year":"2014","journal-title":"Kidney Int. Suppl."},{"issue":"6","key":"10.1016\/j.biopha.2019.109556_bib0040","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.ceca.2008.05.001","article-title":"Synergistic regulation of endogenous TRPM2 channels by adenine dinucleotides in primary human neutrophils","volume":"44","author":"Lange","year":"2008","journal-title":"Cell Calcium"},{"issue":"1","key":"10.1016\/j.biopha.2019.109556_bib0045","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1113\/jphysiol.2006.113886","article-title":"Molecular and electrophysiological characterization of transient receptor potential ion channels in the primary murine megakaryocyte","volume":"576","author":"Carter","year":"2006","journal-title":"J. Physiol."},{"issue":"1","key":"10.1016\/j.biopha.2019.109556_bib0050","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S1097-2765(01)00438-5","article-title":"LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death","volume":"9","author":"Hara","year":"2002","journal-title":"Mol. Cell"},{"issue":"4","key":"10.1016\/j.biopha.2019.109556_bib0055","doi-asserted-by":"crossref","first-page":"C1146","DOI":"10.1152\/ajpcell.00205.2005","article-title":"TRPM2 is an ion channel that modulates hematopoietic cell death through activation of caspases and PARP cleavage","volume":"290","author":"Zhang","year":"2006","journal-title":"Am. J. Physiol.-Cell Physiol."},{"issue":"7","key":"10.1016\/j.biopha.2019.109556_bib0060","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/nm1758","article-title":"TRPM2-mediated Ca 2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration","volume":"14","author":"Yamamoto","year":"2008","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.biopha.2019.109556_bib0065","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1006\/jsre.2001.6314","article-title":"Impaired antioxidant defense system of colonic tissue and cancer development in dextran sulfate sodium-induced colitis in mice","volume":"102","author":"Korenaga","year":"2002","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.biopha.2019.109556_bib0070","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.freeradbiomed.2015.11.021","article-title":"TRPM2 channels in alveolar epithelial cells mediate bleomycin-induced lung inflammation","volume":"90","author":"Yonezawa","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biopha.2019.109556_bib0075","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.27236","article-title":"8\u2010Br\u2010cADPR, a TRPM2 ion channel antagonist, inhibits renal ischemia\u2013reperfusion injury","author":"Eraslan","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"3","key":"10.1016\/j.biopha.2019.109556_bib0080","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/labinvest.2009.149","article-title":"Low-dose paclitaxel ameliorates renal fibrosis in rat UUO model by inhibition of TGF-\u03b2\/Smad activity","volume":"90","author":"Zhang","year":"2010","journal-title":"Lab. Investig."},{"key":"10.1016\/j.biopha.2019.109556_bib0085","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.redox.2017.08.012","article-title":"Reduced levels of methyltransferase DNMT2 sensitize human fibroblasts to oxidative stress and DNA damage that is accompanied by changes in proliferation-related miRNA expression","volume":"14","author":"Lewinska","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.biopha.2019.109556_bib0090","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.redox.2017.08.014","article-title":"Aging-related decline in the induction of Nrf2-regulated antioxidant genes in human bronchial epithelial cells","volume":"14","author":"Zhou","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.biopha.2019.109556_bib0095","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.redox.2017.01.008","article-title":"Snapshot situation of oxidative degradation of the nervous system, kidney, and adrenal glands biomarkers-neuroprostane and dihomo-isoprostanes-urinary biomarkers from infancy to elderly adults","volume":"11","author":"Garc\u00eda-Flores","year":"2017","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.biopha.2019.109556_bib0100","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.kint.2017.05.013","article-title":"Fibroblast growth factor 1 ameliorates diabetic nephropathy by an anti-inflammatory mechanism","volume":"93","author":"Liang","year":"2018","journal-title":"Kidney Int."