{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:01:24Z","timestamp":1788188484994,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T00:00:00Z","timestamp":1572393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2017SZ0070"],"award-info":[{"award-number":["2017SZ0070"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2018SZ0104"],"award-info":[{"award-number":["2018SZ0104"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673084"],"award-info":[{"award-number":["81673084"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.biopha.2019.109600","type":"journal-article","created":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T16:56:10Z","timestamp":1573145770000},"page":"109600","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Protective effects of Cordyceps extract against UVB\u2011induced damage and prediction of application prospects in the topical administration: An experimental validation and network pharmacology study"],"prefix":"10.1016","volume":"121","author":[{"given":"Hailun","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai","family":"Ru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xionghong","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianzheng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidan","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2019.109600_bib0005","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nchembio.1548","article-title":"Multifaceted pathways protect human skin from UV radiation","volume":"10","author":"Natarajan","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.biopha.2019.109600_bib0010","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.arr.2015.01.001","article-title":"Oxidation events and skin aging","volume":"21","author":"Kammeyer","year":"2015","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.biopha.2019.109600_bib0015","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.tiv.2019.05.021","article-title":"Phototoxic risk assessment on benzophenone UV filters: in vitro assessment and a theoretical model","volume":"60","author":"Xiong","year":"2019","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.biopha.2019.109600_bib0020","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1038\/nm.2861","article-title":"Ultraviolet radiation damages self noncoding RNA and is detected by TLR3","volume":"18","author":"Bernard","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.biopha.2019.109600_bib0025","first-page":"442","article-title":"Flavin mononucleotide attenuates the UVA-induced up-regulation of matrix-metalloproteinase-1 and skin fibroblast elastase in human dermal fibroblasts","volume":"9","author":"Nakajima","year":"2010","journal-title":"Ski. Res."},{"key":"10.1016\/j.biopha.2019.109600_bib0030","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1016\/j.jid.2016.07.014","article-title":"Activation of TGF-\u03b21 by AQP3-Mediated H2O2 transport into fibroblasts of a bleomycin-induced mouse model of scleroderma","volume":"136","author":"Luo","year":"2016","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.biopha.2019.109600_bib0035","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1016\/j.jid.2017.04.031","article-title":"Regulation of the glycerol transporter, Aquaporin-3, by histone Deacetylase-3 and p53 in keratinocytes","volume":"137","author":"Choudhary","year":"2017","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.biopha.2019.109600_bib0040","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.steroids.2015.04.006","article-title":"On the role of skin in the regulation of local and systemic steroidogenic activities","volume":"103","author":"Slominski","year":"2015","journal-title":"Steroids"},{"key":"10.1016\/j.biopha.2019.109600_bib0045","first-page":"1","article-title":"Optimal sunscreen use, during a sun holiday with a very high ultraviolet index, allows vitamin D synthesis without sunburn","author":"Young","year":"2019","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.biopha.2019.109600_bib0050","first-page":"1","article-title":"Antioxidant effects of bioactive compounds isolated from cordyceps and their protective effects against UVB-irradiated HaCaT cells","author":"Tang","year":"2019","journal-title":"J. Cosmet. Dermatol."},{"key":"10.1016\/j.biopha.2019.109600_bib0055","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1080\/07388551.2018.1531820","article-title":"A breakthrough in the artificial cultivation of Chinese cordyceps on a large-scale and its impact on science, the economy, and industry","volume":"39","author":"Li","year":"2019","journal-title":"Crit. Rev. Biotechnol."},{"key":"10.1016\/j.biopha.2019.109600_bib0060","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2011-12-11-r116","article-title":"Genome sequence of the insect pathogenic fungus Cordyceps militaris, a valued traditional chinese medicine","volume":"12","author":"Zheng","year":"2011","journal-title":"Genome Biol."