{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:34:30Z","timestamp":1790678070136,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T00:00:00Z","timestamp":1571961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81501815"],"award-info":[{"award-number":["81501815"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672079"],"award-info":[{"award-number":["81672079"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772265"],"award-info":[{"award-number":["81772265"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.biopha.2019.109574","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T12:14:35Z","timestamp":1574165675000},"page":"109574","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Circulating levels of growth differentiation factor 15 and sex hormones in male patients with HBV-associated hepatocellular carcinoma"],"prefix":"10.1016","volume":"121","author":[{"given":"Juanjuan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengliang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.biopha.2019.109574_bib0005","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1002\/hep.27222","article-title":"Epidemiology of hepatocellular carcinoma in the United States: Where are we? Where do we go?","volume":"60","author":"El\u2010Serag","year":"2014","journal-title":"Hepatology"},{"issue":"9","key":"10.1016\/j.biopha.2019.109574_bib0010","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/nrgastro.2017.72","article-title":"The gut microbiome and liver cancer: mechanisms and clinical translation","volume":"14","author":"Yu","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"2","key":"10.1016\/j.biopha.2019.109574_bib0015","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1046\/j.1365-2893.2003.00487.x","article-title":"Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures","volume":"11","author":"Lavanchy","year":"2004","journal-title":"J. Viral Hepat."},{"issue":"6","key":"10.1016\/j.biopha.2019.109574_bib0020","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1053\/jhep.2001.29401","article-title":"Chronic hepatitis B","volume":"34","author":"Lok","year":"2001","journal-title":"Hepatology"},{"issue":"9","key":"10.1016\/j.biopha.2019.109574_bib0025","first-page":"598","article-title":"Gender disparity in infections of hepatitis B virus","volume":"19","author":"Baig","year":"2009","journal-title":"Jcpsp-J. Coll. Phys. Surgeons Pak."},{"issue":"3","key":"10.1016\/j.biopha.2019.109574_bib0030","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/ijc.25298","article-title":"Cellular and molecular mechanisms involved in hepatocellular carcinoma gender disparity","volume":"127","author":"Ruggieri","year":"2010","journal-title":"Int. J. Cancer"},{"issue":"3","key":"10.1016\/j.biopha.2019.109574_bib0035","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/j.1478-3231.2011.02696.x","article-title":"Quantitative methylation analysis reveals gender and age differences in p16INK4a hypermethylation in hepatitis B virus-related hepatocellular carcinoma","volume":"32","author":"Wang","year":"2012","journal-title":"Liver Int."},{"issue":"20","key":"10.1016\/j.biopha.2019.109574_bib0040","doi-asserted-by":"crossref","first-page":"6252","DOI":"10.3748\/wjg.v20.i20.6252","article-title":"Molecular mechanisms of gender disparity in hepatitis B virus-associated hepatocellular carcinoma","volume":"20","author":"Liu","year":"2014","journal-title":"World J. Gastroenterol."},{"issue":"2","key":"10.1016\/j.biopha.2019.109574_bib0045","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1365-2265.2012.04347.x","article-title":"Low testosterone levels as an independent predictor of mortality in men with chronic liver disease","volume":"77","author":"Grossmann","year":"2012","journal-title":"Clin. Endocrinol."},{"issue":"21","key":"10.1016\/j.biopha.2019.109574_bib0050","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1093\/jnci\/93.21.1644","article-title":"Hormonal markers and hepatitis B virus-related hepatocellular carcinoma risk: a nested case-control study among men","volume":"93","author":"Yu","year":"2001","journal-title":"J. Natl. Cancer Inst."