},{"key":"10.1016\/j.biopha.2019.109556_bib0105","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.freeradbiomed.2017.12.013","article-title":"CKIP-1 affects the polyubiquitination of Nrf2 and Keap1 via mediating Smurf1 to resist HG-induced renal fibrosis in GMCs and diabetic mice kidneys","volume":"115","author":"Gong","year":"2018","journal-title":"Free Radic. Biol. Med."},{"issue":"7085","key":"10.1016\/j.biopha.2019.109556_bib0110","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/nature04662","article-title":"Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes","volume":"440","author":"Jones","year":"2006","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.biopha.2019.109556_bib0115","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0304-3940(00)01368-9","article-title":"Analysis of neurogenesis and programmed cell death reveals a self-renewing capacity in the adult rat brain","volume":"291","author":"Biebl","year":"2000","journal-title":"Neurosci. Lett."},{"issue":"8","key":"10.1016\/j.biopha.2019.109556_bib0120","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1007\/s00467-008-1046-0","article-title":"Inflammation in chronic kidney disease: role in the progression of renal and cardiovascular disease","volume":"24","author":"Silverstein","year":"2009","journal-title":"Pediatr. Nephrol."},{"issue":"3","key":"10.1016\/j.biopha.2019.109556_bib0125","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.taap.2013.08.011","article-title":"Calcineurin inhibitors recruit protein kinases JAK2 and JNK, TLR signaling and the UPR to activate NF-\u03baB-mediated inflammatory responses in kidney tubular cells","volume":"272","author":"Gonz\u00e1lez-Guerrero","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.biopha.2019.109556_bib0130","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.redox.2017.11.022","article-title":"Redox system and phospholipid metabolism in the kidney of hypertensive rats after FAAH inhibitor URB597 administration","volume":"15","author":"Biernacki","year":"2018","journal-title":"Redox Biol."},{"issue":"10","key":"10.1016\/j.biopha.2019.109556_bib0135","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1172\/JCI200319270","article-title":"Targeted disruption of TGF-\u03b21\/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction","volume":"112","author":"Sato","year":"2003","journal-title":"J. Clin. Invest."},{"issue":"9","key":"10.1016\/j.biopha.2019.109556_bib0140","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1038\/sj.emboj.7601083","article-title":"TRPM2 activation by cyclic ADP\u2010ribose at body temperature is involved in insulin secretion","volume":"25","author":"Togashi","year":"2006","journal-title":"EMBO J."},{"issue":"8","key":"10.1016\/j.biopha.2019.109556_bib0145","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.1073\/pnas.1322657111","article-title":"TRPM2 channels mediate acetaminophen-induced liver damage","volume":"111","author":"Kheradpezhouh","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.biopha.2019.109556_bib0150","doi-asserted-by":"crossref","first-page":"3","DOI":"10.23861\/EJBM20102573","article-title":"The association of blood urea nitrogen levels and coronary artery disease","volume":"25","author":"Ostfeld","year":"2016","journal-title":"Einstein J. Biol. Med."},{"issue":"1","key":"10.1016\/j.biopha.2019.109556_bib0155","doi-asserted-by":"crossref","first-page":"F4","DOI":"10.1152\/ajprenal.00045.2005","article-title":"Evidence that inhibition of tubular cell apoptosis protects against renal damage and development of fibrosis following ureteric obstruction","volume":"290","author":"Docherty","year":"2006","journal-title":"Am. J. Physiol.-Renal Physiol."},{"issue":"8","key":"10.1016\/j.biopha.2019.109556_bib0160","doi-asserted-by":"crossref","first-page":"e1847","DOI":"10.1038\/cddis.2015.206","article-title":"Chop deficiency prevents UUO-induced renal fibrosis by attenuating fibrotic signals originated from Hmgb1\/TLR4\/NF\u03baB\/IL-1\u03b2 signaling","volume":"6","author":"Zhang","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.biopha.2019.109556_bib0165","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.phymed.2018.09.009","article-title":"Anti-renal fibrosis effect of asperulosidic acid via TGF-\u03b21\/smad2\/smad3 and NF-\u03baB signaling pathways in a rat model of unilateral ureteral obstruction","volume":"53","author":"Xianyuan","year":"2019","journal-title":"Phytomedicine"},{"issue":"11","key":"10.1016\/j.biopha.2019.109556_bib0170","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1016\/j.cellsig.2013.07.007","article-title":"Induction of renal fibrotic genes by TGF-\u03b21 requires EGFR activation, p53 and reactive oxygen species","volume":"25","author":"Samarakoon","year":"2013","journal-title":"Cell. Signal."