},{"key":"10.1016\/j.biopha.2019.109600_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2018.101080","article-title":"Particulate matter induces inflammatory cytokine production via activation of NF\u03baB by TLR5-NOX4-ROS signaling in human skin keratinocyte and mouse skin","volume":"21","author":"Ryu","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.biopha.2019.109600_bib0070","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1111\/j.1365-2133.2010.10201.x","article-title":"Photoprotective potential of Cordyceps polysaccharides against ultraviolet B radiation-induced DNA damage to human skin cells","volume":"164","author":"Wong","year":"2011","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.biopha.2019.109600_bib0075","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.biopha.2019.109600_bib0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112074","article-title":"Protective effects and network analysis of natural compounds obtained from Radix dipsaci, Eucommiae cortex, and Rhizoma drynariae against RANKL-induced osteoclastogenesis in vitro","volume":"244","author":"Cheng","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2019.109600_bib0085","doi-asserted-by":"crossref","first-page":"34414","DOI":"10.1074\/jbc.M113.508812","article-title":"Differential phospholipid substrates and directional transport by ATP-binding cassette proteins ABCA1, ABCA7, and ABCA4 and disease-causing mutants","volume":"288","author":"Quazi","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2019.109600_bib0090","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1194\/jlr.M300418-JLR200","article-title":"Molecular interactions between apoE and ABCA1: impact on apoE lipidation","volume":"45","author":"Krimbou","year":"2004","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.biopha.2019.109600_bib0095","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/j.febslet.2007.03.038","article-title":"Expression of ATP binding cassette-transporter ABCG1 prevents cell death by transporting cytotoxic 7\u03b2-hydroxycholesterol","volume":"581","author":"Engel","year":"2007","journal-title":"FEBS Lett."},{"key":"10.1016\/j.biopha.2019.109600_bib0100","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jdermsci.2015.11.005","article-title":"The cross-talk between electrophiles, antioxidant defence and the endocannabinoid system in fibroblasts and keratinocytes after UVA and UVB irradiation","volume":"81","author":"Gegotek","year":"2016","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.biopha.2019.109600_bib0105","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1124\/pr.111.005538","article-title":"Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application","volume":"64","author":"Koppaka","year":"2012","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.biopha.2019.109600_bib0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2164-14-147","article-title":"Comparison of the global gene expression of choroid plexus and meninges and associated vasculature under control conditions and after pronounced hyperthermia or amphetamine toxicity","volume":"14","author":"Bowyer","year":"2013","journal-title":"BMC Genomics"},{"key":"10.1016\/j.biopha.2019.109600_bib0115","doi-asserted-by":"crossref","first-page":"17294","DOI":"10.1073\/pnas.0404743101","article-title":"Targeted disruption of luteinizing hormone \u03b2-subunit leads to hypogonadism, defects in gonadal steroidogenesis, and infertility","volume":"101","author":"Ma","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biopha.2019.109600_bib0120","doi-asserted-by":"crossref","first-page":"39655","DOI":"10.1074\/jbc.M204599200","article-title":"Nek11, a new member of the NIMA family of kinases, involved in DNA replication and genotoxic stress responses","volume":"277","author":"Noguchi","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2019.109600_bib0125","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1136\/gut.2003.026526","article-title":"Absence of PRSS1 mutations and association of SPINK1 trypsin inhibitor mutations in hereditary and non-hereditary chronic pancreatitis","volume":"53","author":"Chandak","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.biopha.2019.109600_bib0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2019.00759","article-title":"Environmental stressors on skin aging. Mechanistic Insights","volume":"10","author":"Parrado","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.biopha.2019.109600_bib0135","doi-asserted-by":"crossref","first-page":"7368","DOI":"10.3390\/molecules19067368","article-title":"The fruits of wampee inhibit H2O2-Induced apoptosis in PC12 cells via the NF-??B pathway and regulation of cellular redox status","volume":"19","author":"Zeng","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2019.109600_bib0140","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1021\/acscentsci.6b00230","article-title":"Mimicking melanosomes: polydopamine nanoparticles as artificial microparasols","volume":"3","author":"Huang","year":"2017","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.biopha.2019.109600_bib0145","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/jcp.21336","article-title":"All-trans retinoic acid attenuates ultraviolet radiation-induced