},{"issue":"3","key":"10.1016\/j.biopha.2019.109574_bib0055","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.molmed.2012.12.007","article-title":"Estrogen synthesis and signaling pathways during aging: from periphery to brain","volume":"19","author":"Cui","year":"2013","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.biopha.2019.109574_bib0060","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.atherosclerosis.2017.09.002","article-title":"Circulating levels of sgp130 and sex hormones in male patients with coronary atherosclerotic disease","volume":"266","author":"Cui","year":"2017","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.biopha.2019.109574_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.108792","article-title":"Potential associations of circulating growth differentiation factor-15 with sex hormones in male patients with coronary artery disease","volume":"114","author":"Liu","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.biopha.2019.109574_bib0070","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1093\/cvr\/cvy188","article-title":"Testosterone to oestradiol ratio reflects systemic and plaque inflammation and predicts future cardiovascular events in men with severe atherosclerosis","volume":"115","author":"van Koeverden","year":"2019","journal-title":"Cardiovasc. Res."},{"issue":"4","key":"10.1016\/j.biopha.2019.109574_bib0075","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1210\/er.2017-00025","article-title":"A reappraisal of testosterone\u2019s binding in circulation: physiological and clinical implications","volume":"38","author":"Goldman","year":"2017","journal-title":"Endocr. Rev."},{"issue":"1","key":"10.1016\/j.biopha.2019.109574_bib0080","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1097\/MCG.0b013e3180cabc14","article-title":"Elevated sex hormone binding globulin levels may contribute to sexual dysfunction in men with chronic hepatitis C virus infection","volume":"43","author":"Rao","year":"2009","journal-title":"J. Clin. Gastroenterol."},{"issue":"21","key":"10.1016\/j.biopha.2019.109574_bib0085","doi-asserted-by":"crossref","first-page":"11514","DOI":"10.1073\/pnas.94.21.11514","article-title":"MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily","volume":"94","author":"Bootcov","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.biopha.2019.109574_bib0090","first-page":"2642","article-title":"MIC-1 serum level and genotype: associations with progress and prognosis of colorectal carcinoma","volume":"9","author":"Brown","year":"2003","journal-title":"Clin. Cancer Res."},{"issue":"2","key":"10.1016\/j.biopha.2019.109574_bib0095","doi-asserted-by":"crossref","DOI":"10.15252\/msb.20188636","article-title":"Unsupervised identification of disease states from high-dimensional physiological and histopathological profiles","volume":"15","author":"Shimada","year":"2019","journal-title":"Mol. Syst. Biol."},{"issue":"6","key":"10.1016\/j.biopha.2019.109574_bib0100","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1038\/mi.2017.3","article-title":"Elevated GDF-15 contributes to pulmonary inflammation upon cigarette smoke exposure","volume":"10","author":"Verhamme","year":"2017","journal-title":"Mucosal Immunol."},{"issue":"3","key":"10.1016\/j.biopha.2019.109574_bib0105","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.cmet.2018.07.018","article-title":"The MIC-1\/GDF15-GFRAL pathway in energy homeostasis: implications for obesity, Cachexia, and other associated diseases","volume":"28","author":"Tsai","year":"2018","journal-title":"Cell Metab."},{"issue":"5","key":"10.1016\/j.biopha.2019.109574_bib0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019967","article-title":"Growth differentiation factor 15 is induced by hepatitis C virus infection and regulates hepatocellular carcinoma-related genes","volume":"6","author":"Si","year":"2011","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.biopha.2019.109574_bib0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0127518","article-title":"Association of serum level of growth differentiation factor 15 with liver cirrhosis and hepatocellular carcinoma","volume":"10","author":"Liu","year":"2015","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.biopha.2019.109574_bib0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0179205","article-title":"Panel of three novel serum markers predicts liver stiffness and fibrosis stages in patients with chronic liver disease (vol 12, e0173506, 2017)","volume":"12","author":"Krawczyk","year":"2017","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.biopha.2019.109574_bib0125","doi-asserted-by":"crossref","first-page":"16972","DOI":"10.18632\/oncotarget.15216","article-title":"Growth differentiation factor 15 induces growth and metastasis of human liver cancer stem-like cells via AKT\/GSK-3 beta\/beta-catenin signaling","volume":"8","author":"Xu","year":"2017","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.biopha.2019.109574_bib0130","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.yexcr.2018.07.011","article-title":"Treatment-damaged hepatocellular carcinoma promotes activities of hepatic stellate cells and fibrosis through GDF15","volume":"370","author":"Dong","year":"2018","journal-title":"Exp. Cell Res."