},{"issue":"2","key":"10.1016\/j.biopha.2019.109556_bib0175","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1254\/jphs.11128FP","article-title":"Hypoxic stress induces transient receptor potential melastatin 2 (TRPM2) channel expression in adult rat cardiac fibroblasts","volume":"118","author":"Takahashi","year":"2012","journal-title":"J. Pharmacol. Sci."},{"issue":"136","key":"10.1016\/j.biopha.2019.109556_bib0180","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3003421","article-title":"A peptide derived from endostatin ameliorates organ fibrosis","volume":"4","author":"Yamaguchi","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.biopha.2019.109556_bib0185","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1038\/ncomms2608","article-title":"TRPM2 links oxidative stress to NLRP3 inflammasome activation","volume":"4","author":"Zhong","year":"2013","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.biopha.2019.109556_bib0190","doi-asserted-by":"crossref","first-page":"288","DOI":"10.2353\/ajpath.2008.070726","article-title":"Galectin-3 expression and secretion links macrophages to the promotion of renal fibrosis","volume":"172","author":"Henderson","year":"2008","journal-title":"Am. J. Pathol."},{"issue":"2","key":"10.1016\/j.biopha.2019.109556_bib0195","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1046\/j.1523-1755.2001.059002415.x","article-title":"Transcription factor-\u03baB (NF-\u03baB) and renal disease","volume":"59","author":"Guijarro","year":"2001","journal-title":"Kidney Int."},{"issue":"3","key":"10.1016\/j.biopha.2019.109556_bib0200","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1053\/ajkd.2003.50074","article-title":"Progression of chronic renal disease","volume":"41","author":"Klahr","year":"2003","journal-title":"Am. J. Kidney Dis."},{"issue":"6","key":"10.1016\/j.biopha.2019.109556_bib0205","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/ki.2008.245","article-title":"Association of anemia and erythropoiesis stimulating agents with inflammatory biomarkers in chronic kidney disease","volume":"74","author":"Keithi-Reddy","year":"2008","journal-title":"Kidney Int."},{"key":"10.1016\/j.biopha.2019.109556_bib0210","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.redox.2017.12.004","article-title":"The novel organic mononitrate NDHP attenuates hypertension and endothelial dysfunction in hypertensive rats","volume":"15","author":"Paulo","year":"2018","journal-title":"Redox Biol."},{"issue":"3","key":"10.1016\/j.biopha.2019.109556_bib0215","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s10735-015-9621-8","article-title":"Baicalein attenuates renal fibrosis by inhibiting inflammation via down-regulating NF-\u03baB and MAPK signal pathways","volume":"46","author":"Wang","year":"2015","journal-title":"J. Mol. Histol."},{"issue":"5","key":"10.1016\/j.biopha.2019.109556_bib0220","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.4049\/jimmunol.171.5.2684","article-title":"Therapeutic attenuation of pulmonary fibrosis via targeting of IL-4-and IL-13-responsive cells","volume":"171","author":"Jakubzick","year":"2003","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.biopha.2019.109556_bib0225","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1053\/j.ackd.2005.07.011","article-title":"Progression in chronic kidney disease","volume":"12","author":"Eddy","year":"2005","journal-title":"Adv. Chronic Kidney Dis."},{"issue":"4","key":"10.1016\/j.biopha.2019.109556_bib0230","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/74139","article-title":"Getting a foothold in nephrotic syndrome","volume":"24","author":"Somlo","year":"2000","journal-title":"Nat. Genet."