down-regulation of aquaporin-3 and water permeability in human keratinocytes","volume":"215","author":"Cao","year":"2008","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.biopha.2019.109600_bib0150","doi-asserted-by":"crossref","first-page":"8391","DOI":"10.1021\/jf200931t","article-title":"Chrysin protects epidermal keratinocytes from UVA- and UVB-induced damage","volume":"59","author":"Wu","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.biopha.2019.109600_bib0155","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1007\/s12272-014-0482-6","article-title":"EPA attenuates ultraviolet radiation-induced downregulation of aquaporin-3 in human keratinocytes","volume":"38","author":"Jeon","year":"2015","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.biopha.2019.109600_bib0160","doi-asserted-by":"crossref","first-page":"625","DOI":"10.3892\/ijmm.2011.873","article-title":"Kanglaite attenuates UVB-induced down-regulation of aquaporin-3 in cultured human skin keratinocytes","volume":"29","author":"Shan","year":"2012","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.biopha.2019.109600_bib0165","doi-asserted-by":"crossref","DOI":"10.1042\/BCJ20180974","article-title":"Glycolic acid attenuates UVB-induced aquaporin-3, matrix Metalloproteinase-9 expression, and collagen degradation in keratinocytes and mouse skin","author":"Tang","year":"2019","journal-title":"Biochem. J."},{"key":"10.1016\/j.biopha.2019.109600_bib0170","first-page":"1","article-title":"Skin pigmentation-inspired polydopamine sunscreens","volume":"28","author":"Wang","year":"2018","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.biopha.2019.109600_bib0175","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2174\/18715206113139990308","article-title":"Cytochromes P450 and skin cancer: role of local endocrine pathways","volume":"14","author":"Slominski","year":"2014","journal-title":"Anticancer Agents Med. Chem."},{"key":"10.1016\/j.biopha.2019.109600_bib0180","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.fct.2018.12.025","article-title":"Cordycepin, isolated from medicinal fungus Cordyceps sinensis, enhances radiosensitivity of oral cancer associated with modulation of DNA damage repair","volume":"124","author":"Su","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2019.109600_bib0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12944-018-0910-6","article-title":"Cordycepin reduces weight through regulating gut microbiota in high-fat diet-induced obese rats","volume":"17","author":"An","year":"2018","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.biopha.2019.109600_bib0190","article-title":"Cordycepin alleviates hepatic lipid accumulation by inducing protective autophagy via PKA\/mTOR pathway","author":"Li","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2019.109600_bib0195","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.jpba.2009.02.025","article-title":"Analysis of sterols and fatty acids in natural and cultured Cordyceps by one-step derivatization followed with gas chromatography-mass spectrometry","volume":"49","author":"Yang","year":"2009","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.biopha.2019.109600_bib0200","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1615\/IntJMedMushrooms.v17.i3.40","article-title":"Effect of uv-b irradiation on physiologically active substance content and antioxidant properties of the medicinal caterpillar fungus cordyceps militaris (Ascomycetes)","volume":"17","author":"Huang","year":"2015","journal-title":"Int. J. Med. Mushrooms"},{"key":"10.1016\/j.biopha.2019.109600_bib0205","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.fct.2011.12.020","article-title":"Effect of Cordyceps sinensis and taurine either alone or in combination on streptozotocin induced diabetes","volume":"50","author":"El Ashry","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2019.109600_bib0210","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.ijbiomac.2019.03.078","article-title":"Structural characterisation and cholesterol efflux improving capacity of the novel polysaccharides from Cordyceps militaris","volume":"131","author":"Hu","year":"2019","journal-title":"Int. J. Biol. Macromol."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219352229?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332219352229?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:04:42Z","timestamp":1778241882000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332219352229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":42,"alternative-id":["S0753332219352229"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109600","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effects of Cordyceps extract against UVB\u2011induced damage and prediction of application prospects in the topical administration: An experimental validation and network pharmacology study","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2019.109600","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s). Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}],"article-number":"109600"}}