},{"issue":"4","key":"10.1016\/j.biopha.2019.109574_bib0135","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/pros.10365","article-title":"Down-regulation of macrophage inhibitory cytokine-1\/prostate derived factor in benign prostatic hyperplasia","volume":"59","author":"Kakehi","year":"2004","journal-title":"Prostate"},{"issue":"16","key":"10.1016\/j.biopha.2019.109574_bib0140","first-page":"5034","article-title":"Macrophage inhibitory cytokine 1 reduces cell adhesion and induces apoptosis in prostate cancer cells","volume":"63","author":"Liu","year":"2003","journal-title":"Cancer Res."},{"issue":"16","key":"10.1016\/j.biopha.2019.109574_bib0145","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1016\/S1470-2045(15)00361-7","article-title":"Prostate cancer screening in men aged 50-69 years (STHLM3): a prospective population-based diagnostic study","volume":"16","author":"Gronberg","year":"2015","journal-title":"Lancet Oncol."},{"issue":"7","key":"10.1016\/j.biopha.2019.109574_bib0150","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1158\/1078-0432.CCR-03-0165","article-title":"Serum macrophage inhibitory cytokine 1 as a marker of pancreatic and other periampullary cancers","volume":"10","author":"Koopmann","year":"2004","journal-title":"Clin. Cancer Res."},{"issue":"6","key":"10.1016\/j.biopha.2019.109574_bib0155","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/annonc\/mdu120","article-title":"GDF15 is a potential predictive biomarker for TPF induction chemotherapy and promotes tumorigenesis and progression in oral squamous cell carcinoma","volume":"25","author":"Yang","year":"2014","journal-title":"Ann. Oncol."},{"issue":"3","key":"10.1016\/j.biopha.2019.109574_bib0160","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1053\/j.gastro.2015.05.038","article-title":"Association between plasma levels of macrophage inhibitory Cytokine-1 before diagnosis of colorectal Cancer and mortality","volume":"149","author":"Mehta","year":"2015","journal-title":"Gastroenterology"},{"issue":"16","key":"10.1016\/j.biopha.2019.109574_bib0165","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1093\/eurheartj\/ehv491","article-title":"Growth differentiation factor-15 level predicts major bleeding and cardiovascular events in patients with acute coronary syndromes: results from the PLATO study","volume":"37","author":"Hagstrom","year":"2016","journal-title":"Eur. Heart J."},{"issue":"4","key":"10.1016\/j.biopha.2019.109574_bib0170","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.clinre.2016.12.009","article-title":"Growth differentiation factor 15 promotes cell viability, invasion, migration, and angiogenesis in human liver carcinoma cell line HepG2","volume":"41","author":"Wang","year":"2017","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"issue":"3","key":"10.1016\/j.biopha.2019.109574_bib0175","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1161\/01.RES.0000207919.83894.9d","article-title":"GDF15, a cardioprotective TGF-beta superfamily protein","volume":"98","author":"Ago","year":"2006","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.biopha.2019.109574_bib0180","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1530\/JME-11-0149","article-title":"Growth differentiation factor-15 upregulates interleukin-6 to promote tumorigenesis of prostate carcinoma PC-3 cells","volume":"49","author":"Tsui","year":"2012","journal-title":"J. Mol. Endocrinol."},{"issue":"13","key":"10.1016\/j.biopha.2019.109574_bib0185","doi-asserted-by":"crossref","first-page":"9817","DOI":"10.1074\/jbc.M010840200","article-title":"Phosphatidylinositol 3-kinase\/AKT-mediated activation of estrogen receptor alpha - A new model for anti-estrogen resistance","volume":"276","author":"Campbell","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2019.109574_bib0190","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.taap.2017.07.016","article-title":"Sex-specific differences in the modulation of Growth Differentiation Factor 15 (GDF15) by hyperoxia in vivo and in vitro: role of Hif-1 alpha","volume":"332","author":"Zhang","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.biopha.2019.109574_bib0195","first-page":"92","article-title":"Preponderance of serum and intra-hepatic 5-Alpha-Dihydrotestosterone in males with hepatocellular-carcinoma despite low circulating androgen levels","volume":"109","author":"Iqbal","year":"1985","journal-title":"Acta Endocrinol."