},{"issue":"8","key":"10.1016\/j.biopha.2019.109556_bib0235","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1681\/ASN.2009060596","article-title":"A novel role for nephrin in the maintenance of glomerular structure","volume":"20","author":"Sheerin","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"issue":"8","key":"10.1016\/j.biopha.2019.109556_bib0240","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1681\/ASN.2008111219","article-title":"Nephrin deficiency activates NF-\u03baB and promotes glomerular injury","volume":"20","author":"Hussain","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.biopha.2019.109556_bib0245","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.redox.2017.06.013","article-title":"Renal denervation attenuates hypertension and renal dysfunction in a model of cardiovascular and renal disease, which is associated with reduced NADPH and xanthine oxidase activity","volume":"13","author":"Peleli","year":"2017","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.biopha.2019.109556_bib0250","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.arcmed.2013.01.004","article-title":"Roles of p38 MAPK and JNK in TGF-\u03b21-induced human alveolar epithelial to mesenchymal transition","volume":"44","author":"Chen","year":"2013","journal-title":"Arch. Med. Res."},{"issue":"9","key":"10.1016\/j.biopha.2019.109556_bib0255","doi-asserted-by":"crossref","first-page":"F1210","DOI":"10.1152\/ajprenal.00660.2011","article-title":"PTEN loss defines a TGF-\u03b2-induced tubule phenotype of failed differentiation and JNK signaling during renal fibrosis","volume":"302","author":"Lan","year":"2012","journal-title":"Am. J. Physiol.-Renal Physiol."},{"issue":"04","key":"10.1016\/j.biopha.2019.109556_bib0260","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1142\/S0192415X14500554","article-title":"Lotus leaf (Nelumbo nucifera) and its active constituents prevent inflammatory responses in macrophages via JNK\/NF-\u03baB signaling pathway","volume":"42","author":"Liu","year":"2014","journal-title":"Am. J. Chin. Med. (Gard City N Y)"},{"issue":"10","key":"10.1016\/j.biopha.2019.109556_bib0265","doi-asserted-by":"crossref","first-page":"3637","DOI":"10.1074\/jbc.M117.817635","article-title":"TRPM2 channel\u2013mediated regulation of autophagy maintains mitochondrial function and promotes gastric cancer cell survival via the JNK-signaling pathway","volume":"293","author":"Almasi","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.biopha.2019.109556_bib0270","doi-asserted-by":"crossref","first-page":"F757","DOI":"10.1152\/ajprenal.00470.2011","article-title":"HSP47 regulates ECM accumulation in renal proximal tubular cells induced by TGF-\u03b21 through ERK1\/2 and JNK MAPK pathways","volume":"303","author":"Xiao","year":"2012","journal-title":"Am. J. Physiol.-Renal Physiol."},{"issue":"8","key":"10.1016\/j.biopha.2019.109556_bib0275","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1093\/ndt\/gfn309","article-title":"Delayed inhibition of p38 mitogen-activated protein kinase ameliorates renal fibrosis in obstructive nephropathy","volume":"23","author":"Nishida","year":"2008","journal-title":"Nephrol. Dial. Transplant."},{"issue":"11","key":"10.1016\/j.biopha.2019.109556_bib0280","doi-asserted-by":"crossref","first-page":"F1263","DOI":"10.1152\/ajprenal.00211.2014","article-title":"ASK1\/p38 signaling in renal tubular epithelial cells promotes renal fibrosis in the mouse obstructed kidney","volume":"307","author":"Ma","year":"2014","journal-title":"Am. J. Physiol.-Renal Physiol."},{"issue":"4","key":"10.1016\/j.biopha.2019.109556_bib0285","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1046\/j.1523-1755.2003.00874.x","article-title":"Activation of the ERK pathway precedes tubular proliferation in the obstructed rat kidney","volume":"63","author":"Masaki","year":"2003","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.biopha.2019.109556_bib0290","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/ki.2008.160","article-title":"Activation of Erk1\/2 and Akt following unilateral ureteral obstruction","volume":"74","author":"Rodr\u00edguez-Pe\u00f1a","year":"2008","journal-title":"Kidney Int."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219351790?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219351790?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T11:54:11Z","timestamp":1760097251000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332219351790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":58,"alternative-id":["S0753332219351790"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109556","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Suppression of TRPM2 reduces renal fibrosis and inflammation through blocking TGF-\u03b21-regulated JNK activation","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109556","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"109556"}}