},{"issue":"3","key":"10.1016\/j.biopha.2019.109574_bib0200","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/0016-5085(85)90149-0","article-title":"Serum levels of estrogens and testosterone in cirrhotic men with and without hepatocellular-carcinoma","volume":"88","author":"Nagasue","year":"1985","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.biopha.2019.109574_bib0205","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1159\/000058532","article-title":"Estrogens, testosterone and sex hormone binding globulin in relation to liver cancer in men","volume":"60","author":"Kuper","year":"2001","journal-title":"Oncology"},{"issue":"9","key":"10.1016\/j.biopha.2019.109574_bib0210","first-page":"948","article-title":"Relation between sex hormones and hepatocellular carcinoma","volume":"48","author":"Korah","year":"2016","journal-title":"Andrologia"},{"issue":"2","key":"10.1016\/j.biopha.2019.109574_bib0215","first-page":"139","article-title":"Aromatase and estrogens in man reproduction: a review and latest advances","volume":"53","author":"Carreau","year":"2008","journal-title":"Adv. Med. Sci.-Poland"},{"issue":"4","key":"10.1016\/j.biopha.2019.109574_bib0220","first-page":"790","article-title":"Elevated serum testosterone levels and risk of hepatocellular-carcinoma","volume":"53","author":"Yu","year":"1993","journal-title":"Cancer Res."},{"issue":"24","key":"10.1016\/j.biopha.2019.109574_bib0225","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1093\/jnci\/92.24.2023","article-title":"Androgen-receptor gene CAG repeats, plasma testosterone levels, and risk of hepatitis B-related hepatocellular carcinoma","volume":"92","author":"Yu","year":"2000","journal-title":"J. Natl. Cancer Inst."},{"issue":"6","key":"10.1016\/j.biopha.2019.109574_bib0230","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1002\/hep.20474","article-title":"Randomized trial of leuprorelin and flutamide in male patients with hepatocellular carcinoma treated with tamoxifen","volume":"40","author":"Trinchet","year":"2004","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.biopha.2019.109574_bib0235","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1002\/(SICI)1097-0142(19960215)77:4<635::AID-CNCR8>3.0.CO;2-F","article-title":"Phase II study of flutamide in the treatment of hepatocellular carcinoma","volume":"77","author":"Chao","year":"1996","journal-title":"Cancer"},{"issue":"17","key":"10.1016\/j.biopha.2019.109574_bib0240","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1016\/S0024-3205(99)00427-0","article-title":"Dehydroepiandrosterone (DHEA) facilitates liver regeneration after partial hepatectomy in rats","volume":"65","author":"Kitamura","year":"1999","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.biopha.2019.109574_bib0245","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0303-7207(96)03797-5","article-title":"Effect of testosterone on purine metabolism and morphometric parameters in the rat liver","volume":"119","author":"Vizzotto","year":"1996","journal-title":"Mol. Cell. Endocrinol."},{"issue":"7","key":"10.1016\/j.biopha.2019.109574_bib0250","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1111\/j.1572-0241.2002.05826.x","article-title":"Anabolic-androgenic steroids for alcoholic liver disease: a Cochrane review","volume":"97","author":"Rambaldi","year":"2002","journal-title":"Am. J. Gastroenterol."},{"issue":"5834","key":"10.1016\/j.biopha.2019.109574_bib0255","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1126\/science.1140485","article-title":"Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production","volume":"317","author":"Naugler","year":"2007","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.biopha.2019.109574_bib0260","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.arcmed.2015.11.003","article-title":"Synergistic effect of a physiological ratio of estradiol and testosterone in the treatment of early-stage atherosclerosis","volume":"46","author":"Dai","year":"2015","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.biopha.2019.109574_bib0265","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.tiv.2018.03.018","article-title":"Neuroprotective effect of a physiological ratio of testosterone and estradiol on corticosterone-induced apoptosis in PC12 cells via Traf6\/TAK1 pathway","volume":"50","author":"Peng","year":"2018","journal-title":"Toxicol. In Vitro"}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219351960?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219351960?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:01:55Z","timestamp":1778241715000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332219351960"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":53,"alternative-id":["S0753332219351960"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109574","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circulating levels of growth differentiation factor 15 and sex hormones in male patients with HBV-associated hepatocellular carcinoma","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109574","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s). Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"109574"}}